WO2004041433A1 - Multichannel pipette - Google Patents

Multichannel pipette Download PDF

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Publication number
WO2004041433A1
WO2004041433A1 PCT/FI2003/000846 FI0300846W WO2004041433A1 WO 2004041433 A1 WO2004041433 A1 WO 2004041433A1 FI 0300846 W FI0300846 W FI 0300846W WO 2004041433 A1 WO2004041433 A1 WO 2004041433A1
Authority
WO
WIPO (PCT)
Prior art keywords
suction tube
pipette
tip
tips
multichannel pipette
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FI2003/000846
Other languages
French (fr)
Inventor
Osmo Suovaniemi
Pertti Ekholm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biohit Oy
Original Assignee
Biohit Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8564912&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2004041433(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EA200500793A priority Critical patent/EA006476B1/en
Priority to CA2504373A priority patent/CA2504373C/en
Priority to MXPA05004912A priority patent/MXPA05004912A/en
Priority to AU2003276312A priority patent/AU2003276312A1/en
Priority to DK03810487T priority patent/DK1569754T3/en
Application filed by Biohit Oy filed Critical Biohit Oy
Priority to DE60321821T priority patent/DE60321821D1/en
Priority to EP03810487A priority patent/EP1569754B1/en
Priority to JP2004549235A priority patent/JP4451311B2/en
Priority to US10/533,882 priority patent/US20060123929A1/en
Publication of WO2004041433A1 publication Critical patent/WO2004041433A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B01L3/0279—Interchangeable or disposable dispensing tips co-operating with positive ejection means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing

Definitions

  • This invention relates to a suction device using disposable tips, especially to the construction of a pipette.
  • the invention especially relates to a spring mechanism of the pipette's suction tube to assure an even attachment of the disposable tips in a multichannel pipette.
  • Pipettes are commonly used in laboratory work to dose liquids, whereby the disposable pipette tips are attached by a friction join.
  • the tips are cone-shaped plastic items proportional to the liquid volume to be dosed.
  • a tip is attached to the lower end of the slightly tapered suction tube of the pipette, i.e. the end cone, by inserting this into the corresponding taper of the tip.
  • the tip is removed, usually by activating a mechanism for example by the thumb, causing a downward movement of a removing means arranged around the suction tube, whereby the removing means pushes the tip apart from the suction tube.
  • tips In order to assure the compatibility of the disposable tips and the suction tube, tips should be used the dimensions and other features of which are extensively standardized. This can be achieved with reasonable certainty by always using tips from the same manufacturer, preferably from the manufacturer of the pipette. In practice, the quality and the measurement accuracy of the tips used with a given pipette vary so much that problems arise. A tip is picked up for use by inserting the end of the suction tube into a tip in a rack, without the user touching the tip, and the force used determines how well a tip attaches to the pipette.
  • a pipette usually comprises a body and a cylinder and a plunger in the body to accomplish a suction-and-blow effect, and the required push rods and springs for operating the plunger-cylinder system.
  • adjustable volume pipettes there is additionally a mechanism by which the stroke length of the pipette can be adjusted.
  • a multichannel pipette there are several plunger-cylinder systems, i.e. channels, usually parallel, and to each cylinder a suction tube is connected. With one movement by the user, each cylinder is affected simultaneously.
  • a multichannel pipette thus has a group of identical, parallel suction tubes to which tips can be adapted.
  • Liquid is drawn into the tips in a single suction action, and with a sole dosing action the liquid is simultaneously dosed from the tips.
  • the target is a well row of a micro titering plate.
  • the adaptation of the pipette tips is extremely important in a multichannel pipette, especially in certain types of applications.
  • the significance of an even tip height is emphasized when using multichannel pipettes.
  • the tips are usually delivered fitted in an upright position in a rack so that they can be picked up by all suction tubes of a pipette with one movement, without touching them by hand.
  • a tip rack is described for example in US patent 5,392,914.
  • When picking up the tips it is difficult to align the pipette so accurately in the vertical direction at the picking moment, that all the suction tubes of a multichannel pipette would penetrate absolutely evenly into the tips in the rack.
  • the rack may also yield in an uneven manner.
  • the middle tips tend to remain looser than the others, even leading to their disengagement in the middle of an important work phase.
  • the object of this invention is a multichannel pipette, in which the suction tube arrangement is arranged to yield so, that a disposable tip attaches itself to each suction tube in the same way regardless of the shape and flexibility characteristics of the tip rack.
  • a pipette comprises a body and a plunger-cylinder system with suction tubes for each channel.
  • Each suction tube is so adapted to the body, that the suction tube is movable in the vertical direction between two extreme positions with respect to the body. Thus, the suction tube may be pushed into the body up to an innermost position.
  • a resilient member preferably a compression spring, which holds the suction tube in a corresponding outermost position.
  • the suction tube is provided with appropriate shoulders for fitting of the resilient member, and to hold the tube in the body.
  • each suction tube row of a multichannel pipette according to the invention When a suction tube row of a multichannel pipette according to the invention is brought to the upper end of a disposable tip row in a rack, each suction tube is allowed to penetrate so deep into the upper end of the tip that it yields.
  • the spring factor is chosen to correspond to an appropriate fastening position, and because all of the suction tubes are yielding, each tip settles at the same height.
  • the resilient members are specifically designed for a certain type of tip to ensure an even attachment. Then the resilient members may be replaced when changing the tip type.
  • the resilient members are not identical in each channel of the pipette, but so designed that possible differences due to varying picking techniques are compensated.
  • the resilient members of the middle channels may have a higher spring factor than on the sides, to avoid the aforementioned imperfect attachment of the middle tips.
  • Fig. 1 depicts the lower end of an 8-channel pipette. Only one of the eight identical parallel mechanisms (channels) arranged in a common body 1 is shown.
  • the suction tube and the cylinder are parts of the same component 2, which is arranged movably in the pipette body 1 so, that a compression spring 3 holds the suction tube in an outermost position in a state of rest.
  • a plunger 4 is movable in the cylinder 2, and the upper end of the plunger is attached to the common operation mechanism 5 of the channels.
  • the apparatus usually comprises a tip removing mechanism, whose construction is familiar to a person skilled in the art from several prior art publications.
  • each suction tube yields according to a spring 3 when a tip attaches itself to the suction tube. Then, with a high probability, each tip is attached by the same force, regardless of the small angle differences between different tips and suction tubes. Consequently, the tips also with high probability will penetrate to the same depth into the upper ends of the tips, which makes it easier to use a multichannel pipette because the lower ends of the tips will settle on the same level and each extends exactly to the bottom of a well plate.

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

A multichannel pipette, the suction tube arrangement of which is arranged to be resilient, so that a disposable tip is attached similarly to each suction tube regardless of the shape and elastic characteristics of a tip rack. The pipette comprises a body and a plunger-cylinder system with suction tubes for each channel. Each suction tube is thus adapted to the body, that the suction tube is movable between two extreme positions in its vertical direction with respect to the body.

Description

Multichannel pipette
This invention relates to a suction device using disposable tips, especially to the construction of a pipette. The invention especially relates to a spring mechanism of the pipette's suction tube to assure an even attachment of the disposable tips in a multichannel pipette.
Pipettes are commonly used in laboratory work to dose liquids, whereby the disposable pipette tips are attached by a friction join. The tips are cone-shaped plastic items proportional to the liquid volume to be dosed. A tip is attached to the lower end of the slightly tapered suction tube of the pipette, i.e. the end cone, by inserting this into the corresponding taper of the tip. After use, the tip is removed, usually by activating a mechanism for example by the thumb, causing a downward movement of a removing means arranged around the suction tube, whereby the removing means pushes the tip apart from the suction tube.
In order to assure the compatibility of the disposable tips and the suction tube, tips should be used the dimensions and other features of which are extensively standardized. This can be achieved with reasonable certainty by always using tips from the same manufacturer, preferably from the manufacturer of the pipette. In practice, the quality and the measurement accuracy of the tips used with a given pipette vary so much that problems arise. A tip is picked up for use by inserting the end of the suction tube into a tip in a rack, without the user touching the tip, and the force used determines how well a tip attaches to the pipette.
In US-patent 3,853,012, a pipette is described in which a suction tube is adapted under spring tension, so that when the suction tube is pushed with a certain force towards an object, the tube acts against a spring inside the sleeve of the tip remover. Thus, the force by which the suction tube can be pushed against the upper end of a tip is delimited. Thus, the force needed to remove the tip is also delimited.
In addition a pipette usually comprises a body and a cylinder and a plunger in the body to accomplish a suction-and-blow effect, and the required push rods and springs for operating the plunger-cylinder system. In adjustable volume pipettes there is additionally a mechanism by which the stroke length of the pipette can be adjusted. In a multichannel pipette there are several plunger-cylinder systems, i.e. channels, usually parallel, and to each cylinder a suction tube is connected. With one movement by the user, each cylinder is affected simultaneously. A multichannel pipette thus has a group of identical, parallel suction tubes to which tips can be adapted. Liquid is drawn into the tips in a single suction action, and with a sole dosing action the liquid is simultaneously dosed from the tips. Usually the target is a well row of a micro titering plate. In order to achieve an identical liquid transfer to each well on the micro titering plate, the adaptation of the pipette tips is extremely important in a multichannel pipette, especially in certain types of applications.
The significance of an even tip height is emphasized when using multichannel pipettes. The tips are usually delivered fitted in an upright position in a rack so that they can be picked up by all suction tubes of a pipette with one movement, without touching them by hand. Such a tip rack is described for example in US patent 5,392,914. When picking up the tips, it is difficult to align the pipette so accurately in the vertical direction at the picking moment, that all the suction tubes of a multichannel pipette would penetrate absolutely evenly into the tips in the rack. The rack may also yield in an uneven manner. In particular, the middle tips tend to remain looser than the others, even leading to their disengagement in the middle of an important work phase.
It has been attempted to solve the problem for example by designing the tip rack to be convex so, that the upper ends of the tips in the middle protrude above those on the sides. Such a solution is described in the European Patent 1 Oi l 863.
The object of this invention is a multichannel pipette, in which the suction tube arrangement is arranged to yield so, that a disposable tip attaches itself to each suction tube in the same way regardless of the shape and flexibility characteristics of the tip rack.
A pipette comprises a body and a plunger-cylinder system with suction tubes for each channel. Each suction tube is so adapted to the body, that the suction tube is movable in the vertical direction between two extreme positions with respect to the body. Thus, the suction tube may be pushed into the body up to an innermost position. To each suction tube is arranged a resilient member, preferably a compression spring, which holds the suction tube in a corresponding outermost position. The suction tube is provided with appropriate shoulders for fitting of the resilient member, and to hold the tube in the body. When a suction tube row of a multichannel pipette according to the invention is brought to the upper end of a disposable tip row in a rack, each suction tube is allowed to penetrate so deep into the upper end of the tip that it yields. The spring factor is chosen to correspond to an appropriate fastening position, and because all of the suction tubes are yielding, each tip settles at the same height.
According to one embodiment of the invention, the resilient members are specifically designed for a certain type of tip to ensure an even attachment. Then the resilient members may be replaced when changing the tip type.
According to another embodiment of the invention, the resilient members are not identical in each channel of the pipette, but so designed that possible differences due to varying picking techniques are compensated. For example, the resilient members of the middle channels may have a higher spring factor than on the sides, to avoid the aforementioned imperfect attachment of the middle tips.
The invention is described in more detail with reference to the enclosed drawings, where Fig. 1 depicts the lower end of an 8-channel pipette. Only one of the eight identical parallel mechanisms (channels) arranged in a common body 1 is shown. The suction tube and the cylinder are parts of the same component 2, which is arranged movably in the pipette body 1 so, that a compression spring 3 holds the suction tube in an outermost position in a state of rest. A plunger 4 is movable in the cylinder 2, and the upper end of the plunger is attached to the common operation mechanism 5 of the channels. The apparatus usually comprises a tip removing mechanism, whose construction is familiar to a person skilled in the art from several prior art publications.
When picking up the tips 7 (not shown) from the rack, the user can direct the picking movement so, that each suction tube yields according to a spring 3 when a tip attaches itself to the suction tube. Then, with a high probability, each tip is attached by the same force, regardless of the small angle differences between different tips and suction tubes. Consequently, the tips also with high probability will penetrate to the same depth into the upper ends of the tips, which makes it easier to use a multichannel pipette because the lower ends of the tips will settle on the same level and each extends exactly to the bottom of a well plate.

Claims

1. A multichannel pipette comprising a body and a group of cylinder-plunger systems, whereat to each cylinder a cone-shaped suction tube is attached to which a disposable tip can be adapted, characterized in that the suction tube is arranged movably in its vertical direction with respect to the body between an outermost and an innermost position so, that with each suction tube a resilient member is arranged to force the suction tube to its outermost position.
2. A multichannel pipette according to claim 1 , characterized in that the resilient member is a compression spring.
3. A multichannel pipette according to claim 1 or 2, characterized in that the resilient members in the separate channels are similar and designed for a certain disposable tip type.
4. A multichannel pipette according to claim 1 or 2, characterized in that the resilient members in different channels are different.
PCT/FI2003/000846 2002-11-08 2003-11-07 Multichannel pipette Ceased WO2004041433A1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US10/533,882 US20060123929A1 (en) 2002-11-08 2003-11-07 Multichannel pipette
CA2504373A CA2504373C (en) 2002-11-08 2003-11-07 Multichannel pipette
MXPA05004912A MXPA05004912A (en) 2002-11-08 2003-11-07 MULTICHANNEL PIPETTE.
AU2003276312A AU2003276312A1 (en) 2002-11-08 2003-11-07 Multichannel pipette
DK03810487T DK1569754T3 (en) 2002-11-08 2003-11-07 A multichannel pipette
EA200500793A EA006476B1 (en) 2002-11-08 2003-11-07 Multichannel pipette
DE60321821T DE60321821D1 (en) 2002-11-08 2003-11-07 MULTICHANNEL PIPETTE
EP03810487A EP1569754B1 (en) 2002-11-08 2003-11-07 Multichannel pipette
JP2004549235A JP4451311B2 (en) 2002-11-08 2003-11-07 Multichannel pipette

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20022003A FI120861B (en) 2002-11-08 2002-11-08 a multichannel pipette,
FI20022003 2002-11-08

Publications (1)

Publication Number Publication Date
WO2004041433A1 true WO2004041433A1 (en) 2004-05-21

Family

ID=8564912

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI2003/000846 Ceased WO2004041433A1 (en) 2002-11-08 2003-11-07 Multichannel pipette

Country Status (16)

Country Link
US (1) US20060123929A1 (en)
EP (1) EP1569754B1 (en)
JP (1) JP4451311B2 (en)
KR (1) KR100937762B1 (en)
CN (1) CN1711137A (en)
AT (1) ATE399057T1 (en)
AU (1) AU2003276312A1 (en)
CA (1) CA2504373C (en)
DE (1) DE60321821D1 (en)
DK (1) DK1569754T3 (en)
EA (1) EA006476B1 (en)
ES (1) ES2308037T3 (en)
FI (1) FI120861B (en)
MX (1) MXPA05004912A (en)
PL (1) PL202091B1 (en)
WO (1) WO2004041433A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU211590U1 (en) * 2021-11-08 2022-06-15 Федеральное государственное бюджетное образовательное учреждение высшего образования "Курская государственная сельскохозяйственная академия имени И.И. Иванова" Device for microencapsulation of substances in liquid state

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PL2633913T3 (en) * 2012-03-01 2020-03-31 Eppendorf Ag Pipette device and multi-channel pipette device
KR102041217B1 (en) * 2012-05-30 2019-11-07 주식회사 미코바이오메드 Multi-channel device for downwardly injecting liquid sample, device for extracting nucleic acid comprising the same, and method for extracting nucleic acid using the same
USD772426S1 (en) 2014-01-13 2016-11-22 Gilson, Inc. Pipette system cartridge
KR101964547B1 (en) 2018-01-31 2019-04-01 이충구 Meet Cutting Case
RU204989U1 (en) * 2020-10-06 2021-06-22 Федеральное государственное бюджетное образовательное учреждение высшего образования "Курская государственная сельскохозяйственная академия имени И.И. Иванова" Device for microencapsulation of liquid substances

Citations (4)

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Publication number Priority date Publication date Assignee Title
US3855868A (en) * 1972-02-10 1974-12-24 O Sudvaniemi Multiple pipette
DE19708151A1 (en) * 1997-02-28 1998-09-10 Eppendorf Geraetebau Netheler Pipette
WO1999064159A1 (en) * 1998-06-10 1999-12-16 Biohit Oyj Suction device with means for removing a replaceable tip
US20020053245A1 (en) * 1998-04-09 2002-05-09 Ccs Packard, Inc. Dispensing apparatus having means for loading pipette tips in a dispense head

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US4478094A (en) * 1983-01-21 1984-10-23 Cetus Corporation Liquid sample handling system
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US4824642A (en) * 1986-10-21 1989-04-25 Costar Corporation Multi-channel pipetter
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US5392914A (en) * 1993-09-21 1995-02-28 Rainin Instrument Co., Inc. Refill pack for pipette tip racks
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CA2183638C (en) * 1995-03-20 2001-03-20 Precision System Science Co., Ltd Liquid processing method making use of pipette device and apparatus for same
JP2945848B2 (en) * 1995-04-12 1999-09-06 アロカ株式会社 Dispensing device
JPH09127134A (en) * 1995-11-06 1997-05-16 Sanyo Electric Co Ltd Dispensing head for dispensation device
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Publication number Priority date Publication date Assignee Title
US3855868A (en) * 1972-02-10 1974-12-24 O Sudvaniemi Multiple pipette
DE19708151A1 (en) * 1997-02-28 1998-09-10 Eppendorf Geraetebau Netheler Pipette
US20020053245A1 (en) * 1998-04-09 2002-05-09 Ccs Packard, Inc. Dispensing apparatus having means for loading pipette tips in a dispense head
WO1999064159A1 (en) * 1998-06-10 1999-12-16 Biohit Oyj Suction device with means for removing a replaceable tip

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU211590U1 (en) * 2021-11-08 2022-06-15 Федеральное государственное бюджетное образовательное учреждение высшего образования "Курская государственная сельскохозяйственная академия имени И.И. Иванова" Device for microencapsulation of substances in liquid state

Also Published As

Publication number Publication date
ATE399057T1 (en) 2008-07-15
AU2003276312A1 (en) 2004-06-07
EP1569754B1 (en) 2008-06-25
MXPA05004912A (en) 2005-07-22
JP2006505392A (en) 2006-02-16
DK1569754T3 (en) 2008-10-06
ES2308037T3 (en) 2008-12-01
PL202091B1 (en) 2009-06-30
CA2504373A1 (en) 2004-05-21
EP1569754A1 (en) 2005-09-07
DE60321821D1 (en) 2008-08-07
EA006476B1 (en) 2005-12-29
FI20022003A0 (en) 2002-11-08
KR20050084989A (en) 2005-08-29
PL376711A1 (en) 2006-01-09
FI120861B (en) 2010-04-15
CA2504373C (en) 2011-10-11
EA200500793A1 (en) 2005-10-27
JP4451311B2 (en) 2010-04-14
US20060123929A1 (en) 2006-06-15
FI20022003L (en) 2004-05-09
KR100937762B1 (en) 2010-01-20
CN1711137A (en) 2005-12-21

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