WO2004051697A3 - Apparatus for dispensing a sample in electrospray mass spectrometers - Google Patents

Apparatus for dispensing a sample in electrospray mass spectrometers Download PDF

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Publication number
WO2004051697A3
WO2004051697A3 PCT/EP2003/013328 EP0313328W WO2004051697A3 WO 2004051697 A3 WO2004051697 A3 WO 2004051697A3 EP 0313328 W EP0313328 W EP 0313328W WO 2004051697 A3 WO2004051697 A3 WO 2004051697A3
Authority
WO
WIPO (PCT)
Prior art keywords
sample
microstructures
dispensing
mass spectrometers
electrospray mass
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2003/013328
Other languages
French (fr)
Other versions
WO2004051697A2 (en
Inventor
Joel Stephane Rossier
Frederic Reymond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DiagnoSwiss SA
Original Assignee
DiagnoSwiss SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DiagnoSwiss SA filed Critical DiagnoSwiss SA
Priority to EP03812160A priority Critical patent/EP1576642B1/en
Priority to JP2004556196A priority patent/JP2006505797A/en
Priority to DE60312220T priority patent/DE60312220T2/en
Priority to AU2003302509A priority patent/AU2003302509A1/en
Priority to US10/534,301 priority patent/US7265348B2/en
Publication of WO2004051697A2 publication Critical patent/WO2004051697A2/en
Anticipated expiration legal-status Critical
Publication of WO2004051697A3 publication Critical patent/WO2004051697A3/en
Ceased legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0013—Miniaturised spectrometers, e.g. having smaller than usual scale, integrated conventional components
    • H01J49/0018—Microminiaturised spectrometers, e.g. chip-integrated devices, Micro-Electro-Mechanical Systems [MEMS]
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • H01J49/167—Capillaries and nozzles specially adapted therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

The present invention relates to an apparatus to dispense a sample for subsequent electrospray ionisation (ESI) mass spectrometry (MS) analysis, to a method of fabricating such apparatus and to applications of such apparatus in biological and chemical analysis. The apparatus consists of an electrically non-conductive substrate (100) comprising at least two covered microstructures (1, 2) (generally microchannels) having one extremity (6) formed at the edge of the substrate, one of said microstructures containing the sample to be dispensed into a mass spectrometer by electrospray ionisation and at least a second of said microstructure containing a fluid used as sheath liquid or sheath gas, said at least two microstructures (1, 2) being formed in such a manner that the sample and the sheath liquid/gas come in contact to each other and/or are mixed directly in the Taylor cone of the spray.
PCT/EP2003/013328 2002-11-08 2003-11-07 Apparatus for dispensing a sample in electrospray mass spectrometers Ceased WO2004051697A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP03812160A EP1576642B1 (en) 2002-11-08 2003-11-07 Apparatus for dispensing a sample in electrospray mass spectrometers
JP2004556196A JP2006505797A (en) 2002-11-08 2003-11-07 Sample dispensing device in electrospray mass spectrometer
DE60312220T DE60312220T2 (en) 2002-11-08 2003-11-07 DEVICE FOR GIVING A SAMPLE IN ELECTROSPRAY MASS SPECTROMETERS
AU2003302509A AU2003302509A1 (en) 2002-11-08 2003-11-07 Apparatus for dispensing a sample in electrospray mass spectrometers
US10/534,301 US7265348B2 (en) 2002-11-08 2003-11-07 Apparatus for dispensing a sample in electrospray mass spectrometers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0226160.0 2002-11-08
GBGB0226160.0A GB0226160D0 (en) 2002-11-08 2002-11-08 Apparatus for dispensing a sample in electrospray mass spectrometers

Publications (2)

Publication Number Publication Date
WO2004051697A2 WO2004051697A2 (en) 2004-06-17
WO2004051697A3 true WO2004051697A3 (en) 2005-09-29

Family

ID=9947512

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/013328 Ceased WO2004051697A2 (en) 2002-11-08 2003-11-07 Apparatus for dispensing a sample in electrospray mass spectrometers

Country Status (7)

Country Link
US (1) US7265348B2 (en)
EP (1) EP1576642B1 (en)
JP (1) JP2006505797A (en)
AU (1) AU2003302509A1 (en)
DE (1) DE60312220T2 (en)
GB (1) GB0226160D0 (en)
WO (1) WO2004051697A2 (en)

Cited By (2)

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US7391020B2 (en) 2004-09-21 2008-06-24 Luc Bousse Electrospray apparatus with an integrated electrode
RU2608366C2 (en) * 2014-12-05 2017-01-18 Общество с ограниченной ответственностью "Альфа" (ООО "Альфа") Method for stable electrospraying of solutions in source of ions at atmospheric pressure

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US7495210B2 (en) * 2006-05-04 2009-02-24 Agilent Technologies, Inc. Micro fluidic gas assisted ionization device and method
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US8242441B2 (en) * 2009-12-18 2012-08-14 Thermo Finnigan Llc Apparatus and methods for pneumatically-assisted electrospray emitter array
US8207496B2 (en) 2010-02-05 2012-06-26 Thermo Finnigan Llc Multi-needle multi-parallel nanospray ionization source for mass spectrometry
US8309916B2 (en) 2010-08-18 2012-11-13 Thermo Finnigan Llc Ion transfer tube having single or multiple elongate bore segments and mass spectrometer system
US8847154B2 (en) 2010-08-18 2014-09-30 Thermo Finnigan Llc Ion transfer tube for a mass spectrometer system
WO2013003795A1 (en) * 2011-06-29 2013-01-03 The Regents Of The University Of California Multinozzle emitter arrays for ultrahigh-throughput nanoelectrospray mass spectrometry
CN104081494B (en) 2012-01-06 2016-12-28 洛桑联邦理工学院 electrostatic spray ionization method
US9903845B2 (en) * 2012-02-13 2018-02-27 Waters Technologies Corporation Ionization of analyte molecules comprised in a flow of gas
US9058966B2 (en) * 2012-09-07 2015-06-16 Canon Kabushiki Kaisha Ionization device, mass spectrometer including ionization device, image display system including mass spectrometer, and analysis method
HK1226142A1 (en) * 2013-08-29 2017-09-22 University Of Notre Dame Du Lac High sensitivity electrospray interface
US10933636B2 (en) * 2013-12-06 2021-03-02 Palo Alto Research Center Incorporated Print head design for ballistic aerosol marking with smooth particulate injection from an array of inlets into a matching array of microchannels
DE102015117365A1 (en) * 2014-10-14 2016-04-14 Waters Technologies Corporation IMPROVED DETECTION SENSITIVITY IN ELECTROSPRAY IONIZATION MASS SPECTROMETRY USING A COLUMN-ADJUSTED MODIFYER AND MICROFLUIDIC DEVICE
GB2553937B (en) 2015-03-06 2022-06-08 Micromass Ltd Improved ionisation of gaseous samples
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WO2016142693A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited In vivo endoscopic tissue identification tool
US10777397B2 (en) 2015-03-06 2020-09-15 Micromass Uk Limited Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry (“REIMS”) device
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GB2552602B (en) 2015-03-06 2020-12-30 Micromass Ltd Desorption electrospray ionisation mass spectrometry ("DESI-MS") analysis of swabs
US11289320B2 (en) 2015-03-06 2022-03-29 Micromass Uk Limited Tissue analysis by mass spectrometry or ion mobility spectrometry
US11342170B2 (en) 2015-03-06 2022-05-24 Micromass Uk Limited Collision surface for improved ionisation
GB2551669B (en) 2015-03-06 2021-04-14 Micromass Ltd Physically guided rapid evaporative ionisation mass spectrometry ("Reims")
EP3265823B1 (en) 2015-03-06 2020-05-06 Micromass UK Limited Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue
GB2556436B (en) 2015-03-06 2022-01-26 Micromass Ltd Cell population analysis
GB2554206B (en) 2015-03-06 2021-03-24 Micromass Ltd Spectrometric analysis of microbes
WO2016142675A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Imaging guided ambient ionisation mass spectrometry
EP3741303A3 (en) 2015-03-06 2020-12-30 Micromass UK Limited Chemically guided ambient ionisation mass spectrometry
GB201517195D0 (en) 2015-09-29 2015-11-11 Micromass Ltd Capacitively coupled reims technique and optically transparent counter electrode
US10329079B2 (en) 2015-10-06 2019-06-25 Hamilton Sundstrand Corporation Aerosol/solvent delivery nozzles
EP3957986B1 (en) 2015-11-30 2024-09-18 Intabio, Llc Methods for sample characterization
WO2017178833A1 (en) 2016-04-14 2017-10-19 Micromass Uk Limited Spectrometric analysis of plants
WO2019148198A1 (en) * 2018-01-29 2019-08-01 Intabio, Inc. Devices, methods and kits for sample characterization
US11998907B2 (en) * 2018-04-11 2024-06-04 The Trustees Of Indiana University Cartridges, systems and methods for mass spectrometry
GB201807914D0 (en) * 2018-05-16 2018-06-27 Micromass Ltd Impactor spray or electrospray ionisation ion source
CN112534549B (en) * 2018-05-31 2025-03-21 因塔生物有限责任公司 Software for coupling microfluidics systems to mass spectrometry
US12594557B2 (en) 2019-08-12 2026-04-07 Intabio, Llc Isoelectric focusing devices and fixtures
US11285484B2 (en) 2019-08-12 2022-03-29 Intabio, Llc Multichannel isoelectric focusing devices and high voltage power supplies
JP7759895B2 (en) * 2020-04-28 2025-10-24 インタバイオ， エルエルシー Microfluidic device with gas channels for sample atomization
CN111889155B (en) * 2020-08-25 2025-01-03 苏州福鲁特分精密仪器有限公司 A multi-channel electrospray microfluidic chip and its application
CN113083386B (en) * 2021-04-02 2023-04-18 重庆大学 Simple and rapid discretization chip for liquid sample and using method thereof

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Patent Citations (2)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7391020B2 (en) 2004-09-21 2008-06-24 Luc Bousse Electrospray apparatus with an integrated electrode
RU2608366C2 (en) * 2014-12-05 2017-01-18 Общество с ограниченной ответственностью "Альфа" (ООО "Альфа") Method for stable electrospraying of solutions in source of ions at atmospheric pressure

Also Published As

Publication number Publication date
DE60312220D1 (en) 2007-04-12
US7265348B2 (en) 2007-09-04
GB0226160D0 (en) 2002-12-18
US20060113463A1 (en) 2006-06-01
EP1576642A3 (en) 2005-11-16
EP1576642A2 (en) 2005-09-21
AU2003302509A8 (en) 2004-06-23
AU2003302509A1 (en) 2004-06-23
EP1576642B1 (en) 2007-02-28
WO2004051697A2 (en) 2004-06-17
JP2006505797A (en) 2006-02-16
DE60312220T2 (en) 2007-11-15

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