WO2004065556A3 - Pet family of efflux proteins - Google Patents

Pet family of efflux proteins Download PDF

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Publication number
WO2004065556A3
WO2004065556A3 PCT/US2004/001552 US2004001552W WO2004065556A3 WO 2004065556 A3 WO2004065556 A3 WO 2004065556A3 US 2004001552 W US2004001552 W US 2004001552W WO 2004065556 A3 WO2004065556 A3 WO 2004065556A3
Authority
WO
WIPO (PCT)
Prior art keywords
efflux proteins
family
carboxylic acids
pet family
aromatic carboxylic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/001552
Other languages
French (fr)
Other versions
WO2004065556A2 (en
Inventor
Fateme Sima Sariaslani
Dyk Tina K Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Priority to JP2006501074A priority Critical patent/JP2006525793A/en
Priority to EP04703083A priority patent/EP1592654A2/en
Publication of WO2004065556A2 publication Critical patent/WO2004065556A2/en
Publication of WO2004065556A3 publication Critical patent/WO2004065556A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention provides methods of increasing the production of aromatic carboxylic acids from a host cell via manipulation of the yhcRQP operon encoding a family of efflux proteins. Up-regulation of all or a sub-set of the genes in the yhcRQP were additionally found to enhance tolerance to aromatic carboxylic acids toxicity.
PCT/US2004/001552 2003-01-17 2004-01-16 Pet family of efflux proteins Ceased WO2004065556A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2006501074A JP2006525793A (en) 2003-01-17 2004-01-16 PET family of efflux proteins
EP04703083A EP1592654A2 (en) 2003-01-17 2004-01-16 Pet family of efflux proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44076003P 2003-01-17 2003-01-17
US60/440,760 2003-01-17

Publications (2)

Publication Number Publication Date
WO2004065556A2 WO2004065556A2 (en) 2004-08-05
WO2004065556A3 true WO2004065556A3 (en) 2004-12-29

Family

ID=32771857

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/001552 Ceased WO2004065556A2 (en) 2003-01-17 2004-01-16 Pet family of efflux proteins

Country Status (4)

Country Link
US (2) US7279321B2 (en)
EP (1) EP1592654A2 (en)
JP (1) JP2006525793A (en)
WO (1) WO2004065556A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1752532A1 (en) 2005-08-09 2007-02-14 Helmholtz-Zentrum für Infektionsforschung GmbH Extracellular polyhydroxyalkanoates produced by genetically engineered microorganisms
JP2009278865A (en) * 2006-07-31 2009-12-03 Kinki Univ Method for amplification of dna fragment
CA2693084A1 (en) * 2007-06-08 2008-12-18 Benjamin S. Bower Heterologous and homologous cellulase expression system
EP4159866A1 (en) * 2018-12-26 2023-04-05 Daesang Corporation E. coli variant strain or corynebacterium glutamicum variant strain producing l-amino acids, and method for producing l-amino acids using same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3115340B2 (en) 1990-02-28 2000-12-04 サントリー株式会社 Fusaric acid resistance gene
EP1032677A1 (en) 1997-10-31 2000-09-06 E.I. Du Pont De Nemours And Company A gene encoding a putative efflux protein for solvents/antibiotics in pseudomonas mendocina
US6368837B1 (en) 1999-08-06 2002-04-09 E. I. Du Pont Nemours And Company Bioproduction of para-hydroxycinnamic acid
US6521748B2 (en) 1999-08-06 2003-02-18 E. I. Du Pont De Nemours And Company Polynucleotide encoding a mutant Rhodotorula glutinis tyrosine ammonia lyase polypeptide

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LI XIAN-ZHI ET AL: "Role of the multidrug efflux systems of Pseudomonas aeruginosa in organic solvent tolerance", JOURNAL OF BACTERIOLOGY, vol. 180, no. 11, June 1998 (1998-06-01), pages 2987 - 2991, XP002296733, ISSN: 0021-9193 *
RAMOS JUAN L ET AL: "Efflux pumps involved in Toluene tolerance in Pseudomonas putida DOT-T1E", JOURNAL OF BACTERIOLOGY, vol. 180, no. 13, July 1998 (1998-07-01), pages 3323 - 3329, XP002296734, ISSN: 0021-9193 *
RAMOS JUAN L ET AL: "Mechanisms of solvent tolerance in gram-negative bacteria.", ANNUAL REVIEW OF MICROBIOLOGY. VOLUME 56 ANNUAL REVIEWS, 4139 EL CAMINO WAY, P. O. BOX 10139, PALO ALTO, CA, 94303-0139, USA SERIES : ANNUAL REVIEW OF MICROBIOLOGY (ISSN 0066-4227), 2002, pages 743 - 768, XP002296735, ISSN: 0-8243-1156-6 *

Also Published As

Publication number Publication date
EP1592654A2 (en) 2005-11-09
US7279321B2 (en) 2007-10-09
JP2006525793A (en) 2006-11-16
US20070298473A1 (en) 2007-12-27
WO2004065556A2 (en) 2004-08-05
US20040147000A1 (en) 2004-07-29

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