WO2004079444A3 - Method and device for time-gated amplification of photons - Google Patents

Method and device for time-gated amplification of photons Download PDF

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Publication number
WO2004079444A3
WO2004079444A3 PCT/IB2004/000555 IB2004000555W WO2004079444A3 WO 2004079444 A3 WO2004079444 A3 WO 2004079444A3 IB 2004000555 W IB2004000555 W IB 2004000555W WO 2004079444 A3 WO2004079444 A3 WO 2004079444A3
Authority
WO
WIPO (PCT)
Prior art keywords
amplification
photons
time
pulse
signal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2004/000555
Other languages
French (fr)
Other versions
WO2004079444A2 (en
Inventor
Tim Nielsen
Sascha Krueger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Philips Intellectual Property and Standards GmbH
Koninklijke Philips NV
Original Assignee
Philips Intellectual Property and Standards GmbH
Koninklijke Philips Electronics NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philips Intellectual Property and Standards GmbH, Koninklijke Philips Electronics NV filed Critical Philips Intellectual Property and Standards GmbH
Priority to US10/547,589 priority Critical patent/US20060187533A1/en
Priority to EP04716665A priority patent/EP1604243A2/en
Priority to JP2006506277A priority patent/JP2006523376A/en
Publication of WO2004079444A2 publication Critical patent/WO2004079444A2/en
Publication of WO2004079444A3 publication Critical patent/WO2004079444A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01S—DEVICES USING THE PROCESS OF LIGHT AMPLIFICATION BY STIMULATED EMISSION OF RADIATION [LASER] TO AMPLIFY OR GENERATE LIGHT; DEVICES USING STIMULATED EMISSION OF ELECTROMAGNETIC RADIATION IN WAVE RANGES OTHER THAN OPTICAL
    • H01S3/00—Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
    • H01S3/10—Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating
    • H01S3/102—Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating by controlling the active medium, e.g. by controlling the processes or apparatus for excitation
    • H01S3/1022—Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating by controlling the active medium, e.g. by controlling the processes or apparatus for excitation by controlling the optical pumping
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0073—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by tomography, i.e. reconstruction of 3D images from 2D projections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • G—PHYSICS
    • G02—OPTICS
    • G02F—OPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
    • G02F1/00—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
    • G02F1/35—Non-linear optics
    • G02F1/39—Non-linear optics for parametric generation or amplification of light, infrared or ultraviolet waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis
    • A61B5/7285—Specific aspects of physiological measurement analysis for synchronizing or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/54—Control of apparatus or devices for radiation diagnosis
    • A61B6/541—Control of apparatus or devices for radiation diagnosis involving acquisition triggered by a physiological signal
    • G—PHYSICS
    • G02—OPTICS
    • G02F—OPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
    • G02F2203/00—Function characteristic
    • G02F2203/26—Pulse shaping; Apparatus or methods therefor

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Nonlinear Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Electromagnetism (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Lasers (AREA)
  • X-Ray Techniques (AREA)

Abstract

The invention relates to a method for the selective amplification of signal photons of a signal pulse (4) in a desired time window. For this purpose, the signal photons (4) are passed through an activated amplification medium (1), where amplification takes place by induced emissions. The amplification is terminated at a desired point in time by the irradiation of a quench pulse (7). Optionally, the start of amplification can be determined by an irradiated pump pulse (8). Emissions that are not correlated with the signal pulse (4) can be suppressed by means of a spectral filter (2). Furthermore, an intensity filter such as a saturable absorber (3) can suppress unamplified fractions of the emission (5) leaving the amplification medium (1). Applications of the method include medical optical imaging and tomography by transillumination with time-gated detection of ballistic photons.
PCT/IB2004/000555 2003-03-07 2004-03-03 Method and device for time-gated amplification of photons Ceased WO2004079444A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/547,589 US20060187533A1 (en) 2003-03-07 2004-03-03 Method and device for time-gated amplification of photons
EP04716665A EP1604243A2 (en) 2003-03-07 2004-03-03 Method and device for time-gated amplification of photons
JP2006506277A JP2006523376A (en) 2003-03-07 2004-03-03 Apparatus and method for selective amplification of photons in a time window

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03100569.7 2003-03-07
EP03100569 2003-03-07

Publications (2)

Publication Number Publication Date
WO2004079444A2 WO2004079444A2 (en) 2004-09-16
WO2004079444A3 true WO2004079444A3 (en) 2004-11-11

Family

ID=32946924

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/000555 Ceased WO2004079444A2 (en) 2003-03-07 2004-03-03 Method and device for time-gated amplification of photons

Country Status (4)

Country Link
US (1) US20060187533A1 (en)
EP (1) EP1604243A2 (en)
JP (1) JP2006523376A (en)
WO (1) WO2004079444A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078039A1 (en) * 2003-03-07 2004-09-16 Philips Intellectual Property & Standards Gmbh Device and method for locating an instrument within a body
DE102005045907B4 (en) * 2005-09-26 2014-05-22 Siemens Aktiengesellschaft Device for displaying a tissue containing a fluorescent dye
DE102007039111B4 (en) * 2007-08-18 2014-11-20 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. STED fluorescence microscopy with two-photon excitation
JP5571407B2 (en) * 2010-02-17 2014-08-13 アズビル株式会社 Measuring system and measuring method
US9486142B2 (en) 2010-12-13 2016-11-08 The Trustees Of Columbia University In The City Of New York Medical imaging devices, methods, and systems
GB201611819D0 (en) * 2016-07-07 2016-08-17 Univ Court Of The Univ Of Edinburgh The Imaging method and apparatus
US10219700B1 (en) 2017-12-15 2019-03-05 Hi Llc Systems and methods for quasi-ballistic photon optical coherence tomography in diffusive scattering media using a lock-in camera detector
US10368752B1 (en) 2018-03-08 2019-08-06 Hi Llc Devices and methods to convert conventional imagers into lock-in cameras
US11857316B2 (en) 2018-05-07 2024-01-02 Hi Llc Non-invasive optical detection system and method

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0926783A1 (en) * 1997-12-23 1999-06-30 PIRELLI CAVI E SISTEMI S.p.A. Optical rectangular pulse generator

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
US4751707A (en) * 1986-07-03 1988-06-14 Mcdonnell Douglas Corporation Laser diode array exhibiting transverse lasing
US4825442A (en) * 1988-04-19 1989-04-25 U.S. Government As Represented By Director, National Security Agency Planar optical logic
JPH0357288A (en) * 1989-07-17 1991-03-12 Siemens Ag Devices with semiconductor lasers and their usage
US5089711A (en) * 1990-01-19 1992-02-18 California Jamar, Incorporated Laser plasma X-ray source
US5003543A (en) * 1990-01-19 1991-03-26 California Jamar, Incorporated Laser plasma X-ray source
US5604628A (en) * 1994-12-30 1997-02-18 Cornell Research Foundation, Inc. Optical laser amplifier combined with a spontaneous emission filter
JP2907185B2 (en) * 1997-04-18 1999-06-21 日本電気株式会社 Drive device for optical modulator, drive device for modulator-integrated light source, optical communication module and optical communication system having the same
JP2000214506A (en) * 1998-11-03 2000-08-04 Toshiba Research Europe Ltd Radiation light source and image pickup system
US6445491B2 (en) * 1999-01-29 2002-09-03 Irma America, Inc. Method and apparatus for optical sectioning and imaging using time-gated parametric image amplification
US6331990B1 (en) * 1999-02-01 2001-12-18 The United States Of America As Represented By The Secretary Of The Air Force Demodulating and amplifying systems of lasers with optical gain control (DAS-LOGiC)
US6335943B1 (en) * 1999-07-27 2002-01-01 Lockheed Martin Corporation System and method for ultrasonic laser testing using a laser source to generate ultrasound having a tunable wavelength
KR20010088004A (en) * 2000-03-10 2001-09-26 윤종용 Wavelength converter
US6867903B2 (en) * 2000-03-21 2005-03-15 Nippon Telegraph And Telephone Corporation Optical parametric circuit

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0926783A1 (en) * 1997-12-23 1999-06-30 PIRELLI CAVI E SISTEMI S.p.A. Optical rectangular pulse generator

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HEBDEN J C ET AL: "OPTICAL IMAGING IN MEDICINE: I. EXPERIMENTAL TECHNIQUES", PHYSICS IN MEDICINE AND BIOLOGY, TAYLOR AND FRANCIS LTD. LONDON, GB, vol. 42, no. 5, 1 May 1997 (1997-05-01), pages 825 - 840, XP000690608, ISSN: 0031-9155 *
LANDEN O L ET AL: "ULTRAFAST GAIN QUENCHING IN LASER AMPLIFIERS", OPTICS LETTERS, OPTICAL SOCIETY OF AMERICA, vol. 16, no. 8, 15 April 1991 (1991-04-15), WASHINGTON, US, pages 590 - 592, XP000202040, ISSN: 0146-9592 *
MARENGO S ET AL: "TIME-GATED TRANSILLUMINATION OF OBJECTS IN HIGHLY SCATTERING MEDIA USING A SUBPICOSECOND OPTICAL AMPLIFIER", IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, IEEE SERVICE CENTER, US, vol. 5, no. 4, July 1999 (1999-07-01), pages 895 - 900, XP000893452, ISSN: 1077-260X *
MINOSHIMA K ET AL: "THREE-DIMENSIONAL IMAGING USING A FEMTOSECOND AMPLIFYING OPTICAL KERR GATE", OPTICAL ENGINEERING, SOC. OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS. BELLINGHAM, US, vol. 38, no. 10, October 1999 (1999-10-01), pages 1758 - 1762, XP000859865, ISSN: 0091-3286 *

Also Published As

Publication number Publication date
EP1604243A2 (en) 2005-12-14
US20060187533A1 (en) 2006-08-24
JP2006523376A (en) 2006-10-12
WO2004079444A2 (en) 2004-09-16

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