|
US5897992A
(en)
|
1996-09-27 |
1999-04-27 |
Cold Spring Harbor Laboratory |
Cell-free assay using oncogene-induced apoptosis in drug-resistant cells
|
|
US20030068382A1
(en)
|
1999-05-18 |
2003-04-10 |
Samuel Rose |
Method and composition for the treatment of cancer by the enzymatic conversion of soluble radioactive toxic agents into radioactive toxic precipitates in the cancer
|
|
US7807136B2
(en)
|
1997-01-13 |
2010-10-05 |
David S. Rose |
Method and composition for the treatment of cancer by the enzymatic conversion of soluble radioactive toxic precipitates in the cancer
|
|
US6555339B1
(en)
|
1997-04-14 |
2003-04-29 |
Arena Pharmaceuticals, Inc. |
Non-endogenous, constitutively activated human protein-coupled receptors
|
|
JP2002508660A
(en)
|
1997-06-12 |
2002-03-19 |
スミスクライン ビーチャム コーポレーション |
HM74A receptor
|
|
US20040137563A9
(en)
|
1998-10-13 |
2004-07-15 |
Ruoping Chen |
Endogenous and non-endogenous versions of human G protein-coupled receptors
|
|
CA2371093A1
(en)
|
1999-04-26 |
2000-11-02 |
David M. Manyak |
Receptor selectivity mapping
|
|
US20040117125A1
(en)
|
1999-04-26 |
2004-06-17 |
Hao Chen |
Drug discovery method and apparatus
|
|
US20020187514A1
(en)
|
1999-04-26 |
2002-12-12 |
Hao Chen |
Identification of molecular targets useful in treating substance abuse and addiction
|
|
US6955873B1
(en)
|
2000-08-04 |
2005-10-18 |
Kenneth Blum |
Diagnosis and treatment system for reward deficiency syndrome (RDS) and related behaviors
|
|
IL149569A0
(en)
|
1999-11-17 |
2002-11-10 |
Arena Pharm Inc |
Endogenous and non-endogenous versions of human g protein-coupled receptors
|
|
AU6604901A
(en)
|
2000-06-05 |
2001-12-17 |
Bayer Aktiengesellschaft |
Regulation of human hm74-like g protein coupled receptor
|
|
FR2814952B1
(en)
|
2000-10-06 |
2004-01-02 |
Flamel Tech Sa |
COLLOIDAL SUSPENSION OF SUBMICROMIC PARTICLES FOR VECTORIZATION OF ACTIVE INGREDIENTS AND THEIR METHOD OF PREPARATION
|
|
US6833447B1
(en)
|
2000-07-10 |
2004-12-21 |
Monsanto Technology, Llc |
Myxococcus xanthus genome sequences and uses thereof
|
|
US20030078218A1
(en)
|
2001-08-15 |
2003-04-24 |
Gabor Jarai |
Inflammation related G-protein coupled receptor
|
|
GB0021484D0
(en)
|
2000-09-01 |
2000-10-18 |
Boehringer Ingelheim Pharma |
Method for identifying substances which positively influence inflammatory conditions of chronic inflammatory airway diseases
|
|
WO2002061087A2
(en)
|
2000-12-19 |
2002-08-08 |
Lifespan Biosciences, Inc. |
Antigenic peptides, such as for g protein-coupled receptors (gpcrs), antibodies thereto, and systems for identifying such antigenic peptides
|
|
MXPA03007984A
(en)
|
2001-03-07 |
2003-12-04 |
Bristol Myers Squibb Co |
Polynucleotide encoding a novel human g-protein coupled receptor, hgprbmy27.
|
|
US20040254224A1
(en)
|
2001-04-11 |
2004-12-16 |
Foord Steven Michael |
Medicaments
|
|
US20030143668A1
(en)
|
2001-06-18 |
2003-07-31 |
National Institute Of Advanced Industrial |
Guanosine triphosphate-binding protein coupled receptors
|
|
US20040076955A1
(en)
|
2001-07-03 |
2004-04-22 |
Eos Biotechnology, Inc. |
Methods of diagnosis of bladder cancer, compositions and methods of screening for modulators of bladder cancer
|
|
WO2003042661A2
(en)
|
2001-11-13 |
2003-05-22 |
Protein Design Labs, Inc. |
Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer
|
|
US6902902B2
(en)
|
2001-11-27 |
2005-06-07 |
Arena Pharmaceuticals, Inc. |
Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders
|
|
US20040038201A1
(en)
|
2002-01-22 |
2004-02-26 |
Whitehead Institute For Biomedical Research |
Diagnostic and therapeutic applications for biomarkers of infection
|
|
JP2005514934A
(en)
|
2002-01-23 |
2005-05-26 |
アベンティス・ファーマスーティカルズ・インコーポレイテツド |
Nucleic acids encoding G protein-coupled receptors and uses thereof
|
|
EP1477806A4
(en)
|
2002-02-22 |
2006-09-06 |
Takeda Pharmaceutical |
METHOD OF DETERMINING A LIGAND
|
|
JP2004049004A
(en)
|
2002-05-31 |
2004-02-19 |
Japan Science & Technology Corp |
5-oxo-ETE receptor protein and its gene
|
|
JP2004065120A
(en)
|
2002-08-07 |
2004-03-04 |
Sumitomo Pharmaceut Co Ltd |
Disease marker for inflammatory bowel disease and use thereof
|
|
MXPA05001702A
(en)
|
2002-08-14 |
2005-04-19 |
Neurosearch As |
Novel quinuclidine derivatives and their use.
|
|
AU2003300776A1
(en)
|
2002-09-09 |
2004-05-25 |
Omeros Corporation |
G protein coupled receptors and uses thereof
|
|
US20050260639A1
(en)
*
|
2002-09-30 |
2005-11-24 |
Oncotherapy Science, Inc. |
Method for diagnosing pancreatic cancer
|
|
AU2003282679A1
(en)
|
2002-10-04 |
2004-05-04 |
Arena Pharmaceuticals, Inc. |
Hydroxypyrazoles for use against metabolic-related disorders
|
|
AU2003300014A1
(en)
|
2002-10-10 |
2004-05-04 |
Arena Pharmaceuticals, Inc. |
5-substituted 2h-pyrazone-3-carboxylic acid derivatives as antilipolytic agents for the treatment of metabolic-related disorders such as dyslipidemia
|
|
JP4103537B2
(en)
|
2002-10-17 |
2008-06-18 |
アステラス製薬株式会社 |
New screening method
|
|
US7038085B2
(en)
|
2002-10-25 |
2006-05-02 |
Collegium Pharmaceutical, Inc. |
Stereoisomers of p-hydroxy-milnacipran, and methods of use thereof
|
|
US7129239B2
(en)
|
2002-10-28 |
2006-10-31 |
Pfizer Inc. |
Purine compounds and uses thereof
|
|
CA2503786A1
(en)
|
2002-11-01 |
2004-05-13 |
Pharmacia & Upjohn Company Llc |
Compounds having both alpha7 nicotinic agonist activity and 5ht, antagonist activity for treatment of cns diseases
|
|
EP1578367A4
(en)
|
2002-11-01 |
2012-05-02 |
Genentech Inc |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASES RELATED TO THE IMMUNE SYSTEM
|
|
DE10251244A1
(en)
|
2002-11-04 |
2004-05-19 |
Universität Heidelberg |
Method for detecting compounds with antihyperlipemic activity, useful for identifying therapeutic agents, is based on their interaction with nicotinic acid receptors
|
|
AU2003291342A1
(en)
|
2002-11-05 |
2004-06-07 |
Arena Pharmaceuticals, Inc. |
Benzotriazoles and methods of prophylaxis or treatment of metabolic-related disorders thereof
|
|
EP1562945B1
(en)
|
2002-11-11 |
2006-11-15 |
Neurosearch A/S |
1,4-diazabicyclo(3,2,2)nonane derivatives, preparation and therapeutical use thereof
|
|
US7189524B1
(en)
|
2002-11-25 |
2007-03-13 |
Amgen, Inc. |
Receptor ligands and methods of modulating receptors
|
|
WO2004053454A2
(en)
|
2002-11-27 |
2004-06-24 |
Government Of The United States Of America As Represented By The Sercretary Of The Department Of Health And Human Services National Institutes Of Health |
Methods for detecting invasion of a cell
|
|
ES2462545T3
(en)
|
2002-12-06 |
2014-05-23 |
The Feinstein Institute For Medical Research |
A procedure for the determination of a selective cholinergic agonist for a nicotinic alpha7 receptor
|
|
JP2006510664A
(en)
|
2002-12-06 |
2006-03-30 |
ファルマシア・アンド・アップジョン・カンパニー・エルエルシー |
Crystalline fumarate salt of 1-azabicyclo [2.2.2] octo-substituted furo [2,3-c] pyridinylcarboxamide, composition containing the salt, and process for producing the same
|
|
AU2003283648A1
(en)
|
2002-12-06 |
2004-06-30 |
Pharmacia & Upjohn Company Llc |
Compounds as radioligands for the diagnosis of disease
|
|
US7247628B2
(en)
|
2002-12-12 |
2007-07-24 |
Pfizer, Inc. |
Cannabinoid receptor ligands and uses thereof
|
|
JP2004198202A
(en)
|
2002-12-17 |
2004-07-15 |
Takeda Chem Ind Ltd |
Novel screening method
|
|
JP2007524566A
(en)
|
2002-12-20 |
2007-08-30 |
エンカム ファーマシューティカルズ アクティーゼルスカブ |
Methods for modulating the interaction between receptors and ligands
|
|
BRPI0406834A
(en)
|
2003-01-22 |
2005-12-27 |
Pharmacia & Upjohn Co Llc |
Treatment of disease with nach alfa-7 total receptor agonists
|
|
US20050059153A1
(en)
|
2003-01-22 |
2005-03-17 |
George Frank R. |
Electromagnetic activation of gene expression and cell growth
|
|
US20050084872A1
(en)
|
2003-01-24 |
2005-04-21 |
Lum Pek Y. |
Methods for determining whether an agent possesses a defined biological activity
|
|
EP1597586A2
(en)
|
2003-02-13 |
2005-11-23 |
Bayer HealthCare AG |
Diagnostics and therapeutics for diseases associated with hm74
|
|
WO2004071378A2
(en)
|
2003-02-17 |
2004-08-26 |
Bayer Healthcare Ag |
Diagnostics and therapeutics for diseases associated with g-protein coupled receptor hm74a (hm74a)
|
|
WO2004072648A1
(en)
|
2003-02-17 |
2004-08-26 |
Bayer Healthcare Ag |
Diagnostics and therapeutics for diseases associated with g protein-coupled receptor ox2r (ox2r)
|
|
EP1599476B1
(en)
|
2003-02-27 |
2009-10-14 |
Neurosearch A/S |
Novel diazabicyclic aryl derivatives
|
|
BRPI0407616A
(en)
|
2003-03-07 |
2006-02-14 |
Lilly Co Eli |
compound, pharmaceutical composition, method to block a combination of mu receptor, hood, delta (heterodimer) thereof in mammals, method to treat or prevent obesity and related diseases, use of a compound, and method of suppressing appetite in a patient in need of this "
|
|
EP1651772A1
(en)
|
2003-03-07 |
2006-05-03 |
Arcturus Bioscience, Inc. |
Breast cancer signatures
|
|
US20040180332A1
(en)
|
2003-03-12 |
2004-09-16 |
Millennium Pharmaceuticals, Inc. |
Methods and compositions for treating aids and HIV-related disorders using 9145, 1725, 311, 837, 58305, 156, 14175, 50352, 32678, 5560, 7240, 8865, 12396, 12397, 13644, 19938, 2077, 1735, 1786, 10220, 17822, 33945, 43748, 47161, 81982 or 46777
|
|
WO2004083818A2
(en)
|
2003-03-17 |
2004-09-30 |
Rinat Neuroscience Corp. |
Methods of identifying drug targets and modulators of neurons and compositions comprising the same
|
|
WO2004085433A2
(en)
|
2003-03-28 |
2004-10-07 |
Pharmacia & Upjohn Company Llc |
Positive allosteric modulators of the nicotinic acetylcholine receptor
|
|
CA2520870A1
(en)
|
2003-04-03 |
2004-10-21 |
Merck & Co., Inc. |
Di-aryl substituted pyrazole modulators of metabotropic glutamate receptor-5
|
|
EP1613615A2
(en)
|
2003-04-03 |
2006-01-11 |
Merck & Co., Inc. |
4-ring imidazole derivatives as modulators of metabotropic glutamate receptor-5
|
|
AU2004227833B2
(en)
|
2003-04-04 |
2009-10-01 |
Merck & Co., Inc. |
Di-aryl substituted triazole modulators of metabotropic glutamate receptor-5
|
|
AU2004227854B2
(en)
|
2003-04-04 |
2009-07-23 |
Merck & Co., Inc. |
Di-aryl substituted pyrrole modulators of metabotropic glutamate receptor-5
|
|
US20060234242A1
(en)
|
2003-04-07 |
2006-10-19 |
Ribonomics, Inc. |
Methods for identifying therapeutic targets involved in glucose and lipid metabolism
|
|
US7268133B2
(en)
|
2003-04-23 |
2007-09-11 |
Pfizer, Inc. Patent Department |
Cannabinoid receptor ligands and uses thereof
|
|
US7145012B2
(en)
|
2003-04-23 |
2006-12-05 |
Pfizer Inc. |
Cannabinoid receptor ligands and uses thereof
|
|
US20040214856A1
(en)
|
2003-04-23 |
2004-10-28 |
Pfizer Inc |
Cannabinoid receptor ligands and uses thereof
|
|
US7141669B2
(en)
|
2003-04-23 |
2006-11-28 |
Pfizer Inc. |
Cannabiniod receptor ligands and uses thereof
|
|
US20050003405A1
(en)
|
2003-04-30 |
2005-01-06 |
Hua-Chien Chen |
Treatment and diagnostics of cancer
|
|
WO2004099202A1
(en)
|
2003-05-05 |
2004-11-18 |
Pharmacia & Upjohn Company Llc |
Quinuclidines substituted bentodioxine carboxamides for the treatment of neurodegenerative diseases
|
|
US20040224962A1
(en)
|
2003-05-09 |
2004-11-11 |
Pfizer Inc |
Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss
|
|
AR041089A1
(en)
|
2003-05-15 |
2005-05-04 |
Merck & Co Inc |
PROCEDURE AND PHARMACEUTICAL COMPOSITIONS TO TREAT ATEROSCLEROSIS, DYSLIPIDEMIAS AND RELATED AFFECTIONS
|
|
US20040242641A1
(en)
|
2003-05-27 |
2004-12-02 |
Buckley Michael J. |
(1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane is an effective analgesic agent
|
|
US20040242644A1
(en)
|
2003-05-27 |
2004-12-02 |
Buckley Michael J. |
(IS-5S)-3-(5,6-dichloro-3-pyridinyl-)-3,6-diazabicyclo[3.2.0]heptane is an effective analgesic agent
|
|
WO2004108899A2
(en)
|
2003-06-04 |
2004-12-16 |
The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention |
Pni microarray and uses
|
|
US20060160834A1
(en)
|
2003-06-06 |
2006-07-20 |
Fong Tung M |
Combination therapy for the treatment of hypertension
|
|
EP1635832A2
(en)
|
2003-06-06 |
2006-03-22 |
Merck & Co., Inc. |
Combination therapy for the treatment of diabetes
|
|
US7232823B2
(en)
|
2003-06-09 |
2007-06-19 |
Pfizer, Inc. |
Cannabinoid receptor ligands and uses thereof
|
|
WO2004111197A2
(en)
|
2003-06-10 |
2004-12-23 |
Trustees Of Boston University |
Gene expression signatures, methods and compositions for diagnosing disorders of the lung
|
|
US8030300B2
(en)
|
2003-06-10 |
2011-10-04 |
Georgetown University |
Ligands for nicotinic acetylcholine receptors, and methods of making and using them
|
|
CA2528834A1
(en)
|
2003-06-13 |
2005-02-10 |
Arena Pharmaceuticals, Inc. |
5-substituted 2h-pyrazole-3-carboxylic acid derivatives as agonists for the nicotinic acid receptor rup25 for the treatment of dyslipidemia and related diseases
|
|
US20040259887A1
(en)
|
2003-06-18 |
2004-12-23 |
Pfizer Inc |
Cannabinoid receptor ligands and uses thereof
|
|
MXPA06000892A
(en)
|
2003-07-21 |
2006-03-30 |
Pfizer Prod Inc |
Aryl fused azapolycyclic compounds.
|
|
ES2331245T3
(en)
|
2003-07-21 |
2009-12-28 |
Pfizer Products Inc. |
AZAPOLICICLIC COMPOUNDS CONDENSED WITH HETEROARILO THAT REDUCE THE ADDICTION TO NICOTINE.
|
|
GB0319126D0
(en)
|
2003-08-14 |
2003-09-17 |
Smithkline Beecham Corp |
Chemical compounds
|
|
GB0319124D0
(en)
|
2003-08-14 |
2003-09-17 |
Smithkline Beecham Corp |
Chemical compounds
|
|
DE602004008658T2
(en)
|
2003-09-05 |
2008-06-12 |
Cellzome Ag |
TREATMENT OF NEURODEGENERATIVE DISEASES
|
|
WO2005023858A1
(en)
|
2003-09-05 |
2005-03-17 |
Cellzome Ag |
Protein complexes associated with app-processing
|
|
EP1678172B1
(en)
|
2003-10-15 |
2009-12-09 |
Targacept, Inc. |
Azabicyclic compounds for relieving pain and treating central nervous system disorders
|
|
WO2005041971A1
(en)
|
2003-10-21 |
2005-05-12 |
Merck & Co., Inc. |
Triazolo-pyridazine compounds and derivatives thereof useful in the treatment of neuropathic pain
|
|
WO2005041878A2
(en)
|
2003-10-29 |
2005-05-12 |
Tawakol Raif M D |
Compositions and methods for increasing hdl and hdl-2b levels
|
|
TWI258478B
(en)
|
2003-10-31 |
2006-07-21 |
Arena Pharm Inc |
Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof
|
|
US20050209181A1
(en)
|
2003-11-05 |
2005-09-22 |
Huda Akil |
Compositions and methods for diagnosing and treating mental disorders
|
|
US7151097B2
(en)
|
2003-11-07 |
2006-12-19 |
Pfizer Inc. |
Bicyclic pyrazolyl and imidazolyl compounds and uses thereof
|
|
US7816356B2
(en)
|
2003-11-14 |
2010-10-19 |
Daniel Yohannes |
Aryl and heteroaryltetrahydrocyclobutapyrroles as nicotinic acetylcholine receptor ligands
|
|
EP1687275A4
(en)
|
2003-11-21 |
2009-01-14 |
Merck & Co Inc |
PYRIDIN-4-YLAMINE COMPOUNDS SUITABLE FOR THE TREATMENT OF NEUROPATHIC PAIN
|
|
US20070093545A1
(en)
|
2003-11-21 |
2007-04-26 |
Arena Pharmaceuticals, Inc. |
4-Oxo-4,5-dihydro-furan-2-carboxylic acid derivatives and methods of treatment of metabolic-related disorders thereof
|
|
JP2005198640A
(en)
|
2003-11-25 |
2005-07-28 |
Biomarker Science:Kk |
Method for expressing gene
|
|
SI1541197T1
(en)
|
2003-12-02 |
2009-08-31 |
Pharmaneuroboost N V |
Use of pipamperone and an SNDRI, SNRI or SSRI for the treatment of mood or anxiety disorders
|
|
DE602004010299T2
(en)
|
2003-12-22 |
2008-09-18 |
Memory Pharmaceuticals Corp. |
INDOLE, 1H-INDAZOLE, 1,2-BENZISOXAZOLE AND 1,2-BENZISOTHIAZOLE AND THEIR PREPARATION AND APPLICATIONS
|
|
US7309699B2
(en)
|
2003-12-22 |
2007-12-18 |
Abbott Laboratories |
3-Quinuclidinyl amino-substituted biaryl derivatives
|
|
WO2005066129A2
(en)
|
2003-12-31 |
2005-07-21 |
University Of Kentucky Research Foundation |
Bis-pyridino containing compounds for use in the treatment of cns pathologies
|
|
WO2005067649A2
(en)
|
2004-01-08 |
2005-07-28 |
The Ohio State University |
Use of databases to create gene expression microarrays
|
|
EP1713809B1
(en)
|
2004-02-04 |
2009-07-29 |
Neurosearch A/S |
Dimeric azacyclic compounds and their use
|
|
CA2555311A1
(en)
|
2004-02-04 |
2005-08-18 |
Neurosearch A/S |
Diazabicyclic aryl derivatives as nicotinic acetylcholine receptor ligands
|
|
WO2005076939A2
(en)
|
2004-02-09 |
2005-08-25 |
University Of Kentucky Research Foundation |
Assay and method for diagnosing and treating alzheimer’s disease
|
|
HRP20130406T1
(en)
|
2004-02-14 |
2013-06-30 |
Glaxosmithkline Intellectual Property Development Limited |
Medicaments with hm74a receptor activity
|
|
KR20060127141A
(en)
|
2004-02-20 |
2006-12-11 |
아벤티스 파마슈티칼스 인크. |
Furosemide derivatives as modulators of HM74 and its use for the treatment of inflammation
|
|
ME00059B
(en)
|
2004-02-20 |
2010-06-10 |
|
Oxydecahydronaphthalene modulators of hm74
|
|
CA2558366A1
(en)
|
2004-02-23 |
2005-09-01 |
Erasmus Universiteit Rotterdam |
Classification, diagnosis and prognosis of acute myeloid leukemia by gene expression profiling
|
|
JP2005253442A
(en)
|
2004-03-09 |
2005-09-22 |
Hitachi Medical Corp |
Gene group having expression profile different between human dental pulp stem cell and mesenchymal stem cell
|
|
DE102004016437A1
(en)
|
2004-04-04 |
2005-10-20 |
Oligene Gmbh |
Method for detecting signatures in complex gene expression profiles
|
|
WO2005103052A1
(en)
|
2004-04-21 |
2005-11-03 |
Pfizer Products Inc. |
Pyrazolo [1,5-a] pyrimidin-7-one compounds and uses thereof
|
|
US20060003959A1
(en)
*
|
2004-06-10 |
2006-01-05 |
Steven Burden |
Methods and agents for maintaining muscle mass and for preventing muscle atrophy and biomarkers for monitoring same
|
|
WO2006023312A2
(en)
*
|
2004-08-20 |
2006-03-02 |
Carl Deirmengian |
Diagnostic assay for source of inflammation
|
|
US20060154275A1
(en)
*
|
2004-12-02 |
2006-07-13 |
The Board Of Trustees Of The Leland Stanford Junior University |
Regulated genes in cervical cancer
|
|
EP1677113A1
(en)
|
2004-12-29 |
2006-07-05 |
Max-Delbrück-Centrum für Molekulare Medizin (MDC) |
Method for the identification of protein-protein interactions in disease related protein networks
|
|
KR100955112B1
(en)
*
|
2005-06-14 |
2010-04-28 |
에프. 호프만-라 로슈 아게 |
Anthranilic acid derivatives
|
|
DK1901731T3
(en)
*
|
2005-06-28 |
2011-06-14 |
Merck Sharp & Dohme |
Niacin receptor agonists, compositions containing such compounds and methods of treatment
|