WO2004087949A3 - Verfahren zur erkennung akuter generalisierter entzündlicher zustände (sirs), sepsis, sepsisähnlichen zuständen und systemischen infektionen - Google Patents

Verfahren zur erkennung akuter generalisierter entzündlicher zustände (sirs), sepsis, sepsisähnlichen zuständen und systemischen infektionen Download PDF

Info

Publication number
WO2004087949A3
WO2004087949A3 PCT/EP2004/003419 EP2004003419W WO2004087949A3 WO 2004087949 A3 WO2004087949 A3 WO 2004087949A3 EP 2004003419 W EP2004003419 W EP 2004003419W WO 2004087949 A3 WO2004087949 A3 WO 2004087949A3
Authority
WO
WIPO (PCT)
Prior art keywords
sepsis
conditions
sirs
systemic infections
recognising
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2004/003419
Other languages
English (en)
French (fr)
Other versions
WO2004087949A2 (de
Inventor
Stefan Russwurm
Konrad Reinhart
Hans-Peter Saluz
Eberhard Straube
Peter F Zipfel
Hans-Peter Deigner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SIRS Lab GmbH
Original Assignee
SIRS Lab GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2003115031 external-priority patent/DE10315031B4/de
Priority claimed from DE2003136511 external-priority patent/DE10336511A1/de
Priority claimed from DE2003140395 external-priority patent/DE10340395A1/de
Application filed by SIRS Lab GmbH filed Critical SIRS Lab GmbH
Priority to US10/551,874 priority Critical patent/US20080070235A1/en
Priority to EP04724591A priority patent/EP1611255A2/de
Publication of WO2004087949A2 publication Critical patent/WO2004087949A2/de
Anticipated expiration legal-status Critical
Publication of WO2004087949A3 publication Critical patent/WO2004087949A3/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Die vorliegende Erfindung betrifft ein Verfahren zur in vitro Erkennung von SIRS, Sepsis und/oder sepsisähnlichen Zuständen, das es ermöglicht, den Schweregrad und/oder den therapiebegleitenden Verlauf von Sepsis und schweren Infektionen, insbesondere sepsisähnlichen systemischen Infektionen zu beurteilen. Ferner betrifft die vorliegende Erfindung die Verwendung von rekombinant oder synthetisch hergestellten Nukleinsäuresequenzen oder davon abgeleiteten Peptidsequenzen als Kalibrator in Sepsis-Assays und/oder zur Bewertung der Wirkung und Toxizität beim Wirkstoffscreening und/oder zur Herstellung von Therapeutika zur Vorbeugung und Behandlung von SIRS, Sepsis, sepsisähnlichen systemischen entzündlichen Zuständen und sepsisähnlichen systemischen Infektionen.
PCT/EP2004/003419 2003-04-02 2004-03-31 Verfahren zur erkennung akuter generalisierter entzündlicher zustände (sirs), sepsis, sepsisähnlichen zuständen und systemischen infektionen Ceased WO2004087949A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/551,874 US20080070235A1 (en) 2003-04-02 2004-03-31 Method for Recognizing Acute Generalized Inflammatory Conditions (Sirs), Sepsis, Sepsis-Like Conditions and Systemic Infections
EP04724591A EP1611255A2 (de) 2003-04-02 2004-03-31 Verfahren zur erkennung akuter generalisierter entzündlicher zustände (sirs), sepsis, sepsis ähnlichen zuständen und systemischen infektionen

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE10315031.5 2003-04-02
DE2003115031 DE10315031B4 (de) 2003-04-02 2003-04-02 Verfahren zur Erkennung von Sepsis und/oder sepsisähnlichen Zuständen
DE10336511.7 2003-08-08
DE2003136511 DE10336511A1 (de) 2003-08-08 2003-08-08 Verfahren zur Erkennung von schwerer Sepsis
DE10340395.7 2003-09-02
DE2003140395 DE10340395A1 (de) 2003-09-02 2003-09-02 Verfahren zur Erkennung akuter generalisierter entzündlicher Zustände (SIRS)

Publications (2)

Publication Number Publication Date
WO2004087949A2 WO2004087949A2 (de) 2004-10-14
WO2004087949A3 true WO2004087949A3 (de) 2005-10-06

Family

ID=33135446

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/003419 Ceased WO2004087949A2 (de) 2003-04-02 2004-03-31 Verfahren zur erkennung akuter generalisierter entzündlicher zustände (sirs), sepsis, sepsisähnlichen zuständen und systemischen infektionen

Country Status (3)

Country Link
US (1) US20080070235A1 (de)
EP (2) EP1611255A2 (de)
WO (1) WO2004087949A2 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8029982B2 (en) 2004-01-20 2011-10-04 Alere San Diego, Inc. Biomarkers for sepsis
CN110664831A (zh) * 2019-11-13 2020-01-10 北京大学 一种特异性长效rna在制备治疗乳腺癌的药物中的用途

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1829730A (zh) 2002-11-12 2006-09-06 贝克顿迪金森公司 使用生物标记谱诊断脓毒或者sirs
EP1565570A4 (de) 2002-11-12 2005-12-28 Becton Dickinson Co Sepsis- oder sirs-diagnose mittels biomarkerprofilen
DE102004009952B4 (de) * 2004-03-01 2011-06-01 Sirs-Lab Gmbh Verfahren zur Erkennung von Sepsis
DE102004015605B4 (de) * 2004-03-30 2012-04-26 Sirs-Lab Gmbh Verfahren zur Vorhersage des individuellen Krankheitsverlaufs bei Sepsis
DE102004049897B4 (de) * 2004-10-13 2007-11-22 Sirs-Lab Gmbh Verfahren zur Unterscheidung zwischen nichtinfektiösen und infektiösen Ursachen eines Multiorganversagens
FR2881437B1 (fr) 2005-01-31 2010-11-19 Biomerieux Sa Procede pour le diagnostic/pronostic d'un syndrome septique
DE102005013013A1 (de) * 2005-03-21 2006-09-28 Sirs-Lab Gmbh Verwendung von Genaktivitäts-Klassifikatoren für die in vitro Klassifizierung von Genexpressionsprofilen von Patienten mit infektiösem/nichtinfektiösem Multiorganversagen
JP2008538007A (ja) 2005-04-15 2008-10-02 ベクトン，ディッキンソン アンド カンパニー 敗血症の診断
DE102005050933A1 (de) * 2005-10-21 2007-04-26 Justus-Liebig-Universität Giessen Erfindung betreffend Expressionsprofile zur Vorhersage von septischen Zuständen
GB0610078D0 (en) * 2006-05-20 2006-06-28 Secr Defence Sepsis detection microarray
DE102006027842B4 (de) * 2006-06-16 2014-07-31 Analytik Jena Ag Verfahren zur Feststellung der Infektionsquelle bei Fieber unklarer Genese
DE102007010252B4 (de) * 2007-03-02 2013-07-04 Sirs-Lab Gmbh Kontrollgene zur Normalisierung von Genexpressionsanalysedaten
US8221995B2 (en) 2007-03-23 2012-07-17 Seok-Won Lee Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
GB0722582D0 (en) * 2007-11-16 2007-12-27 Secr Defence Early detection of sepsis
DE102008000715B9 (de) 2008-03-17 2013-01-17 Sirs-Lab Gmbh Verfahren zur in vitro Erfasssung und Unterscheidung von pathophysiologischen Zuständen
WO2009123737A2 (en) 2008-04-03 2009-10-08 Becton, Dickinson And Company Advanced detection of sepsis
WO2010041232A2 (en) * 2008-10-09 2010-04-15 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin A method of estimating sepsis risk in an individual with infection
EP2379752B1 (de) * 2009-01-19 2015-09-30 Biomérieux S.A. Verfahren zur bestimmung der anfälligkeit eines subjekts für eine nosokomiale infektion und zur prognose der entwicklung eines septischen syndroms
EP2391738B1 (de) * 2009-02-02 2016-11-02 Cepheid Verfahren für den nachweis von sepsis
DE102009044085A1 (de) 2009-09-23 2011-11-17 Sirs-Lab Gmbh Verfahren zur in vitro Erfassung und Unterscheidung von pathophysiologischen Zuständen
EP2985352A1 (de) 2009-09-23 2016-02-17 Analytik Jena AG Verfahren zur in vitro erfassung und unterscheidung von pathophysiologischen zuständen
US20110076685A1 (en) * 2009-09-23 2011-03-31 Sirs-Lab Gmbh Method for in vitro detection and differentiation of pathophysiological conditions
EP2308999A1 (de) * 2009-09-24 2011-04-13 Ludwig-Maximilians-Universität München Markerkombination zur Vorhersage des Sterblichkeitsrisikos von polytraumatisierten Patienten
DE102011005235B4 (de) * 2011-03-08 2017-05-24 Sirs-Lab Gmbh Verfahren zum Identifizieren einer Teilmenge von Polynucleotiden aus einer dem Humangenom entsprechenden Ausgangsmenge von Polynucleotiden zur in vitro Bestimmung eines Schweregrads der Wirtsantwort eines Patienten
FR3000966B1 (fr) * 2013-01-11 2016-10-28 Biomerieux Sa Procede pour etablir in vitro un pronostic de severite chez un patient en choc septique
CN105518153A (zh) 2013-06-20 2016-04-20 因姆内克斯普雷斯私人有限公司 生物标志物鉴定
EP3013985A4 (de) * 2013-06-28 2017-07-19 Acumen Research Laboratories Pte. Ltd. Sepsisbiomarker und verwendungen davon
WO2015020960A1 (en) * 2013-08-09 2015-02-12 Novartis Ag Novel lncrna polynucleotides
WO2015117204A1 (en) 2014-02-06 2015-08-13 Immunexpress Pty Ltd Biomarker signature method, and apparatus and kits therefor
DK3356558T3 (da) 2015-09-30 2022-04-25 Immunexpress Pty Ltd Sirs patogenbiomarkører og anvendelser deraf
AU2016349950B2 (en) * 2015-11-06 2022-10-06 Immunexpress Pty Ltd Viral biomarkers and uses therefor
CN110095603B (zh) * 2019-04-15 2022-05-17 中国人民解放军陆军特色医学中心 血浆或血清中vnn1在用于脓毒症早期预警的标志物中的应用
US20220283153A1 (en) * 2019-08-05 2022-09-08 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Compositions and methods for detecting sepsis
CN111413497A (zh) * 2020-04-15 2020-07-14 上海市东方医院（同济大学附属东方医院） 组蛋白甲基转移酶ezh2在制备用于诊断脓毒症的生物标记物中的用途
GB2596142B (en) * 2020-06-19 2023-11-29 Secr Defence Methods and associated uses, kits and systems for assessing sepsis
WO2025056769A1 (en) * 2023-09-14 2025-03-20 Roche Diagnostics Gmbh Method for assessing systemic inflammation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999040434A1 (en) * 1998-02-04 1999-08-12 Invitrogen Corporation Microarrays and uses therefor
EP1270740A1 (de) * 2001-06-29 2003-01-02 SIRS-Lab GmbH Biochip und dessen Verwendung zur Bestimmung von Entzündungen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7625697B2 (en) * 1994-06-17 2009-12-01 The Board Of Trustees Of The Leland Stanford Junior University Methods for constructing subarrays and subarrays made thereby
US5830679A (en) * 1996-03-01 1998-11-03 New England Medical Center Hospitals, Inc. Diagnostic blood test to identify infants at risk for sepsis
USH2191H1 (en) * 2000-10-24 2007-06-05 Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
US7465555B2 (en) * 2002-04-02 2008-12-16 Becton, Dickinson And Company Early detection of sepsis
CN1829730A (zh) * 2002-11-12 2006-09-06 贝克顿迪金森公司 使用生物标记谱诊断脓毒或者sirs
DE102004009952B4 (de) * 2004-03-01 2011-06-01 Sirs-Lab Gmbh Verfahren zur Erkennung von Sepsis
DE102005013013A1 (de) * 2005-03-21 2006-09-28 Sirs-Lab Gmbh Verwendung von Genaktivitäts-Klassifikatoren für die in vitro Klassifizierung von Genexpressionsprofilen von Patienten mit infektiösem/nichtinfektiösem Multiorganversagen

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999040434A1 (en) * 1998-02-04 1999-08-12 Invitrogen Corporation Microarrays and uses therefor
EP1270740A1 (de) * 2001-06-29 2003-01-02 SIRS-Lab GmbH Biochip und dessen Verwendung zur Bestimmung von Entzündungen
WO2003002763A1 (en) * 2001-06-29 2003-01-09 Sirs-Lab Gmbh Use of a biochip for the diagnosis of sepsis or sepsis related syndrome

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
CHINNAIYAN A M ET AL.: "Molecular signatures of sepsis. Multiorgan gene expression profiles of systemic inflammation", AMERICAN JOURNAL OF PATHOLOGY, vol. 159, October 2001 (2001-10-01), pages 1199 - 1209, XP008037039 *
COBB P J ET AL.: "Sepsis gene expression profiling: Murine splenic compared with hepatic responses determined by using complementary DNA microarrays", CRITICAL CARE MEDICINE, vol. 30, 2002, pages 2711 - 2721, XP008037048 *
DATABASE EMBL EUROPEAN MOLECULAR BIOLOGY LABORATORY; 18 January 1995 (1995-01-18), WOZNEY J M ET AL.: "Homo sapiens (clone KT2) bone morphogenetic protein-1 (BMP-1) mRNA and alternatively spliced mammalian tolloid protein (mTld)", XP002307377, Database accession no. L35279 *
HELLER R A ET AL: "Discovery and analysis of inflammatory disease-related genes using cDNA microarrays", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 94, no. 94, 1997, pages 2150 - 2155, XP002076789, ISSN: 0027-8424 *
MEMBERS OF THE AMERICAN COLLEGE OF CHEST PHYSICIANS: "Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis", CRITICAL CARE MEDICINE, vol. 20, 1992, pages 864 - 874, XP008036965 *
OBERHOFFER M ET AL.: "Discriminative power of inflammatory markers for prediction of tumor necrosis factor-alpha and interleukin-6 inICU patients with systemic inflammatory response syndrome (SIRS) or sepsis at arbitrary time points", INTENSIVE CARE MEDICINE, vol. 26, 2000, pages S170 - S174, XP002307376 *
PATHAN N ET AL.: "The complexity of the inflammatory response to meningcoccal sepsis revealed by gene expression profiling using cDNA microarrays", CRITICAL CARE MEDICINE, vol. 30, no. 12, December 2002 (2002-12-01), pages A47, XP008037050 *
PRUCHA M ET AL.: "Expression profling: Toward an application in sepsis diagnostics", SHOCK, vol. 22, no. 1, 2004, pages 29 - 33, XP008036997 *
ROWE C A ET AL: "AN ARRAY IMMUNOSENSOR FOR SIMULTANEOUS DETECTION OF CLINICAL ANALYTES", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 71, no. 2, 15 January 1999 (1999-01-15), pages 433 - 439, XP000825701, ISSN: 0003-2700 *
WIEGAND G ET AL.: "Gene expression pattern in human monocytes as a surrogate marker for systemic inflammatory response syndrome (SIRS)", MOLECULAR MEDICINE, vol. 5, 1999, pages 192 - 202, XP008037023 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8029982B2 (en) 2004-01-20 2011-10-04 Alere San Diego, Inc. Biomarkers for sepsis
CN110664831A (zh) * 2019-11-13 2020-01-10 北京大学 一种特异性长效rna在制备治疗乳腺癌的药物中的用途

Also Published As

Publication number Publication date
EP2366799A2 (de) 2011-09-21
WO2004087949A2 (de) 2004-10-14
EP1611255A2 (de) 2006-01-04
EP2366799A3 (de) 2012-06-20
US20080070235A1 (en) 2008-03-20

Similar Documents

Publication Publication Date Title
Freitas et al. Optical probes for detection and quantification of neutrophils’ oxidative burst. A review
Wang et al. PROTACS: a technology with a gold rush-like atmosphere
WO2006125227A3 (en) Fibroblast activation protein inhibitor compounds and methods
WO2006040357A3 (en) Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
WO2003073822A3 (en) Methods of diagnosing liver fibrosis
IL158866A0 (en) Use of il-18 inhibitors for the treatment or prevention of sepsis
WO2010070248A3 (fr) Toile a peindre renfermant un agent apte a pieger le formaldehyde et procede de fabrication
WO2004085475A3 (en) Anti-il-20 antibodies and binding partners and methods of using in inflammation
WO2004057017A3 (en) Detection of small nucleic acids
WO2005039397A3 (en) Methods of diagnosing tissue fibrosis
WO2010017369A3 (en) Macromolecular diffusion and release from self-assembled b-hairpin peptide hydrogels
WO2007149699A3 (en) Desizing and scouring process
WO2007024556A3 (en) Methods and compositions for acid treatment of a metal surface
WO2005000888A3 (en) NOVEL β-ACTIN AND RPS21 PROMOTERS AND USES THEREOF
AU2003243097A1 (en) Novel compounds
WO2005021765A3 (en) Enhancing accumulation of heterologous polypeptides in plant seeds through targeted suppression of endogenous storage proteins
WO2005007675A3 (en) TRIAZOLE ϵ-AMINO ACIDS
WO2004099240A3 (en) Peptides and mixtures thereof for use in the detection of severe acute respiratory syndrome-associated coronavirus (sars)
WO2003046135A3 (en) Osteopontin-related compositions and methods
UA88573C2 (ru) Способ изготовления холоднотянутой прецизионной стальной трубы
ZA201002991B (en) Process for treatment of a fabric
WO2005046562A3 (de) Verwendung sulfatierter hyaluronsäure
WO2026057757A3 (en) Pore monomers and their uses
WO2005009361A3 (en) Method of treating hit patients with argatroban
WO2006029173A3 (en) Treatment of glomerular basement membrane disease involving matrix metalloproteinase-12

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2004724591

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2004724591

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10551874

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 10551874

Country of ref document: US