WO2004089380A3 - Pharmaceutical use of fused 1,2,4-triazoles - Google Patents

Pharmaceutical use of fused 1,2,4-triazoles Download PDF

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Publication number
WO2004089380A3
WO2004089380A3 PCT/DK2004/000251 DK2004000251W WO2004089380A3 WO 2004089380 A3 WO2004089380 A3 WO 2004089380A3 DK 2004000251 W DK2004000251 W DK 2004000251W WO 2004089380 A3 WO2004089380 A3 WO 2004089380A3
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WO
WIPO (PCT)
Prior art keywords
triazoles
fused
compounds
βhsd1
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DK2004/000251
Other languages
French (fr)
Other versions
WO2004089380A2 (en
Inventor
Henrik Sune Andersen
Gita Camilla Tejlgaard Kampen
Inge Thoeger Christensen
John Patrick Mogensen
Annette Rosendal Larsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Priority to AT04725884T priority Critical patent/ATE455547T1/en
Priority to DE602004025220T priority patent/DE602004025220D1/en
Priority to DK04725884.3T priority patent/DK1615647T3/en
Priority to EP04725884A priority patent/EP1615647B1/en
Priority to JP2006504354A priority patent/JP2006522747A/en
Publication of WO2004089380A2 publication Critical patent/WO2004089380A2/en
Publication of WO2004089380A3 publication Critical patent/WO2004089380A3/en
Priority to US11/247,847 priority patent/US7358238B2/en
Anticipated expiration legal-status Critical
Priority to US12/038,255 priority patent/US7723323B2/en
Priority to US12/760,254 priority patent/US20100197658A1/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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Abstract

The use of fused 1,2,4-triazoles for modulating the activity of 11 β-hydroxysteroid dehydrogenase type 1 (11 βHSD1) and the use of these compounds as pharmaceutical compositions has been described. Also a novel class of fused 1,2,4-triazoles, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments has been described. The present compounds are modulators and more specifically inhibitors of the activity of 11 βHSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.
PCT/DK2004/000251 2003-04-11 2004-04-06 Pharmaceutical use of fused 1,2,4-triazoles Ceased WO2004089380A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AT04725884T ATE455547T1 (en) 2003-04-11 2004-04-06 PHARMACEUTICAL USES OF CONDENSED 1,2,4-TRIAZOLES
DE602004025220T DE602004025220D1 (en) 2003-04-11 2004-04-06 PHARMACEUTICAL USES OF CONDENSED 1,2,4-TRIAZOLENE
DK04725884.3T DK1615647T3 (en) 2003-04-11 2004-04-06 Pharmaceutical use of condensed 1,2,4-triazoles
EP04725884A EP1615647B1 (en) 2003-04-11 2004-04-06 Pharmaceutical use of fused 1,2,4-triazoles
JP2006504354A JP2006522747A (en) 2003-04-11 2004-04-06 Pharmaceutical use of condensed 1,2,4-triazole
US11/247,847 US7358238B2 (en) 2003-04-11 2005-10-11 Pharmaceutical use of fused 1,2,4-triazoles
US12/038,255 US7723323B2 (en) 2003-04-11 2008-02-27 Pharmaceutical use of fused 1,2,4-triazoles
US12/760,254 US20100197658A1 (en) 2003-04-11 2010-04-14 Pharmaceutical use of fused 1,2,4-triazoles

Applications Claiming Priority (8)

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DKPA200300571 2003-04-11
DKPA200300571 2003-04-11
US46728403P 2003-05-02 2003-05-02
US60/467,284 2003-05-02
DKPA200300776 2003-05-22
DKPA200300776 2003-05-22
US47515703P 2003-06-02 2003-06-02
US60/475,157 2003-06-02

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WO2004089380A3 true WO2004089380A3 (en) 2004-12-23

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US20060106008A1 (en) 2006-05-18
ES2338656T3 (en) 2010-05-11
US7723323B2 (en) 2010-05-25
US20080153807A1 (en) 2008-06-26
WO2004089380A2 (en) 2004-10-21
ATE455547T1 (en) 2010-02-15
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US7358238B2 (en) 2008-04-15
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