WO2004092734A3 - Novel approach to molecular diagnosis of human papilloma virus-related diseases - Google Patents

Novel approach to molecular diagnosis of human papilloma virus-related diseases Download PDF

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Publication number
WO2004092734A3
WO2004092734A3 PCT/US2004/010966 US2004010966W WO2004092734A3 WO 2004092734 A3 WO2004092734 A3 WO 2004092734A3 US 2004010966 W US2004010966 W US 2004010966W WO 2004092734 A3 WO2004092734 A3 WO 2004092734A3
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WO
WIPO (PCT)
Prior art keywords
sequential
hpv
molecular diagnosis
related diseases
papilloma virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/010966
Other languages
French (fr)
Other versions
WO2004092734A2 (en
Inventor
Inna R Williams
Attila T Lorincz
Aisling O'hara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Qiagen Gaithersburg LLC
Original Assignee
Qiagen Gaithersburg LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qiagen Gaithersburg LLC filed Critical Qiagen Gaithersburg LLC
Priority to EP04759327.2A priority Critical patent/EP1616177B1/en
Publication of WO2004092734A2 publication Critical patent/WO2004092734A2/en
Publication of WO2004092734A3 publication Critical patent/WO2004092734A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/708—Specific hybridization probes for papilloma

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to an accurate, sensitive, and efficient sequential or concurrently sequential method for molecular diagnosis of human papillomavirus (HPV)-based disease, where the method improves the accuracy and reliability of diagnostic and prognostic assessments of HPV-based disease. The method of the invention comprises a primary screen of a sample for HPV nucleic acids, followed by a secondary screen for molecular markers, such as proliferation and celll cycle control group protein markers. The sequential or concurrently sequential method significantly reduces the number of false positive results.
PCT/US2004/010966 2003-04-11 2004-04-08 Novel approach to molecular diagnosis of human papilloma virus-related diseases Ceased WO2004092734A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04759327.2A EP1616177B1 (en) 2003-04-11 2004-04-08 Novel approach to molecular diagnosis of human papilloma virus-related diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/411,830 US7361460B2 (en) 2003-04-11 2003-04-11 Approach to molecular diagnosis of human papillomavirus-related diseases
US10/411,830 2003-04-11

Publications (2)

Publication Number Publication Date
WO2004092734A2 WO2004092734A2 (en) 2004-10-28
WO2004092734A3 true WO2004092734A3 (en) 2005-04-21

Family

ID=33131086

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/010966 Ceased WO2004092734A2 (en) 2003-04-11 2004-04-08 Novel approach to molecular diagnosis of human papilloma virus-related diseases

Country Status (3)

Country Link
US (2) US7361460B2 (en)
EP (1) EP1616177B1 (en)
WO (1) WO2004092734A2 (en)

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DE60300339T2 (en) * 2003-08-25 2006-04-13 Mtm Laboratories Ag Method for the detection of carcinomas in solubilized cervical body samples
DE602004025509D1 (en) * 2003-11-28 2010-03-25 Univ Sydney VIRAL LATENT PHASE INTERLEUKIN-10- (VII-10) AND USES THEREOF
ATE549625T1 (en) * 2004-03-24 2012-03-15 Tripath Imaging Inc METHODS AND COMPOSITIONS FOR DETECTING CERVICAL DISEASE
US7211391B2 (en) * 2004-11-15 2007-05-01 Institut Curie Methods and compositions for predicting the outcome of cervical intra-epithelial neoplasia
US7595380B2 (en) * 2005-04-27 2009-09-29 Tripath Imaging, Inc. Monoclonal antibodies and methods for their use in the detection of cervical disease
US7732166B2 (en) * 2005-11-15 2010-06-08 Oncohealth Corporation Detection method for human pappilomavirus (HPV) and its application in cervical cancer
US7972776B2 (en) * 2005-11-15 2011-07-05 Oncohealth Corporation Protein chips for HPV detection
US7632498B2 (en) 2005-12-19 2009-12-15 Tripath Imaging, Inc. MCM6 and MCM7 monoclonal antibodies and methods for their use in the detection of cervical disease
CN103424541B (en) 2006-05-18 2018-01-30 分子压型学会股份有限公司 It is determined that the system and method intervened for the personalized medicine of symptom
US8768629B2 (en) * 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors
US8968995B2 (en) * 2008-11-12 2015-03-03 Oncohealth Corp. Detection, screening, and diagnosis of HPV-associated cancers
US20100003704A1 (en) * 2008-06-13 2010-01-07 Shuling Cheng IN SITU detection of early stages and late stages HPV infection
WO2009091501A1 (en) 2008-01-18 2009-07-23 Response Biomedical Corporation Heated assays for influenza
JP2011513763A (en) * 2008-03-13 2011-04-28 フェレニギング フォール クリステリーク ホゲル オンデルウィース，ヴェテンシャッペリーク オンデルゾエク エン パティエンテンツォルク Cervical screening algorithm
CN102232117A (en) * 2008-10-14 2011-11-02 卡里斯Mpi公司 Gene targets and protein targets of gene expression to delineate tumor type biomarker patterns and signature sets
WO2011109440A1 (en) 2010-03-01 2011-09-09 Caris Life Sciences Luxembourg Holdings Biomarkers for theranostics
GB2463401B (en) 2008-11-12 2014-01-29 Caris Life Sciences Luxembourg Holdings S A R L Characterizing prostate disorders by analysis of microvesicles
EP2427763A4 (en) 2009-05-07 2013-08-21 Oncohealth Corp IDENTIFICATION OF HIGH GRADE OR CIN2 FOR DETECTION, MONITORING AND DIAGNOSIS, AT EARLY STAGES AND ADVANCED STAGES, OF HUMAN PAPILLOMAVIRUS (HPV) AND HPV ASSOCIATED CANCERS
WO2011084598A1 (en) 2010-01-08 2011-07-14 Oncohealth Corporation High throughput cell-based hpv immunoassays for diagnosis and screening of hpv-associated cancers
WO2011127219A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
CN107771285A (en) 2015-06-08 2018-03-06 阿奎尔诊断有限公司 Method
EP4060344A1 (en) 2015-06-08 2022-09-21 Arquer Diagnostics Limited Methods and kits
WO2019173280A1 (en) * 2018-03-06 2019-09-12 The Regents Of The University Of California Compositions and methods for the diagnosis and detection of tumors and cancer prognosis
EP3921441A1 (en) 2019-02-08 2021-12-15 Charité - Universitätsmedizin Berlin A method for determining the severity or grade of human papillomavirus (hpv)-induced dysplasia

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WO1999029890A2 (en) * 1997-12-12 1999-06-17 Digene Corporation Assessment of human papilloma virus-related disease

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Also Published As

Publication number Publication date
US8227190B2 (en) 2012-07-24
US20070243552A1 (en) 2007-10-18
WO2004092734A2 (en) 2004-10-28
US20040202996A1 (en) 2004-10-14
EP1616177B1 (en) 2015-08-19
EP1616177A2 (en) 2006-01-18
US7361460B2 (en) 2008-04-22

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