WO2004097051A3 - Methods for diagnosing aml and mds differential gene expression - Google Patents

Methods for diagnosing aml and mds differential gene expression Download PDF

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Publication number
WO2004097051A3
WO2004097051A3 PCT/US2004/013230 US2004013230W WO2004097051A3 WO 2004097051 A3 WO2004097051 A3 WO 2004097051A3 US 2004013230 W US2004013230 W US 2004013230W WO 2004097051 A3 WO2004097051 A3 WO 2004097051A3
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Prior art keywords
mds
aml
methods
gene expression
differential gene
Prior art date
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Ceased
Application number
PCT/US2004/013230
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French (fr)
Other versions
WO2004097051A2 (en
Inventor
Michael E Burczynski
Andrew Dorner
Natalie C Twine
William L Trepicchio
Jennifer Stover
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Wyeth LLC
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Wyeth LLC
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Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Priority to CA002524173A priority Critical patent/CA2524173A1/en
Priority to AU2004235382A priority patent/AU2004235382A1/en
Priority to EP04750901A priority patent/EP1629119A2/en
Publication of WO2004097051A2 publication Critical patent/WO2004097051A2/en
Publication of WO2004097051A3 publication Critical patent/WO2004097051A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Methods, systems and equipment for diagnosing or monitoring the progression or treatment of AML or MDS. This invention identifies a plurality of AML or MDS disease genes which are differentially expressed in bone marrow cells of AML or MDS patients as compared to disease-free humans. These AML or MDS disease genes can be used as molecular markers for detecting the presence or absence of AML or MDS. These genes can also be used for the early identification of MDS patients who eventually progress to AML.
PCT/US2004/013230 2003-04-29 2004-04-29 Methods for diagnosing aml and mds differential gene expression Ceased WO2004097051A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002524173A CA2524173A1 (en) 2003-04-29 2004-04-29 Methods for diagnosing aml and mds differential gene expression
AU2004235382A AU2004235382A1 (en) 2003-04-29 2004-04-29 Methods for diagnosing AML and MDS differential gene expression
EP04750901A EP1629119A2 (en) 2003-04-29 2004-04-29 Methods for diagnosing aml and mds by differential gene expression

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46605503P 2003-04-29 2003-04-29
US60/466,055 2003-04-29

Publications (2)

Publication Number Publication Date
WO2004097051A2 WO2004097051A2 (en) 2004-11-11
WO2004097051A3 true WO2004097051A3 (en) 2004-12-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/013230 Ceased WO2004097051A2 (en) 2003-04-29 2004-04-29 Methods for diagnosing aml and mds differential gene expression

Country Status (5)

Country Link
US (2) US20050202451A1 (en)
EP (1) EP1629119A2 (en)
AU (1) AU2004235382A1 (en)
CA (1) CA2524173A1 (en)
WO (1) WO2004097051A2 (en)

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US20100215644A1 (en) * 2009-02-25 2010-08-26 Nodality, Inc. A Delaware Corporation Analysis of nodes in cellular pathways
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RU2603742C2 (en) 2010-02-04 2016-11-27 Торэй Индастриз, Инк. Pharmaceutical composition for treatment and/or prevention of cancer
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Also Published As

Publication number Publication date
AU2004235382A1 (en) 2004-11-11
US20070198198A1 (en) 2007-08-23
CA2524173A1 (en) 2004-11-11
US20050202451A1 (en) 2005-09-15
EP1629119A2 (en) 2006-03-01
WO2004097051A2 (en) 2004-11-11

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