WO2004099165A3 - Heterocyclic compounds and hydro isomers thereof - Google Patents

Heterocyclic compounds and hydro isomers thereof Download PDF

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Publication number
WO2004099165A3
WO2004099165A3 PCT/US2004/013452 US2004013452W WO2004099165A3 WO 2004099165 A3 WO2004099165 A3 WO 2004099165A3 US 2004013452 W US2004013452 W US 2004013452W WO 2004099165 A3 WO2004099165 A3 WO 2004099165A3
Authority
WO
WIPO (PCT)
Prior art keywords
heterocyclic compounds
hydro isomers
hcv
iii
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/013452
Other languages
French (fr)
Other versions
WO2004099165A2 (en
Inventor
Rajinder Singh
Dane Goff
John J Partridge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rigel Pharmaceuticals Inc
Original Assignee
Rigel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Priority to EP04751046A priority Critical patent/EP1620412A2/en
Publication of WO2004099165A2 publication Critical patent/WO2004099165A2/en
Anticipated expiration legal-status Critical
Publication of WO2004099165A3 publication Critical patent/WO2004099165A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to substituted diphenyl heterocycle compounds according to formula (I), (II), (III) and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the use of the compounds and/or compositions to inhibit HCV replication and/or proliferation and to treat or prevent HCV infections. Formula (I), (II), (III).
PCT/US2004/013452 2003-05-02 2004-04-30 Heterocyclic compounds and hydro isomers thereof Ceased WO2004099165A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04751046A EP1620412A2 (en) 2003-05-02 2004-04-30 Heterocyclic compounds and hydro isomers thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46765003P 2003-05-02 2003-05-02
US60/467,650 2003-05-02

Publications (2)

Publication Number Publication Date
WO2004099165A2 WO2004099165A2 (en) 2004-11-18
WO2004099165A3 true WO2004099165A3 (en) 2005-11-03

Family

ID=33435099

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/013452 Ceased WO2004099165A2 (en) 2003-05-02 2004-04-30 Heterocyclic compounds and hydro isomers thereof

Country Status (3)

Country Link
US (1) US7326790B2 (en)
EP (1) EP1620412A2 (en)
WO (1) WO2004099165A2 (en)

Families Citing this family (12)

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US7410979B2 (en) 2003-11-19 2008-08-12 Rigel Pharmaceuticals, Inc. Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections
US7514434B2 (en) 2004-02-23 2009-04-07 Rigel Pharmaceuticals, Inc. Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof
JP4434818B2 (en) * 2004-03-31 2010-03-17 京セラ株式会社 Error correction method for portable communication terminal and its geomagnetic sensor
US7449486B2 (en) 2004-10-19 2008-11-11 Array Biopharma Inc. Mitotic kinesin inhibitors and methods of use thereof
CA2606106A1 (en) * 2005-05-02 2007-03-08 Rigel Pharmaceuticals, Inc. Heterocyclic anti-viral compounds comprising metabolizable moieties and their uses
UA95907C2 (en) 2005-05-02 2011-09-26 Эррей Биофарма Инк. Mitotic kinesin inhibitors and methods of use thereof
EP2081918A2 (en) * 2006-10-03 2009-07-29 Array Biopharma, Inc. Mitotic kinesin inhibitors and methods of use thereof
US20080262057A1 (en) * 2007-04-20 2008-10-23 Dow Agrosciences Llc Diarylisoxazolines
US20120065247A1 (en) * 2009-03-27 2012-03-15 Discoverybiomed, Inc. Modulating ires-mediated translation
MX347218B (en) 2010-04-12 2017-04-20 Supernus Pharmaceuticals Inc METHODS TO PRODUCE SALTS OF VILOXAZINE AND NEW POLYMORPHES OF THE SAME.
CN112062735B (en) * 2020-09-10 2022-11-08 温州大学 Synthetic method of isselenazole derivatives
CN115961298B (en) * 2022-12-31 2024-10-01 广西师范大学 Electrochemically mediated synthesis of 2,3-dialkoxy substituted indole compounds from vinylaniline and alcohol, synthesis method and application thereof

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WO2004018463A2 (en) * 2002-08-23 2004-03-04 Rigel Pharmaceuticals, Inc. Pyridyl substituted heterocycles useful for treating or preventing hcv infection
WO2004103366A1 (en) * 2003-05-15 2004-12-02 Rigel Pharmaceuticals Heterocyclic compounds useful to treat hcv

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Publication number Priority date Publication date Assignee Title
US2852503A (en) * 1953-12-31 1958-09-16 American Cyanamid Co 2, 5-bis (p-aminophenyl) furan azo derivatives
US3257203A (en) * 1958-08-20 1966-06-21 Azoplate Corp Electrophotographic reproduction material
US3335149A (en) * 1963-08-21 1967-08-08 Monsanto Co Thiazole diamines
FR1459375A (en) * 1965-10-20 1966-04-29 Westinghouse Electric Corp Linear oxadiazole-imide copolymers
CH559195A5 (en) * 1971-07-22 1975-02-28 Lepetit Spa
DE2137719A1 (en) * 1971-07-28 1973-02-08 Basf Ag Aminobenzonitrile prepn - from halogen - substd triphenylphosphine phenylimines and metal cyanides, esp cuprous cyanide, and hydrolysis
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US3910942A (en) * 1973-04-02 1975-10-07 Squibb & Sons Inc Anthelmintic (isothiocyanophenyl) oxadiazoles
DE2721955A1 (en) * 1977-05-14 1978-11-23 Basf Ag AZO DYES
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WO2002055025A2 (en) * 2001-01-13 2002-07-18 Univ North Carolina Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (bvdv) infection and hepatitis c virus (hcv) infection
WO2003040112A1 (en) * 2001-11-02 2003-05-15 Rigel Pharmaceuticals, Inc. Substituted diphenyl heterocycles useful for treating hcv infection
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DATABASE CHEMCATS [online] 1999, XP002310049, retrieved from STN Database accession no. RN 247059-16-1 *

Also Published As

Publication number Publication date
EP1620412A2 (en) 2006-02-01
WO2004099165A2 (en) 2004-11-18
US7326790B2 (en) 2008-02-05
US20040254227A1 (en) 2004-12-16

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