WO2004110472A3 - Fusion proteins - Google Patents

Fusion proteins Download PDF

Info

Publication number
WO2004110472A3
WO2004110472A3 PCT/US2004/016611 US2004016611W WO2004110472A3 WO 2004110472 A3 WO2004110472 A3 WO 2004110472A3 US 2004016611 W US2004016611 W US 2004016611W WO 2004110472 A3 WO2004110472 A3 WO 2004110472A3
Authority
WO
WIPO (PCT)
Prior art keywords
fusion proteins
reduced
immunogenic
disorders
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/016611
Other languages
French (fr)
Other versions
WO2004110472A2 (en
Inventor
Wolfgang Glaesner
Rohn Lee Millican Jr
Yu Tian
Sheng-Hung Rainbow Tschang
Andrew Mark Vick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Priority to BRPI0411112-5A priority Critical patent/BRPI0411112A/en
Priority to PL04753440T priority patent/PL1641483T3/en
Priority to EP04753440A priority patent/EP1641483B1/en
Priority to CA002526169A priority patent/CA2526169A1/en
Priority to CNA2004800159578A priority patent/CN1802167A/en
Priority to SI200430704T priority patent/SI1641483T1/en
Priority to JP2006533432A priority patent/JP2007505643A/en
Priority to US10/558,862 priority patent/US20070253966A1/en
Priority to DE602004011770T priority patent/DE602004011770T2/en
Priority to DK04753440T priority patent/DK1641483T3/en
Priority to MXPA05013564A priority patent/MXPA05013564A/en
Priority to AU2004247042A priority patent/AU2004247042A1/en
Publication of WO2004110472A2 publication Critical patent/WO2004110472A2/en
Publication of WO2004110472A3 publication Critical patent/WO2004110472A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides active therapeutic peptides fused to specific IgG4-Fc derivatives. These fusion proteins have an increased half-life, reduced half antibody formation, and reduced effector activity, while not being immunogenic. The fusion proteins are useful in treating human diseases as well as a variety of other conditions or disorders.
PCT/US2004/016611 2003-06-12 2004-06-10 Fusion proteins Ceased WO2004110472A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
BRPI0411112-5A BRPI0411112A (en) 2003-06-12 2004-06-10 heterologous fusion protein, polynucleotide, vector, host cell, process for producing a heterologous fusion protein, method for treating a patient, and use of heterologous fusion protein
PL04753440T PL1641483T3 (en) 2003-06-12 2004-06-10 Fusion proteins
EP04753440A EP1641483B1 (en) 2003-06-12 2004-06-10 Fusion proteins
CA002526169A CA2526169A1 (en) 2003-06-12 2004-06-10 Fusion proteins
CNA2004800159578A CN1802167A (en) 2003-06-12 2004-06-10 fusion protein
SI200430704T SI1641483T1 (en) 2003-06-12 2004-06-10 Fusion proteins
JP2006533432A JP2007505643A (en) 2003-06-12 2004-06-10 Fusion protein
US10/558,862 US20070253966A1 (en) 2003-06-12 2004-06-10 Fusion Proteins
DE602004011770T DE602004011770T2 (en) 2003-06-12 2004-06-10 FUSION PROTEIN
DK04753440T DK1641483T3 (en) 2003-06-12 2004-06-10 Fusion Proteins
MXPA05013564A MXPA05013564A (en) 2003-06-12 2004-06-10 Fusion proteins.
AU2004247042A AU2004247042A1 (en) 2003-06-12 2004-06-10 Fusion proteins

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US47788003P 2003-06-12 2003-06-12
US60/477,880 2003-06-12
US57090804P 2004-05-13 2004-05-13
US60/570,908 2004-05-13

Publications (2)

Publication Number Publication Date
WO2004110472A2 WO2004110472A2 (en) 2004-12-23
WO2004110472A3 true WO2004110472A3 (en) 2005-02-03

Family

ID=33555478

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/016611 Ceased WO2004110472A2 (en) 2003-06-12 2004-06-10 Fusion proteins

Country Status (17)

Country Link
US (1) US20070253966A1 (en)
EP (1) EP1641483B1 (en)
JP (1) JP2007505643A (en)
CN (1) CN1802167A (en)
AT (1) ATE385806T1 (en)
AU (1) AU2004247042A1 (en)
BR (1) BRPI0411112A (en)
CA (1) CA2526169A1 (en)
CY (1) CY1107248T1 (en)
DE (1) DE602004011770T2 (en)
DK (1) DK1641483T3 (en)
ES (1) ES2298785T3 (en)
MX (1) MXPA05013564A (en)
PL (1) PL1641483T3 (en)
PT (1) PT1641483E (en)
SI (1) SI1641483T1 (en)
WO (1) WO2004110472A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8324160B2 (en) 2009-06-17 2012-12-04 Amgen Inc. Chimeric polypeptides and uses thereof
US8372952B2 (en) 2009-12-02 2013-02-12 Amgen Inc. Binding proteins that bind to human FGFR1C, human β-klotho and both human FGFR1C and human β-klotho
US9434778B2 (en) 2014-10-24 2016-09-06 Bristol-Myers Squibb Company Modified FGF-21 polypeptides comprising an internal deletion and uses thereof
US9475881B2 (en) 2010-01-19 2016-10-25 Xencor, Inc. Antibody variants with enhanced complement activity

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7459540B1 (en) 1999-09-07 2008-12-02 Amgen Inc. Fibroblast growth factor-like polypeptides
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US7662925B2 (en) 2002-03-01 2010-02-16 Xencor, Inc. Optimized Fc variants and methods for their generation
US8188231B2 (en) 2002-09-27 2012-05-29 Xencor, Inc. Optimized FC variants
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
US8388955B2 (en) 2003-03-03 2013-03-05 Xencor, Inc. Fc variants
US8084582B2 (en) 2003-03-03 2011-12-27 Xencor, Inc. Optimized anti-CD20 monoclonal antibodies having Fc variants
US20090010920A1 (en) 2003-03-03 2009-01-08 Xencor, Inc. Fc Variants Having Decreased Affinity for FcyRIIb
US9051373B2 (en) 2003-05-02 2015-06-09 Xencor, Inc. Optimized Fc variants
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
US9714282B2 (en) 2003-09-26 2017-07-25 Xencor, Inc. Optimized Fc variants and methods for their generation
US8101720B2 (en) 2004-10-21 2012-01-24 Xencor, Inc. Immunoglobulin insertions, deletions and substitutions
US20070148170A1 (en) 2005-10-03 2007-06-28 Desjarlais John R Fc Variants With Optimized Fc Receptor Binding Properties
CA2550050A1 (en) * 2003-12-18 2005-06-30 Novo Nordisk A/S Novel glp-1 analogues linked to albumin-like agents
WO2005092925A2 (en) 2004-03-24 2005-10-06 Xencor, Inc. Immunoglobulin variants outside the fc region
PL1751184T3 (en) 2004-05-13 2010-02-26 Lilly Co Eli Fgf-21 fusion proteins
US20150010550A1 (en) 2004-07-15 2015-01-08 Xencor, Inc. OPTIMIZED Fc VARIANTS
BRPI0517837A (en) 2004-11-12 2008-10-21 Xencor Inc fc variants with altered link to fcrn
US8802820B2 (en) 2004-11-12 2014-08-12 Xencor, Inc. Fc variants with altered binding to FcRn
US8367805B2 (en) 2004-11-12 2013-02-05 Xencor, Inc. Fc variants with altered binding to FcRn
US8546543B2 (en) 2004-11-12 2013-10-01 Xencor, Inc. Fc variants that extend antibody half-life
US7833979B2 (en) 2005-04-22 2010-11-16 Amgen Inc. Toxin peptide therapeutic agents
CN101166545B (en) * 2005-05-13 2011-06-15 伊莱利利公司 Glp-1 pegylated compounds
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
JP4860703B2 (en) 2005-10-06 2012-01-25 ゼンコー・インコーポレイテッド Optimized anti-CD30 antibody
AU2007240313B2 (en) 2006-04-20 2012-02-02 Amgen Inc. GLP-1 compounds
ES2352561T3 (en) * 2006-06-30 2011-02-21 Conaris Research Institute Ag IMPROVED SGP DIMMERS 130FC.
PL2383297T3 (en) 2006-08-14 2013-06-28 Xencor Inc Optimized antibodies that target CD19
CA2660795C (en) 2006-09-18 2014-11-18 Xencor, Inc. Optimized antibodies that target hm1.24
AR063384A1 (en) 2006-10-25 2009-01-28 Amgen Inc THERAPEUTIC AGENTS BASED ON PEPTIDES DERIVED FROM TOXINS
KR100888022B1 (en) * 2006-12-21 2009-03-09 재단법인 목암생명공학연구소 Fusion protein between immunoglobulin Fc and human apolipoprotein (a) kringle fragment L8 8Fc
US20090098130A1 (en) * 2007-01-05 2009-04-16 Bradshaw Curt W Glucagon-like protein-1 receptor (glp-1r) agonist compounds
KR101476472B1 (en) 2007-03-30 2015-01-05 암브룩스, 인코포레이티드 Modified FGF-21 polypeptides and uses thereof
EP2738257A1 (en) 2007-05-22 2014-06-04 Amgen Inc. Compositions and methods for producing bioactive fusion proteins
AU2008345242B2 (en) 2007-10-31 2014-02-27 Xencor, Inc. Fc variants with altered binding to FcRn
US12492253B1 (en) 2008-02-25 2025-12-09 Xencor, Inc. Anti-human C5 antibodies
MX2010013333A (en) 2008-06-04 2011-04-05 Amgen Inc Fgf21 mutants and uses thereof.
EA032727B1 (en) 2008-10-10 2019-07-31 Амген Инк. Fgf21 mutant proteolysis-resistant polypeptide and use thereof
TWI560197B (en) 2009-05-05 2016-12-01 Amgen Inc Fgf21 mutants and uses thereof
US20120052069A1 (en) 2009-05-05 2012-03-01 Amgen Inc Fgf21 mutants and uses thereof
CN101993485B (en) 2009-08-20 2013-04-17 重庆富进生物医药有限公司 Peptide analog homologous dimer capable of accelerating insulin secretion and application thereof
WO2011028952A1 (en) 2009-09-02 2011-03-10 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
UA109888C2 (en) 2009-12-07 2015-10-26 ANTIBODY OR ANTIBODILITY ANTIBODY OR ITS BINDING TO THE β-CLOTE, FGF RECEPTORS AND THEIR COMPLEXES
EP2359843A1 (en) 2010-01-21 2011-08-24 Sanofi Pharmaceutical composition for treating a metabolic syndrome
JP2013523184A (en) 2010-04-15 2013-06-17 アムジエン・インコーポレーテツド Human FGF receptor and β-KLOTHO binding protein
HRP20191305T1 (en) 2010-07-09 2019-10-18 Bioverativ Therapeutics Inc. Processable single chain molecules and polypeptides made using same
WO2012059873A2 (en) * 2010-11-05 2012-05-10 Covx Technologies Ireland, Ltd. Anti-diabetic compounds
US9340590B2 (en) 2011-03-16 2016-05-17 Amgen Inc. Potent and selective inhibitors of NaV1.3 and NaV1.7
JP4857396B1 (en) 2011-04-13 2012-01-18 日本製薬株式会社 Fusion protein
SG10201601621PA (en) 2011-06-28 2016-04-28 Inhibrx Llc Serpin fusion polypeptides and methods of use thereof
WO2013006486A2 (en) 2011-07-01 2013-01-10 Ngm Biopharmaceuticals, Inc. Compositions, uses and methods for treatment of metabolic disorders and diseases
EP2548570A1 (en) 2011-07-19 2013-01-23 Sanofi Pharmaceutical composition for treating a metabolic syndrome
EP2834270B1 (en) * 2012-04-05 2019-10-30 AC Immune S.A. Humanized tau antibody
US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
WO2014085365A2 (en) 2012-11-28 2014-06-05 Ngm Biopharmaceuticals, Inc. Compositions and methods for treatment of metabolic disorders and diseases
IL292303A (en) 2012-12-27 2022-06-01 Ngm Biopharmaceuticals Inc Methods of regulating bile acid homeostasis and treatment of bile acid disorders and diseases
US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
WO2014165277A2 (en) 2013-03-12 2014-10-09 Amgen Inc. POTENT AND SELECTIVE INHIBITORS OF Nav1.7
US9587235B2 (en) 2013-03-15 2017-03-07 Atyr Pharma, Inc. Histidyl-tRNA synthetase-Fc conjugates
EP3038657A2 (en) 2013-08-28 2016-07-06 Bioasis Technologies Inc. Cns-targeted conjugates having modified fc regions and methods of use thereof
SG11201602870YA (en) 2013-10-28 2016-05-30 Ngm Biopharmaceuticals Inc Cancer models and associated methods
PL3097122T3 (en) 2014-01-24 2020-10-19 Ngm Biopharmaceuticals, Inc. Antibodies binding beta klotho domain 2 and methods of use thereof
EP3125921B1 (en) 2014-03-11 2020-07-08 Novartis AG Fgf21 variants for use in treating hiv-haart induced partial lipodystrophy
WO2015183890A2 (en) 2014-05-28 2015-12-03 Ngm Biopharmaceuticals, Inc. Methods and compositions for the treatment of metabolic disorders and diseases
EP3155002B1 (en) 2014-06-10 2019-11-27 Amgen Inc. Apelin polypeptides
WO2015195509A2 (en) 2014-06-16 2015-12-23 Ngm Biopharmaceuticals, Inc. Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
TWI713453B (en) * 2014-06-23 2020-12-21 美商健生生物科技公司 Interferon alpha and omega antibody antagonists
WO2016065106A1 (en) 2014-10-23 2016-04-28 Ngm Biopharmaceuticals, Inc. Pharmaceutical compositions comprising peptide variants and methods of use thereof
WO2016073855A1 (en) 2014-11-07 2016-05-12 Ngm Biopharmaceuticals, Inc. Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders
US10800843B2 (en) 2015-07-29 2020-10-13 Ngm Biopharmaceuticals, Inc. Beta klotho-binding proteins
CN106397569B (en) * 2015-08-01 2020-09-01 深圳红石科创生物科技发展有限公司 Mutant cell factor fusion protein for treating metabolic diseases
CN108137653B (en) 2015-08-05 2021-07-13 陕西麦科奥特科技有限公司 Multi-target compound with anticoagulant and antiplatelet activity, preparation method and use
AU2016353988B2 (en) 2015-11-09 2019-09-26 Ngm Biopharmaceuticals, Inc. Methods for treatment of bile acid-related disorders
WO2018032638A1 (en) 2016-08-19 2018-02-22 安源医药科技（上海）有限公司 Linker peptide for constructing fusion protein
CN106279437B (en) 2016-08-19 2017-10-31 安源医药科技（上海）有限公司 Hyperglycosylated human coagulation factor VIII fusion proteins and preparation method thereof and purposes
CN107759696A (en) 2016-08-19 2018-03-06 安源医药科技（上海）有限公司 Fusion protein of human interleukin 7 and preparation method thereof
WO2018039557A1 (en) 2016-08-26 2018-03-01 Ngm Biopharmaceuticals, Inc. Methods of treating fibroblast growth factor 19-mediated cancers and tumors
ES3014984T3 (en) * 2017-03-14 2025-04-28 Sunshine Lake Pharma Co Ltd Dual-target fusion proteins comprising the fc portion of an immunoglobulin
CN110536694A (en) 2017-04-20 2019-12-03 Atyr 医药公司 Compositions and methods for treating pulmonary inflammation
EP3678686A1 (en) 2017-09-08 2020-07-15 Bristol-Myers Squibb Company Modified fibroblast growth factor 21 (fgf-21) for use in methods for treating nonalcoholic steatohepatitis (nash)
CN111601613A (en) 2017-12-22 2020-08-28 诺华股份有限公司 Methods of treating metabolic disorders with FGF21 variants
AU2019297327A1 (en) 2018-07-03 2021-02-18 Bristol-Myers Squibb Company FGF21 formulations
JP7490925B2 (en) 2018-07-26 2024-05-28 エータイアー ファーマ， インコーポレイテッド Compositions and methods for treating NRP2-associated diseases
CN109206523A (en) * 2018-08-27 2019-01-15 沣潮医药科技（上海）有限公司 TIGIT immunoadhesin, Preparation method and use
CN109748972B (en) * 2019-01-31 2021-12-03 泉州师范学院 Cytoglobin-human lactoferrin peptide fusion protein, gene and application
KR20220125289A (en) 2020-01-08 2022-09-14 브리스톨-마이어스 스큅 컴퍼니 FGF-21 conjugate preparation
WO2021139744A1 (en) 2020-01-11 2021-07-15 Beijing Ql Biopharmaceutical Co., Ltd. Conjugates of fusion proteins of glp-1 and fgf21
US11981718B2 (en) 2020-05-27 2024-05-14 Ampsource Biopharma Shanghai Inc. Dual-function protein for lipid and blood glucose regulation
WO2022032187A1 (en) 2020-08-07 2022-02-10 Bristol-Myers Squibb Company Fgf21 combined with ccr2/5 antagonists for the treatment of fibrosis
US20240123031A1 (en) 2020-11-25 2024-04-18 Bristol-Myers Squibb Company Methods of treating liver diseases
CN119947756A (en) 2022-09-26 2025-05-06 中美华世通生物医药科技(武汉)股份有限公司 Ultra-long-acting platform containing Fc-higher fatty acid chains
JP2026502133A (en) 2022-12-22 2026-01-21 ライフアーク Galanin-2 receptor agonist
WO2024145006A1 (en) * 2022-12-29 2024-07-04 Akston Biosciences Corporation Insulin-fc fusion proteins and methods of use to treat cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996004388A1 (en) * 1994-07-29 1996-02-15 Smithkline Beecham Plc Novel compounds
WO1997000319A2 (en) * 1995-06-13 1997-01-03 Smithkline Beecham Plc Chimeric leptin fused to immunoglobulin domain and use
WO2002046227A2 (en) * 2000-12-07 2002-06-13 Eli Lilly And Company Glp-1 fusion proteins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0307434B2 (en) * 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
US6750334B1 (en) * 1996-02-02 2004-06-15 Repligen Corporation CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor
US6900292B2 (en) * 2001-08-17 2005-05-31 Lee-Hwei K. Sun Fc fusion proteins of human erythropoietin with increased biological activities

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996004388A1 (en) * 1994-07-29 1996-02-15 Smithkline Beecham Plc Novel compounds
WO1997000319A2 (en) * 1995-06-13 1997-01-03 Smithkline Beecham Plc Chimeric leptin fused to immunoglobulin domain and use
WO2002046227A2 (en) * 2000-12-07 2002-06-13 Eli Lilly And Company Glp-1 fusion proteins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANGAL S ET AL: "A SINGLE AMINO ACID SUBSTITUTION ABOLISHES THE HETEROGENEITY OF CHIMERIC MOUSE/HUMAN (IGG4) ANTIBODY", MOLECULAR IMMUNOLOGY, ELMSFORD, NY, US, vol. 30, no. 1, January 1993 (1993-01-01), pages 105 - 108, XP000770218, ISSN: 0161-5890 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8324160B2 (en) 2009-06-17 2012-12-04 Amgen Inc. Chimeric polypeptides and uses thereof
US8372952B2 (en) 2009-12-02 2013-02-12 Amgen Inc. Binding proteins that bind to human FGFR1C, human β-klotho and both human FGFR1C and human β-klotho
US9475881B2 (en) 2010-01-19 2016-10-25 Xencor, Inc. Antibody variants with enhanced complement activity
US9434778B2 (en) 2014-10-24 2016-09-06 Bristol-Myers Squibb Company Modified FGF-21 polypeptides comprising an internal deletion and uses thereof

Also Published As

Publication number Publication date
WO2004110472A2 (en) 2004-12-23
EP1641483B1 (en) 2008-02-13
EP1641483A2 (en) 2006-04-05
BRPI0411112A (en) 2006-07-18
PT1641483E (en) 2008-04-29
CA2526169A1 (en) 2004-12-23
ES2298785T3 (en) 2008-05-16
US20070253966A1 (en) 2007-11-01
CY1107248T1 (en) 2012-11-21
CN1802167A (en) 2006-07-12
MXPA05013564A (en) 2006-03-09
AU2004247042A1 (en) 2004-12-23
ATE385806T1 (en) 2008-03-15
DE602004011770D1 (en) 2008-03-27
DK1641483T3 (en) 2008-06-02
JP2007505643A (en) 2007-03-15
PL1641483T3 (en) 2008-07-31
SI1641483T1 (en) 2008-08-31
DE602004011770T2 (en) 2009-02-05

Similar Documents

Publication Publication Date Title
MXPA05013564A (en) Fusion proteins.
WO2003099771A3 (en) Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases
WO2000078344A8 (en) Prion protein peptides and uses thereof
WO2000055125A3 (en) N-cyanomethyl amides as protease inhibitors
WO2005021579A3 (en) Epo mimetic peptides and fusion proteins
WO2003096990A3 (en) Protein cages for the delivery of medical imaging and therapy
WO2003011115A3 (en) Peptide-based multimeric targeted contrast agents
WO2005063820A3 (en) Il-7 fusion proteins
WO2001079443A3 (en) Albumin fusion proteins
WO2003068920A3 (en) Humanized gm-csf antibodies
WO2002021141A3 (en) Methods and compositions for diseases associated with amyloidosis
WO2002074337A8 (en) Hmgb1 protein inhibitors and/or antagonists for the treatment of vascular diseases
AU2003229284A1 (en) Active substances for the treatment, diagnosis and prophylaxis of diseases in which abnormal protein structures occur
WO2002051379A3 (en) Thixotropic nasal spray
WO2006060021A3 (en) Bifunctional fusion proteins containing the flt3 ligand
WO2005000891A3 (en) Thrombopoietin proteins with improved properties
WO2004113386A3 (en) Modified hirudin proteins and t-cell epitopes in hirudin
WO2005023979A3 (en) Isolated s. mansoni nucleic acid molecules and uses thereof
WO2003014293A3 (en) Novel polypeptide analogs and fusions and their methods of use
WO2003022883A3 (en) Use of proteins for the production of a medicament for stimulating the innate non specific immune system
AU2001289930A1 (en) Method for the production of human antibodies, antibodies thus obtained and their use in therapy and diagnosis
WO2003099863A3 (en) Resistin binding proteins, their preparation and use
WO2006110367A3 (en) Methods and compositions for mycoplasma toxins
AU3553700A (en) Preparation for the treatment of pigmentation disorders
WO2001075021A3 (en) A novel polypeptide, glucose transport-associated human protein 10 and the polynucleotide encoding the polypeptide

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2004247042

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2526169

Country of ref document: CA

ENP Entry into the national phase

Ref document number: 2004247042

Country of ref document: AU

Date of ref document: 20040610

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2004247042

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 10558862

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 02526/KOLNP/2005

Country of ref document: IN

Ref document number: 2526/KOLNP/2005

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 20048159578

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: 2006533432

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: PA/a/2005/013564

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2004753440

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2004753440

Country of ref document: EP

ENP Entry into the national phase

Ref document number: PI0411112

Country of ref document: BR

WWP Wipo information: published in national office

Ref document number: 10558862

Country of ref document: US

WWG Wipo information: grant in national office

Ref document number: 2004753440

Country of ref document: EP