WO2004111636A3 - Peptide combos and their uses - Google Patents

Peptide combos and their uses Download PDF

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Publication number
WO2004111636A3
WO2004111636A3 PCT/EP2004/051158 EP2004051158W WO2004111636A3 WO 2004111636 A3 WO2004111636 A3 WO 2004111636A3 EP 2004051158 W EP2004051158 W EP 2004051158W WO 2004111636 A3 WO2004111636 A3 WO 2004111636A3
Authority
WO
WIPO (PCT)
Prior art keywords
reference peptides
peptide
sample
methods
synthetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2004/051158
Other languages
French (fr)
Other versions
WO2004111636A2 (en
Inventor
Koen Kas
Joel Vandekerckhove
Luc Krols
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universiteit Gent
Vlaams Instituut voor Biotechnologie VIB
Original Assignee
Universiteit Gent
Vlaams Instituut voor Biotechnologie VIB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universiteit Gent, Vlaams Instituut voor Biotechnologie VIB filed Critical Universiteit Gent
Priority to JP2006516163A priority Critical patent/JP2007527503A/en
Priority to CA002529863A priority patent/CA2529863A1/en
Priority to EP04741829A priority patent/EP1634083A2/en
Publication of WO2004111636A2 publication Critical patent/WO2004111636A2/en
Publication of WO2004111636A3 publication Critical patent/WO2004111636A3/en
Priority to US11/305,737 priority patent/US20070254371A1/en
Anticipated expiration legal-status Critical
Priority to US12/459,278 priority patent/US20100021881A1/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention provides reagents and methods for the accurate quantification of proteins in complex biological samples. Quantification is obtained by adding to a sample a peptide combo which is essentially a collection of synthetic reference peptides. Said synthetic reference peptides have a small mass difference when compared to the biological reference peptides that originate upon digestion from the proteins present in the sample. Reference peptides and synthetic reference peptides are selected and the identity and accurate amounts of reference peptides are determined by mass spectrometry. The methods can be used in high throughput assays to interrogate proteomes.
PCT/EP2004/051158 2003-06-17 2004-06-17 Peptide combos and their uses Ceased WO2004111636A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2006516163A JP2007527503A (en) 2003-06-17 2004-06-17 Peptide combos and their use
CA002529863A CA2529863A1 (en) 2003-06-17 2004-06-17 Peptide combos and their uses
EP04741829A EP1634083A2 (en) 2003-06-17 2004-06-17 Peptide combos and their uses
US11/305,737 US20070254371A1 (en) 2003-06-17 2005-12-16 Peptide combos and their uses
US12/459,278 US20100021881A1 (en) 2003-06-17 2009-06-29 Peptide combos and their uses

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US47906103P 2003-06-17 2003-06-17
EP03101775 2003-06-17
US60/479,061 2003-06-17
EP03101775.9 2003-06-17

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/305,737 Continuation US20070254371A1 (en) 2003-06-17 2005-12-16 Peptide combos and their uses

Publications (2)

Publication Number Publication Date
WO2004111636A2 WO2004111636A2 (en) 2004-12-23
WO2004111636A3 true WO2004111636A3 (en) 2005-03-31

Family

ID=46045401

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/051158 Ceased WO2004111636A2 (en) 2003-06-17 2004-06-17 Peptide combos and their uses

Country Status (5)

Country Link
US (2) US20070254371A1 (en)
EP (1) EP1634083A2 (en)
JP (1) JP2007527503A (en)
CA (1) CA2529863A1 (en)
WO (1) WO2004111636A2 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10354403A1 (en) 2003-11-20 2005-06-23 Dade Behring Marburg Gmbh Antibodies directed against the prothrombin fragment F 1 + 2, their preparation and use
US20080213271A1 (en) * 2005-05-05 2008-09-04 Center For Addiction And Mental Health Compositions and Methods For Modulating Dopamine Nerutransmission
WO2007033233A2 (en) * 2005-09-12 2007-03-22 Mayo Foundation For Medical Education And Research Stimulating g protein-coupled receptors
JP5294548B2 (en) * 2006-08-22 2013-09-18 株式会社日立ハイテクノロジーズ Method and apparatus for identifying sugar chain-modified protein or sugar chain-modified peptide
CN103435694A (en) * 2006-10-31 2013-12-11 美国政府卫生与公共服务部 Smoothened polypeptides and methods of use
US7511267B2 (en) * 2006-11-10 2009-03-31 Thermo Finnigan Llc Data-dependent accurate mass neutral loss analysis
EP2134365B1 (en) * 2007-03-21 2019-03-13 Effat Emamian Compositions and methods for inhibiting tumor cell growth
ES2613866T3 (en) * 2008-06-12 2017-05-26 Centre For Addiction And Mental Health Compositions and methods to modulate the interaction and function of the D1-D2 dopamine receptor
US9202678B2 (en) * 2008-11-14 2015-12-01 Board Of Trustees Of Michigan State University Ultrafast laser system for biological mass spectrometry
EP2486130A1 (en) * 2009-10-06 2012-08-15 Tallinn University Of Technology Inhibition or activation of serine/threonine ulk3 kinase activity
US8835361B2 (en) * 2010-06-01 2014-09-16 The Curators Of The University Of Missouri High-throughput quantitation of crop seed proteins
ES2719427T3 (en) 2010-12-08 2019-07-10 Expression Pathology Inc Quantitative analysis of truncated forms of HER2 by the SRM / MRM technique
EP2665742B1 (en) 2011-01-20 2016-04-20 Oneday - Biotech And Pharma Ltd. Antioxidant, anti-inflammatory, anti-radiation, metal chelating compounds and uses thereof
US9303063B2 (en) 2011-03-18 2016-04-05 Duke University Peptide compounds for suppressing inflammation
CN103429610B (en) * 2011-03-18 2017-03-01 杜克大学 Peptides for Inhibiting Inflammation
WO2013165262A1 (en) * 2012-04-30 2013-11-07 Auckland Uniservices Limited Peptides, constructs and uses therefor
CN104717970A (en) 2012-07-23 2015-06-17 万德-生物技术及制药有限公司 Compositions for increasing glutathione and uses thereof
WO2014016837A1 (en) 2012-07-25 2014-01-30 Oneday - Biotech And Pharma Ltd. Compositions and methods for increasing carnitine level in muscle tissues
WO2015063613A2 (en) 2013-11-01 2015-05-07 Spherium Biomed S.L. Inclusion bodies for transdermal delivery of therapeutic and cosmetic agents
WO2016011386A1 (en) * 2014-07-18 2016-01-21 University Of Washington Cancer vaccine compositions and methods of use thereof
CA2983351C (en) * 2015-04-20 2024-06-04 F. Hoffmann-La Roche Ag Specific peptide binders to proteins identified via systemic discovery, maturation and extension process
WO2017100663A1 (en) 2015-12-09 2017-06-15 Expression Pathology, Inc. Improved methods for treating her2-positive breast cancer
CN112730643B (en) * 2020-12-07 2022-09-16 江苏大学 Method and device for characterizing fermented bean curd flavor based on visual fusion technology
WO2025186514A1 (en) * 2024-03-07 2025-09-12 University Of Helsinki Cancer cell targeting peptide

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002077016A2 (en) * 2001-03-22 2002-10-03 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Methods and apparatus for gel-free qualitative and quantitative proteome analysis, and uses therefore
WO2003016861A2 (en) * 2001-08-14 2003-02-27 President And Fellows Of Harvard College Absolute quantification of proteins and modified forms thereof by multistage mass spectrometry

Family Cites Families (2)

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Publication number Priority date Publication date Assignee Title
DE69912444T3 (en) * 1998-08-25 2010-05-06 University Of Washington, Seattle FAST QUANTITATIVE ANALYSIS OF PROTEINS OR PROTEIN FUNCTIONS IN COMPLEX MIXTURES
US20030129760A1 (en) * 2001-11-13 2003-07-10 Aguilera Frank Reinaldo Morales Mass intensity profiling system and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002077016A2 (en) * 2001-03-22 2002-10-03 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Methods and apparatus for gel-free qualitative and quantitative proteome analysis, and uses therefore
WO2003016861A2 (en) * 2001-08-14 2003-02-27 President And Fellows Of Harvard College Absolute quantification of proteins and modified forms thereof by multistage mass spectrometry

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ARNOTT D ET AL: "Rapid identification of comigrating gel-isolation proteins by ion trap-mass spectrometry", ELECTROPHORESIS, WEINHEIM, DE, vol. 19, 1998, pages 968 - 980, XP002963575, ISSN: 0173-0835 *
MURPHY M P ET AL: "gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 17, 23 April 1999 (1999-04-23), pages 11914 - 11923, XP002254470, ISSN: 0021-9258 *
PASSER BRENT ET AL: "Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor", JOURNAL OF ALZHEIMER'S DISEASE, vol. 2, no. 3-4, November 2000 (2000-11-01), pages 289 - 301, XP009043393, ISSN: 1387-2877 *
VARESIO E ET AL: "Nanoscale liquid chromatography and capillary electrophoresis coupled to electrospray mass spectrometry for the detection of amyloid-beta peptide related to Alzheimer's disease", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER SCIENCE, NL, vol. 974, no. 1-2, 18 October 2002 (2002-10-18), pages 135 - 142, XP004387545, ISSN: 0021-9673 *

Also Published As

Publication number Publication date
JP2007527503A (en) 2007-09-27
CA2529863A1 (en) 2004-12-23
US20100021881A1 (en) 2010-01-28
EP1634083A2 (en) 2006-03-15
US20070254371A1 (en) 2007-11-01
WO2004111636A2 (en) 2004-12-23

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