WO2004112762A3 - Pharmaceutical formulations of amyloid inhibiting compounds - Google Patents

Pharmaceutical formulations of amyloid inhibiting compounds Download PDF

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Publication number
WO2004112762A3
WO2004112762A3 PCT/IB2004/002381 IB2004002381W WO2004112762A3 WO 2004112762 A3 WO2004112762 A3 WO 2004112762A3 IB 2004002381 W IB2004002381 W IB 2004002381W WO 2004112762 A3 WO2004112762 A3 WO 2004112762A3
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WO
WIPO (PCT)
Prior art keywords
pharmaceutical formulations
inhibiting compounds
amyloid
amyloid inhibiting
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2004/002381
Other languages
French (fr)
Other versions
WO2004112762A2 (en
Inventor
Audley Legore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bellus Health International Ltd
Original Assignee
Neurochem International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA2529268A priority Critical patent/CA2529268C/en
Priority to MXPA05013974A priority patent/MXPA05013974A/en
Priority to SI200431261T priority patent/SI1635799T1/en
Priority to PL04744039T priority patent/PL1635799T3/en
Priority to BRPI0411808-1A priority patent/BRPI0411808A/en
Priority to JP2006516600A priority patent/JP4903561B2/en
Priority to DK04744039T priority patent/DK1635799T3/en
Priority to AU2004248995A priority patent/AU2004248995B2/en
Priority to NZ544685A priority patent/NZ544685A/en
Priority to DE602004022408T priority patent/DE602004022408D1/en
Priority to EP04744039A priority patent/EP1635799B1/en
Priority to AT04744039T priority patent/ATE438391T1/en
Application filed by Neurochem International Ltd filed Critical Neurochem International Ltd
Publication of WO2004112762A2 publication Critical patent/WO2004112762A2/en
Priority to CA002504471A priority patent/CA2504471A1/en
Publication of WO2004112762A3 publication Critical patent/WO2004112762A3/en
Priority to IL172193A priority patent/IL172193A0/en
Anticipated expiration legal-status Critical
Priority to US12/362,971 priority patent/US8835500B2/en
Priority to AU2010201299A priority patent/AU2010201299A1/en
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biotechnology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Therapeutic formulations and methods for inhibiting amyloid deposition in a subject, whatever its clinical setting, are described. Therapeutic formulations and methods for preventing or treating amyloidosis and/or amyloid-related disease are also described.
PCT/IB2004/002381 2003-06-23 2004-06-21 Pharmaceutical formulations of amyloid inhibiting compounds Ceased WO2004112762A2 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
EP04744039A EP1635799B1 (en) 2003-06-23 2004-06-21 Pharmaceutical formulations of amyloid inhibiting compounds
SI200431261T SI1635799T1 (en) 2003-06-23 2004-06-21 Pharmaceutical formulations of amyloid inhibiting compounds
PL04744039T PL1635799T3 (en) 2003-06-23 2004-06-21 Pharmaceutical formulations of amyloid inhibiting compounds
BRPI0411808-1A BRPI0411808A (en) 2003-06-23 2004-06-21 pharmaceutical formulations of amyloid inhibiting compounds
JP2006516600A JP4903561B2 (en) 2003-06-23 2004-06-21 Pharmaceutical formulations of amyloid inhibitory compounds
DK04744039T DK1635799T3 (en) 2003-06-23 2004-06-21 Pharmaceutical formulations of amyloid-inhibiting compounds
AU2004248995A AU2004248995B2 (en) 2003-06-23 2004-06-21 Pharmaceutical formulations of amyloid inhibiting compounds
NZ544685A NZ544685A (en) 2003-06-23 2004-06-21 Pharmaceutical formulations of amyloid inhibiting compounds
DE602004022408T DE602004022408D1 (en) 2003-06-23 2004-06-21 PHARMACEUTICAL PREPARATIONS OF AMYLOID-INHIBITING COMPOUNDS
CA2529268A CA2529268C (en) 2003-06-23 2004-06-21 Pharmaceutical formulations of amyloid inhibiting compounds
MXPA05013974A MXPA05013974A (en) 2003-06-23 2004-06-21 Pharmaceutical formulations of amyloid inhibiting compounds.
AT04744039T ATE438391T1 (en) 2003-06-23 2004-06-21 PHARMACEUTICAL PREPARATIONS OF AMYLOID-INHIBITING COMPOUNDS
CA002504471A CA2504471A1 (en) 2004-06-18 2005-04-12 Pharmaceutical formulations of amyloid inhibiting compounds
IL172193A IL172193A0 (en) 2003-06-23 2005-11-24 Pharmaceutical formulations of amyloid inhibiting compounds
US12/362,971 US8835500B2 (en) 2003-06-23 2009-01-30 Pharmaceutical formulations of amyloid inhibiting compounds
AU2010201299A AU2010201299A1 (en) 2003-06-23 2010-03-31 Pharmaceutical formulations of amyloid inhibiting compounds

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US48098403P 2003-06-23 2003-06-23
US60/480984 2003-06-23
US51211603P 2003-10-17 2003-10-17
US60/512116 2003-10-17
US10/871,549 2004-06-18
US10/871,549 US20050142191A1 (en) 2003-06-23 2004-06-18 Pharmaceutical formulations of amyloid inhibiting compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/871,549 Continuation-In-Part US20050142191A1 (en) 2003-06-23 2004-06-18 Pharmaceutical formulations of amyloid inhibiting compounds

Publications (2)

Publication Number Publication Date
WO2004112762A2 WO2004112762A2 (en) 2004-12-29
WO2004112762A3 true WO2004112762A3 (en) 2005-06-02

Family

ID=33545348

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/002381 Ceased WO2004112762A2 (en) 2003-06-23 2004-06-21 Pharmaceutical formulations of amyloid inhibiting compounds

Country Status (18)

Country Link
US (2) US20050142191A1 (en)
EP (2) EP1635799B1 (en)
JP (1) JP4903561B2 (en)
CN (1) CN103550196A (en)
AT (1) ATE438391T1 (en)
AU (2) AU2004248995B2 (en)
BR (1) BRPI0411808A (en)
CA (1) CA2529268C (en)
DE (1) DE602004022408D1 (en)
DK (1) DK1635799T3 (en)
ES (1) ES2328818T3 (en)
IL (1) IL172193A0 (en)
MX (1) MXPA05013974A (en)
NZ (1) NZ544685A (en)
PL (1) PL1635799T3 (en)
PT (1) PT1635799E (en)
SI (1) SI1635799T1 (en)
WO (1) WO2004112762A2 (en)

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US9499480B2 (en) 2006-10-12 2016-11-22 Bhi Limited Partnership Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid

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AU5994900A (en) * 1999-07-09 2001-01-30 Isis Innovation Limited Compounds for inhibiting diseases and preparing cells for transplantation
WO2004058239A1 (en) * 2002-12-24 2004-07-15 Neurochem (International) Limited Therapeutic formulations for the treatment of beta-amyloid related diseases
US20070010573A1 (en) * 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
US7244764B2 (en) * 2003-06-23 2007-07-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US20050142191A1 (en) 2003-06-23 2005-06-30 Neurochem (International) Limited Pharmaceutical formulations of amyloid inhibiting compounds
WO2006085149A2 (en) 2004-12-22 2006-08-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US20060257480A1 (en) * 2005-04-12 2006-11-16 Julie Laurin Pharmaceutical formulations of amyloid inhibiting compounds
TW200716088A (en) * 2005-04-15 2007-05-01 Neurochem Int Ltd Formulations and methods for treating amyloidosis
US20070049638A1 (en) * 2005-07-21 2007-03-01 Neurochem (International) Limited Polymorphic forms of 3-amino-1-propanesulfonic acid
EP2120905A1 (en) * 2006-12-22 2009-11-25 BELLUS Health (International) Limited Methods, compounds, and compositions for treating metabolic disorders and diabetes
US20100008983A1 (en) * 2008-06-10 2010-01-14 Muhammad Safadi Rasagiline soft gelatin capsules
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9499480B2 (en) 2006-10-12 2016-11-22 Bhi Limited Partnership Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid

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CA2529268C (en) 2013-10-29
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MXPA05013974A (en) 2006-03-09
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US20050142191A1 (en) 2005-06-30
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