WO2005008238A3 - Procede et dispositif pour l'analyse de milieux reactionnels vivants - Google Patents

Procede et dispositif pour l'analyse de milieux reactionnels vivants Download PDF

Info

Publication number
WO2005008238A3
WO2005008238A3 PCT/FR2004/001810 FR2004001810W WO2005008238A3 WO 2005008238 A3 WO2005008238 A3 WO 2005008238A3 FR 2004001810 W FR2004001810 W FR 2004001810W WO 2005008238 A3 WO2005008238 A3 WO 2005008238A3
Authority
WO
WIPO (PCT)
Prior art keywords
analysis
reaction media
living reaction
living
media
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2004/001810
Other languages
English (en)
Other versions
WO2005008238A2 (fr
Inventor
Julien Reboud
Beatrice Schaack
Francois Chatelain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat a lEnergie Atomique CEA filed Critical Commissariat a lEnergie Atomique CEA
Priority to EP04767642A priority Critical patent/EP1644731B1/fr
Priority to CA002531765A priority patent/CA2531765A1/fr
Priority to JP2006518304A priority patent/JP4504980B2/ja
Priority to DE602004015990T priority patent/DE602004015990D1/de
Priority to US10/563,817 priority patent/US7785890B2/en
Publication of WO2005008238A2 publication Critical patent/WO2005008238A2/fr
Publication of WO2005008238A3 publication Critical patent/WO2005008238A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/112499—Automated chemical analysis with sample on test slide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Procédé et dispositif pour l'analyse de milieux réactionnels comportant une ou plusieurs cellules, ce procédé et ce dispositif permettant de réaliser une analyse automatisée à haut débit.
PCT/FR2004/001810 2003-07-11 2004-07-09 Procede et dispositif pour l'analyse de milieux reactionnels vivants Ceased WO2005008238A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP04767642A EP1644731B1 (fr) 2003-07-11 2004-07-09 Procede et dispositif pour l analyse de milieux reactionnels vivants
CA002531765A CA2531765A1 (fr) 2003-07-11 2004-07-09 Procede et dispositif pour l'analyse de milieux reactionnels vivants
JP2006518304A JP4504980B2 (ja) 2003-07-11 2004-07-09 生きた反応媒体の分析のための方法及び装置
DE602004015990T DE602004015990D1 (de) 2003-07-11 2004-07-09 Verfahren und vorrichtung zur analyse lebender reaktionsmedien
US10/563,817 US7785890B2 (en) 2003-07-11 2004-07-09 Method and device for the analysis of living reaction media

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0308526A FR2857451B1 (fr) 2003-07-11 2003-07-11 Procede et dispositif pour l'analyse de milieux reactionnels vivants
FR03/08526 2003-07-11

Publications (2)

Publication Number Publication Date
WO2005008238A2 WO2005008238A2 (fr) 2005-01-27
WO2005008238A3 true WO2005008238A3 (fr) 2005-03-17

Family

ID=33522972

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2004/001810 Ceased WO2005008238A2 (fr) 2003-07-11 2004-07-09 Procede et dispositif pour l'analyse de milieux reactionnels vivants

Country Status (8)

Country Link
US (1) US7785890B2 (fr)
EP (1) EP1644731B1 (fr)
JP (1) JP4504980B2 (fr)
AT (1) ATE405826T1 (fr)
CA (1) CA2531765A1 (fr)
DE (1) DE602004015990D1 (fr)
FR (1) FR2857451B1 (fr)
WO (1) WO2005008238A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2842747B1 (fr) * 2002-07-23 2004-10-15 Commissariat Energie Atomique Procede et dispositif pour le criblage de molecules dans des cellules
TWI510781B (zh) * 2010-10-29 2015-12-01 Scinopharm Taiwan Ltd 即時監測固相胜肽合成反應之質譜系統
US8592754B2 (en) * 2011-05-12 2013-11-26 Illinois State University High sensitivity mass spectrometry systems
DE102012011647B4 (de) 2012-06-08 2020-07-02 Bruker Daltonik Gmbh Analyse von Mikroben aus Mikrokolonien mittels MALDI-Massenspektrometrie
DE102012011648B4 (de) 2012-06-08 2018-06-14 Bruker Daltonik Gmbh Analyse von Mikroben aus Mikrokolonien mittels MALDI-Massenspektrometrie
GB201518392D0 (en) * 2015-10-16 2015-12-02 Isis Innovation Microfluidic arrangements
WO2017165791A1 (fr) * 2016-03-25 2017-09-28 President And Fellows Of Harvard College Détermination microfluidique de cellules immunes et d'autres cellules
CN106501298B (zh) * 2016-10-31 2017-12-15 重庆大学 大孔隙煤岩体二氧化碳驱替瓦斯过程动态分析方法
EP4417975A1 (fr) * 2016-11-30 2024-08-21 Bruker Daltonics GmbH & Co. KG Préparation d'échantillons microbiens vivants et de microorganismes pour effectuer ensuite une mesure et une évaluation par spectrométrie de masse
WO2022066588A1 (fr) * 2020-09-25 2022-03-31 Ut-Battelle, Llc Interface d'introduction rapide de gouttelettes (rdii) destinée à une spectrométrie de masse
WO2024102720A2 (fr) 2022-11-07 2024-05-16 Shennon Biotechnologies Inc. Dispositifs microfluidiques pour le criblage à haut débit d'interactions cellule-cellule

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001026460A1 (fr) * 1999-10-08 2001-04-19 The General Hospital Corporation Procedes et appareil d'analyse cellulaire
WO2001084143A1 (fr) * 2000-04-13 2001-11-08 Thermo Finnigan Llc Analyse proteomique par spectrometrie de masse parallele
US20020158196A1 (en) * 2001-03-29 2002-10-31 Berggren William Travis Piezoelectric charged droplet source
EP1284495A2 (fr) * 2001-08-17 2003-02-19 Micromass Limited Spectromètre de masse

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6071610A (en) * 1993-11-12 2000-06-06 Waters Investments Limited Enhanced resolution matrix-laser desorption and ionization TOF-MS sample surface
AUPN923596A0 (en) * 1996-04-12 1996-05-09 Australian Biomedical Corporation Limited Method and apparatus for treatment of human or animal cell samples
DE19754978C2 (de) * 1997-12-11 2000-07-13 Bruker Daltonik Gmbh Probenträger für die MALDI-Massenspektrometrie nebst Verfahren zur Herstellung der Platten und zum Aufbringen der Proben
US6265715B1 (en) * 1998-02-02 2001-07-24 Helene Perreault Non-porous membrane for MALDI-TOFMS
GB9808836D0 (en) * 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
EP1329513B1 (fr) * 1998-08-25 2011-12-07 University of Washington Analyse quantitative rapide de protéines ou de fonction protéique dans des mélanges complexes
WO2000048004A1 (fr) * 1999-02-11 2000-08-17 Maxygen, Inc. Spectrometrie de masse a haut rendement
US20030010908A1 (en) * 2001-07-02 2003-01-16 Phillip Clark Conductive card suitable as a MALDI-TOF target
DE60206526T2 (de) * 2001-07-16 2006-07-13 The President And Fellows Of Harvard College, Cambridge Nicht auf affinität basierende, isotopenmarkierte peptide und verfahren zu deren anwendung
DE10140499B4 (de) * 2001-08-17 2005-02-03 Bruker Daltonik Gmbh Probenträgerplatten für Massenspektrometrie mit Ionisierung durch matrixunterstützte Laserdesorption
EP1478925A1 (fr) * 2002-02-22 2004-11-24 Sunyx Surface Nanotechnologies GmbH Utilisation de surfaces ultraphobes dotees d'une pluralite de zones hydrophiles pour l'analyse d'echantillons
FR2842747B1 (fr) * 2002-07-23 2004-10-15 Commissariat Energie Atomique Procede et dispositif pour le criblage de molecules dans des cellules

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001026460A1 (fr) * 1999-10-08 2001-04-19 The General Hospital Corporation Procedes et appareil d'analyse cellulaire
WO2001084143A1 (fr) * 2000-04-13 2001-11-08 Thermo Finnigan Llc Analyse proteomique par spectrometrie de masse parallele
US20020158196A1 (en) * 2001-03-29 2002-10-31 Berggren William Travis Piezoelectric charged droplet source
EP1284495A2 (fr) * 2001-08-17 2003-02-19 Micromass Limited Spectromètre de masse

Also Published As

Publication number Publication date
FR2857451A1 (fr) 2005-01-14
WO2005008238A2 (fr) 2005-01-27
FR2857451B1 (fr) 2005-09-30
JP4504980B2 (ja) 2010-07-14
ATE405826T1 (de) 2008-09-15
US7785890B2 (en) 2010-08-31
US20070065946A1 (en) 2007-03-22
CA2531765A1 (fr) 2005-01-27
EP1644731B1 (fr) 2008-08-20
JP2007525656A (ja) 2007-09-06
EP1644731A2 (fr) 2006-04-12
DE602004015990D1 (de) 2008-10-02

Similar Documents

Publication Publication Date Title
WO2007065025A3 (fr) Procede d'analyse d'adn au moyen de micro/nano-canaux
WO2008005321A3 (fr) Systèmes et procédés de réaction en chaîne de la polymérase en temps réel
WO2005017646A3 (fr) Système, logiciel et procédés pour l'identification de biomarqueurs
AU2003259722A1 (en) Systems and methods for high-throughput microfluidic sample analysis
WO2006121997A3 (fr) Analyse biologique autonome
WO2006095129A8 (fr) Instrument et procede d'evaluation et d'analyse de performance
WO2008140568A3 (fr) Analyse biologique auto-contenue haute densité
EP2305809A3 (fr) Procédés d'isolation d'acide nucléique et kits utilisant un dispositif microfluidique et étape de concentration
AU2003216010A1 (en) Microfluidic cell and method for sample handling
AU2003212954A1 (en) Skin cell biomarkers and methods for identifying biomarkers using nucleic acid microarrays
WO2003100012A3 (fr) Jeux ordonnes de microechantillons et procede permettant de declencher une reaction d'hybridation pour plusieurs echantillons sur un seul jeu ordonne
ZA200810188B (en) Device and method for chemical, biochemical, biological and physical analysis, reaction, assay and more
AU2003298245A1 (en) Method for analyzing the luminescence of chemical and/or biological samples
WO2005014850A3 (fr) Systemes et procedes d'analyse de sequences d'acides nucleiques
EP1820021B8 (fr) Procede ameliore d'analyse electrochimique d'un analyte
CA2545989A1 (fr) Procede et dispositif de purification d'acides nucleiques
WO2005033982A3 (fr) Procede pour simuler l'interaction de substances chimiques avec des organismes vivants
WO2007085827A3 (fr) Analyses epigenetiques
AU2003265768A1 (en) Automated framework for the analysis of biological data
AU2003261795A1 (en) Method for detecting microbe or cell
EP2006393A4 (fr) Procede d'analyse d'acides nucleiques
WO2009042522A3 (fr) Lyse microfluidique
WO2005031004A3 (fr) Procede de detection specifique rapide de micro-organismes nocifs pour les boissons
WO2006031591A3 (fr) Procedes et ensembles d'isolement de cellules du sperme
WO2004010143A3 (fr) Dispositifs electrochimiques a ecoulement lateral et a ecoulement continu

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2531765

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2006518304

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2004767642

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2004767642

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2007065946

Country of ref document: US

Ref document number: 10563817

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 10563817

Country of ref document: US

WWG Wipo information: grant in national office

Ref document number: 2004767642

Country of ref document: EP