WO2005016323A3 - Use of c-kit inhibitors for treating type ii diabetes - Google Patents

Use of c-kit inhibitors for treating type ii diabetes Download PDF

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Publication number
WO2005016323A3
WO2005016323A3 PCT/IB2004/002934 IB2004002934W WO2005016323A3 WO 2005016323 A3 WO2005016323 A3 WO 2005016323A3 IB 2004002934 W IB2004002934 W IB 2004002934W WO 2005016323 A3 WO2005016323 A3 WO 2005016323A3
Authority
WO
WIPO (PCT)
Prior art keywords
diabetes
treating type
kit inhibitors
inhibitors
kit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2004/002934
Other languages
French (fr)
Other versions
WO2005016323A2 (en
Inventor
Alain Moussy
Jean-Pierre Kinet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AB Science SA
Original Assignee
AB Science SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AB Science SA filed Critical AB Science SA
Priority to DE602004013792T priority Critical patent/DE602004013792D1/en
Priority to JP2006523710A priority patent/JP2007502809A/en
Priority to CA002535242A priority patent/CA2535242A1/en
Priority to US10/567,557 priority patent/US20070032521A1/en
Priority to EP04769332A priority patent/EP1653934B1/en
Publication of WO2005016323A2 publication Critical patent/WO2005016323A2/en
Publication of WO2005016323A3 publication Critical patent/WO2005016323A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a method for treating type II diabetes, comprising administering a compound capable of depleting mast cells to a human in need of such treatment. Such compounds can be chosen from non-toxic, selective and potent c-kit inhibitors.
PCT/IB2004/002934 2003-08-15 2004-08-16 Use of c-kit inhibitors for treating type ii diabetes Ceased WO2005016323A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE602004013792T DE602004013792D1 (en) 2003-08-15 2004-08-16 USE OF C-KIT INHIBITORS FOR THE TREATMENT OF TYPE-2 DIABETES
JP2006523710A JP2007502809A (en) 2003-08-15 2004-08-16 Methods of using c-kit inhibitors for treating type II diabetes
CA002535242A CA2535242A1 (en) 2003-08-15 2004-08-16 Use of c-kit inhibitors for treating type ii diabetes
US10/567,557 US20070032521A1 (en) 2003-08-15 2004-08-16 Use of c-kit inhibitors for treating type II diabetes
EP04769332A EP1653934B1 (en) 2003-08-15 2004-08-16 Use of c-kit inhibitors for treating type ii diabetes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49508803P 2003-08-15 2003-08-15
US60/495,088 2003-08-15

Publications (2)

Publication Number Publication Date
WO2005016323A2 WO2005016323A2 (en) 2005-02-24
WO2005016323A3 true WO2005016323A3 (en) 2005-04-07

Family

ID=34193274

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/002934 Ceased WO2005016323A2 (en) 2003-08-15 2004-08-16 Use of c-kit inhibitors for treating type ii diabetes

Country Status (7)

Country Link
US (1) US20070032521A1 (en)
EP (1) EP1653934B1 (en)
JP (1) JP2007502809A (en)
AT (1) ATE395052T1 (en)
CA (1) CA2535242A1 (en)
DE (1) DE602004013792D1 (en)
WO (1) WO2005016323A2 (en)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100600550B1 (en) * 2000-10-20 2006-07-13 에자이 가부시키가이샤 Nitrogen-containing aromatic ring derivative
EP1604665B1 (en) * 2003-03-10 2011-05-11 Eisai R&D Management Co., Ltd. C-kit kinase inhibitor
MXPA06003123A (en) 2003-09-22 2006-05-31 Euro Celtique Sa Therapeutic agents useful for treating pain.
SI1664041T1 (en) 2003-09-22 2008-12-31 Euro Celtique Sa Phenyl-carboxamide compounds useful for treating pain
JP4303726B2 (en) * 2003-11-11 2009-07-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 Urea derivative and method for producing the same
WO2005063709A1 (en) * 2003-12-25 2005-07-14 Nippon Shinyaku Co., Ltd. Amide derivative and medicine
US8969379B2 (en) * 2004-09-17 2015-03-03 Eisai R&D Management Co., Ltd. Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide
AU2006244203B2 (en) 2005-05-09 2012-05-03 Achillion Pharmaceuticals, Inc. Thiazole compounds and methods of use
JP5066446B2 (en) * 2005-08-01 2012-11-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 Methods for predicting the effects of angiogenesis inhibitors
JP4989476B2 (en) 2005-08-02 2012-08-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 Methods for assaying the effects of angiogenesis inhibitors
CN102716490A (en) * 2005-09-01 2012-10-10 卫材R&D管理有限公司 Method for improving disintegration of pharmaceutical composition
KR101353763B1 (en) 2005-11-07 2014-01-21 에자이 알앤드디 매니지먼트 가부시키가이샤 USE OF COMBINATION OF ANTI-ANGIOGENIC SUBSTANCE AND c-kit KINASE INHIBITOR
US20090247576A1 (en) * 2005-11-22 2009-10-01 Eisai R & D Management Co., Ltd. Anti-tumor agent for multiple myeloma
DE102005062986A1 (en) * 2005-12-28 2007-07-05 Grünenthal GmbH Substituted propiolic acid amides and their use for the preparation of medicaments
CN104706637A (en) * 2006-05-18 2015-06-17 卫材R&D管理有限公司 Antitumor agent for thyroid cancer
US20090203693A1 (en) * 2006-06-29 2009-08-13 Eisai R & D Management Co., Ltd. Therapeutic agent for liver fibrosis
JP5368096B2 (en) * 2006-08-28 2013-12-18 エーザイ・アール・アンド・ディー・マネジメント株式会社 Anti-tumor agent for undifferentiated gastric cancer
JP2010504359A (en) 2006-09-20 2010-02-12 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム Method for delivering volatile anesthetics for local anesthesia and / or pain relief
WO2008093855A1 (en) * 2007-01-29 2008-08-07 Eisai R & D Management Co., Ltd. Composition for treatment of undifferentiated-type of gastric cancer
US9187485B2 (en) 2007-02-02 2015-11-17 Baylor College Of Medicine Methods and compositions for the treatment of cancer and related hyperproliferative disorders
HRP20110709T1 (en) 2007-02-13 2011-11-30 Ab Science PROCESS OF SYNTHESIS OF 2-AMINOTHYAZOL COMPOUNDS AS KINASE INHIBITOR
EA200901573A1 (en) 2007-05-22 2010-04-30 Ачиллион Фармасьютикалз, Инк. Heteroaryl Thiazole Substituents
CA2704000C (en) 2007-11-09 2016-12-13 Eisai R&D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
EP2060565A1 (en) 2007-11-16 2009-05-20 4Sc Ag Novel bifunctional compounds which inhibit protein kinases and histone deacetylases
CA2712731C (en) 2008-01-22 2016-05-03 The Board Of Regents Of The University Of Texas System Volatile anesthetic compositions comprising extractive solvents for regional anesthesia and/or pain relief
WO2009096377A1 (en) * 2008-01-29 2009-08-06 Eisai R & D Management Co., Ltd. Combined use of angiogenesis inhibitor and taxane
US8106209B2 (en) 2008-06-06 2012-01-31 Achillion Pharmaceuticals, Inc. Substituted aminothiazole prodrugs of compounds with anti-HCV activity
CA2771403C (en) 2009-08-19 2015-02-24 Eisai R&D Management Co. Ltd. Quinoline derivative-containing pharmaceutical composition
CN102958523B (en) 2010-06-25 2014-11-19 卫材R&D管理有限公司 Use of combined antineoplastic agents with kinase inhibitory effects
AU2012246490B2 (en) 2011-04-18 2016-08-04 Eisai R&D Management Co., Ltd. Therapeutic agent for tumor
JP6038128B2 (en) 2011-06-03 2016-12-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 A biomarker for predicting and evaluating the reactivity of thyroid and renal cancer subjects to lenvatinib compounds
JPWO2014098176A1 (en) 2012-12-21 2017-01-12 エーザイ・アール・アンド・ディー・マネジメント株式会社 Amorphous quinoline derivative and method for producing the same
CA2912219C (en) 2013-05-14 2021-11-16 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
EP3187491A4 (en) 2014-08-28 2018-08-01 Eisai R&D Management Co., Ltd. High-purity quinoline derivative and method for manufacturing same
US20180028662A1 (en) 2015-02-25 2018-02-01 Eisai R&D Management Co., Ltd. Method for Suppressing Bitterness of Quinoline Derivative
KR20240064733A (en) 2015-03-04 2024-05-13 머크 샤프 앤드 돔 코포레이션 Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer
CA2988707C (en) 2015-06-16 2023-10-10 Eisai R&D Management Co., Ltd. Combination of cbp/catenin inhibitor and immune checkpoint inhibitor for treating cancer
CN108135894B (en) 2015-08-20 2021-02-19 卫材R&D管理有限公司 Therapeutic agent for tumor
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WO2022036104A1 (en) * 2020-08-12 2022-02-17 University Of Iowa Research Foundation Insulin sensitizers for the treatment of diabetes mellitus
WO2025264860A2 (en) 2024-06-18 2025-12-26 Yale University Methods of treating post-covid airway disease

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0934931A2 (en) * 1995-06-07 1999-08-11 Sugen, Inc. 3-Benzylidene-2-indolinones and their analogues as tyrosine kinase activity modulators
WO2001064200A2 (en) * 2000-03-03 2001-09-07 Novartis Ag Use of pdgf receptor tyrosine kinase inhibitors for the treatment of diabetic nephropathy
WO2004014903A1 (en) * 2002-08-02 2004-02-19 Ab Science 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors
WO2004076693A1 (en) * 2003-02-27 2004-09-10 Ab Science Tailored treatment suitable for different forms of mastocytosis
WO2004098612A2 (en) * 2003-05-07 2004-11-18 Ab Science Calcitriol analogs of uses thereof
WO2004105763A2 (en) * 2003-05-27 2004-12-09 Haegerkvist Robert Per Use of tyrosine kinase inhibitor to treat diabetes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0934931A2 (en) * 1995-06-07 1999-08-11 Sugen, Inc. 3-Benzylidene-2-indolinones and their analogues as tyrosine kinase activity modulators
WO2001064200A2 (en) * 2000-03-03 2001-09-07 Novartis Ag Use of pdgf receptor tyrosine kinase inhibitors for the treatment of diabetic nephropathy
WO2004014903A1 (en) * 2002-08-02 2004-02-19 Ab Science 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors
WO2004076693A1 (en) * 2003-02-27 2004-09-10 Ab Science Tailored treatment suitable for different forms of mastocytosis
WO2004098612A2 (en) * 2003-05-07 2004-11-18 Ab Science Calcitriol analogs of uses thereof
WO2004105763A2 (en) * 2003-05-27 2004-12-09 Haegerkvist Robert Per Use of tyrosine kinase inhibitor to treat diabetes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MA Y ET AL: "INDOLINONE DERIVATIVES INHIBIT CONSTITUTIVELY ACTIVATED KIT MUTANTS AND KILL NEOPLASTIC MAST CELLS", JOURNAL OF INVESTIGATIVE DERMATOLOGY, NEW YORK, NY, US, vol. 114, no. 2, February 2001 (2001-02-01), pages 392 - 394, XP001127437, ISSN: 0022-202X *
ZERMATI Y ET AL: "Effect of tyrosine kinase inhibitor STI571 on the kinase activity of wild-type and various mutated c - kit receptors found i mast cell neoplasms", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 22, 2003, pages 660 - 664, XP002286458, ISSN: 0950-9232 *

Also Published As

Publication number Publication date
DE602004013792D1 (en) 2008-06-26
US20070032521A1 (en) 2007-02-08
CA2535242A1 (en) 2005-02-24
WO2005016323A2 (en) 2005-02-24
EP1653934B1 (en) 2008-05-14
JP2007502809A (en) 2007-02-15
EP1653934A2 (en) 2006-05-10
ATE395052T1 (en) 2008-05-15

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