WO2005020958A3 - Aerosol delivery of curcumin - Google Patents

Aerosol delivery of curcumin Download PDF

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Publication number
WO2005020958A3
WO2005020958A3 PCT/US2004/027640 US2004027640W WO2005020958A3 WO 2005020958 A3 WO2005020958 A3 WO 2005020958A3 US 2004027640 W US2004027640 W US 2004027640W WO 2005020958 A3 WO2005020958 A3 WO 2005020958A3
Authority
WO
WIPO (PCT)
Prior art keywords
subject
aerosol delivery
curcumin
disclosed
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/027640
Other languages
French (fr)
Other versions
WO2005020958A2 (en
Inventor
Bharat B Aggarwal
Jack V Knight
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Development Foundation
Original Assignee
Research Development Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Development Foundation filed Critical Research Development Foundation
Priority to CA002536738A priority Critical patent/CA2536738A1/en
Priority to EP04782190A priority patent/EP1658061A2/en
Publication of WO2005020958A2 publication Critical patent/WO2005020958A2/en
Publication of WO2005020958A3 publication Critical patent/WO2005020958A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Pharmaceutical compositions suitable for aerosol delivery to a subject that include curcumin dispersed in a lipid vehicle, wherein the lipid has a transition temperature of less than about 15 °C, are disclosed. In addition, methods of treating a pathological condition in a subject that include providing one of the claimed pharmaceutical compositions and administering the composition to the subject are disclosed. For example, the pathological condition can be a hyperproliferative disease, such as cancer, an inflammatory disease, or a pulmonary disease.
PCT/US2004/027640 2003-08-26 2004-08-25 Aerosol delivery of curcumin Ceased WO2005020958A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002536738A CA2536738A1 (en) 2003-08-26 2004-08-25 Aerosol delivery of curcumin
EP04782190A EP1658061A2 (en) 2003-08-26 2004-08-25 Aerosol delivery of curcumin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49813503P 2003-08-26 2003-08-26
US60/498,135 2003-08-26

Publications (2)

Publication Number Publication Date
WO2005020958A2 WO2005020958A2 (en) 2005-03-10
WO2005020958A3 true WO2005020958A3 (en) 2005-06-30

Family

ID=34272642

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/027640 Ceased WO2005020958A2 (en) 2003-08-26 2004-08-25 Aerosol delivery of curcumin

Country Status (4)

Country Link
US (1) US20050181036A1 (en)
EP (1) EP1658061A2 (en)
CA (1) CA2536738A1 (en)
WO (1) WO2005020958A2 (en)

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WO2003090681A2 (en) * 2002-04-24 2003-11-06 Research Development Foundation SYNERGISTIC EFFECTS OF NUCLEAR TRANSCRIPTION FACTOR NF-κB INHIBITORS AND ANTI-NEOPLASTIC AGENTS
EP1523318A4 (en) * 2002-06-24 2007-07-04 Res Dev Foundation Treatment of human multiple myeloma by curcumin
US7968115B2 (en) * 2004-03-05 2011-06-28 Board Of Regents, The University Of Texas System Liposomal curcumin for treatment of cancer
JP2007503475A (en) 2003-08-26 2007-02-22 リサーチ ディベロップメント ファウンデーション Osteoclast formation inhibitor and method of use thereof
WO2005020908A2 (en) * 2003-08-26 2005-03-10 Research Development Foundation Selective inhibitors of stat-3 activation and uses thereof
US8841326B2 (en) 2004-02-12 2014-09-23 Stc.Unm Therapeutic curcumin derivatives
US8784881B2 (en) 2004-03-05 2014-07-22 Board Of Regents, The University Of Texas System Liposomal curcumin for treatment of diseases
US20080103213A1 (en) * 2004-03-05 2008-05-01 Board Of Regents, The University Of Texas System Liposomal curcumin for treatment of neurofibromatosis
WO2007027963A2 (en) * 2005-08-30 2007-03-08 The Board Of Trustees Of The Leland Stanford Junior University Methods of screening bifunctional molecules for modulated pharmacokinetic properties
FR2897755A1 (en) * 2006-02-24 2007-08-31 Greenforce Sarl Food product e.g. tapioca, flakes or granules generating method, involves cooking sufficient quantity of cleaned vegetable for permitting passage of potato masher, where passage of masher is operated in presence of curcumin type antioxidant
EP1837030A1 (en) * 2006-03-09 2007-09-26 INDENA S.p.A. Phospholipid complexes of curcumin having improved bioavailability
CN1895239B (en) * 2006-06-20 2010-05-12 中国人民解放军第二军医大学 A kind of curcumin preparation and preparation method thereof
US20080075671A1 (en) * 2006-09-22 2008-03-27 Di Mauro Thomas M Intranasally administering curcumin to the brain to treat alzheimer's disease
WO2008131059A2 (en) 2007-04-17 2008-10-30 Codman & Shurtleff, Inc. Intranasally administering curcumin in a bolus of helium gas to treat alzheimer's disease
US8383865B2 (en) * 2007-04-17 2013-02-26 Codman & Shurtleff, Inc. Curcumin derivatives
US7745670B2 (en) * 2008-06-27 2010-06-29 Codman & Shurtleff, Inc. Curcumin-Resveratrol hybrid molecule
US20090264514A1 (en) * 2008-04-18 2009-10-22 The Research Foundation Of State University Of New York SPHINGOMYELIN SYNTHASE 2 (SMS2) DEFICIENCY ATTENUATES NFkB ACTIVATION, A POTENTIAL ANTI-ATHEROGENIC PROPERTY
US7985776B2 (en) * 2008-06-27 2011-07-26 Codman & Shurtleff, Inc. Iontophoretic delivery of curcumin and curcumin analogs for the treatment of Alzheimer's Disease
US7723515B1 (en) 2009-01-26 2010-05-25 Codman & Shurtleff, Inc. Methylene blue—curcumin analog for the treatment of alzheimer's disease
US20100286585A1 (en) * 2009-01-26 2010-11-11 Codman & Shurtleff, Inc. Shunt Delivery of Curcumin
US9359196B2 (en) * 2009-09-10 2016-06-07 The Board Of Regents Of The University Of Oklahoma Antiproliferative compositions comprising curcumin analogs and methods of producing and using same
US8747890B2 (en) * 2009-11-19 2014-06-10 Signpath Pharma Inc. Intravenous infusion of curcumin and a calcium channel blocker
CA2786255A1 (en) 2009-12-31 2011-07-07 Organomed Corporation Formulations from natural products, turmeric, and aspirin
WO2011097480A1 (en) * 2010-02-05 2011-08-11 University Of Louisville Research Foundation, Inc. Exosomal compositions and methods for the treatment of disease
TW201208690A (en) * 2010-08-05 2012-03-01 Indian Inst Of Technology Iit Bombay Lipid formulations
US10349884B2 (en) 2011-06-03 2019-07-16 Sighpath Pharma Inc. Liposomal mitigation of drug-induced inhibition of the cardiac ikr channel
US10449193B2 (en) 2011-06-03 2019-10-22 Signpath Pharma Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, lysoPG and lysoPC against drugs that cause channelopathies
US10117881B2 (en) 2011-06-03 2018-11-06 Signpath Pharma, Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, LYSOPG and LYSOPC against drugs that cause channelopathies
WO2012167212A2 (en) 2011-06-03 2012-12-06 Signpath Pharma Inc. Liposomal mitigation of drug-induced long qt syndrome and potassium delayed-rectifier current
US12004868B2 (en) 2011-06-03 2024-06-11 Signpath Pharma Inc. Liposomal mitigation of drug-induced inhibition of the cardiac IKr channel
US10238602B2 (en) 2011-06-03 2019-03-26 Signpath Pharma, Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, LysoPG and LysoPC against drugs that cause channelopathies
AT515178A5 (en) 2012-08-31 2015-07-15 Univ North Texas CURCUMIN-ER, A NANOCURCUMIN FROM LIPOSOMAL PLGA WITH CONTINUED RELEASE TO MINIMIZE QT EXTENSION TO CANCER THERAPY
WO2015077640A1 (en) * 2013-11-22 2015-05-28 Signpath Pharma, Inc. Intravenous synthetic curcumin (s-curcumin) for the treatment of proliferative disorders
WO2015095576A1 (en) 2013-12-18 2015-06-25 Signpath Pharma, Inc. Liposomal mitigation of drug-induced inhibition of the cardiac ikr channel
US9161932B1 (en) 2015-01-15 2015-10-20 Michael Smith Anesthetic and cooling mixture
WO2016154143A1 (en) 2015-03-20 2016-09-29 Georgia State University Research Foundation, Inc. Compositions and methods for treating copd and other inflammatory conditions
DE102015008823A1 (en) * 2015-07-15 2017-01-19 Hans Muerth Use of the method and apparatus for vaporizing curcumin powder with a high performance evaporator to produce an inhalable curcumin aerosol
KR102638618B1 (en) 2016-04-27 2024-02-21 사인패스 파마 인코포레이티드 Prevention of drug-induced atrio-ventricular block
WO2022003685A1 (en) * 2020-06-29 2022-01-06 Magon Eran Water soluble curcuminoids composition for treating mouth and throat conditions
WO2025186842A1 (en) * 2024-03-08 2025-09-12 Midascare Pharmaceuticals Pvt Ltd "a curcumin based powder spray formulation"
WO2025231430A1 (en) * 2024-05-03 2025-11-06 Amalfi Bio, Inc. Compositions and methods for localized adipocyte cell death

Citations (2)

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US5401777A (en) * 1991-11-14 1995-03-28 Steigerwald Arzneimittelwerk Gmbh Use of preparations of curcuma plants
WO2004091578A2 (en) * 2003-04-09 2004-10-28 Biodelivery Sciences International, Inc. Novel encochleation methods, cochleates and methods of use

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US5049388A (en) * 1986-11-06 1991-09-17 Research Development Foundation Small particle aerosol liposome and liposome-drug combinations for medical use
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EP1242379A1 (en) * 1999-12-03 2002-09-25 Emory University Curcumin analogues for treating cancer
RU2270683C2 (en) * 1999-12-04 2006-02-27 Рисерч Дивелопмент Фаундейшн Improvement inhalation therapy effectiveness using carbon dioxide
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Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US5401777A (en) * 1991-11-14 1995-03-28 Steigerwald Arzneimittelwerk Gmbh Use of preparations of curcuma plants
WO2004091578A2 (en) * 2003-04-09 2004-10-28 Biodelivery Sciences International, Inc. Novel encochleation methods, cochleates and methods of use

Also Published As

Publication number Publication date
CA2536738A1 (en) 2005-03-10
EP1658061A2 (en) 2006-05-24
WO2005020958A2 (en) 2005-03-10
US20050181036A1 (en) 2005-08-18

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