WO2005021497A3 - Tethered dimers and trimers of 1,4-diphenylazetidn-2-ones - Google Patents

Tethered dimers and trimers of 1,4-diphenylazetidn-2-ones Download PDF

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Publication number
WO2005021497A3
WO2005021497A3 PCT/US2004/027813 US2004027813W WO2005021497A3 WO 2005021497 A3 WO2005021497 A3 WO 2005021497A3 US 2004027813 W US2004027813 W US 2004027813W WO 2005021497 A3 WO2005021497 A3 WO 2005021497A3
Authority
WO
WIPO (PCT)
Prior art keywords
ones
diphenylazetidn
trimers
tethered
dimers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/027813
Other languages
French (fr)
Other versions
WO2005021497A2 (en
Inventor
Eduardo J Martinez
John Jeffrey Talley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbia Inc
Original Assignee
Microbia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbia Inc filed Critical Microbia Inc
Priority to EP04782312A priority Critical patent/EP1660446A2/en
Priority to US10/569,561 priority patent/US20070161577A1/en
Publication of WO2005021497A2 publication Critical patent/WO2005021497A2/en
Publication of WO2005021497A3 publication Critical patent/WO2005021497A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Derivatives of 1,4-diphenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of the general Formula (I).
PCT/US2004/027813 2003-08-28 2004-08-27 Tethered dimers and trimers of 1,4-diphenylazetidn-2-ones Ceased WO2005021497A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP04782312A EP1660446A2 (en) 2003-08-28 2004-08-27 Tethered dimers and trimers of 1,4-diphenylazetidn-2-ones
US10/569,561 US20070161577A1 (en) 2003-08-28 2004-08-27 Tethered dimers and trimers of 1,4-diphenylazetidin-2-ones

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49847603P 2003-08-28 2003-08-28
US60/498,476 2003-08-28

Publications (2)

Publication Number Publication Date
WO2005021497A2 WO2005021497A2 (en) 2005-03-10
WO2005021497A3 true WO2005021497A3 (en) 2005-06-09

Family

ID=34272682

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/027813 Ceased WO2005021497A2 (en) 2003-08-28 2004-08-27 Tethered dimers and trimers of 1,4-diphenylazetidn-2-ones

Country Status (3)

Country Link
US (1) US20070161577A1 (en)
EP (1) EP1660446A2 (en)
WO (1) WO2005021497A2 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215579D0 (en) * 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
US20090005321A1 (en) * 2005-02-09 2009-01-01 Microbia, Inc. Phenylazetidinone Derivatives
US20090131395A1 (en) * 2005-05-05 2009-05-21 Microbia, Inc. Biphenylazetidinone cholesterol absorption inhibitors
WO2006124713A2 (en) * 2005-05-13 2006-11-23 Microbia, Inc. 4-biarylyl-1-phenylazetidin-2-ones
DE602006010870D1 (en) 2005-06-20 2010-01-14 Schering Corp PIPERIDINE DERIVATIVES SUITED AS ANTAGONISTS OF HISTAMINE H3
UY29607A1 (en) 2005-06-20 2007-01-31 Astrazeneca Ab CHEMICAL COMPOUNDS
SA06270191B1 (en) 2005-06-22 2010-03-29 استرازينيكا ايه بي Novel 2-Azetidinone Derivatives as Cholesterol Absorption Inhibitors for the Treatment of Hyperlipidaemic Conditions
MY148538A (en) 2005-06-22 2013-04-30 Astrazeneca Ab Novel 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions
TW200811098A (en) 2006-04-27 2008-03-01 Astrazeneca Ab Chemical compounds
JP2010500300A (en) 2006-08-08 2010-01-07 サノフィ−アベンティス Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for their preparation, agents containing these compounds, and uses thereof
DE102007005045B4 (en) 2007-01-26 2008-12-18 Sanofi-Aventis Phenothiazine derivatives, process for their preparation and their use as medicines
EP2025674A1 (en) 2007-08-15 2009-02-18 sanofi-aventis Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
DE102007054497B3 (en) 2007-11-13 2009-07-23 Sanofi-Aventis Deutschland Gmbh Novel crystalline diphenylazetidinone hydrates and process for their preparation
US20090312302A1 (en) * 2008-06-17 2009-12-17 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating nonalcoholic fatty liver disease-associated disorders
WO2009157019A2 (en) * 2008-06-23 2009-12-30 Ind-Swift Laboratories Limited Process for preparing ezetimibe using novel allyl intermediates
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
CA2754384A1 (en) 2009-03-06 2010-09-10 Lipideon Biotechnology Ag Pharmaceutical hypocholesterolemic compositions
MX2012001729A (en) 2009-08-26 2012-06-13 Sanofi Sa Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use.
WO2011157827A1 (en) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
US8895547B2 (en) 2011-03-08 2014-11-25 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
EP2683702B1 (en) 2011-03-08 2014-12-24 Sanofi New substituted phenyl oxathiazine derivatives, method for their manufacture, medicines containing these compounds and their application
EP2683701B1 (en) 2011-03-08 2014-12-24 Sanofi Oxathiazine derivatives substituted with benzyl or heteromethylene groups, method for their preparation, their usage as medicament, medicament containing same and its use
EP2683705B1 (en) 2011-03-08 2015-04-22 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120052A1 (en) 2011-03-08 2012-09-13 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
EP2683699B1 (en) 2011-03-08 2015-06-24 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683698B1 (en) 2011-03-08 2017-10-04 Sanofi Benzyl-oxathiazine derivates substituted with adamantane or noradamantane, medicaments containing said compounds and use thereof
KR102919209B1 (en) 2018-08-10 2026-01-28 다이아핀 테라퓨틱스, 엘엘씨 Tripeptides and the treatment of metabolic, cardiovascular, and inflammatory disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6632933B2 (en) * 1999-04-16 2003-10-14 Schering Corporation Use of azetidinone compounds
US6703386B2 (en) * 2000-12-21 2004-03-09 Aventis Pharma Deutschland Gmbh Diphenylazetidinone derivatives, process for their preparation, medicaments comprising these compounds and their use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6632933B2 (en) * 1999-04-16 2003-10-14 Schering Corporation Use of azetidinone compounds
US6703386B2 (en) * 2000-12-21 2004-03-09 Aventis Pharma Deutschland Gmbh Diphenylazetidinone derivatives, process for their preparation, medicaments comprising these compounds and their use

Also Published As

Publication number Publication date
US20070161577A1 (en) 2007-07-12
WO2005021497A2 (en) 2005-03-10
EP1660446A2 (en) 2006-05-31

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