WO2005023331A3 - Hydrogel nanocompsites for ophthalmic applications - Google Patents

Hydrogel nanocompsites for ophthalmic applications Download PDF

Info

Publication number
WO2005023331A3
WO2005023331A3 PCT/US2004/028637 US2004028637W WO2005023331A3 WO 2005023331 A3 WO2005023331 A3 WO 2005023331A3 US 2004028637 W US2004028637 W US 2004028637W WO 2005023331 A3 WO2005023331 A3 WO 2005023331A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrogel
solution
nanocompsites
ophthalmic applications
copolymers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/028637
Other languages
French (fr)
Other versions
WO2005023331A2 (en
Inventor
Nathan Ravi
Aliyar H Ali
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Veterans Affairs
Original Assignee
US Department of Veterans Affairs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/706,081 external-priority patent/US8192485B2/en
Application filed by US Department of Veterans Affairs filed Critical US Department of Veterans Affairs
Priority to US10/574,667 priority Critical patent/US8153156B2/en
Priority to CA002542512A priority patent/CA2542512A1/en
Priority to EP04783018A priority patent/EP1660153A2/en
Priority to JP2006525445A priority patent/JP4988345B2/en
Publication of WO2005023331A2 publication Critical patent/WO2005023331A2/en
Anticipated expiration legal-status Critical
Publication of WO2005023331A3 publication Critical patent/WO2005023331A3/en
Priority to US13/019,412 priority patent/US8877227B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Prostheses (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

The present invention relates to reversible hydrogel systems. Particularly, the hydrogel of the present invention is made up of copolymers that can be a hydrogel when in an oxidized state and can be a solution when in a reduced state. A solution of the copolymer can be oxidized to form a hydrogel; and the hydrogel can be reduced to form a solution of the copolymer. Reversible nanogels can also be formed from a dilute solution of the copolymers. The hydrogel is formed with nanoparticles embedded therein to form a nanocomposite whose refractive index and modulus can be controlled by varying the amounts of nanoparticles and the polymer concentration of the hydrogel, respectively
PCT/US2004/028637 2002-11-13 2004-09-03 Hydrogel nanocompsites for ophthalmic applications Ceased WO2005023331A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US10/574,667 US8153156B2 (en) 2002-11-13 2004-09-03 Hydrogel nanocompsites for ophthalmic applications
CA002542512A CA2542512A1 (en) 2003-09-04 2004-09-03 Hydrogel nanocompsites for ophthalmic applications
EP04783018A EP1660153A2 (en) 2003-09-04 2004-09-03 Hydrogel nanocompsites for ophthalmic applications
JP2006525445A JP4988345B2 (en) 2003-09-04 2004-09-03 Ophthalmic hydrogel nanocomposites
US13/019,412 US8877227B2 (en) 2002-11-13 2011-02-02 Hydrogel nanocomposites for intraocular lens applicatons

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US49988703P 2003-09-04 2003-09-04
US60/499,887 2003-09-04
US10/706,081 2003-11-13
US10/706,081 US8192485B2 (en) 2002-11-13 2003-11-13 Reversible hydrogel systems and methods therefor
US56459204P 2004-04-23 2004-04-23
US60/564,592 2004-04-23

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/706,081 Continuation-In-Part US8192485B2 (en) 2002-11-13 2003-11-13 Reversible hydrogel systems and methods therefor

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/574,667 A-371-Of-International US8153156B2 (en) 2002-11-13 2004-09-03 Hydrogel nanocompsites for ophthalmic applications
US13/019,412 Division US8877227B2 (en) 2002-11-13 2011-02-02 Hydrogel nanocomposites for intraocular lens applicatons

Publications (2)

Publication Number Publication Date
WO2005023331A2 WO2005023331A2 (en) 2005-03-17
WO2005023331A3 true WO2005023331A3 (en) 2007-05-03

Family

ID=34279817

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/028637 Ceased WO2005023331A2 (en) 2002-11-13 2004-09-03 Hydrogel nanocompsites for ophthalmic applications

Country Status (4)

Country Link
EP (1) EP1660153A2 (en)
JP (2) JP4988345B2 (en)
CA (1) CA2542512A1 (en)
WO (1) WO2005023331A2 (en)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7473738B2 (en) * 2004-09-30 2009-01-06 Johnson & Johnson Vision Care, Inc. Lactam polymer derivatives
JP4879554B2 (en) * 2005-10-21 2012-02-22 株式会社メニコン Method for producing post-imprintable hydrogel material
JP4974533B2 (en) * 2006-01-30 2012-07-11 富士フイルム株式会社 Disulfide-crosslinked protein nanoparticles
CA2651715C (en) 2006-05-03 2015-03-24 Vision Crc Limited Ocular replacement material production method and the use thereof
CN101721349B (en) * 2008-10-16 2011-07-20 常州百瑞吉生物医药有限公司 Injectable in-situ crosslinking aquogel and preparation method and application thereof
EP3395957B1 (en) 2011-04-25 2020-08-12 Bio-Rad Laboratories, Inc. Methods and compositions for nucleic acid analysis
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) * 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
AU2013302756C1 (en) 2012-08-14 2018-05-17 10X Genomics, Inc. Microcapsule compositions and methods
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US20240376519A1 (en) * 2012-08-14 2024-11-14 10X Genomics, Inc. Compositions and methods for sample processing
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
CA2894694C (en) 2012-12-14 2023-04-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
KR20200140929A (en) 2013-02-08 2020-12-16 10엑스 제노믹스, 인크. Polynucleotide barcode generation
US9486311B2 (en) 2013-02-14 2016-11-08 Shifamed Holdings, Llc Hydrophilic AIOL with bonding
CA3193600A1 (en) 2013-03-21 2014-09-25 Shifamed Holdings, Llc Accommodating intraocular lens
US10195018B2 (en) 2013-03-21 2019-02-05 Shifamed Holdings, Llc Accommodating intraocular lens
US10395758B2 (en) 2013-08-30 2019-08-27 10X Genomics, Inc. Sequencing methods
US9824068B2 (en) 2013-12-16 2017-11-21 10X Genomics, Inc. Methods and apparatus for sorting data
US10178950B2 (en) * 2013-12-20 2019-01-15 Novartis Ag Imaging probes and associated devices, systems, and methods utilizing an elastomeric optical element
JP6427811B2 (en) * 2014-03-20 2018-11-28 国立大学法人愛媛大学 Protein storage method
BR112016023625A2 (en) 2014-04-10 2018-06-26 10X Genomics, Inc. fluidic devices, systems and methods for encapsulating and partitioning reagents, and applications thereof
KR20170023979A (en) 2014-06-26 2017-03-06 10엑스 제노믹스, 인크. Processes and systems for nucleic acid sequence assembly
CA2953469A1 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Analysis of nucleic acid sequences
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
WO2015200893A2 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
EP4574093A3 (en) 2014-08-26 2025-09-17 Shifamed Holdings, LLC Accommodating intraocular lens
BR112017008877A2 (en) 2014-10-29 2018-07-03 10X Genomics Inc methods and compositions for targeting nucleic acid sequencing
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
JP6769969B2 (en) 2015-01-12 2020-10-14 １０エックス ジェノミクス， インコーポレイテッド Processes and systems for making nucleic acid sequencing libraries, and libraries made using them
WO2016115273A1 (en) 2015-01-13 2016-07-21 10X Genomics, Inc. Systems and methods for visualizing structural variation and phasing information
WO2016130578A1 (en) 2015-02-09 2016-08-18 10X Genomics, Inc. Systems and methods for determining structural variation and phasing using variant call data
MX2017010857A (en) 2015-02-24 2017-12-11 10X Genomics Inc Methods for targeted nucleic acid sequence coverage.
EP3262407B1 (en) 2015-02-24 2023-08-30 10X Genomics, Inc. Partition processing methods and systems
CA3005338A1 (en) 2015-11-18 2017-05-26 Shifamed Holdings, Llc Multi-piece accommodating intraocular lens
US11141263B2 (en) 2015-11-18 2021-10-12 Shifamed Holdings, Llc Multi-piece accommodating intraocular lens
JP6954899B2 (en) 2015-12-04 2021-10-27 １０エックス ゲノミクス，インコーポレイテッド Methods and compositions for nucleic acid analysis
WO2017138984A1 (en) 2016-02-11 2017-08-17 10X Genomics, Inc. Systems, methods, and media for de novo assembly of whole genome sequence data
WO2017197343A2 (en) 2016-05-12 2017-11-16 10X Genomics, Inc. Microfluidic on-chip filters
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
WO2018000242A1 (en) * 2016-06-29 2018-01-04 南京大学 Application of self-repairing material for use in 3d printing
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10350056B2 (en) 2016-12-23 2019-07-16 Shifamed Holdings, Llc Multi-piece accommodating intraocular lenses and methods for making and using same
CN120000379A (en) 2016-12-23 2025-05-16 施菲姆德控股有限责任公司 Multi-piece accommodative intraocular lens and methods of making and using the same
US12264411B2 (en) 2017-01-30 2025-04-01 10X Genomics, Inc. Methods and systems for analysis
EP4029939B1 (en) 2017-01-30 2023-06-28 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
EP3625715A4 (en) 2017-05-19 2021-03-17 10X Genomics, Inc. SYSTEMS AND PROCEDURES FOR THE ANALYSIS OF DATA SETS
US10400235B2 (en) 2017-05-26 2019-09-03 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
EP3445876B1 (en) 2017-05-26 2023-07-05 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
EP3634308A4 (en) 2017-05-30 2021-02-24 Shifamed Holdings, LLC SURFACE TREATMENTS FOR ACCOMMODATION INTRAOCULAR LENSES AND RELATED METHODS AND DEVICES
EP3634309B1 (en) 2017-06-07 2023-05-24 Shifamed Holdings, LLC Adjustable optical power intraocular lenses
SG11201913654QA (en) 2017-11-15 2020-01-30 10X Genomics Inc Functionalized gel beads
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
CN108276593B (en) * 2018-01-31 2020-06-05 合肥工业大学 A kind of preparation method of ultraviolet-visible-near-infrared light-induced self-healing nanocomposite hydrogel
CN112262218B (en) 2018-04-06 2024-11-08 10X基因组学有限公司 Systems and methods for quality control in single cell processing
CN109351204A (en) * 2018-09-12 2019-02-19 济南大学 A kind of preparation method and application of fluorine-containing hydrogel film
US12521232B2 (en) 2019-07-11 2026-01-13 Shifamed Holdings, Llc Accommodating intraocular lenses and associated methods
CN110403920B (en) * 2019-08-26 2022-12-02 江苏远恒药业有限公司 Disposable medical hydrogel eye patch
CN115428088A (en) 2020-02-13 2022-12-02 10X基因组学有限公司 Systems and methods for joint interactive visualization of gene expression and DNA chromatin accessibility
WO2022080493A1 (en) * 2020-10-15 2022-04-21 Ｋｊケミカルズ株式会社 Polymerizable composition, product of polymerization of same, and molded article obtained using these
CN112646069B (en) * 2020-12-15 2022-10-21 内蒙古民族大学 A kind of carbon nitride composite hydrogel and its preparation method and application
CN117752867B (en) * 2023-12-21 2025-03-14 大连医科大学附属第一医院 Cell-carrying microgel for ophthalmic injection and preparation method and application thereof
CN119081001A (en) * 2024-08-05 2024-12-06 东华大学 A degradable thermally physically cross-linked colored hydrogel and facial mask
CN119198280A (en) * 2024-10-18 2024-12-27 福建省集力生物技术有限公司 Method and device for chromatographic concentration of macromolecule dilute sample

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6222754A (en) * 1985-07-23 1987-01-30 Nippon Shokubai Kagaku Kogyo Co Ltd N,n-dimethacryloylcystamine
US6132765A (en) * 1996-04-12 2000-10-17 Uroteq Inc. Drug delivery via therapeutic hydrogels
US6514535B2 (en) * 1999-05-21 2003-02-04 Noveon Ip Holdings Corp. Bioadhesive hydrogels with functionalized degradable crosslinks
JP4219485B2 (en) * 1999-05-21 2009-02-04 株式会社メニコン Ophthalmic material composed of optical hydrous gel
WO2001005586A1 (en) * 1999-07-16 2001-01-25 Wm. Marsh Rice University Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery
WO2001005578A1 (en) * 1999-07-16 2001-01-25 Wesley-Jessen Corporation Thermoformable ophthalmic lens
IL133196A0 (en) * 1999-11-29 2001-03-19 Yissum Res Dev Co Gastroretentive controlled release pharmaceutical dosage forms
AUPR569501A0 (en) * 2001-06-14 2001-07-12 Proteome Systems Ltd Dissolvable gels

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RAVI N. ET AL.: "Characterization of the Network Properties of the Poly(ethylene glycol)-Acrylate Hydrogels Prepared by Variation in the Ethanol-Water Solvent Composition during Crosslinking Copolymerization", J. POLYMER SCI., vol. 40, pages 2677 - 2684, XP003011101 *

Also Published As

Publication number Publication date
WO2005023331A2 (en) 2005-03-17
CA2542512A1 (en) 2005-03-17
JP4988345B2 (en) 2012-08-01
JP2007517077A (en) 2007-06-28
JP2011063816A (en) 2011-03-31
EP1660153A2 (en) 2006-05-31

Similar Documents

Publication Publication Date Title
WO2005023331A3 (en) Hydrogel nanocompsites for ophthalmic applications
WO2003015701A3 (en) Lipobeads and their production
AU2002319231A1 (en) Polymer solutions with shear reversible properties
DK1366774T3 (en) Bone cement mixture and X-ray contrast agent
WO2003061329A3 (en) Method and hybrid optical-electronic switching node for optimizing use of optical bandwidth
ATE513886T1 (en) HYDRAULIC FRACTURE FLUID CONTAINING BLOCK COPOLYMERS WITH HYDROPHILIC AND HYDROPHOBIC BLOCKS
DE50214611D1 (en) SOLID, WATER SOURCING AND SUCKING, ANIONIC POLYMERS WITH SPONGE STRUCTURE, AND THEIR MANUFACTURE AND USE
WO2006093799A3 (en) Metal phosphate sols, metal nanoparticles, metal-chalcogenide nanoparticles, and nanocomposites made therefrom
DE60218814D1 (en) STABLE, CONJUGATED POLYMER-CONTAINING ELECTROCHROMIC DEVICES WITH IONIC LIQUIDS
DE60230537D1 (en) AROMATED SILYLMONOMERS WITH HIGH BREAKING INDEX
EP1284583A3 (en) Cell selection
DE60231511D1 (en) STRUCTURES WITH INORGANIC POLYMER PARTICULAR MIXTURES
CA2527234A1 (en) Zinc oxide
WO2018213616A3 (en) Battery cell with novel construction
WO2002044728A3 (en) Chemical compositions comprising crystalline colloidal arrays
EP1217393A3 (en) Reduced temperature sensitive polymeric optical article and method of making same
WO2008108251A1 (en) Polymer crystal
EP1840167A4 (en) Transparent gel and contact lens comprising the same
EP2752432A3 (en) Fluoropolymer dispersion and method for making the same
EP1217034A3 (en) Polymethylmethacrylate nanocomposite optical plastic article and method of making same
WO2007075502A3 (en) Thermo-responsive block co-polymers, and use thereof
TW200722870A (en) Control of birefringence dispersion utilizing nanocomposites
EP1217031A3 (en) Polysulfone nanocomposite optical plastic article and method of making same
EP1217032A3 (en) Polystyrene nanocomposite optical plastic article and method of making same
WO2003026707A3 (en) Absorbent structure, absorbent article, water-absorbent resin, and its production process and evaluation method

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2542512

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2006525445

Country of ref document: JP

Ref document number: 1135/DELNP/2006

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2004783018

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 200480030085.2

Country of ref document: CN

WWP Wipo information: published in national office

Ref document number: 2004783018

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10574667

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 10574667

Country of ref document: US