WO2005025549A3 - Multi-layer transdermal drug delivery device - Google Patents

Multi-layer transdermal drug delivery device Download PDF

Info

Publication number
WO2005025549A3
WO2005025549A3 PCT/US2004/029789 US2004029789W WO2005025549A3 WO 2005025549 A3 WO2005025549 A3 WO 2005025549A3 US 2004029789 W US2004029789 W US 2004029789W WO 2005025549 A3 WO2005025549 A3 WO 2005025549A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
delivery device
transdermal drug
administration
layer transdermal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/029789
Other languages
French (fr)
Other versions
WO2005025549A2 (en
Inventor
Robert C Strauss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noven Pharmaceuticals Inc
Original Assignee
Noven Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noven Pharmaceuticals Inc filed Critical Noven Pharmaceuticals Inc
Priority to EP04783850A priority Critical patent/EP1682102A2/en
Publication of WO2005025549A2 publication Critical patent/WO2005025549A2/en
Publication of WO2005025549A3 publication Critical patent/WO2005025549A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A drug delivery device initially having two adhesive layers containing at least one active agent in each layer are kept separate from each other prior to administration of the active agent. At the time of administration, the separated layers are combined to form a dual layer adhesive transdermal drug delivery device which results in the administration of the at least one active compound after topical application of the device.
PCT/US2004/029789 2003-09-10 2004-09-10 Multi-layer transdermal drug delivery device Ceased WO2005025549A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04783850A EP1682102A2 (en) 2003-09-10 2004-09-10 Multi-layer transdermal drug delivery device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50170903P 2003-09-10 2003-09-10
US60/501,709 2003-09-10

Publications (2)

Publication Number Publication Date
WO2005025549A2 WO2005025549A2 (en) 2005-03-24
WO2005025549A3 true WO2005025549A3 (en) 2005-05-26

Family

ID=34312300

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/029789 Ceased WO2005025549A2 (en) 2003-09-10 2004-09-10 Multi-layer transdermal drug delivery device

Country Status (3)

Country Link
US (1) US8784874B2 (en)
EP (1) EP1682102A2 (en)
WO (1) WO2005025549A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8524272B2 (en) 2003-08-15 2013-09-03 Mylan Technologies, Inc. Transdermal patch incorporating active agent migration barrier layer
MEP23508A (en) * 2003-10-28 2010-06-10 Noven Pharma Compositions and methods for comtrolling drug loss and delivery in transdermal drug delivery systems
US9205062B2 (en) 2004-03-09 2015-12-08 Mylan Pharmaceuticals, Inc. Transdermal systems containing multilayer adhesive matrices to modify drug delivery
US20050202073A1 (en) 2004-03-09 2005-09-15 Mylan Technologies, Inc. Transdermal systems containing multilayer adhesive matrices to modify drug delivery
US8343538B2 (en) * 2004-10-08 2013-01-01 Noven Pharmaceuticals, Inc. Compositions and methods for controlling the flux of a drug from a transdermal drug delivery systems
DE202005014347U1 (en) * 2005-09-09 2007-01-18 Grünenthal GmbH Application system for a medicated plaster and Wirkstoffgabgaberegulierungsmittel
DE102006011340A1 (en) * 2006-03-09 2007-09-20 Grünenthal GmbH Active substance-containing patches with improved handling
US20080008747A1 (en) * 2006-07-07 2008-01-10 Royds Robert B Transdermal patch
US20110150766A1 (en) * 2006-07-07 2011-06-23 Royds Robert B Transdermal patch with fatal overdose protection
US20090010998A1 (en) * 2007-07-03 2009-01-08 Marchitto Kevin S Drug-delivery patch comprising a dissolvable layer and uses thereof
EP2254561A2 (en) * 2008-03-26 2010-12-01 AllTranz Inc. Abuse deterrent transdermal formulations of opiate agonists and agonist-antagonists
US8231906B2 (en) 2008-07-10 2012-07-31 Noven Pharmaceuticals, Inc. Transdermal estrogen device and delivery
GB201019761D0 (en) 2010-11-22 2011-01-05 Chowdhury Dewan F H Multilayered transdermal patch
US9314470B2 (en) 2012-12-28 2016-04-19 Noven Pharmaceuticals, Inc. Transdermal drug delivery systems for levonorgestrel and ethinyl estradiol
MX366230B (en) 2012-12-28 2019-07-03 Noven Pharma Multi-polymer compositions for transdermal drug delivery.
WO2014159582A1 (en) 2013-03-14 2014-10-02 Noven Pharmaceuticals, Inc Amphetamine transdermal compositions with acrylic block copolymer
AR095259A1 (en) 2013-03-15 2015-09-30 Noven Pharma COMPOSITIONS AND METHODS FOR THE TRANSDERMAL ADMINISTRATION OF TERTIARY AMINE DRUGS
AR095260A1 (en) 2013-03-15 2015-09-30 Noven Pharma COMPOSITIONS OF STABLE TRANSDERMAL AMPHETAMINS AND MANUFACTURING METHODS
EP3017809A1 (en) * 2014-11-07 2016-05-11 Ferring B.V. Drug-device unit containing quinagolide
JP2020518325A (en) 2016-12-29 2020-06-25 ピュア レイシオス ホールディングス， インコーポレイテッド Modular transdermal delivery system and related methods of manufacture and use
US10953096B2 (en) * 2017-04-28 2021-03-23 Nitto Denko Corporation Transdermal absorption preparation precursor
DE102017125281A1 (en) 2017-10-27 2019-05-02 Dermatools Biotech Gmbh Device for providing a skin or wound dressing

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4911707A (en) * 1987-02-13 1990-03-27 Ciba-Geigy Corporation Monolithic user-activated transdermal therapeutic system
WO1991003998A1 (en) * 1989-09-14 1991-04-04 Cygnus Research Corporation Transdermal delivery device having delayed onset
WO2001026705A2 (en) * 1999-10-11 2001-04-19 Samyang Corporation A dual adhesive transdermal drug delivery system

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5843368B2 (en) * 1980-10-30 1983-09-27 日東電工株式会社 Anti-inflammatory analgesic patch
GB2105990B (en) * 1981-08-27 1985-06-19 Nitto Electric Ind Co Adhesive skin patches
US4559222A (en) * 1983-05-04 1985-12-17 Alza Corporation Matrix composition for transdermal therapeutic system
US4591622A (en) * 1984-10-29 1986-05-27 Dow Corning Corporation Silicone pressure-sensitive adhesive process and product thereof
US4585836A (en) * 1984-10-29 1986-04-29 Dow Corning Corporation Silicone pressure-sensitive adhesive process and product with improved lap-shear stability-II
US4584355A (en) 1984-10-29 1986-04-22 Dow Corning Corporation Silicone pressure-sensitive adhesive process and product with improved lap-shear stability-I
US4655767A (en) * 1984-10-29 1987-04-07 Dow Corning Corporation Transdermal drug delivery devices with amine-resistant silicone adhesives
US4746515A (en) * 1987-02-26 1988-05-24 Alza Corporation Skin permeation enhancer compositions using glycerol monolaurate
US4983395A (en) * 1987-11-12 1991-01-08 Theratech Inc. Device for administering an active agent to the skin or mucosa
US4915950A (en) * 1988-02-12 1990-04-10 Cygnus Research Corporation Printed transdermal drug delivery device
US5474783A (en) 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5656286A (en) * 1988-03-04 1997-08-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5446070A (en) * 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US4994278A (en) * 1988-03-04 1991-02-19 Noven Pharmaceuticals, Inc. Breathable backing
US4994267A (en) * 1988-03-04 1991-02-19 Noven Pharmaceuticals, Inc. Transdermal acrylic multipolymer drug delivery system
US5271940A (en) * 1989-09-14 1993-12-21 Cygnus Therapeutic Systems Transdermal delivery device having delayed onset
US5350581A (en) * 1989-12-14 1994-09-27 Pharmetrix Corporation Method for manufacturing transdermal devices
US5633009A (en) * 1990-11-28 1997-05-27 Sano Corporation Transdermal administration of azapirones
JP2960832B2 (en) * 1992-05-08 1999-10-12 ペルマテック テクノロジー アクチェンゲゼルシャフト Estradiol administration system
GB2273044B (en) * 1992-12-02 1997-04-09 Pacific Chem Co Ltd Medicinal patches for percutaneous administration
US5762952A (en) * 1993-04-27 1998-06-09 Hercon Laboratories Corporation Transdermal delivery of active drugs
US5567488A (en) * 1993-09-16 1996-10-22 The Dow Chemical Company Multilayer barrier film for transdermal drug delivery system and ostomy applications
US5474787A (en) * 1994-10-21 1995-12-12 The Wm. Wrigley Jr. Company Chewing gum containing a lecithin/glycerol triacetate blend
IL122484A0 (en) * 1995-06-07 1998-06-15 Noven Pharma Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures
US5906830A (en) * 1995-09-08 1999-05-25 Cygnus, Inc. Supersaturated transdermal drug delivery systems, and methods for manufacturing the same
US5902603A (en) * 1995-09-14 1999-05-11 Cygnus, Inc. Polyurethane hydrogel drug reservoirs for use in transdermal drug delivery systems, and associated methods of manufacture and use
IL135258A0 (en) * 1997-09-26 2001-05-20 Noven Pharma Bioadhesive compositions and methods for topical administration of active agents
AU778992B2 (en) 1998-12-07 2004-12-23 Agi Therapeutics Research Limited Transdermal patch for delivering volatile liquid drugs
EP1449527A3 (en) 1998-12-07 2004-09-08 Elan Pharma International Limited Transdermal patch for administering a volatile liquid drug
CA2422267C (en) * 2000-09-24 2010-02-16 3M Innovative Properties Company Drying method for selectively removing volatile components from wet coatings
JP4323138B2 (en) * 2002-06-05 2009-09-02 日東電工株式会社 Transdermal preparation and method for producing the same
MEP23508A (en) * 2003-10-28 2010-06-10 Noven Pharma Compositions and methods for comtrolling drug loss and delivery in transdermal drug delivery systems
US8343538B2 (en) * 2004-10-08 2013-01-01 Noven Pharmaceuticals, Inc. Compositions and methods for controlling the flux of a drug from a transdermal drug delivery systems

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4911707A (en) * 1987-02-13 1990-03-27 Ciba-Geigy Corporation Monolithic user-activated transdermal therapeutic system
WO1991003998A1 (en) * 1989-09-14 1991-04-04 Cygnus Research Corporation Transdermal delivery device having delayed onset
WO2001026705A2 (en) * 1999-10-11 2001-04-19 Samyang Corporation A dual adhesive transdermal drug delivery system

Also Published As

Publication number Publication date
EP1682102A2 (en) 2006-07-26
WO2005025549A2 (en) 2005-03-24
US8784874B2 (en) 2014-07-22
US20050129749A1 (en) 2005-06-16

Similar Documents

Publication Publication Date Title
WO2005025549A3 (en) Multi-layer transdermal drug delivery device
AU2003230032A1 (en) Transdermal delivery system with two superimposed adhesive layers having different affinities to the active substance comprised
WO2003039519A3 (en) Dual controlled release dosage form
WO2006044206A3 (en) Transdermal drug delivery device including an occlusive backing
WO2004103336A3 (en) Drug delivery system
WO2009043341A3 (en) Cosmetic or pharmaceutical composition for topical application
MY163892A (en) Drug delivery system
WO2008011169A3 (en) Controlled release formulations and associated methods
WO2007127815A3 (en) Microprojection array application with multilayered microprojection member for high drug loading
WO2004093883A3 (en) Sachet for a pharmaceutical composition
WO2009059701A3 (en) Sustained release tablets with hydromorphone
WO2009062746A3 (en) Topical drugs for use in antifungal therapy
WO2012002640A3 (en) Transdermal drug delivery system containing donepezil
WO2006058234A3 (en) Medical devices with highly flexible coated hypotube
CA2637297A1 (en) Transdermal patch incorporating active agent migration barrier layer
WO2006101882A3 (en) Medicament delivery formulations, devices and methods
WO2008060963A3 (en) Layered pharmaceutical formulations comprising an intermediate rapidly dissolving layer
WO2010042471A3 (en) Medical devices for delivery of therapeutic agents to body lumens
MX2010004265A (en) Composition for administering an active ingredient and method for making and using the same.
SI1737406T2 (en) Transdermal systems containing multilayer adhesive matrices to modify drug delivery
WO2006138735A3 (en) Gel compositions for topical administration
WO2005110418A3 (en) Transdermal administration of phycotoxins
WO2007133944A3 (en) Topical administration of acyclovir
WO2007132296A3 (en) Multilayer tablet
WO2005117895A3 (en) Compositions comprising meloxicam

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BW BY BZ CA CH CN CO CR CU CZ DK DM DZ EC EE EG ES FI GB GD GE GM HR HU ID IL IN IS JP KE KG KP KZ LC LK LR LS LT LU LV MA MD MK MN MW MX MZ NA NI NO NZ PG PH PL PT RO RU SC SD SE SG SK SY TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SZ TZ UG ZM ZW AM AZ BY KG MD RU TJ TM AT BE BG CH CY DE DK EE ES FI FR GB GR HU IE IT MC NL PL PT RO SE SI SK TR BF CF CG CI CM GA GN GQ GW ML MR SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2004783850

Country of ref document: EP

DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
WWP Wipo information: published in national office

Ref document number: 2004783850

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2004783850

Country of ref document: EP