WO2005041932A3 - Method for selecting cationic or anionic liposomes for treatment of a mucosa membrane, and kit comprising the same - Google Patents

Method for selecting cationic or anionic liposomes for treatment of a mucosa membrane, and kit comprising the same Download PDF

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Publication number
WO2005041932A3
WO2005041932A3 PCT/IL2004/001005 IL2004001005W WO2005041932A3 WO 2005041932 A3 WO2005041932 A3 WO 2005041932A3 IL 2004001005 W IL2004001005 W IL 2004001005W WO 2005041932 A3 WO2005041932 A3 WO 2005041932A3
Authority
WO
WIPO (PCT)
Prior art keywords
mucosa
treatment
charged lipid
disorder
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2004/001005
Other languages
French (fr)
Other versions
WO2005041932A2 (en
Inventor
Yechezkel Barenholz
Abraham Rubinstein
Tareq Jubeh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Priority to US10/578,090 priority Critical patent/US20070212403A1/en
Priority to AT04799314T priority patent/ATE470435T1/en
Priority to EP04799314A priority patent/EP1694298B1/en
Priority to DE602004027655T priority patent/DE602004027655D1/en
Publication of WO2005041932A2 publication Critical patent/WO2005041932A2/en
Publication of WO2005041932A3 publication Critical patent/WO2005041932A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

The present invention is based on the use of electrical surface charge as a docking tool to bring charged lipid assemblies in the vicinity of a diseased, e.g. inflamed epithelium of the mucosa, or alternatively, to a normal epithelium, for executing a desired medical procedure. Thus, the present invention provides a method for selecting a medicament for a medical procedure has now been designed. The medical procedure is selected from treatment, for the healing of a disease or disorder of a mucosa, prophylaxis of a disease or disorder or a mucosa, or a combination of same. The method steps are based on the observation that there are differences in the attachment properties of charged lipid assemblies, such as liposomes, when examined in healthy or inflamed mucosal tissues. The invention also provides a kit making use of the method of the invention. Yet, the invention concerns a method and a medicament for the treatment or prevention of a disease or disorder of the gastrointestinal mucosa, as well as the use of charged lipid assemblies for obtaining said medicament, based on the principles of the differential adhesion of positively vs. negatively charged lipid assemblies to healthy and diseased mucosa, respectively.
PCT/IL2004/001005 2003-11-03 2004-11-03 Method for selecting cationic or anionic liposomes for treatment of a mucosa membrane, and kit comprising the same Ceased WO2005041932A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/578,090 US20070212403A1 (en) 2003-11-03 2004-11-03 Method for Selecting Cationic or Anionic Liposomes for Treatment of a Mucosa Membrane, and Kit Comprising the Same
AT04799314T ATE470435T1 (en) 2003-11-03 2004-11-03 METHOD FOR SELECTING CATIONIC OR ANIONIC LIPOSOMES FOR THE TREATMENT OF A MUCOUS MEMBRANE AND SET CONTAINING THE SAME
EP04799314A EP1694298B1 (en) 2003-11-03 2004-11-03 Method for selecting cationic or anionic liposomes for treatment of a mucosa membrane, and kit comprising the same
DE602004027655T DE602004027655D1 (en) 2003-11-03 2004-11-03 METHOD FOR SELECTING CATIONIC OR ANIONIC LIPOSOMES FOR THE TREATMENT OF A TREATMENT MASK AND THIS SET

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51631603P 2003-11-03 2003-11-03
US60/516,316 2003-11-03

Publications (2)

Publication Number Publication Date
WO2005041932A2 WO2005041932A2 (en) 2005-05-12
WO2005041932A3 true WO2005041932A3 (en) 2005-06-02

Family

ID=34549524

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2004/001005 Ceased WO2005041932A2 (en) 2003-11-03 2004-11-03 Method for selecting cationic or anionic liposomes for treatment of a mucosa membrane, and kit comprising the same

Country Status (5)

Country Link
US (1) US20070212403A1 (en)
EP (1) EP1694298B1 (en)
AT (1) ATE470435T1 (en)
DE (1) DE602004027655D1 (en)
WO (1) WO2005041932A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060015534A (en) 2003-04-25 2006-02-17 더 펜 스테이트 리서치 파운데이션 Methods and systems for growth inhibition, systemic delivery of lipid-derived bioactive compounds
US20070087045A1 (en) * 2005-10-14 2007-04-19 Industrial Technology Research Institute Lipid carrier and method of preparing the same
WO2008087803A1 (en) * 2007-01-16 2008-07-24 Hokkaido University Liposome preparation for iontophoresis having antioxidant component encapsulated therein
EP2368627A4 (en) * 2008-12-24 2015-01-14 Biomedcore Inc Method for producing liposome and method for dissolving cholesterol
AU2012217685B2 (en) 2011-02-15 2017-05-18 Merrimack Pharmaceuticals, Inc. Compositions and methods for delivering nucleic acid to a cell
CN102192978B (en) * 2011-03-15 2013-09-04 中国科学院武汉病毒研究所 Method and application for safety evaluation of drugs and xenobiotics both effecting on internal mucous membranes
US20220296514A1 (en) * 2021-03-18 2022-09-22 FormuRx Pharmaceuticals Co., Ltd. Composition and Method of Preparation for Lipid Formulations Comprising Charged Lipids

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0287198A2 (en) * 1987-02-17 1988-10-19 Board Of Regents, The University Of Texas System Mixtures of polar and neutral lipids for protecting the gastronointestinal tract
WO1993014744A1 (en) * 1992-02-04 1993-08-05 Chiron Corporation Non-toxic lipid vaccine formulations
CA2451846A1 (en) * 2001-06-29 2003-01-09 Chugai Seiyaku Kabushiki Kaisha Cancer vaccine comprizing a cancer antigen based on the product of a tumor suppressor gene wt1 and a cationic liposome

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0714865B2 (en) * 1986-10-28 1995-02-22 武田薬品工業株式会社 Liposome preparation and method for producing the same
US20020039556A1 (en) * 1995-09-27 2002-04-04 Kari Dyvik Stabilised phospholipid compositions
AU753196B2 (en) * 1998-02-09 2002-10-10 Bracco Research S.A. Targeted delivery of biologically active media
US6872406B2 (en) * 2000-02-11 2005-03-29 Children's Hospital Research Foundation Fusogenic properties of saposin C and related proteins and polypeptides for application to transmembrane drug delivery systems
US6616944B2 (en) * 2000-03-08 2003-09-09 Medinnova Gesellschaft Fur Medizinsche Innovationen Aus Adkademischer Forschung Mbh Self-assembling colloidal carriers for protein delivery
GB0111279D0 (en) * 2001-05-10 2001-06-27 Nycomed Imaging As Radiolabelled liposomes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0287198A2 (en) * 1987-02-17 1988-10-19 Board Of Regents, The University Of Texas System Mixtures of polar and neutral lipids for protecting the gastronointestinal tract
WO1993014744A1 (en) * 1992-02-04 1993-08-05 Chiron Corporation Non-toxic lipid vaccine formulations
CA2451846A1 (en) * 2001-06-29 2003-01-09 Chugai Seiyaku Kabushiki Kaisha Cancer vaccine comprizing a cancer antigen based on the product of a tumor suppressor gene wt1 and a cationic liposome

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BLAU SIGAL ET AL: "Drug targeting by surface cationization", CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, vol. 17, no. 5, 2000, pages 425 - 465, XP009042815, ISSN: 0743-4863 *
JUBEH TAREQ ET AL: "The effect of liposomal charge density, dimensions, incubation time and tissue inflammation on the mucoadhesion properties of cationic liposomes in the rat colon", AAPS PHARM SCI, vol. 4, no. 4, 2002, pages ABSTRACT R6152, XP002315936, ISSN: 1522-1059 *
RENGEL RUZICA GALOVIC ET AL: "High efficiency entrapment of superoxide dismutase into mucoadhesive chitosan-coated liposomes", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 15, no. 5, June 2002 (2002-06-01), pages 441 - 448, XP002315937, ISSN: 0928-0987 *
YASUI KIYOTADA ET AL: "Positively charged liposomes containing tumor necrosis factor in solid tumors", BIOLOGICAL AND PHARMACEUTICAL BULLETIN, vol. 23, no. 3, March 2000 (2000-03-01), pages 318 - 322, XP001205127, ISSN: 0918-6158 *

Also Published As

Publication number Publication date
EP1694298A2 (en) 2006-08-30
EP1694298B1 (en) 2010-06-09
US20070212403A1 (en) 2007-09-13
WO2005041932A2 (en) 2005-05-12
ATE470435T1 (en) 2010-06-15
DE602004027655D1 (en) 2010-07-22

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