WO2005043167A3 - Method for distinguishing aml subtypes with differents gene dosages - Google Patents

Method for distinguishing aml subtypes with differents gene dosages Download PDF

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Publication number
WO2005043167A3
WO2005043167A3 PCT/EP2004/012469 EP2004012469W WO2005043167A3 WO 2005043167 A3 WO2005043167 A3 WO 2005043167A3 EP 2004012469 W EP2004012469 W EP 2004012469W WO 2005043167 A3 WO2005043167 A3 WO 2005043167A3
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WO
WIPO (PCT)
Prior art keywords
aml
differents
gene dosages
aml subtypes
distinguishing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2004/012469
Other languages
French (fr)
Other versions
WO2005043167A2 (en
Inventor
Torsten Haferlach
Martin Dugas
Wolfgang Kern
Alexander Kohlmann
Susanne Schnittger
Claudia Schoch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Original Assignee
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Roche Diagnostics GmbH filed Critical F Hoffmann La Roche AG
Priority to EP04797596A priority Critical patent/EP1682906A2/en
Priority to US10/575,704 priority patent/US20070128607A1/en
Publication of WO2005043167A2 publication Critical patent/WO2005043167A2/en
Publication of WO2005043167A3 publication Critical patent/WO2005043167A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57505—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the blood, e.g. leukaemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Disclosed is a method for distinguishing AML subtypes with different gene dosages selected from AML-TRI8-AML-TRI11-AML-TRI13, AML-,MO7, and/or AML-DEL5q in a sample by determinig the expression level of markers, as well as a diagnostic kit and an apparatus containing the markers.
PCT/EP2004/012469 2003-11-04 2004-11-04 Method for distinguishing aml subtypes with differents gene dosages Ceased WO2005043167A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP04797596A EP1682906A2 (en) 2003-11-04 2004-11-04 Method for distinguishing aml subtypes with differents gene dosages
US10/575,704 US20070128607A1 (en) 2003-11-04 2004-11-04 Method for distinguishing aml subtypes with different gene dosages

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03025342 2003-11-04
EP03025342.1 2003-11-04

Publications (2)

Publication Number Publication Date
WO2005043167A2 WO2005043167A2 (en) 2005-05-12
WO2005043167A3 true WO2005043167A3 (en) 2005-09-15

Family

ID=34530668

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/012469 Ceased WO2005043167A2 (en) 2003-11-04 2004-11-04 Method for distinguishing aml subtypes with differents gene dosages

Country Status (3)

Country Link
US (1) US20070128607A1 (en)
EP (1) EP1682906A2 (en)
WO (1) WO2005043167A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3796911A4 (en) * 2018-04-25 2022-05-04 Martner, Anna METHODS AND COMPOSITIONS FOR REDUCING THE RISK OF RECURRENCE AND PROLONGING SURVIVAL IN ACUTE MYELOUS LEUKEMIA

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1043676A2 (en) * 1999-04-09 2000-10-11 Whitehead Institute For Biomedical Research Methods for classifying samples and ascertaining previously unknown classes
WO2003039443A2 (en) * 2001-11-05 2003-05-15 Deutsches Krebsforschungszentrum Novel genetic markers for leukemias
WO2003083140A2 (en) * 2002-03-22 2003-10-09 St.Jude Children's Research Hospital, Inc. Classification and prognosis prediction of acute lymphoblasstic leukemia by gene expression profiling

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700637A (en) * 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
DE69527585T2 (en) * 1994-06-08 2003-04-03 Affymetrix, Inc. Method and device for packaging chips
JP4540754B2 (en) * 1996-06-04 2010-09-08 ユニバーシティ オブ ユタ リサーチ ファウンデーション Monitoring of hybridization during PCR
WO2002101357A2 (en) * 2001-06-10 2002-12-19 Irm Llc Molecular signatures of commonly fatal carcinomas

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1043676A2 (en) * 1999-04-09 2000-10-11 Whitehead Institute For Biomedical Research Methods for classifying samples and ascertaining previously unknown classes
WO2003039443A2 (en) * 2001-11-05 2003-05-15 Deutsches Krebsforschungszentrum Novel genetic markers for leukemias
WO2003083140A2 (en) * 2002-03-22 2003-10-09 St.Jude Children's Research Hospital, Inc. Classification and prognosis prediction of acute lymphoblasstic leukemia by gene expression profiling

Non-Patent Citations (18)

* Cited by examiner, † Cited by third party
Title
ALIZADEH A ET AL: "THE LYMPHOCHIP: A SPECIALIZED CDNA MICROARRAY FOR THE GENOMIC-SCALE ANALYSIS OF GENE EXPRESSION IN NORMAL AND MALIGNANT LYMPHOCYTES", COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, BIOLOGICAL LABORATORY, COLD SPRING HARBOR, NY, US, vol. 64, no. 1, 1999, pages 71 - 78, XP001099007, ISSN: 0091-7451 *
BLOOD, vol. 100, no. 11, 16 November 2002 (2002-11-16), 44th Annual Meeting of the American Society of Hematology;Philadelphia, PA, USA; December 06-10, 2002, pages Abstract No. 1206, ISSN: 0006-4971 *
BLOOD, vol. 100, no. 11, 16 November 2002 (2002-11-16), 44th Annual Meeting of the American Society of Hematology;Philadelphia, PA, USA; December 06-10, 2002, pages Abstract No. 2949, ISSN: 0006-4971 *
BLOOD, vol. 100, no. 11, 16 November 2002 (2002-11-16), 44th Annual Meeting of the American Society of Hematology;Philadelphia, PA, USA; December 06-10, 2002, pages Abstract No. 4287, ISSN: 0006-4971 *
BLOOD, vol. 100, no. 11, 16 November 2002 (2002-11-16), 44th Annual Meeting of the American Society of Hematology;Philadelphia, PA, USA; December 06-10, 2002, pages Abstract No. 4309, ISSN: 0006-4971 *
BLOOD, vol. 98, no. 11 Part 1, 16 November 2001 (2001-11-16), 43rd Annual Meeting of the American Society of Hematology, Part 1;Orlando, Florida, USA; December 07-11, 2001, pages 728a - 729a, ISSN: 0006-4971 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2001 (2001-11-16), CHEN GUIBIN ET AL: "Distinct gene expression profile in CD34 cells from patients with specific karyotypic defects in myelodysplasia", XP002273025, Database accession no. PREV200200250081 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), KOHLMANN ALEXANDER ET AL: "A Simplified and Partially Automated Target Preparation Method for Gene Expression Profiling.", XP002269495, Database accession no. PREV200300367771 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), QIAN ZHIJIAN ET AL: "Expression Profiling of CD34+ Hematopoietic Progenitors Reveals Distinct Subtypes of Therapy-Related Acute Myeloid Leukemia.", XP002273027, Database accession no. PREV200300335806 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), RITTER MARKUS ET AL: "Differentially Regulated Signaling Pathways in AML with Monosomy 7 and 7q-.", XP002273028, Database accession no. PREV200300367793 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), VEY NORBERT ET AL: "Gene Expression Profiling of Acute Myeloid Leukemias with Normal Karyotype.", XP002273026, Database accession no. PREV200300357083 *
DUGAS M ET AL: "A comprehensive leukemia database: integration of cytogenetics, molecular genetics and microarray data with clinical information, cytomorphology and immunophenotyping", LEUKEMIA, MACMILLAN PRESS LTD, US, vol. 15, no. 12, December 2001 (2001-12-01), pages 1805 - 1810, XP002263731, ISSN: 0887-6924 *
DUGAS MARTIN ET AL: "Impact of integrating clinical and genetic information.", IN SILICO BIOLOGY, vol. 2, no. 3, 2002, pages 383 - 391, XP001179418, ISSN: 1386-6338 (ISSN print) *
GOLUB T R ET AL: "Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 286, no. 5439, 15 October 1999 (1999-10-15), pages 531 - 537, XP002207658, ISSN: 0036-8075 *
HAFERLACH T ET AL: "The Diagnosis of 14 Specific Subtypes of Leukemia Is Possible Based on Gene Expression Profiles: A Study on 263 Patients with AML, ALL, CML, or CLL", BLOOD, W.B.SAUNDERS COMPAGNY, ORLANDO, FL, US, vol. 100, no. 11, 16 November 2002 (2002-11-16), pages 139A, XP002263227, ISSN: 0006-4971 *
KOHLMANN A ET AL: "MOLECULAR CHARACTERIZATION OF ACUTE LEUKEMIAS BY USE OF MICROARRAY TECHNOLOGY", GENES, CHROMOSOMES & CANCER, XX, XX, vol. 37, no. 4, August 2003 (2003-08-01), pages 396 - 405, XP008025253 *
QIAN ZHIJIAN ET AL: "Expression profiling of CD34+ hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 99, no. 23, 12 November 2002 (2002-11-12), pages 14925 - 14930, XP002261373, ISSN: 0027-8424 *
VIRTANEVA K ET AL: "EXPRESSION PROFILING REVEALS FUNDAMENTAL BIOLOGICAL DIFFERENCES IN ACUTE MYELOID LEUKEMIA WITH ISOLATED TRISOMY 8 AND NORMAL CYTOGENETICS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 98, no. 3, 30 January 2001 (2001-01-30), pages 1124 - 1129, XP002952627, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
US20070128607A1 (en) 2007-06-07
EP1682906A2 (en) 2006-07-26
WO2005043167A2 (en) 2005-05-12

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