WO2005044294A3 - Method of therapy for cancers expressing the cd40 antigen - Google Patents

Method of therapy for cancers expressing the cd40 antigen Download PDF

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Publication number
WO2005044294A3
WO2005044294A3 PCT/US2004/036958 US2004036958W WO2005044294A3 WO 2005044294 A3 WO2005044294 A3 WO 2005044294A3 US 2004036958 W US2004036958 W US 2004036958W WO 2005044294 A3 WO2005044294 A3 WO 2005044294A3
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WIPO (PCT)
Prior art keywords
antigen
dosing regimen
methods
antibody
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/036958
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French (fr)
Other versions
WO2005044294A2 (en
Inventor
Li Long
Mohammad Luqman
Asha Yabannavar
Isabel Zaror
Deborah Hurst
De Menezes Daniel E Lopes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34577667&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2005044294(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to DE602004028037T priority Critical patent/DE602004028037D1/en
Priority to DK04810421.0T priority patent/DK1682178T3/en
Priority to JP2006538514A priority patent/JP4765039B2/en
Priority to AT04810421T priority patent/ATE473016T1/en
Priority to SI200431514T priority patent/SI1682178T1/en
Priority to PL04810421T priority patent/PL1682178T3/en
Priority to HK07100959.2A priority patent/HK1094156B/en
Application filed by Chiron Corp filed Critical Chiron Corp
Priority to CA002544948A priority patent/CA2544948A1/en
Priority to EP04810421A priority patent/EP1682178B8/en
Publication of WO2005044294A2 publication Critical patent/WO2005044294A2/en
Publication of WO2005044294A3 publication Critical patent/WO2005044294A3/en
Anticipated expiration legal-status Critical
Priority to US11/932,472 priority patent/US8277810B2/en
Priority to US13/612,070 priority patent/US8637032B2/en
Priority to US14/134,339 priority patent/US20140205602A1/en
Priority to US15/241,136 priority patent/US20170081416A1/en
Ceased legal-status Critical Current

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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Abstract

Methods of treating a subject for a cancer comprising neoplastic cells expressing the CD40 cell surface antigen are provided. The methods comprise combination therapy with interleukin-2 (IL-2) or biologically active variant thereof and at least one antagonist anti-CD40 antibody or antigen-binding fragment thereof. In some embodiments, these two therapeutic agents are concurrently administered as two separate pharmaceutical compositions, one containing IL-2 or biologically active variant thereof, which is administered according to a constant IL-2 dosing regimen or a two-level IL-2 dosing regimen, the other containing the antagonist anti-CD40 antibody or suitable antigen­ binding fragment thereof, which is administered according to a weekly dosing regimen, or alternatively is dosed once every two, three, or four weeks. Administering of these two agents together potentiates their effectiveness in promoting a positive therapeutic response. The methods find use in treating CD40-expressing cancers, including B-cell related cancers and solid tumors.
PCT/US2004/036958 2003-11-04 2004-11-04 Method of therapy for cancers expressing the cd40 antigen Ceased WO2005044294A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
EP04810421A EP1682178B8 (en) 2003-11-04 2004-11-04 Methods of therapy for cancers expressing the cd40 antigen
CA002544948A CA2544948A1 (en) 2003-11-04 2004-11-04 Methods of therapy for cancers expressing the cd40 antigen
JP2006538514A JP4765039B2 (en) 2003-11-04 2004-11-04 A method for treating cancer expressing CD40 antigen.
AT04810421T ATE473016T1 (en) 2003-11-04 2004-11-04 METHOD FOR TREATING CANCER WITH EXPRESSION OF THE CD40 ANTIGEN
SI200431514T SI1682178T1 (en) 2003-11-04 2004-11-04 Methods of therapy for cancers expressing the cd40 antigen
PL04810421T PL1682178T3 (en) 2003-11-04 2004-11-04 Methods of therapy for cancers expressing the cd40 antigen
HK07100959.2A HK1094156B (en) 2003-11-04 2004-11-04 Methods of therapy for cancers expressing the cd40 antigen
DE602004028037T DE602004028037D1 (en) 2003-11-04 2004-11-04 METHOD FOR THE TREATMENT OF CANCER WITH EXPRESSION OF CD40 ANTIGEN
DK04810421.0T DK1682178T3 (en) 2003-11-04 2004-11-04 Methods for therapy of cancers expressing the CD-40 antigen
US11/932,472 US8277810B2 (en) 2003-11-04 2007-10-31 Antagonist anti-CD40 antibodies
US13/612,070 US8637032B2 (en) 2003-11-04 2012-09-12 Antagonist anti-CD40 monoclonal antibodies and methods for their use
US14/134,339 US20140205602A1 (en) 2003-11-04 2013-12-19 Antagonist anti-cd40 monoclonal antibodies and methods for their use
US15/241,136 US20170081416A1 (en) 2003-11-04 2016-08-19 Antagonist anti-cd40 monoclonal antibodies and methods for their use

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US51733703P 2003-11-04 2003-11-04
US60/517,337 2003-11-04
US52557903P 2003-11-26 2003-11-26
US60/525,579 2003-11-26
US56571004P 2004-04-27 2004-04-27
US60/565,710 2004-04-27

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2004/036957 Continuation-In-Part WO2005044306A2 (en) 2003-11-04 2004-11-04 Use of antagonist anti-cd40 antibodies for treatment of autoimmune and inflammatory diseases and organ transplant rejection
US10576943 Continuation-In-Part 2006-12-01

Related Child Applications (4)

Application Number Title Priority Date Filing Date
PCT/US2004/037159 Continuation-In-Part WO2005044307A2 (en) 2003-11-04 2004-11-04 Methods of therapy for b cell-related cancers
US10578590 A-371-Of-International 2004-11-04
US10/578,401 Continuation-In-Part US20070098718A1 (en) 2003-11-04 2004-11-04 Methods of therapy for b cell-related cancers
US11/932,472 Continuation-In-Part US8277810B2 (en) 2003-11-04 2007-10-31 Antagonist anti-CD40 antibodies

Publications (2)

Publication Number Publication Date
WO2005044294A2 WO2005044294A2 (en) 2005-05-19
WO2005044294A3 true WO2005044294A3 (en) 2005-09-15

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Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2004/037152 Ceased WO2005044854A2 (en) 2003-11-04 2004-11-04 Antagonist anti-cd40 monoclonal antibodies and methods for their use
PCT/US2004/036957 Ceased WO2005044306A2 (en) 2003-11-04 2004-11-04 Use of antagonist anti-cd40 antibodies for treatment of autoimmune and inflammatory diseases and organ transplant rejection
PCT/US2004/036958 Ceased WO2005044294A2 (en) 2003-11-04 2004-11-04 Method of therapy for cancers expressing the cd40 antigen

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/US2004/037152 Ceased WO2005044854A2 (en) 2003-11-04 2004-11-04 Antagonist anti-cd40 monoclonal antibodies and methods for their use
PCT/US2004/036957 Ceased WO2005044306A2 (en) 2003-11-04 2004-11-04 Use of antagonist anti-cd40 antibodies for treatment of autoimmune and inflammatory diseases and organ transplant rejection

Country Status (22)

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EP (6) EP1694360B1 (en)
JP (6) JP4746552B2 (en)
KR (2) KR101403910B1 (en)
CN (2) CN1905897B (en)
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