WO2005044854A3 - Antagonist anti-cd40 monoclonal antibodies and methods for their use - Google Patents

Antagonist anti-cd40 monoclonal antibodies and methods for their use Download PDF

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Publication number
WO2005044854A3
WO2005044854A3 PCT/US2004/037152 US2004037152W WO2005044854A3 WO 2005044854 A3 WO2005044854 A3 WO 2005044854A3 US 2004037152 W US2004037152 W US 2004037152W WO 2005044854 A3 WO2005044854 A3 WO 2005044854A3
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WO
WIPO (PCT)
Prior art keywords
antigen
antibody
methods
binding fragment
antagonist
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/037152
Other languages
French (fr)
Other versions
WO2005044854A2 (en
Inventor
Li Long
Mohammad Luqman
Asha Yabannavar
Isabel Zaror
Bao-Lu Chen
Xiaofeng Lu
Sang Hoon Lee
Deborah Hurst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34577667&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2005044854(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EP04810510A priority Critical patent/EP1682180B1/en
Priority to DK04810510T priority patent/DK1682180T3/en
Priority to CA2544949A priority patent/CA2544949C/en
Priority to US10/577,390 priority patent/US20080057070A1/en
Priority to SI200431280T priority patent/SI1682180T1/en
Priority to DE602004023961T priority patent/DE602004023961D1/en
Priority to RSP-2010/0041A priority patent/RS51230B/en
Priority to AT04810510T priority patent/ATE447412T1/en
Priority to HR20100066T priority patent/HRP20100066T1/en
Priority to KR1020067010885A priority patent/KR101403910B1/en
Priority to HK07100895.9A priority patent/HK1095270B/en
Priority to PL04810510T priority patent/PL1682180T3/en
Priority to CN2004800390435A priority patent/CN1905897B/en
Priority to JP2006538540A priority patent/JP5019881B2/en
Priority to AU2004287879A priority patent/AU2004287879C1/en
Priority to ZA200604419A priority patent/ZA200604419B/en
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of WO2005044854A2 publication Critical patent/WO2005044854A2/en
Publication of WO2005044854A3 publication Critical patent/WO2005044854A3/en
Priority to IL175225A priority patent/IL175225A/en
Anticipated expiration legal-status Critical
Priority to US11/932,472 priority patent/US8277810B2/en
Priority to AU2011201529A priority patent/AU2011201529B2/en
Priority to US13/612,070 priority patent/US8637032B2/en
Priority to US14/134,339 priority patent/US20140205602A1/en
Priority to US15/241,136 priority patent/US20170081416A1/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Abstract

Methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40­expressing cells, such as B cells.
PCT/US2004/037152 2003-11-04 2004-11-04 Antagonist anti-cd40 monoclonal antibodies and methods for their use Ceased WO2005044854A2 (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
DK04810510T DK1682180T3 (en) 2003-11-04 2004-11-04 Monoclonal antagonist anti-CD40 antibodies and methods for their use
CN2004800390435A CN1905897B (en) 2003-11-04 2004-11-04 Antagonistic anti-CD40 monoclonal antibodies and methods of their use
CA2544949A CA2544949C (en) 2003-11-04 2004-11-04 Antagonist anti-cd40 monoclonal antibodies and methods for their use
US10/577,390 US20080057070A1 (en) 2004-11-04 2004-11-04 Antagonist Anti-Cd40 Monoclonal Antibodies and Methods for Their Use
SI200431280T SI1682180T1 (en) 2003-11-04 2004-11-04 Antagonist anti-cd40 monoclonal antibodies and methods for their use
DE602004023961T DE602004023961D1 (en) 2003-11-04 2004-11-04 ANTAGONIST ANTI CD40 MONOCLONAL ANTIBODIES AND METHOD OF USE
RSP-2010/0041A RS51230B (en) 2003-11-04 2004-11-04 ANTAGONIST ANT-CD40 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE
AT04810510T ATE447412T1 (en) 2003-11-04 2004-11-04 ANTAGONIST ANTI-CD40 MONOCLONAL ANTIBODIES AND METHODS OF USE
HR20100066T HRP20100066T1 (en) 2003-11-04 2004-11-04 ANTAGONISTS OF ANTI-CD-40 MONOCLONAL ANTIBODIES AND METHODS OF THEIR USE
KR1020067010885A KR101403910B1 (en) 2003-11-04 2004-11-04 Antagonist anti-cd40 monoclonal antibodies and methods for their use
HK07100895.9A HK1095270B (en) 2003-11-04 2004-11-04 Antagonist anti-cd40 monoclonal antibodies and methods for their use
AU2004287879A AU2004287879C1 (en) 2003-11-04 2004-11-04 Antagonist anti-CD40 monoclonal antibodies and methods for their use
JP2006538540A JP5019881B2 (en) 2003-11-04 2004-11-04 Antagonist anti-CD40 monoclonal antibodies and methods for using them
EP04810510A EP1682180B1 (en) 2003-11-04 2004-11-04 Antagonist anti-cd40 monoclonal antibodies and methods for their use
PL04810510T PL1682180T3 (en) 2003-11-04 2004-11-04 Antagonist anti-cd40 monoclonal antibodies and methods for their use
ZA200604419A ZA200604419B (en) 2003-11-04 2004-11-04 Antagonist anti-CD40 monoclonal antibodies and methods for their use
IL175225A IL175225A (en) 2003-11-04 2006-04-26 Antagonist anti-cd40 monoclonal antibody, an isolated nucleic acid encoding the antibody, a hybridoma cell line capable of producing the antibody, use of the antibody and pharmaceutical compositions comprising it
US11/932,472 US8277810B2 (en) 2003-11-04 2007-10-31 Antagonist anti-CD40 antibodies
AU2011201529A AU2011201529B2 (en) 2003-11-04 2011-04-05 Antagonist anti-CD40 monoclonal antibodies and methods for their use
US13/612,070 US8637032B2 (en) 2003-11-04 2012-09-12 Antagonist anti-CD40 monoclonal antibodies and methods for their use
US14/134,339 US20140205602A1 (en) 2003-11-04 2013-12-19 Antagonist anti-cd40 monoclonal antibodies and methods for their use
US15/241,136 US20170081416A1 (en) 2003-11-04 2016-08-19 Antagonist anti-cd40 monoclonal antibodies and methods for their use

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US51733703P 2003-11-04 2003-11-04
US60/517,337 2003-11-04
US52557903P 2003-11-26 2003-11-26
US60/525,579 2003-11-26
US56571004P 2004-04-27 2004-04-27
US60/565,710 2004-04-27

Related Parent Applications (2)

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PCT/US2004/037281 Continuation-In-Part WO2005044855A2 (en) 2003-11-04 2004-11-04 Use of antagonist anti-cd40 monoclonal antibodies for treatment of multiple myeloma
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