WO2005045876A3 - Improved high performance ion mobility spectrometry using hourglass electrodynamic funnel and internal ion funnel - Google Patents

Improved high performance ion mobility spectrometry using hourglass electrodynamic funnel and internal ion funnel Download PDF

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Publication number
WO2005045876A3
WO2005045876A3 PCT/US2004/029181 US2004029181W WO2005045876A3 WO 2005045876 A3 WO2005045876 A3 WO 2005045876A3 US 2004029181 W US2004029181 W US 2004029181W WO 2005045876 A3 WO2005045876 A3 WO 2005045876A3
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WO
WIPO (PCT)
Prior art keywords
funnel
drift tube
ions
ion
exit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/029181
Other languages
French (fr)
Other versions
WO2005045876A2 (en
Inventor
Richard D Smith
Keqi Tang
Alexandre A Shvartsburg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Battelle Memorial Institute Inc
Original Assignee
Battelle Memorial Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/699,006 external-priority patent/US6818890B1/en
Application filed by Battelle Memorial Institute Inc filed Critical Battelle Memorial Institute Inc
Priority to EP04788617A priority Critical patent/EP1678738B1/en
Priority to CA2539899A priority patent/CA2539899C/en
Priority to JP2006537986A priority patent/JP2007510272A/en
Publication of WO2005045876A2 publication Critical patent/WO2005045876A2/en
Anticipated expiration legal-status Critical
Publication of WO2005045876A3 publication Critical patent/WO2005045876A3/en
Ceased legal-status Critical Current

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/065—Ion guides having stacked electrodes, e.g. ring stack, plate stack
    • H01J49/066—Ion funnels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Electrochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

A method and apparatus enabling increased sensitivity in ion mobility spectrometry/mass spectrometry instruments which substantially reduces or eliminates the loss of ions in ion mobility spectrometer drift tubes utilizing a device for transmitting ions from an ion source which allows the transmission of ions without significant delay to an hourglass electrodynamic ion funnel at the entrance to the drift tube and/or an internal ion funnel at the exit of the drift tube. An hourglass electrodynamic funnel is formed of at least an entry element, a center element, and an exit element, wherein the aperture of the center element is smaller than the aperture of the entry element and the aperture of the exit elements. Ions generated in a relatively high pressure region by an ion source at the exterior of the hourglass electrodynamic funnel are transmitted to a relatively low pressure region at the entrance of the hourglass funnel through a conductance limiting orifice. Alternating and direct electrical potentials are applied to the elements of the hourglass electrodynamic funnel thereby drawing ions into and through the hourglass electrodynamic funnel thereby introducing relatively large quantities of ions into the drift tube while maintaining the gas pressure and composition at the interior of the drift tube as distinct from those at the entrance of the electrodynamic funnel and allowing a positive gas pressure to be maintained within the drift tube, if desired. An internal ion funnel is provided within the drift tube and is positioned at the exit of said drift tube. The advantage of the internal ion funnel is that ions that are dispersed away from the exit aperture within the drift tube, such as those that are typically lost in conventional drift tubes to any subsequent analysis or measurement, are instead directed through the exit of the drift tube, vastly increasing the amount of ions exiting the drift tube.
PCT/US2004/029181 2003-10-30 2004-09-07 Improved high performance ion mobility spectrometry using hourglass electrodynamic funnel and internal ion funnel Ceased WO2005045876A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP04788617A EP1678738B1 (en) 2003-10-30 2004-09-07 Improved high performance ion mobility spectrometry using hourglass electrodynamic funnel and internal ion funnel
CA2539899A CA2539899C (en) 2003-10-30 2004-09-07 Improved high performance ion mobility spectrometry using hourglass electrodynamic funnel and internal ion funnel
JP2006537986A JP2007510272A (en) 2003-10-30 2004-09-07 Improved fast ion mobility spectroscopy using an hourglass-type electrodynamic funnel and internal ion funnel

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/699,006 2003-10-30
US10/699,006 US6818890B1 (en) 2003-10-30 2003-10-30 High performance ion mobility spectrometry using hourglass electrodynamic funnel and internal ion funnel
US10/933,661 US6967325B2 (en) 2003-10-30 2004-09-02 High performance ion mobility spectrometry using hourglass electrodynamic funnel and internal ion funnel
US10/933,661 2004-09-02

Publications (2)

Publication Number Publication Date
WO2005045876A2 WO2005045876A2 (en) 2005-05-19
WO2005045876A3 true WO2005045876A3 (en) 2006-05-26

Family

ID=34577166

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/029181 Ceased WO2005045876A2 (en) 2003-10-30 2004-09-07 Improved high performance ion mobility spectrometry using hourglass electrodynamic funnel and internal ion funnel

Country Status (5)

Country Link
US (1) US6967325B2 (en)
EP (1) EP1678738B1 (en)
JP (1) JP2007510272A (en)
CA (1) CA2539899C (en)
WO (1) WO2005045876A2 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050194543A1 (en) * 2004-02-23 2005-09-08 Ciphergen Biosystems, Inc. Methods and apparatus for controlling ion current in an ion transmission device
US8003934B2 (en) * 2004-02-23 2011-08-23 Andreas Hieke Methods and apparatus for ion sources, ion control and ion measurement for macromolecules
CA2604820A1 (en) * 2004-02-23 2005-09-09 Gemio Technologies, Inc. Ion source with controlled superposition of electrostatic and gas flow fields
GB0424426D0 (en) * 2004-11-04 2004-12-08 Micromass Ltd Mass spectrometer
US7148474B2 (en) * 2005-04-11 2006-12-12 Battelle Memorial Institute Device for two-dimensional gas-phase separation and characterization of ion mixtures
US7351960B2 (en) * 2005-05-16 2008-04-01 Thermo Finnigan Llc Enhanced ion desolvation for an ion mobility spectrometry device
US7312444B1 (en) 2005-05-24 2007-12-25 Chem - Space Associates, Inc. Atmosperic pressure quadrupole analyzer
DE102005044307B4 (en) * 2005-09-16 2008-04-17 Bruker Daltonik Gmbh Ionization of desorbed molecules
US20070114382A1 (en) * 2005-11-23 2007-05-24 Clemmer David E Ion mobility spectrometer
US7339166B2 (en) * 2006-02-24 2008-03-04 Battelle Memorial Institute Interface and process for enhanced transmission of non-circular ion beams between stages at unequal pressure
US7547891B2 (en) * 2007-02-16 2009-06-16 Agilent Technologies, Inc. Ion sampling apparatuses in fast polarity-switching ion sources
CN104849342B (en) * 2007-12-27 2019-07-30 同方威视技术股份有限公司 Ionic migration spectrometer and its method
WO2010045049A1 (en) * 2008-10-13 2010-04-22 Purdue Research Foundation Systems and methods for transfer of ions for analysis
CN101738429B (en) 2008-11-26 2013-04-03 岛津分析技术研发（上海）有限公司 Ion separation, enrichment and detection device
EP2405463A1 (en) 2010-07-06 2012-01-11 ETH Zurich Laser-ablation ion source with ion funnel
WO2013067366A2 (en) * 2011-11-02 2013-05-10 Leco Corporation Ion mobility spectrometer
CN103779169B (en) * 2012-10-17 2016-01-06 中国科学院大连化学物理研究所 A kind of surface discharge ionization source-without ion gate transference tube
WO2015026727A1 (en) * 2013-08-19 2015-02-26 Virgin Instruments Corporation Ion optical system for maldi-tof mass spectrometer
JP6549130B2 (en) * 2013-12-31 2019-07-24 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド Injection injector inlet for differential mobility spectrometers
US9558925B2 (en) 2014-04-18 2017-01-31 Battelle Memorial Institute Device for separating non-ions from ions
WO2015179709A1 (en) 2014-05-22 2015-11-26 Benner W Henry Instruments for measuring ion size distribution and concentration
EP3155414B8 (en) 2014-06-11 2021-12-01 Micromass UK Limited Monitoring ion mobility spectrometry environment for improved collision cross section accuracy and precision
US9564305B2 (en) * 2014-07-29 2017-02-07 Smiths Detection Inc. Ion funnel for efficient transmission of low mass-to-charge ratio ions with reduced gas flow at the exit
WO2017019852A1 (en) * 2015-07-28 2017-02-02 The University Of Florida Research Foundation, Inc. Atmospheric pressure ion guide
GB201519830D0 (en) * 2015-11-10 2015-12-23 Micromass Ltd A method of transmitting ions through an aperture
US20180076014A1 (en) * 2016-09-09 2018-03-15 Science And Engineering Services, Llc Sub-atmospheric pressure laser ionization source using an ion funnel
CN107870194B (en) * 2016-09-27 2020-08-28 中国科学院生态环境研究中心 Matrix-assisted laser desorption-gas phase polarization-induced proton transfer mass spectrometry
CN108956750B (en) * 2018-06-01 2021-07-27 清华大学深圳研究生院 Ion mobility spectrometry device working under low-pressure condition
EP3629365A1 (en) * 2018-09-28 2020-04-01 Ionicon Analytik Gesellschaft m.b.H. Imr-ms reaction chamber
CN112671352B (en) * 2020-11-26 2024-05-24 钢研纳克检测技术股份有限公司 A radio frequency driving power supply for an ion funnel of a portable mass spectrometer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6107628A (en) * 1998-06-03 2000-08-22 Battelle Memorial Institute Method and apparatus for directing ions and other charged particles generated at near atmospheric pressures into a region under vacuum
US20020185606A1 (en) * 2001-05-18 2002-12-12 Smith Richard D. Ionization source utilizing a jet disturber in combination with an ion funnel and method of operation
US20030141447A1 (en) * 2000-04-10 2003-07-31 Anatoli Verentchikov Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6107628A (en) * 1998-06-03 2000-08-22 Battelle Memorial Institute Method and apparatus for directing ions and other charged particles generated at near atmospheric pressures into a region under vacuum
US20030141447A1 (en) * 2000-04-10 2003-07-31 Anatoli Verentchikov Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis
US20020185606A1 (en) * 2001-05-18 2002-12-12 Smith Richard D. Ionization source utilizing a jet disturber in combination with an ion funnel and method of operation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEROKEE S. HOAGLUND-HYZER, YOUNG JIN LEE, ANNE E. COUNTERMAN, DAVID E. CLEMMER: "Coupling Ion Mobility Separations, Collisional Activation Techniques, and Multiple Stages of MS for Analysis of Complex Peptide Mixtures", ANALYTICAL CHEMISTRY, vol. 74, no. 5, 1 March 2002 (2002-03-01), pages 992 - 1006, XP002371949 *
GUEVREMONT R ET AL: "COMBINED ION MOBILITY/TIME-OF-FLIGHT MASS SPECTROMETRY STUDY OF ELECTROSPRAY-GENERATED IONS", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 69, no. 19, October 1997 (1997-10-01), pages 3959 - 3965, XP000917362, ISSN: 0003-2700 *
VALENTINE S J ET AL: "Multidimensional separations of complex peptide mixtures: a combined high-performance liquid chromatography/ion mobility/time-of-flight mass spectrometry approach", INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 212, no. 1-3, 15 November 2001 (2001-11-15), pages 97 - 109, XP004339995, ISSN: 1387-3806 *

Also Published As

Publication number Publication date
EP1678738B1 (en) 2012-08-15
WO2005045876A2 (en) 2005-05-19
US6967325B2 (en) 2005-11-22
US20050092918A1 (en) 2005-05-05
CA2539899C (en) 2012-08-07
JP2007510272A (en) 2007-04-19
CA2539899A1 (en) 2005-05-19
EP1678738A2 (en) 2006-07-12

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