WO2005065657A3 - Solid compositions of low-solubility drugs and poloxamers - Google Patents

Solid compositions of low-solubility drugs and poloxamers Download PDF

Info

Publication number
WO2005065657A3
WO2005065657A3 PCT/IB2004/004287 IB2004004287W WO2005065657A3 WO 2005065657 A3 WO2005065657 A3 WO 2005065657A3 IB 2004004287 W IB2004004287 W IB 2004004287W WO 2005065657 A3 WO2005065657 A3 WO 2005065657A3
Authority
WO
WIPO (PCT)
Prior art keywords
poloxamers
low
solid compositions
solubility drugs
drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2004/004287
Other languages
French (fr)
Other versions
WO2005065657A2 (en
Inventor
Daniel Tod Smithey
Warren Kenyon Miller
Dwayne Thomas Friesen
Walter Christian Babcock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Priority to EP04806454A priority Critical patent/EP1701704A2/en
Priority to BRPI0418330-4A priority patent/BRPI0418330A/en
Priority to US10/596,876 priority patent/US8974823B2/en
Priority to CA002548376A priority patent/CA2548376A1/en
Priority to JP2006546397A priority patent/JP2007517016A/en
Publication of WO2005065657A2 publication Critical patent/WO2005065657A2/en
Publication of WO2005065657A3 publication Critical patent/WO2005065657A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Solid compositions of low-solubility drugs and poloxamers that provide concentration enhancement when administered to an aqueous environment of use are disclosed.
PCT/IB2004/004287 2003-12-31 2004-12-20 Solid compositions of low-solubility drugs and poloxamers Ceased WO2005065657A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP04806454A EP1701704A2 (en) 2003-12-31 2004-12-20 Solid compositions of low-solubility drugs and poloxamers
BRPI0418330-4A BRPI0418330A (en) 2003-12-31 2004-12-20 solid compositions of low solubility drugs and poloxamers
US10/596,876 US8974823B2 (en) 2003-12-31 2004-12-20 Solid compositions of low-solubility drugs and poloxamers
CA002548376A CA2548376A1 (en) 2003-12-31 2004-12-20 Solid compositions of low-solubility drugs and poloxamers
JP2006546397A JP2007517016A (en) 2003-12-31 2004-12-20 Solid composition of low solubility drug and poloxamer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53383603P 2003-12-31 2003-12-31
US60/533,836 2003-12-31

Publications (2)

Publication Number Publication Date
WO2005065657A2 WO2005065657A2 (en) 2005-07-21
WO2005065657A3 true WO2005065657A3 (en) 2006-06-22

Family

ID=34748969

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/004287 Ceased WO2005065657A2 (en) 2003-12-31 2004-12-20 Solid compositions of low-solubility drugs and poloxamers

Country Status (6)

Country Link
US (1) US8974823B2 (en)
EP (1) EP1701704A2 (en)
JP (1) JP2007517016A (en)
BR (1) BRPI0418330A (en)
CA (1) CA2548376A1 (en)
WO (1) WO2005065657A2 (en)

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DE102005047561A1 (en) * 2005-10-04 2007-04-05 Bayer Healthcare Ag Drug delivery system, useful to treat and/or prevent e.g. thromboembolic disease, comprises 5-chloro-N-(((5S)-2-oxo-3-(4-(3-oxo-4-morpholinyl)-phenyl)-1,3-oxazolidine-5-yl)-methyl)-2-thiophene carboxamide with fast release active substance
EP2142178B1 (en) * 2007-03-29 2012-01-11 F. Hoffmann-La Roche AG Pharmaceutical composition and process
HRP20191104T1 (en) 2007-09-25 2019-09-20 Solubest Ltd. Compositions comprising lipophilic active compounds and method for their preparation
US8889193B2 (en) 2010-02-25 2014-11-18 The Johns Hopkins University Sustained delivery of therapeutic agents to an eye compartment
SMT202000390T1 (en) * 2010-07-12 2020-09-10 Salix Pharmaceuticals Inc Formulations of rifaximin and uses thereof
US20170087134A1 (en) * 2010-07-12 2017-03-30 Salix Pharmaceuticals, Ltd Formulations of rifaximin and uses thereof
WO2012039979A2 (en) 2010-09-10 2012-03-29 The Johns Hopkins University Rapid diffusion of large polymeric nanoparticles in the mammalian brain
EP2455068A1 (en) * 2010-11-09 2012-05-23 F. Hoffmann-La Roche AG Pharmaceutical composition for treating HCV infections
JP2014532658A (en) * 2011-10-28 2014-12-08 セルジーン アヴィロミクス リサーチ， インコーポレイテッド Methods for treating Breton tyrosine kinase diseases or disorders
US8962577B2 (en) 2012-03-16 2015-02-24 The Johns Hopkins University Controlled release formulations for the delivery of HIF-1 inhibitors
CA2867203C (en) 2012-03-16 2016-09-20 The Johns Hopkins University Non-linear multiblock copolymer-drug conjugates for the delivery of active agents
WO2013166408A1 (en) 2012-05-03 2013-11-07 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
CN111700878A (en) * 2012-05-03 2020-09-25 卡拉制药公司 Drug nanoparticles exhibiting enhanced mucosal transport
US9827191B2 (en) 2012-05-03 2017-11-28 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
US9056057B2 (en) 2012-05-03 2015-06-16 Kala Pharmaceuticals, Inc. Nanocrystals, compositions, and methods that aid particle transport in mucus
US11596599B2 (en) 2012-05-03 2023-03-07 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
CA2872519C (en) 2012-05-04 2017-09-05 The Johns Hopkins University Lipid-based drug carriers for rapid penetration through mucus linings
US10568975B2 (en) 2013-02-05 2020-02-25 The Johns Hopkins University Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof
CN105188371A (en) 2013-02-08 2015-12-23 西建阿维拉米斯研究公司 Erk inhibitors and uses thereof
JP5946798B2 (en) * 2013-06-18 2016-07-06 住友ゴム工業株式会社 Rubber composition for tire and pneumatic tire
JP5934677B2 (en) * 2013-06-18 2016-06-15 住友ゴム工業株式会社 Rubber composition for tire and pneumatic tire
US9492471B2 (en) 2013-08-27 2016-11-15 Celgene Avilomics Research, Inc. Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
JP6010060B2 (en) * 2014-02-21 2016-10-19 住友ゴム工業株式会社 Rubber composition for tire and pneumatic tire
WO2016025561A1 (en) 2014-08-13 2016-02-18 Celgene Avilomics Research, Inc. Forms and compositions of an erk inhibitor
RU2639819C2 (en) * 2014-12-30 2017-12-22 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Composition inhibiting telomerase
JP6846351B2 (en) 2015-01-27 2021-03-24 ザ・ジョンズ・ホプキンス・ユニバーシティー Hypotonic hydrogel formulation for enhanced transport of active agents on mucosal surfaces
CA3038312A1 (en) 2016-09-30 2018-04-05 Salix Pharmaceuticals, Inc. Solid dispersion forms of rifaximin
WO2020210805A1 (en) 2019-04-11 2020-10-15 The Johns Hopkins University Nanoparticles for drug delivery to brain
CA3184054A1 (en) 2020-06-26 2021-12-30 Jacob Cole Targeted release rifaximin compositions

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002089835A2 (en) * 2001-05-03 2002-11-14 F. Hoffmann-La Roche Ag Pharmaceutical dosage form of amorphous nelfinavir mesylate
US20030054042A1 (en) * 2001-09-14 2003-03-20 Elaine Liversidge Stabilization of chemical compounds using nanoparticulate formulations
WO2003074026A1 (en) * 2002-03-07 2003-09-12 Biocompatibles Uk Limited Drug carriers comprising amphiphilic block copolymers

Family Cites Families (21)

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Publication number Priority date Publication date Assignee Title
IE80467B1 (en) 1995-07-03 1998-07-29 Elan Corp Plc Controlled release formulations for poorly soluble drugs
DK0996429T3 (en) 1997-10-27 2003-05-26 Merck Patent Gmbh Solid solutions and solid dispersions in water heavily soluble drugs
AU4797999A (en) 1998-07-22 2000-02-14 Yamanouchi Pharmaceutical Co., Ltd. Solid preparation containing sparingly soluble nsaids
US6368622B2 (en) 1999-01-29 2002-04-09 Abbott Laboratories Process for preparing solid formulations of lipid regulating agents with enhanced dissolution and absorption
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US6264981B1 (en) 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
EP1175205B1 (en) 1999-11-12 2006-06-14 Abbott Laboratories Solid dispersion comprising ritonavir, fenofibrate or griseofulvin
WO2001034118A2 (en) 1999-11-12 2001-05-17 Abbott Laboratories Solid dispersion pharmaceutical formulations
JP2004500358A (en) 1999-12-08 2004-01-08 ファルマシア　コーポレイション Celecoxib in the solid state with increased bioavailability
YU43702A (en) 1999-12-23 2004-11-25 Pfizer Products Inc. Pharmaceutical compositions providing enhanced drug concentrations
KR100806412B1 (en) 2000-01-28 2008-02-21 스미스클라인 비참 코포레이션 Electrospinning Pharmaceutical Compositions
AR028253A1 (en) * 2000-03-16 2003-04-30 Pfizer Prod Inc INHIBITORS OF THE GLUCOGENO FOSFORILASA
PE20011184A1 (en) * 2000-03-16 2001-11-15 Pfizer Prod Inc PHARMACEUTICAL COMPOSITIONS OF GLUCOGENO-PHOSPHORYLASE INHIBITORS
US20010036959A1 (en) 2000-04-03 2001-11-01 Gabel Rolf Dieter Carvedilol-hydrophilic solutions
AU2001257115B2 (en) 2000-04-20 2005-01-27 Rtp Pharma Inc. Improved water-insoluble drug particle process
US6316029B1 (en) 2000-05-18 2001-11-13 Flak Pharma International, Ltd. Rapidly disintegrating solid oral dosage form
GB0015239D0 (en) 2000-06-21 2000-08-16 Biochemie Gmbh Organic compounds
DE10038571A1 (en) 2000-08-03 2002-02-14 Knoll Ag Compositions and dosage forms for use in the oral cavity in the treatment of mycoses
KR20020014570A (en) 2000-08-18 2002-02-25 김충섭 Process for Preparing Amorphous-type Ipriflavone by Solid-Dispersion
PL372247A1 (en) * 2002-02-01 2005-07-11 Pfizer Products Inc. Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002089835A2 (en) * 2001-05-03 2002-11-14 F. Hoffmann-La Roche Ag Pharmaceutical dosage form of amorphous nelfinavir mesylate
US20030054042A1 (en) * 2001-09-14 2003-03-20 Elaine Liversidge Stabilization of chemical compounds using nanoparticulate formulations
WO2003074026A1 (en) * 2002-03-07 2003-09-12 Biocompatibles Uk Limited Drug carriers comprising amphiphilic block copolymers

Also Published As

Publication number Publication date
BRPI0418330A (en) 2007-05-02
CA2548376A1 (en) 2005-07-21
US20070141143A1 (en) 2007-06-21
JP2007517016A (en) 2007-06-28
US8974823B2 (en) 2015-03-10
WO2005065657A2 (en) 2005-07-21
EP1701704A2 (en) 2006-09-20

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