WO2005079314A3 - Compositions and methods used to treat acne and candida - Google Patents

Compositions and methods used to treat acne and candida Download PDF

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Publication number
WO2005079314A3
WO2005079314A3 PCT/US2005/004430 US2005004430W WO2005079314A3 WO 2005079314 A3 WO2005079314 A3 WO 2005079314A3 US 2005004430 W US2005004430 W US 2005004430W WO 2005079314 A3 WO2005079314 A3 WO 2005079314A3
Authority
WO
WIPO (PCT)
Prior art keywords
agp
long acting
candida
compositions
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/004430
Other languages
French (fr)
Other versions
WO2005079314A2 (en
Inventor
David Platt
Eliezer Zomer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pro Pharmaceuticals Inc
Original Assignee
Pro Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pro Pharmaceuticals Inc filed Critical Pro Pharmaceuticals Inc
Priority to EP05713396A priority Critical patent/EP1718146A2/en
Priority to US10/597,930 priority patent/US20070078109A1/en
Publication of WO2005079314A2 publication Critical patent/WO2005079314A2/en
Publication of WO2005079314A3 publication Critical patent/WO2005079314A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4933—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having sulfur as an exocyclic substituent, e.g. pyridinethione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/736—Chitin; Chitosan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed herein is a water-soluble chelated complex of a co-polymer of N-acetylglucosamine-glucosamine pyrithione sale (AGP). This composition is characterized by a highly viscose texture with excellent surface properties and extremely long acting antimicrobial activity. AGP's antimicrobial activity against acne bacteria has been found superior to the benzyl peroxide the leading acne medication. In addition, AGP has been proven to be effective against many pathogenic yeast. AGP has the potential to be useful as a long acting broad-spectrum antimicrobial composition in a variety of dermatological medicaments and cosmetics.
PCT/US2005/004430 2004-02-13 2005-02-14 Compositions and methods used to treat acne and candida Ceased WO2005079314A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP05713396A EP1718146A2 (en) 2004-02-13 2005-02-14 Compositions and methods used to treat acne and candida
US10/597,930 US20070078109A1 (en) 2004-02-13 2005-02-14 Compositions and methods used to treat acne and candida

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54440204P 2004-02-13 2004-02-13
US60/544,402 2004-02-13

Publications (2)

Publication Number Publication Date
WO2005079314A2 WO2005079314A2 (en) 2005-09-01
WO2005079314A3 true WO2005079314A3 (en) 2006-01-19

Family

ID=34886034

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/004430 Ceased WO2005079314A2 (en) 2004-02-13 2005-02-14 Compositions and methods used to treat acne and candida

Country Status (3)

Country Link
US (1) US20070078109A1 (en)
EP (1) EP1718146A2 (en)
WO (1) WO2005079314A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050053664A1 (en) * 2003-09-08 2005-03-10 Eliezer Zomer Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of cancer
GB0710899D0 (en) * 2007-06-07 2007-07-18 Syntopix Ltd Formulations

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0382210A1 (en) * 1989-02-08 1990-08-16 Unitika Ltd. The use of deacetylated chitin for preparing a medicament for the treatment of inflammatory skin diseases
JPH04288017A (en) * 1991-03-13 1992-10-13 Pias Arise Kk Treating agent for pimple
JPH05124956A (en) * 1991-10-31 1993-05-21 Snow Brand Milk Prod Co Ltd Sheet for skin sanitation and its usage
US5626856A (en) * 1995-06-30 1997-05-06 Safe & Dry Company, Inc. Cosmetic delivery vehicles and related compositions

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US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
DK149080C (en) * 1980-06-06 1986-07-28 Sankyo Co METHOD FOR PREPARING ML-236B CARBOXYLIC ACID DERIVATIVES
US4450171A (en) * 1980-08-05 1984-05-22 Merck & Co., Inc. Antihypercholesterolemic compounds
US5308838A (en) * 1982-05-07 1994-05-03 Carrington Laboratories, Inc. Uses of aloe products
US5118673A (en) * 1982-05-07 1992-06-02 Carrington Laboratories, Inc. Uses of aloe products
US4739073A (en) * 1983-11-04 1988-04-19 Sandoz Pharmaceuticals Corp. Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
ES2058070T3 (en) * 1986-05-09 1994-11-01 Pulverer Gerhard USE OF SPECIFIC MONOSACCHARIDES FOR THE PREPARATION OF A MEDICINAL PRODUCT TO PREVENT METASTASIS OF MALIGNANT TUMORS.
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
JP2569746B2 (en) * 1987-08-20 1997-01-08 日産化学工業株式会社 Quinoline mevalonolactones
US4804770A (en) * 1988-04-29 1989-02-14 E. R. Squibb & Sons, Inc. Process for preparing a keto-phosphonate intermediate useful in preparing HMG-CoA reductase inhibitors
JPH0220292A (en) * 1988-07-06 1990-01-23 Agency Of Ind Science & Technol Production of depolymerized chitosan
FR2642065B1 (en) * 1989-01-24 1991-05-24 Lipha DERIVATIVES OF ALCOHANIC BENZOCYCLOALCENYL DIHYDROXY ACIDS, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM
US5569483A (en) * 1989-02-10 1996-10-29 Alko Group Ltd. Degraded polysaccharide derivatives
FI94339C (en) * 1989-07-21 1995-08-25 Warner Lambert Co Process for the preparation of pharmaceutically acceptable [R- (R *, R *)] - 2- (4-fluorophenyl) -, - dihydroxy-5- (1-methylethyl) -3-phenyl-4 - [(phenylamino) carbonyl] -1H- for the preparation of pyrrole-1-heptanoic acid and its pharmaceutically acceptable salts
US5015632A (en) * 1990-01-08 1991-05-14 Olin Corporation Chitosan pyrithione as an antimicrobial agent useful in personal care products
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
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US20020107222A1 (en) * 1993-03-01 2002-08-08 David Platt Modified polysaccharides for treatment of cancer
DE4309553A1 (en) * 1993-03-24 1994-09-29 Bayer Ag Process for the preparation of 3R, 5S - (+) - sodium erythro- (E) -7- (4- (4-flurophenyl) -2,6-diisopropyl-5-methoxymethyl-pyrid-3-yl) -3, 5-dihydroxy-hept-6-enoate
US5620961A (en) * 1994-04-25 1997-04-15 Markovic; Nenad S. Fructose ester-β-cyclodextrin complexes and processes for making and using same
GB9412394D0 (en) * 1994-06-21 1994-08-10 Danbiosyst Uk Colonic drug delivery composition
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Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0382210A1 (en) * 1989-02-08 1990-08-16 Unitika Ltd. The use of deacetylated chitin for preparing a medicament for the treatment of inflammatory skin diseases
JPH04288017A (en) * 1991-03-13 1992-10-13 Pias Arise Kk Treating agent for pimple
JPH05124956A (en) * 1991-10-31 1993-05-21 Snow Brand Milk Prod Co Ltd Sheet for skin sanitation and its usage
US5626856A (en) * 1995-06-30 1997-05-06 Safe & Dry Company, Inc. Cosmetic delivery vehicles and related compositions

Also Published As

Publication number Publication date
WO2005079314A2 (en) 2005-09-01
EP1718146A2 (en) 2006-11-08
US20070078109A1 (en) 2007-04-05

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