WO2005108427A3 - Verfahren zur herstellung löslicher mhc-proteine - Google Patents

Verfahren zur herstellung löslicher mhc-proteine Download PDF

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Publication number
WO2005108427A3
WO2005108427A3 PCT/EP2005/004056 EP2005004056W WO2005108427A3 WO 2005108427 A3 WO2005108427 A3 WO 2005108427A3 EP 2005004056 W EP2005004056 W EP 2005004056W WO 2005108427 A3 WO2005108427 A3 WO 2005108427A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
mhc proteins
producing soluble
soluble mhc
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2005/004056
Other languages
English (en)
French (fr)
Other versions
WO2005108427A2 (de
Inventor
Rainer Blasczyk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imusyn & Co KG GmbH
Original Assignee
Imusyn & Co KG GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imusyn & Co KG GmbH filed Critical Imusyn & Co KG GmbH
Priority to AT05735130T priority Critical patent/ATE521637T1/de
Priority to EP05735130A priority patent/EP1745072B1/de
Priority to US11/579,705 priority patent/US20080064060A1/en
Publication of WO2005108427A2 publication Critical patent/WO2005108427A2/de
Publication of WO2005108427A3 publication Critical patent/WO2005108427A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Die Erfindung betrifft ein rekombinantes, aufgereinigtes MHC-Protein, welches im wesentlichen die gleiche Konformation, funktionelle Aktivität sowie die Bindungseigenschaften für spezifische Antikörper und Antigene wie das native MHC-Protein aufweist sowie ein Verfahren zur Herstellung des Proteins. Um ein Protein zu erhalten, was dem nativen Protein in der Gesamtheit dieser Eigenschaften möglichst nahe kommt, wird vorgeschlagen, dass es löslich und nicht trunkiert ist.
PCT/EP2005/004056 2004-05-06 2005-04-16 Verfahren zur herstellung löslicher mhc-proteine Ceased WO2005108427A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AT05735130T ATE521637T1 (de) 2004-05-06 2005-04-16 Verfahren zur herstellung loeslicher mhc-proteine
EP05735130A EP1745072B1 (de) 2004-05-06 2005-04-16 Verfahren zur herstellung loeslicher mhc-proteine
US11/579,705 US20080064060A1 (en) 2004-05-06 2005-04-16 Method For Productoin Of Soluble Mhc Proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004022435A DE102004022435A1 (de) 2004-05-06 2004-05-06 Verfahren zur Herstellung löslicher MHC-Proteine
DE102004022435.8 2004-05-06

Publications (2)

Publication Number Publication Date
WO2005108427A2 WO2005108427A2 (de) 2005-11-17
WO2005108427A3 true WO2005108427A3 (de) 2006-04-27

Family

ID=35276195

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/004056 Ceased WO2005108427A2 (de) 2004-05-06 2005-04-16 Verfahren zur herstellung löslicher mhc-proteine

Country Status (5)

Country Link
US (1) US20080064060A1 (de)
EP (1) EP1745072B1 (de)
AT (1) ATE521637T1 (de)
DE (1) DE102004022435A1 (de)
WO (1) WO2005108427A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8236771B2 (en) 2004-05-18 2012-08-07 National Institute Of Transplantation Foundation Vectors and methods for long-term immune evasion to prolong transplant viability
KR101703540B1 (ko) * 2012-06-04 2017-02-08 대한민국 3'' 영역의 염기 변이를 통한 전체 단백질의 발현 조절 방법

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010220A1 (en) * 1991-11-19 1993-05-27 Anergen, Inc. Soluble mhc molecules and their uses
US20020197672A1 (en) * 2000-10-10 2002-12-26 Hildebrand William H. Comparative ligand mapping from MHC positive cells

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090587A (en) * 1993-10-25 2000-07-18 Corixa Corporation Prokaryotic expression of MHC proteins
US20040072262A1 (en) * 2002-10-11 2004-04-15 Montero-Julian Felix A. Methods and systems for detecting MHC class I binding peptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010220A1 (en) * 1991-11-19 1993-05-27 Anergen, Inc. Soluble mhc molecules and their uses
US20020197672A1 (en) * 2000-10-10 2002-12-26 Hildebrand William H. Comparative ligand mapping from MHC positive cells

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FERNANDEZ-FRESNEDO GEMA ET AL: "Relationship of donor-specific class-I anti-HLA antibodies detected by ELISA after kidney transplantation on the development of acute rejection and graft survival.", NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 18, no. 5, May 2003 (2003-05-01), pages 990 - 995, XP002355242, ISSN: 0931-0509 *
KAWANA-TACHIKAWA AI ET AL: "An efficient and versatile mammalian viral vector system for major histocompatibility complex class I/peptide complexes.", JOURNAL OF VIROLOGY, vol. 76, no. 23, December 2002 (2002-12-01), pages 11982 - 11988, XP002355241, ISSN: 0022-538X *
SATO Y ET AL: "Improved generation of HLA class I/peptide tetramers", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER, AMSTERDAM, NL, vol. 271, no. 1-2, 20 December 2002 (2002-12-20), pages 177 - 184, XP004393936, ISSN: 0022-1759 *

Also Published As

Publication number Publication date
ATE521637T1 (de) 2011-09-15
EP1745072A2 (de) 2007-01-24
WO2005108427A2 (de) 2005-11-17
US20080064060A1 (en) 2008-03-13
EP1745072B1 (de) 2011-08-24
DE102004022435A1 (de) 2005-12-08

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