WO2005112640A3 - Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases - Google Patents

Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases Download PDF

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Publication number
WO2005112640A3
WO2005112640A3 PCT/US2005/016867 US2005016867W WO2005112640A3 WO 2005112640 A3 WO2005112640 A3 WO 2005112640A3 US 2005016867 W US2005016867 W US 2005016867W WO 2005112640 A3 WO2005112640 A3 WO 2005112640A3
Authority
WO
WIPO (PCT)
Prior art keywords
viral infections
prophylaxis
hepatitis
treatment
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/016867
Other languages
French (fr)
Other versions
WO2005112640A2 (en
Inventor
Thomas R Bailey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Viropharma Biologics LLC
Original Assignee
Wyeth LLC
Viropharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC, Viropharma Inc filed Critical Wyeth LLC
Priority to EP05748433A priority Critical patent/EP1746888A2/en
Publication of WO2005112640A2 publication Critical patent/WO2005112640A2/en
Anticipated expiration legal-status Critical
Publication of WO2005112640A3 publication Critical patent/WO2005112640A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed are novel benzofuran, naphthalene, benzimidazole, benzothiophene, isoindole, and indole derivatives and analogs thereof, as well as compositions containing the same and, the use thereof for the treatment of prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.
PCT/US2005/016867 2004-05-13 2005-05-13 Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases Ceased WO2005112640A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05748433A EP1746888A2 (en) 2004-05-13 2005-05-13 Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases

Applications Claiming Priority (28)

Application Number Priority Date Filing Date Title
US57145404P 2004-05-13 2004-05-13
US57144804P 2004-05-13 2004-05-13
US57118804P 2004-05-13 2004-05-13
US57101904P 2004-05-13 2004-05-13
US57145304P 2004-05-13 2004-05-13
US57113004P 2004-05-13 2004-05-13
US60/571,188 2004-05-13
US60/571,453 2004-05-13
US60/571,019 2004-05-13
US60/571,448 2004-05-13
US60/571,130 2004-05-13
US60/571,454 2004-05-13
US57281604P 2004-05-20 2004-05-20
US57279604P 2004-05-20 2004-05-20
US57281404P 2004-05-20 2004-05-20
US57298204P 2004-05-20 2004-05-20
US57280504P 2004-05-20 2004-05-20
US57284004P 2004-05-20 2004-05-20
US57281704P 2004-05-20 2004-05-20
US60/572,817 2004-05-20
US60/572,805 2004-05-20
US60/572,814 2004-05-20
US60/572,840 2004-05-20
US60/572,816 2004-05-20
US60/572,982 2004-05-20
US60/572,796 2004-05-20
US57354004P 2004-05-21 2004-05-21
US60/573,540 2004-05-21

Publications (2)

Publication Number Publication Date
WO2005112640A2 WO2005112640A2 (en) 2005-12-01
WO2005112640A3 true WO2005112640A3 (en) 2007-03-29

Family

ID=35428774

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/016867 Ceased WO2005112640A2 (en) 2004-05-13 2005-05-13 Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases

Country Status (2)

Country Link
EP (1) EP1746888A2 (en)
WO (1) WO2005112640A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9085587B2 (en) 2010-10-26 2015-07-21 Presidio Pharmaceuticals, Inc. Inhibitors of hepatitis C virus

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2134683A2 (en) * 2007-02-12 2009-12-23 Intermune, Inc. Novel inhibitors hepatitis c virus replication
GB0707000D0 (en) * 2007-04-12 2007-05-30 Istituto Di Ricerche D Biolog Antiviral agents
MX2009011930A (en) 2007-05-04 2009-11-18 Vertex Pharma Combination therapy for the treatment of hcv infection.
US8324212B2 (en) * 2010-02-25 2012-12-04 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
WO2012087833A1 (en) 2010-12-22 2012-06-28 Abbott Laboratories Hepatitis c inhibitors and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4636456A (en) * 1984-05-07 1987-01-13 Fuji Photo Film Co., Ltd. Process for forming a photographic image
WO1994026738A1 (en) * 1993-05-19 1994-11-24 Fujisawa Pharmaceutical Co., Ltd. N'-heterocyclyl-n-benzofuranyl urea derivatives and their analogs as acat inhibitors
WO2004106328A1 (en) * 2003-05-30 2004-12-09 Gemin X Biotechnologies Inc. Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4636456A (en) * 1984-05-07 1987-01-13 Fuji Photo Film Co., Ltd. Process for forming a photographic image
WO1994026738A1 (en) * 1993-05-19 1994-11-24 Fujisawa Pharmaceutical Co., Ltd. N'-heterocyclyl-n-benzofuranyl urea derivatives and their analogs as acat inhibitors
WO2004106328A1 (en) * 2003-05-30 2004-12-09 Gemin X Biotechnologies Inc. Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BERGMAN J. ET AL.: "The reaction of indole and the indole grignard reagent with phosgene. A facile synthese of indole-3-carboxylic acid derivatives", J. HET. CHEM., vol. 14, no. 7, November 1977 (1977-11-01), pages 1123 - 1134, XP003013586 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9085587B2 (en) 2010-10-26 2015-07-21 Presidio Pharmaceuticals, Inc. Inhibitors of hepatitis C virus
US9309260B2 (en) 2010-10-26 2016-04-12 Presidio Pharmaceuticals, Inc. Inhibitors of hepatitis C virus

Also Published As

Publication number Publication date
WO2005112640A2 (en) 2005-12-01
EP1746888A2 (en) 2007-01-31

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