WO2006022933A3 - System and method for drug delivery and microfluidic applications using microneedles - Google Patents

System and method for drug delivery and microfluidic applications using microneedles Download PDF

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Publication number
WO2006022933A3
WO2006022933A3 PCT/US2005/017627 US2005017627W WO2006022933A3 WO 2006022933 A3 WO2006022933 A3 WO 2006022933A3 US 2005017627 W US2005017627 W US 2005017627W WO 2006022933 A3 WO2006022933 A3 WO 2006022933A3
Authority
WO
WIPO (PCT)
Prior art keywords
microneedles
drug delivery
patient
substances
substrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/017627
Other languages
French (fr)
Other versions
WO2006022933A2 (en
Inventor
Nevenka Golubovic-Liakopoulos
Glenn Fricano
Michael Stephen Danielson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
APOGEE TECHNOLOGIES Inc
Original Assignee
APOGEE TECHNOLOGIES Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by APOGEE TECHNOLOGIES Inc filed Critical APOGEE TECHNOLOGIES Inc
Priority to EP05754822A priority Critical patent/EP1789127A2/en
Publication of WO2006022933A2 publication Critical patent/WO2006022933A2/en
Publication of WO2006022933A3 publication Critical patent/WO2006022933A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
    • B81C1/00111—Tips, pillars, i.e. raised structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00526—Methods of manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/055—Microneedles

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Manufacturing & Machinery (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Dermatology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to a method of fabricating a microneedle array in a substrate, a drug delivery device comprising one or more microneedles extending upwards from the front surface of the substrate, the microneedles having a generally conical-shaped body defined by a plurality of surfaces sloping upwards from a relatively broad base to a tip, and one or more substances coating the microneedles, the one or more substances being operable to be administered to a patient, wherein the tips of the one or more microneedles are sufficiently sharp to penetrate an outer layer of the skin of the patient, and a method of administering one or more substances to a patient using the device.
PCT/US2005/017627 2004-08-05 2005-05-20 System and method for drug delivery and microfluidic applications using microneedles Ceased WO2006022933A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05754822A EP1789127A2 (en) 2004-08-05 2005-05-20 System and method for drug delivery and microfluidic applications using microneedles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59883104P 2004-08-05 2004-08-05
US60/598,831 2004-08-05

Publications (2)

Publication Number Publication Date
WO2006022933A2 WO2006022933A2 (en) 2006-03-02
WO2006022933A3 true WO2006022933A3 (en) 2006-10-05

Family

ID=35967989

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/017627 Ceased WO2006022933A2 (en) 2004-08-05 2005-05-20 System and method for drug delivery and microfluidic applications using microneedles

Country Status (4)

Country Link
US (1) US7560036B2 (en)
EP (1) EP1789127A2 (en)
TW (1) TW200613029A (en)
WO (1) WO2006022933A2 (en)

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IL134997A0 (en) * 2000-03-09 2001-05-20 Yehoshua Yeshurun Health care system based on micro device
US7785459B2 (en) 2004-10-22 2010-08-31 Hewlett-Packard Development Company, L.P. Microneedles and methods of fabricating
JP5026980B2 (en) * 2004-11-18 2012-09-19 ナノ パス テクノロジーズ リミテッド Device for supplying fluid into a flexible biological barrier
US7279110B2 (en) * 2004-12-27 2007-10-09 Asml Holding N.V. Method and apparatus for creating a phase step in mirrors used in spatial light modulator arrays
CA2612005C (en) 2005-06-17 2013-10-29 Georgia Tech Research Corporation Coated microstructures and method of manufacture thereof
US20080214952A1 (en) * 2005-07-11 2008-09-04 Jose Mir Replaceable Cartridge for Allergy Testing System
US20080319404A1 (en) * 2005-12-21 2008-12-25 Pekurovsky Mikhail L Microneedle Devices
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9610459B2 (en) 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
US7699819B2 (en) * 2006-02-21 2010-04-20 The Hong Kong University Of Science And Technology Molecular sieve and zeolite microneedles and preparation thereof
US20070276330A1 (en) * 2006-05-28 2007-11-29 Beck Patricia A Microneedles and methods of fabricating thereof
JP4265696B2 (en) * 2006-07-04 2009-05-20 凸版印刷株式会社 Manufacturing method of microneedle
US20100100005A1 (en) * 2006-07-11 2010-04-22 Infotonics Technology Center, Inc. Minimally invasive allergy testing system with coated allergens
WO2008020632A1 (en) * 2006-08-18 2008-02-21 Toppan Printing Co., Ltd. Microneedle and microneedle patch
DE102006040642A1 (en) * 2006-08-30 2008-03-13 Robert Bosch Gmbh Microneedles for placement in the skin for transdermal application of pharmaceuticals
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
JP2010505471A (en) 2006-10-02 2010-02-25 エムキネティクス， インコーポレイテッド Method and apparatus for magnetic induction therapy
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US8778012B2 (en) * 2012-11-27 2014-07-15 Cormatrix Cardiovascular, Inc. ECM constructs for tissue regeneration
US7959969B2 (en) 2007-07-10 2011-06-14 California Institute Of Technology Fabrication of anchored carbon nanotube array devices for integrated light collection and energy conversion
US20100196446A1 (en) 2007-07-10 2010-08-05 Morteza Gharib Drug delivery and substance transfer facilitated by nano-enhanced device having aligned carbon nanotubes protruding from device surface
MY157968A (en) * 2007-11-14 2016-08-30 Mimos Berhad Method for fabricating microneedled and microneedle fabricated from the same
JP2012523270A (en) 2009-04-10 2012-10-04 スリーエム イノベイティブ プロパティズ カンパニー Method for producing hollow microneedle array, product derived therefrom and use thereof
FI20095433A0 (en) 2009-04-20 2009-04-20 Valtion Teknillinen micro-needle
WO2011015650A2 (en) * 2009-08-06 2011-02-10 University College Cork, National University Of Ireland, Cork Method of producing microneedles
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
AU2010313487A1 (en) 2009-10-26 2012-05-24 Emkinetics, Inc. Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues
US9115424B2 (en) 2010-04-07 2015-08-25 California Institute Of Technology Simple method for producing superhydrophobic carbon nanotube array
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
WO2012079066A2 (en) 2010-12-10 2012-06-14 California Institute Of Technology Method for producing graphene oxide with tunable gap
JP2014519344A (en) * 2011-03-18 2014-08-14 ユニヴェルシテ リブル ドゥ ブリュッセル Device for drilling holes in the membrane of the human or animal body
US8976507B2 (en) 2011-03-29 2015-03-10 California Institute Of Technology Method to increase the capacitance of electrochemical carbon nanotube capacitors by conformal deposition of nanoparticles
GB201116143D0 (en) 2011-09-16 2011-11-02 Univ Greenwich Method of coating microneedle devices
WO2013090844A1 (en) 2011-12-14 2013-06-20 California Institute Of Technology Sharp tip carbon nanotube microneedle devices and their fabrication
CN102530848A (en) * 2012-03-06 2012-07-04 大连理工大学 Method for manufacturing mosquito-mouth-imitated hollow microneedle array
EP4112112A1 (en) 2012-05-01 2023-01-04 University of Pittsburgh - Of the Commonwealth System of Higher Education Tip-loaded microneedle arrays for transdermal insertion
US9349543B2 (en) 2012-07-30 2016-05-24 California Institute Of Technology Nano tri-carbon composite systems and manufacture
JP6236905B2 (en) * 2013-06-20 2017-11-29 凸版印刷株式会社 Method for manufacturing hollow needle body device
JP6317690B2 (en) * 2015-03-03 2018-04-25 富士フイルム株式会社 Transdermal absorption sheet and method for producing the same
JP6482323B2 (en) * 2015-03-03 2019-03-13 富士フイルム株式会社 Transdermal absorption sheet
WO2016149673A1 (en) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bioactive components conjugated to substrates of microneedle arrays
US11684763B2 (en) 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
US11744889B2 (en) 2016-01-05 2023-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
SG11201805837SA (en) * 2016-01-28 2018-08-30 Ricoh Co Ltd Microneedle array, microneedle sheet
US10406336B2 (en) 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device
WO2019058328A1 (en) * 2017-09-22 2019-03-28 Sabic Global Technologies B.V. Microneedle arrays
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US10525244B2 (en) * 2017-09-28 2020-01-07 Medtronic Minimed, Inc. Microneedle arrays and methods for fabricating microneedle arrays
CN108751120B (en) * 2018-04-13 2021-03-05 杭州电子科技大学 Preparation method of silicon-based microneedle array patch
JP2022532215A (en) 2019-05-16 2022-07-13 ユニバーシティ オブ ピッツバーグ － オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション Microneedle array with undercut features for skin and non-skin drug delivery
EP3772331A1 (en) * 2019-08-08 2021-02-10 PKvitality Body monitoring system comprising a microneedle
CN110711312B (en) * 2019-11-07 2021-07-30 河南大学 Microelectromechanical system-based strong permeation skin drug release microsystem and its manufacturing method
CN112807561A (en) * 2021-01-26 2021-05-18 上海烨映微电子科技股份有限公司 Microneedle structure and method for producing same
CN114849051B (en) * 2022-04-02 2024-05-28 相邦(苏州)生物材料科技有限公司 Preparation method of silicon-based microneedle
CN114588527A (en) * 2022-04-06 2022-06-07 苏州大学 Silicon-based ice microneedle and preparation method thereof
TW202408430A (en) * 2022-05-18 2024-03-01 美商梅柯諾斯公司 Fabrication methods for high aspect ratio microneedles and tools
TR2022013871A2 (en) * 2022-09-06 2023-03-21 Bilkent Ueniversitesi Ulusal Nanoteknoloji Arastirma Merkezi A MICRONEEDLE PRODUCTION METHOD

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Also Published As

Publication number Publication date
US20060030812A1 (en) 2006-02-09
TW200613029A (en) 2006-05-01
EP1789127A2 (en) 2007-05-30
WO2006022933A2 (en) 2006-03-02
US7560036B2 (en) 2009-07-14

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