WO2006032441A3 - Stöchiometrisch definierte farbstoffmarkierte substanzen zur messung der glomerulären filtrationsrate - Google Patents

Stöchiometrisch definierte farbstoffmarkierte substanzen zur messung der glomerulären filtrationsrate Download PDF

Info

Publication number
WO2006032441A3
WO2006032441A3 PCT/EP2005/010093 EP2005010093W WO2006032441A3 WO 2006032441 A3 WO2006032441 A3 WO 2006032441A3 EP 2005010093 W EP2005010093 W EP 2005010093W WO 2006032441 A3 WO2006032441 A3 WO 2006032441A3
Authority
WO
WIPO (PCT)
Prior art keywords
filtration rate
glomerular filtration
labeled substances
stoichiometrically defined
measuring glomerular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2005/010093
Other languages
English (en)
French (fr)
Other versions
WO2006032441A2 (de
Inventor
Johannes Pill
Uwe Kraemer
Norbert Gretz
Carsten Deus
Bernd Hagenbruch
Hans-Martin Kloetzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Original Assignee
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Roche Diagnostics GmbH filed Critical F Hoffmann La Roche AG
Priority to EP05791107A priority Critical patent/EP1809340B1/de
Priority to DE502005009878T priority patent/DE502005009878D1/de
Priority to AT05791107T priority patent/ATE473018T1/de
Publication of WO2006032441A2 publication Critical patent/WO2006032441A2/de
Publication of WO2006032441A3 publication Critical patent/WO2006032441A3/de
Priority to US11/725,951 priority patent/US20070218563A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Spectrometry And Color Measurement (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Die Erfindung betrifft neue chemische Verbindungen, die als Markersubstanzen in der Nierendiagnostik eingesetzt werden können, ihre Herstellung und Verwendung sowie sie enthaltende Nierendiagnostika.
PCT/EP2005/010093 2004-09-21 2005-09-20 Stöchiometrisch definierte farbstoffmarkierte substanzen zur messung der glomerulären filtrationsrate Ceased WO2006032441A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP05791107A EP1809340B1 (de) 2004-09-21 2005-09-20 Stöchiometrisch definierte farbstoffmarkierte substanzen zur messung der glomerulären filtrationsrate
DE502005009878T DE502005009878D1 (de) 2004-09-21 2005-09-20 Stöchiometrisch definierte farbstoffmarkierte substanzen zur messung der glomerulären filtrationsrate
AT05791107T ATE473018T1 (de) 2004-09-21 2005-09-20 Stöchiometrisch definierte farbstoffmarkierte substanzen zur messung der glomerulären filtrationsrate
US11/725,951 US20070218563A1 (en) 2004-09-21 2007-03-20 Stiochiometrically defined dye-labelled substances for measuring glomerular filtration rate, the production thereof and their use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004045748.4 2004-09-21
DE102004045748A DE102004045748A1 (de) 2004-09-21 2004-09-21 Stöchiometrisch definierte farbstoffmarkierte Substanzen zur Messung der glomerulären Filtrationsrate, ihre Herstellung und Verwendung

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/725,951 Continuation US20070218563A1 (en) 2004-09-21 2007-03-20 Stiochiometrically defined dye-labelled substances for measuring glomerular filtration rate, the production thereof and their use

Publications (2)

Publication Number Publication Date
WO2006032441A2 WO2006032441A2 (de) 2006-03-30
WO2006032441A3 true WO2006032441A3 (de) 2007-02-01

Family

ID=35811774

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/010093 Ceased WO2006032441A2 (de) 2004-09-21 2005-09-20 Stöchiometrisch definierte farbstoffmarkierte substanzen zur messung der glomerulären filtrationsrate

Country Status (5)

Country Link
US (1) US20070218563A1 (de)
EP (1) EP1809340B1 (de)
AT (1) ATE473018T1 (de)
DE (2) DE102004045748A1 (de)
WO (1) WO2006032441A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1986701B1 (de) * 2006-02-24 2012-06-13 Mallinckrodt LLC Optische mittel zur chirurgisher anwendung
DE102007007738A1 (de) * 2007-02-09 2008-08-14 Südzucker AG Mannheim/Ochsenfurt Farbmarkierte Oligo- oder Polysaccharide
EP1964846A1 (de) * 2007-02-27 2008-09-03 Bracco Imaging, S.P.A. Herstellungsverfahren für Kontrastmittel
US20110112291A1 (en) * 2007-11-30 2011-05-12 Eva Hoess Stabilization of conjugates comprising a thiourea linker
KR100919766B1 (ko) 2008-01-25 2009-10-07 웅진코웨이주식회사 형광 발색 기능을 갖는 생분해성 트리블록 공중합체 및그의 제조 방법
DK2317911T3 (en) 2008-08-22 2019-01-28 Medibeacon Inc TRANSCUTAN ORGAN FUNCTION MEASUREMENT
US20120276014A1 (en) * 2009-04-30 2012-11-01 Pharmacophotonics, Inc. Measurement of body fluid volumes
US10264977B2 (en) 2013-10-22 2019-04-23 Medibeacon Inc. Transcutaneous organ function measurement
SG11201906938WA (en) 2017-01-30 2019-08-27 Medibeacon Inc Method for non-invasive monitoring of fluorescent tracer agent with diffuse reflection corrections
JP7706329B2 (ja) * 2021-10-15 2025-07-11 富士フイルム株式会社 蛍光性化合物及びこれを用いた蛍光標識生体物質
USD1052412S1 (en) 2023-01-06 2024-11-26 Medibeacon Inc. Sensor
USD1051738S1 (en) 2023-01-06 2024-11-19 Medibeacon Inc. Sensor ring

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0538230A1 (de) * 1991-10-15 1993-04-21 Oxford Glycosystems Ltd. Verfahren zur Herstellung von synthetischen N-verbundener Glykokonjugaten
EP0543333A1 (de) * 1991-11-18 1993-05-26 Roche Diagnostics GmbH Neue pentacyclische Verbindungen und ihre Verwendung als Absorptions- oder Fluoreszenzfarbstoffe
WO1997010847A1 (en) * 1995-09-21 1997-03-27 University Of Utah Research Foundation Targeting of conjugates of poly(ethylene glycol) and antibodies against glutamic acid decarboxylase to islet cells
WO1999031183A1 (de) * 1997-12-17 1999-06-24 Roche Diagnostics Gmbh Neue farbstoff-polysaccharid-konjugate und deren verwendung als diagnostikum
WO2001085799A1 (de) * 2000-05-11 2001-11-15 Roche Diagnostics Gmbh Fluoresceinisothiocyanat-(fitc)-sinistrin, seine herstellung und verwendung

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4101910A1 (de) * 1991-01-23 1992-07-30 Laevosan Gmbh & Co Kg Verfahren zur herstellung eines pyrogenfreien gut wasserloeslichen fructans sowie ein nierendiagnostikum, das ein solches fructan enthaelt

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0538230A1 (de) * 1991-10-15 1993-04-21 Oxford Glycosystems Ltd. Verfahren zur Herstellung von synthetischen N-verbundener Glykokonjugaten
EP0543333A1 (de) * 1991-11-18 1993-05-26 Roche Diagnostics GmbH Neue pentacyclische Verbindungen und ihre Verwendung als Absorptions- oder Fluoreszenzfarbstoffe
WO1997010847A1 (en) * 1995-09-21 1997-03-27 University Of Utah Research Foundation Targeting of conjugates of poly(ethylene glycol) and antibodies against glutamic acid decarboxylase to islet cells
WO1999031183A1 (de) * 1997-12-17 1999-06-24 Roche Diagnostics Gmbh Neue farbstoff-polysaccharid-konjugate und deren verwendung als diagnostikum
WO2001085799A1 (de) * 2000-05-11 2001-11-15 Roche Diagnostics Gmbh Fluoresceinisothiocyanat-(fitc)-sinistrin, seine herstellung und verwendung

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LINDSTROEM K. E. ET AL.: "Physiological and Morphological effects of perfusing isolated rat kidneys with hyperosmolal mannitol solutions", ACTA PHYSIOL SCAND, vol. 166, 1999, pages 231 - 238, XP002395607 *
OHLSON M. ET AL.: "Glomerular size and charge selectivity in the rat as revealed by FITC-FIcoll and albumin", AM J PHYSIOL RENAL PHYSIOL, vol. 279, 2000, pages F84 - F91, XP002395608 *
SOHTELL M ET AL.: "FITC-INULIN as a kidney tubule marker in the rat", ACTA PHYSIOL SCAND, vol. 119, 1983, pages 313 - 316, XP008067913 *

Also Published As

Publication number Publication date
DE102004045748A1 (de) 2006-04-06
US20070218563A1 (en) 2007-09-20
DE502005009878D1 (de) 2010-08-19
WO2006032441A2 (de) 2006-03-30
EP1809340B1 (de) 2010-07-07
ATE473018T1 (de) 2010-07-15
EP1809340A2 (de) 2007-07-25

Similar Documents

Publication Publication Date Title
WO2007136980A3 (en) Diagnostic test media and methods for the manufacture thereof
EP1996309A4 (de) Filter mit abflussummantelung, versiegelungsanzeige/sperrmittel und dichtungssperre
DE502005009723D1 (de) Arylsubstituierte heterozyklen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP1733206A4 (de) Körperflüssigkeitsanalyt-messgerät, kassettensystem zur durchführung kombinierter allgemeiner chemischer und spezifischer bindungstests
WO2014153099A3 (en) Method for using exhaled breath to determine the presence of drug
WO2005064349A3 (en) Detection cartridges, modules, systems and methods
WO2013059293A9 (en) Single, direct detection of hemoglobin a1c percentage using enzyme triggered redox altering chemical elimination (e-trace) immunoassay
SG118408A1 (en) Methods of monitoring the concentration of an analyte
EP2047268A4 (de) Indikatorsystem zur bestimmung einer analytenkonzentration
GB2404743B (en) Measurement system for the determination of the concentration of propofol (2,6 diisopropylphenol) in the respiratory flow
WO2008131361A3 (en) Biosensors for measuring analytes in the interstitial fluid
IL191142A0 (en) An isolated nucleic acid which encodes a ligand binding fluorescent indicator, multimeric biosensors and methods of using the same
WO2005003086A3 (de) Sulfonsäurederivate polycyclischer farbstoffe für analytische anwendungen
PL2005164T3 (pl) Test fluorescencyjny
WO2009013884A1 (ja) 鉛濃度測定用試薬及び鉛濃度測定方法
HK1206423A1 (en) Oligomeric a in the diagnosis, prognosis, and monitoring of alzheimer's disease
PL2040072T3 (pl) System analityczny do określania koncentracji analitu w płynie ustrojowym
WO2009021908A3 (en) Disposable enzymatic sensor for liquid samples
ATE473018T1 (de) Stöchiometrisch definierte farbstoffmarkierte substanzen zur messung der glomerulären filtrationsrate
WO2005124356A3 (en) Use of protein cbp2 as a marker for colorectal cancer
WO2009047462A9 (fr) Feuille de verre silico-sodo-calcique
Midorikawa et al. Extraction and characterization of organic ligands from oceanic water columns by immobilized metal ion affinity chromatography
WO2011123677A3 (en) Signal locking label free biosensing
ATE551603T1 (de) Kontinuierliche gegenstrom chromatographie anlage
WO2006113477A3 (en) Use of phosphonazo iii for the measurement of calcium, magnesium and sodium in analytical samples

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2005791107

Country of ref document: EP

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 11725951

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

WWP Wipo information: published in national office

Ref document number: 2005791107

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 11725951

Country of ref document: US