WO2006032441A3 - Stöchiometrisch definierte farbstoffmarkierte substanzen zur messung der glomerulären filtrationsrate - Google Patents

Stöchiometrisch definierte farbstoffmarkierte substanzen zur messung der glomerulären filtrationsrate Download PDF

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Publication number
WO2006032441A3
WO2006032441A3 PCT/EP2005/010093 EP2005010093W WO2006032441A3 WO 2006032441 A3 WO2006032441 A3 WO 2006032441A3 EP 2005010093 W EP2005010093 W EP 2005010093W WO 2006032441 A3 WO2006032441 A3 WO 2006032441A3
Authority
WO
WIPO (PCT)
Prior art keywords
filtration rate
glomerular filtration
labeled substances
stoichiometrically defined
measuring glomerular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2005/010093
Other languages
English (en)
French (fr)
Other versions
WO2006032441A2 (de
Inventor
Johannes Pill
Uwe Kraemer
Norbert Gretz
Carsten Deus
Bernd Hagenbruch
Hans-Martin Kloetzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Original Assignee
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Roche Diagnostics GmbH filed Critical F Hoffmann La Roche AG
Priority to DE502005009878T priority Critical patent/DE502005009878D1/de
Priority to AT05791107T priority patent/ATE473018T1/de
Priority to EP05791107A priority patent/EP1809340B1/de
Publication of WO2006032441A2 publication Critical patent/WO2006032441A2/de
Publication of WO2006032441A3 publication Critical patent/WO2006032441A3/de
Priority to US11/725,951 priority patent/US20070218563A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Spectrometry And Color Measurement (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Die Erfindung betrifft neue chemische Verbindungen, die als Markersubstanzen in der Nierendiagnostik eingesetzt werden können, ihre Herstellung und Verwendung sowie sie enthaltende Nierendiagnostika.
PCT/EP2005/010093 2004-09-21 2005-09-20 Stöchiometrisch definierte farbstoffmarkierte substanzen zur messung der glomerulären filtrationsrate Ceased WO2006032441A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE502005009878T DE502005009878D1 (de) 2004-09-21 2005-09-20 Stöchiometrisch definierte farbstoffmarkierte substanzen zur messung der glomerulären filtrationsrate
AT05791107T ATE473018T1 (de) 2004-09-21 2005-09-20 Stöchiometrisch definierte farbstoffmarkierte substanzen zur messung der glomerulären filtrationsrate
EP05791107A EP1809340B1 (de) 2004-09-21 2005-09-20 Stöchiometrisch definierte farbstoffmarkierte substanzen zur messung der glomerulären filtrationsrate
US11/725,951 US20070218563A1 (en) 2004-09-21 2007-03-20 Stiochiometrically defined dye-labelled substances for measuring glomerular filtration rate, the production thereof and their use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004045748A DE102004045748A1 (de) 2004-09-21 2004-09-21 Stöchiometrisch definierte farbstoffmarkierte Substanzen zur Messung der glomerulären Filtrationsrate, ihre Herstellung und Verwendung
DE102004045748.4 2004-09-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/725,951 Continuation US20070218563A1 (en) 2004-09-21 2007-03-20 Stiochiometrically defined dye-labelled substances for measuring glomerular filtration rate, the production thereof and their use

Publications (2)

Publication Number Publication Date
WO2006032441A2 WO2006032441A2 (de) 2006-03-30
WO2006032441A3 true WO2006032441A3 (de) 2007-02-01

Family

ID=35811774

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/010093 Ceased WO2006032441A2 (de) 2004-09-21 2005-09-20 Stöchiometrisch definierte farbstoffmarkierte substanzen zur messung der glomerulären filtrationsrate

Country Status (5)

Country Link
US (1) US20070218563A1 (de)
EP (1) EP1809340B1 (de)
AT (1) ATE473018T1 (de)
DE (2) DE102004045748A1 (de)
WO (1) WO2006032441A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2390314T3 (es) * 2006-02-24 2012-11-08 Medibeacon Development, Llc Agentes ópticos para uso en cirugía
DE102007007738A1 (de) * 2007-02-09 2008-08-14 Südzucker AG Mannheim/Ochsenfurt Farbmarkierte Oligo- oder Polysaccharide
EP1964846A1 (de) * 2007-02-27 2008-09-03 Bracco Imaging, S.P.A. Herstellungsverfahren für Kontrastmittel
ES2369717T3 (es) * 2007-11-30 2011-12-05 F. Hoffmann-La Roche Ag Estabilización de conjugados que comprenden una molécula conectora de tiourea.
KR100919766B1 (ko) 2008-01-25 2009-10-07 웅진코웨이주식회사 형광 발색 기능을 갖는 생분해성 트리블록 공중합체 및그의 제조 방법
WO2010020673A2 (de) * 2008-08-22 2010-02-25 Basf Se Transkutane organfunktionsmessung
WO2010127136A2 (en) * 2009-04-30 2010-11-04 Pharmacophotonics, Inc. Measurement of body fluid volumes
EP3060098B1 (de) 2013-10-22 2019-02-27 MediBeacon Inc. Verbesserte transkutane organfunktionsmessung
CN115120241B (zh) 2017-01-30 2025-10-14 麦迪贝肯有限公司 利用漫反射校正的荧光示踪剂的非入侵监测方法
JP7706329B2 (ja) * 2021-10-15 2025-07-11 富士フイルム株式会社 蛍光性化合物及びこれを用いた蛍光標識生体物質
USD1051738S1 (en) 2023-01-06 2024-11-19 Medibeacon Inc. Sensor ring
USD1052412S1 (en) 2023-01-06 2024-11-26 Medibeacon Inc. Sensor

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0538230A1 (de) * 1991-10-15 1993-04-21 Oxford Glycosystems Ltd. Verfahren zur Herstellung von synthetischen N-verbundener Glykokonjugaten
EP0543333A1 (de) * 1991-11-18 1993-05-26 Roche Diagnostics GmbH Neue pentacyclische Verbindungen und ihre Verwendung als Absorptions- oder Fluoreszenzfarbstoffe
WO1997010847A1 (en) * 1995-09-21 1997-03-27 University Of Utah Research Foundation Targeting of conjugates of poly(ethylene glycol) and antibodies against glutamic acid decarboxylase to islet cells
WO1999031183A1 (de) * 1997-12-17 1999-06-24 Roche Diagnostics Gmbh Neue farbstoff-polysaccharid-konjugate und deren verwendung als diagnostikum
WO2001085799A1 (de) * 2000-05-11 2001-11-15 Roche Diagnostics Gmbh Fluoresceinisothiocyanat-(fitc)-sinistrin, seine herstellung und verwendung

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4101910A1 (de) * 1991-01-23 1992-07-30 Laevosan Gmbh & Co Kg Verfahren zur herstellung eines pyrogenfreien gut wasserloeslichen fructans sowie ein nierendiagnostikum, das ein solches fructan enthaelt

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0538230A1 (de) * 1991-10-15 1993-04-21 Oxford Glycosystems Ltd. Verfahren zur Herstellung von synthetischen N-verbundener Glykokonjugaten
EP0543333A1 (de) * 1991-11-18 1993-05-26 Roche Diagnostics GmbH Neue pentacyclische Verbindungen und ihre Verwendung als Absorptions- oder Fluoreszenzfarbstoffe
WO1997010847A1 (en) * 1995-09-21 1997-03-27 University Of Utah Research Foundation Targeting of conjugates of poly(ethylene glycol) and antibodies against glutamic acid decarboxylase to islet cells
WO1999031183A1 (de) * 1997-12-17 1999-06-24 Roche Diagnostics Gmbh Neue farbstoff-polysaccharid-konjugate und deren verwendung als diagnostikum
WO2001085799A1 (de) * 2000-05-11 2001-11-15 Roche Diagnostics Gmbh Fluoresceinisothiocyanat-(fitc)-sinistrin, seine herstellung und verwendung

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LINDSTROEM K. E. ET AL.: "Physiological and Morphological effects of perfusing isolated rat kidneys with hyperosmolal mannitol solutions", ACTA PHYSIOL SCAND, vol. 166, 1999, pages 231 - 238, XP002395607 *
OHLSON M. ET AL.: "Glomerular size and charge selectivity in the rat as revealed by FITC-FIcoll and albumin", AM J PHYSIOL RENAL PHYSIOL, vol. 279, 2000, pages F84 - F91, XP002395608 *
SOHTELL M ET AL.: "FITC-INULIN as a kidney tubule marker in the rat", ACTA PHYSIOL SCAND, vol. 119, 1983, pages 313 - 316, XP008067913 *

Also Published As

Publication number Publication date
EP1809340B1 (de) 2010-07-07
EP1809340A2 (de) 2007-07-25
US20070218563A1 (en) 2007-09-20
DE502005009878D1 (de) 2010-08-19
WO2006032441A2 (de) 2006-03-30
DE102004045748A1 (de) 2006-04-06
ATE473018T1 (de) 2010-07-15

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