WO2006041945A3 - A counterion exchange process for peptides - Google Patents

A counterion exchange process for peptides Download PDF

Info

Publication number
WO2006041945A3
WO2006041945A3 PCT/US2005/035868 US2005035868W WO2006041945A3 WO 2006041945 A3 WO2006041945 A3 WO 2006041945A3 US 2005035868 W US2005035868 W US 2005035868W WO 2006041945 A3 WO2006041945 A3 WO 2006041945A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
exchange process
peptide
column
counterion exchange
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/035868
Other languages
French (fr)
Other versions
WO2006041945A2 (en
Inventor
Avi Tovi
Chaim Eidelman
Shimon Shushan
Shai Elster
Hagi Alon
Alexander Ivchenko
Gabriel-Marcus Butilca
Gil Zaovi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Novetide Ltd
Teva Pharmaceuticals USA Inc
Original Assignee
Teva Pharmaceutical Industries Ltd
Novetide Ltd
Teva Pharmaceuticals USA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd, Novetide Ltd, Teva Pharmaceuticals USA Inc filed Critical Teva Pharmaceutical Industries Ltd
Priority to JP2006542906A priority Critical patent/JP2007513192A/en
Priority to DK05811089.1T priority patent/DK1709065T3/en
Priority to DE602005021614T priority patent/DE602005021614D1/en
Priority to CA002582083A priority patent/CA2582083A1/en
Priority to AT05811089T priority patent/ATE469912T1/en
Priority to EP05811089A priority patent/EP1709065B1/en
Publication of WO2006041945A2 publication Critical patent/WO2006041945A2/en
Publication of WO2006041945A3 publication Critical patent/WO2006041945A3/en
Priority to IL182157A priority patent/IL182157A0/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention encompasses a process for purifying a peptide comprising loading a peptide onto a RP-HPLC column; washing the column with an aqueous solution of a pharmaceutically acceptable counterion salt; and eluting the peptide from the column with a solvent mixture of a organic solvent and an acid of the pharmaceutically acceptable counterion, wherein the aqueous solution has a pH of at least about 6.
PCT/US2005/035868 2004-10-04 2005-10-04 A counterion exchange process for peptides Ceased WO2006041945A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2006542906A JP2007513192A (en) 2004-10-04 2005-10-04 Counterion exchange method for peptides
DK05811089.1T DK1709065T3 (en) 2004-10-04 2005-10-04 Modion exchange method for peptides
DE602005021614T DE602005021614D1 (en) 2004-10-04 2005-10-04 Replacement Methods for PEPTIDES
CA002582083A CA2582083A1 (en) 2004-10-04 2005-10-04 A counterion exchange process for peptides
AT05811089T ATE469912T1 (en) 2004-10-04 2005-10-04 COUNTERION EXCHANGE PROCESS FOR PEPTIDES
EP05811089A EP1709065B1 (en) 2004-10-04 2005-10-04 A counterion exchange process for peptides
IL182157A IL182157A0 (en) 2004-10-04 2007-03-25 A counterion exchange process for peptides

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US61601004P 2004-10-04 2004-10-04
US60/616,010 2004-10-04
US63052804P 2004-11-22 2004-11-22
US60/630,528 2004-11-22

Publications (2)

Publication Number Publication Date
WO2006041945A2 WO2006041945A2 (en) 2006-04-20
WO2006041945A3 true WO2006041945A3 (en) 2006-08-24

Family

ID=36096369

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/035868 Ceased WO2006041945A2 (en) 2004-10-04 2005-10-04 A counterion exchange process for peptides

Country Status (10)

Country Link
US (1) US20060148699A1 (en)
EP (2) EP2163558A3 (en)
JP (1) JP2007513192A (en)
AT (1) ATE469912T1 (en)
CA (1) CA2582083A1 (en)
DE (1) DE602005021614D1 (en)
DK (1) DK1709065T3 (en)
ES (1) ES2344657T3 (en)
IL (1) IL182157A0 (en)
WO (1) WO2006041945A2 (en)

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NL2000126C2 (en) * 2005-07-15 2008-01-29 Solvay Process for the manufacture of eptifibatide.
WO2008109079A2 (en) * 2007-03-01 2008-09-12 Novetide, Ltd. High purity peptides
AU2008271608A1 (en) * 2007-06-29 2009-01-08 Lonza Ag Process for the production of pramlintide
US9051349B2 (en) 2007-11-21 2015-06-09 Alba Therapeutics Corporation Larazotide acetate compositions
EP2062909A1 (en) * 2007-11-21 2009-05-27 SOLVAY (Société Anonyme) Peptide production and purification process
CN101981048A (en) * 2008-02-06 2011-02-23 拜康有限公司 A method of purifying a peptide
CN101314613B (en) * 2008-05-08 2012-04-25 吉尔生化（上海）有限公司 Solid-phase synthesis method of atosiban
WO2009150657A1 (en) * 2008-06-09 2009-12-17 Natco Pharma Limited Improved process for preparation of eptifibatide by fmoc solid phase synthesis
CN101463080B (en) * 2009-01-09 2011-09-14 深圳翰宇药业股份有限公司 Method for purifying nesiritide
CN101696236B (en) * 2009-02-11 2012-02-15 海南中和药业有限公司 Method for synthesizing atosiban by solid phase
EP2417150A2 (en) 2009-04-06 2012-02-15 Matrix Laboratories Ltd An improved process for the preparation of desmopressin or its pharmaceutically acceptable salts
WO2011011342A1 (en) * 2009-07-20 2011-01-27 Mallinckrodt Inc. Synthesis of desmopressin
EP2464655B1 (en) * 2009-08-11 2017-02-15 Biocon Limited Chromatographic processes
CN101787071B (en) * 2010-02-26 2012-11-07 深圳翰宇药业股份有限公司 Purification method of vapreotide
CN101780267A (en) * 2010-03-12 2010-07-21 深圳翰宇药业股份有限公司 Platelet aggregation inhibition preparation and preparation method thereof
RU2441018C1 (en) * 2010-09-28 2012-01-27 Закрытое Акционерное Общество "Фарм-Синтез" Method of chromatographic purification of octreotide
CN102146121A (en) * 2010-11-19 2011-08-10 深圳市健元医药科技有限公司 Process for producing antagonist medicament containing OXT (oxytocin)
RU2494105C2 (en) * 2010-12-29 2013-09-27 Общество с ограниченной ответственностью "Химфармресурс" Method of producing cyclic peptide
US9388212B2 (en) 2013-02-21 2016-07-12 Chemical & Biopharmaceutical Laboratories Of Patras S.A. Solid phase peptide synthesis via side chain attachment
CN102875663B (en) * 2012-09-26 2014-06-11 深圳翰宇药业股份有限公司 Purification method of lixisenatide
JP6382488B2 (en) * 2013-02-21 2018-08-29 ケミカル アンド バイオファーマシューティカル ラボラトリーズ オブ パトラ エス．エー． Solid phase peptide synthesis via side chain bonds
CN103965291B (en) * 2014-05-27 2016-09-21 上海第一生化药业有限公司 Octreotide, the preparation method of octreotide acetate
CN106699847B (en) * 2017-01-04 2020-08-14 陕西慧康生物科技有限责任公司 Method for purifying hexapeptide at low cost
JP6707576B2 (en) * 2018-04-03 2020-06-10 ケミカル アンド バイオファーマシューティカル ラボラトリーズ オブ パトラ エス．エー． Solid-phase peptide synthesis via side chain binding
EP3645550B1 (en) 2018-04-06 2021-11-03 The Trustees Of The University Of Pennsylvania Compstatin analogs with increased solubility and improved pharmacokinetic properties
WO2020170185A1 (en) * 2019-02-21 2020-08-27 Dr. Reddy’S Laboratories Limited Substantially pure lanreotide or its salt & process thereof
CN109942686B (en) * 2019-05-06 2021-06-25 上海上药第一生化药业有限公司 Purification method of vasopressin acetylated impurities
CN109929011B (en) * 2019-05-06 2021-04-06 上海上药第一生化药业有限公司 Method for refining vasopressin [5-Asp ] impurity
MX2022001062A (en) * 2019-07-26 2022-02-14 Allegro Pharmaceuticals Llc Peptides for treating non-exudative macular degeneration and other disorders of the eye.
WO2024112250A1 (en) * 2022-11-23 2024-05-30 Polypeptide Laboratories Holding (Ppl) Ab Method of preparing vasopressin

Citations (6)

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Publication number Priority date Publication date Assignee Title
US5767239A (en) * 1994-06-02 1998-06-16 Boehringer Mannheim Gmbh Process for preparing cardiodilatin fragments; highly purified cardiodilatin fragments and intermediate products for the preparation of same
US6303340B1 (en) * 1998-07-10 2001-10-16 Scios Inc. Method for producing a peptide with a pI above 8 or below 5
US20030104553A1 (en) * 2000-02-22 2003-06-05 Gianfranco Paradisi Process of purification of hcg and recombinant hcg purified by that method
US20030186893A1 (en) * 2000-02-22 2003-10-02 Gianfranco Paradisi Purified lh
WO2004092202A1 (en) * 2003-04-07 2004-10-28 Novetide, Ltd. Process for production of cyclic peptides
WO2005100381A2 (en) * 2004-04-08 2005-10-27 Millennium Pharmaceuticals, Inc. Processes for preparing eptifibatide and pertinent intermediate compounds

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US4235886A (en) * 1979-10-31 1980-11-25 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4310518A (en) * 1979-10-31 1982-01-12 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
EP0029579B1 (en) * 1979-11-27 1983-02-16 Sandoz Ag Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use
GB8813160D0 (en) * 1988-06-03 1988-07-06 Soc D Etudes Prod Chimique Therapeutic methods
DK0710243T3 (en) * 1993-06-29 2000-10-16 Ferring Bv Synthesis of cyclic peptides
US5889146A (en) * 1997-11-26 1999-03-30 Institute Of Nuclear Energy Research Method for synthesis of bifunctional chelating agents-peptides

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5767239A (en) * 1994-06-02 1998-06-16 Boehringer Mannheim Gmbh Process for preparing cardiodilatin fragments; highly purified cardiodilatin fragments and intermediate products for the preparation of same
US6303340B1 (en) * 1998-07-10 2001-10-16 Scios Inc. Method for producing a peptide with a pI above 8 or below 5
US20030104553A1 (en) * 2000-02-22 2003-06-05 Gianfranco Paradisi Process of purification of hcg and recombinant hcg purified by that method
US20030186893A1 (en) * 2000-02-22 2003-10-02 Gianfranco Paradisi Purified lh
WO2004092202A1 (en) * 2003-04-07 2004-10-28 Novetide, Ltd. Process for production of cyclic peptides
WO2005100381A2 (en) * 2004-04-08 2005-10-27 Millennium Pharmaceuticals, Inc. Processes for preparing eptifibatide and pertinent intermediate compounds

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LIGHT P: "NESIRITIDE CITRATE", IDRUGS, CURRENT DRUGS LTD, GB, vol. 2, no. 3, 1999, pages 259 - 264, XP008065093, ISSN: 1369-7056 *
SCARBOROUGH R M; NAUGHTON M A; TENG W; ROSE J W; PHILLIPS D R; NANNIZZI L; ARFSTEN A; CAMPBELL A M; CHARO I F: "Design of potent and specific integrin antagonists. Peptide antagonists with high specificity for glycoprotein IIb-IIIa", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, no. 2, 15 January 1993 (1993-01-15), pages 1066 - 1073, XP002384020 *

Also Published As

Publication number Publication date
CA2582083A1 (en) 2006-04-20
ES2344657T3 (en) 2010-09-02
EP1709065B1 (en) 2010-06-02
EP2163558A3 (en) 2010-10-27
EP2163558A2 (en) 2010-03-17
ATE469912T1 (en) 2010-06-15
JP2007513192A (en) 2007-05-24
DE602005021614D1 (en) 2010-07-15
IL182157A0 (en) 2007-07-24
DK1709065T3 (en) 2010-08-23
EP1709065A2 (en) 2006-10-11
WO2006041945A2 (en) 2006-04-20
US20060148699A1 (en) 2006-07-06

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