WO2006046134A3 - Method of screening by using conformation sensitive peptides - Google Patents

Method of screening by using conformation sensitive peptides Download PDF

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Publication number
WO2006046134A3
WO2006046134A3 PCT/IB2005/003323 IB2005003323W WO2006046134A3 WO 2006046134 A3 WO2006046134 A3 WO 2006046134A3 IB 2005003323 W IB2005003323 W IB 2005003323W WO 2006046134 A3 WO2006046134 A3 WO 2006046134A3
Authority
WO
WIPO (PCT)
Prior art keywords
screening
peptides
sensitive peptides
conformation sensitive
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2005/003323
Other languages
French (fr)
Other versions
WO2006046134A2 (en
Inventor
Majid Mehtali
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vivalis SA
Original Assignee
Vivalis SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34931388&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2006046134(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vivalis SA filed Critical Vivalis SA
Priority to US11/662,873 priority Critical patent/US9182408B2/en
Priority to EP05850660.1A priority patent/EP1789799B2/en
Priority to AT05850660T priority patent/ATE533055T1/en
Publication of WO2006046134A2 publication Critical patent/WO2006046134A2/en
Publication of WO2006046134A3 publication Critical patent/WO2006046134A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to a screening technology that allows the isolation of peptides able to bind to target protein, the binding of which being sensitive to the protein conformation. The invention further provides a method to identify compounds that specifically and precisely modify the protein conformation and its biological activity. Finally, the invention relates to certain peptides obtained by the method of screening of the present invention and their use as therapeutic agent for the prevention or treatement of diseases.
PCT/IB2005/003323 2004-09-16 2005-09-16 Method of screening by using conformation sensitive peptides Ceased WO2006046134A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US11/662,873 US9182408B2 (en) 2004-09-16 2005-09-16 Method of screening by using conformation sensitive peptides
EP05850660.1A EP1789799B2 (en) 2004-09-16 2005-09-16 Method of screening by using conformation sensitive peptides
AT05850660T ATE533055T1 (en) 2004-09-16 2005-09-16 METHOD FOR SCREENING USING CONFORMATION-SENSITIVE PEPTIDES

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04292224A EP1637885A1 (en) 2004-09-16 2004-09-16 Method of screening by using conformation sensitive peptides
EP04292224.5 2004-09-16

Publications (2)

Publication Number Publication Date
WO2006046134A2 WO2006046134A2 (en) 2006-05-04
WO2006046134A3 true WO2006046134A3 (en) 2006-12-07

Family

ID=34931388

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/003323 Ceased WO2006046134A2 (en) 2004-09-16 2005-09-16 Method of screening by using conformation sensitive peptides

Country Status (4)

Country Link
US (1) US9182408B2 (en)
EP (2) EP1637885A1 (en)
AT (1) ATE533055T1 (en)
WO (1) WO2006046134A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006019955A2 (en) * 2004-07-14 2006-02-23 President And Fellows Of Harvard College Antiviral methods and compositions
WO2009055010A2 (en) * 2007-10-25 2009-04-30 President And Fellows Of Harvard College Systems and methods for studying influenza
EP2101173A1 (en) * 2008-03-14 2009-09-16 Vivalis In vitro method to determine whether a drug candidate active against a target protein is active against a variant of said protein
AU2010270153A1 (en) 2009-07-10 2012-02-02 Vivalis Substituted pyrrolidinone as inhibitors of hepatitis C NS5B polymerase, the pharmaceutical composition thereof and their therapeutic use
JP2012532849A (en) 2009-07-10 2012-12-20 ビバリス 1- (6-membered azoheterocyclic) -pyrrolin-2-one compounds as inhibitors of hepatitis C NS5B polymerase, pharmaceutical compositions thereof, and their therapeutic use
WO2012093174A1 (en) 2011-01-07 2012-07-12 Vivalis 1-(6-membered azo-heterocyclic)-2,5-dihydro-1h-pyrrol-2-one derivatives as anti-hepatitis c virus, the pharmaceutical composition thereof and their therapeutic use
JP6518656B2 (en) 2013-06-13 2019-05-22 バイオデシー， インコーポレイテッド Method of screening candidate biochemical entities targeting a target biological entity

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997020952A1 (en) * 1995-12-07 1997-06-12 Scriptgen Pharmaceuticals, Inc. A fluorescence-based screening method for identifying ligands
WO1999054728A2 (en) * 1998-04-23 1999-10-28 Karo Bio Usa, Inc. Method of predicting receptor modulating activity
US20030082827A1 (en) * 1999-02-26 2003-05-01 Craig Roger K Methods And Compositions Using Protein Binding Partners
US20040043420A1 (en) * 2001-07-11 2004-03-04 Dana Fowlkes Method of identifying conformation-sensitive binding peptides and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071773A (en) 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US5217867A (en) 1988-11-30 1993-06-08 The Salk Institute For Biological Studies Receptors: their identification, characterization, preparation and use
US5445941A (en) 1993-06-21 1995-08-29 Eli Lilly And Company Method for screening anti-osteoporosis agents
US5723291A (en) 1993-09-01 1998-03-03 The Regents Of The University Of California Methods for screening compounds for estrogenic activity
WO1997031646A1 (en) * 1996-02-28 1997-09-04 University Of Colorado Steroid receptor antagonist co-modulator and methods for using same
EP1360501A2 (en) 2000-07-12 2003-11-12 Karo Bio USA, Inc. Method of identifying conformation-sensitive binding peptides and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997020952A1 (en) * 1995-12-07 1997-06-12 Scriptgen Pharmaceuticals, Inc. A fluorescence-based screening method for identifying ligands
WO1999054728A2 (en) * 1998-04-23 1999-10-28 Karo Bio Usa, Inc. Method of predicting receptor modulating activity
US20030082827A1 (en) * 1999-02-26 2003-05-01 Craig Roger K Methods And Compositions Using Protein Binding Partners
US20040043420A1 (en) * 2001-07-11 2004-03-04 Dana Fowlkes Method of identifying conformation-sensitive binding peptides and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KARIMOVA ET AL: "A bacterial two-hybrid system based on a reconstituted signal transduction pathway", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 95, May 1998 (1998-05-01), pages 5752 - 5756, XP002100623, ISSN: 0027-8424 *
NORRIS ET AL: "Peptide antagonists of the human estrogen receptor", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 285, no. 5428, 1999, pages 744 - 746, XP002113864, ISSN: 0036-8075 *
PAIGE ET AL: "Estrogen receptor (ER) modulators each induce distinct conformational changes in ER.alpha. and ER.beta", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 96, no. 7, March 1999 (1999-03-01), pages 3999 - 4004, XP002113865, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
US9182408B2 (en) 2015-11-10
ATE533055T1 (en) 2011-11-15
EP1789799A2 (en) 2007-05-30
WO2006046134A2 (en) 2006-05-04
EP1789799B1 (en) 2011-11-09
EP1637885A1 (en) 2006-03-22
EP1789799B2 (en) 2015-03-11
US20080076669A1 (en) 2008-03-27

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