WO2006052608A3 - Treatment of obesity and related disorders - Google Patents

Treatment of obesity and related disorders Download PDF

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Publication number
WO2006052608A3
WO2006052608A3 PCT/US2005/039686 US2005039686W WO2006052608A3 WO 2006052608 A3 WO2006052608 A3 WO 2006052608A3 US 2005039686 W US2005039686 W US 2005039686W WO 2006052608 A3 WO2006052608 A3 WO 2006052608A3
Authority
WO
WIPO (PCT)
Prior art keywords
obesity
related disorders
treatment
agents directed
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/039686
Other languages
French (fr)
Other versions
WO2006052608A2 (en
Inventor
Jonathan Roth
Christen M Anderson
Alain Baron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amylin Pharmaceuticals LLC
Original Assignee
Amylin Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36336990&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2006052608(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amylin Pharmaceuticals LLC filed Critical Amylin Pharmaceuticals LLC
Priority to DK05820773.9T priority Critical patent/DK1814590T4/en
Priority to CA2584806A priority patent/CA2584806C/en
Priority to EP05820773.9A priority patent/EP1814590B2/en
Priority to US11/665,675 priority patent/US20090156474A1/en
Priority to DE602005013811T priority patent/DE602005013811D1/en
Priority to JP2007539329A priority patent/JP4926069B2/en
Priority to KR1020077012269A priority patent/KR101123549B1/en
Priority to AU2005305036A priority patent/AU2005305036B2/en
Priority to CN2005800456795A priority patent/CN101094689B/en
Priority to BRPI0518241-7A priority patent/BRPI0518241A/en
Priority to PCT/US2006/017529 priority patent/WO2007055728A1/en
Priority to AU2006312307A priority patent/AU2006312307A1/en
Priority to EP06752351A priority patent/EP1954313A1/en
Priority to CA002628051A priority patent/CA2628051A1/en
Publication of WO2006052608A2 publication Critical patent/WO2006052608A2/en
Priority to PCT/US2006/022584 priority patent/WO2007055743A2/en
Publication of WO2006052608A3 publication Critical patent/WO2006052608A3/en
Priority to IL182764A priority patent/IL182764A/en
Anticipated expiration legal-status Critical
Priority to ZA2007/04239A priority patent/ZA200704239B/en
Priority to US11/940,317 priority patent/US8394765B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2264—Obesity-gene products, e.g. leptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2207—Gastrins; Cholecystokinins [CCK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)

Abstract

Methods for treating obesity or obesity related disorders are disclosed. These methods include the use of anti-obesity agents directed to the forebrain in combination with anti-obesity agents directed to the hindbrain.
PCT/US2005/039686 2004-11-01 2005-11-01 Treatment of obesity and related disorders Ceased WO2006052608A2 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
DK05820773.9T DK1814590T4 (en) 2004-11-01 2005-11-01 Treatment of obesity and related diseases.
CA2584806A CA2584806C (en) 2004-11-01 2005-11-01 Treatment of obesity and related disorders
EP05820773.9A EP1814590B2 (en) 2004-11-01 2005-11-01 Treatment of obesity and related disorders
US11/665,675 US20090156474A1 (en) 2004-11-01 2005-11-01 Methods for treating obesity and obesity related diseases and disorders
DE602005013811T DE602005013811D1 (en) 2004-11-01 2005-11-01 TREATMENT OF FAT AND HEALTHY DISEASES
JP2007539329A JP4926069B2 (en) 2004-11-01 2005-11-01 Methods for treating obesity and obesity-related diseases and disorders
KR1020077012269A KR101123549B1 (en) 2004-11-01 2005-11-01 Treatment of obesity and related disorders
AU2005305036A AU2005305036B2 (en) 2004-11-01 2005-11-01 Treatment of obesity and related disorders
CN2005800456795A CN101094689B (en) 2004-11-01 2005-11-01 Methods of treating obesity and obesity-related diseases and conditions
BRPI0518241-7A BRPI0518241A (en) 2004-11-01 2005-11-01 Methods to Treat Obesity and Obesity-Related Diseases and Disorders
CA002628051A CA2628051A1 (en) 2004-11-01 2006-05-03 Treatment of obesity and related disorders
PCT/US2006/017529 WO2007055728A1 (en) 2005-11-01 2006-05-03 Treatment of obesity and related disorders
AU2006312307A AU2006312307A1 (en) 2005-11-01 2006-05-03 Treatment of obesity and related disorders
EP06752351A EP1954313A1 (en) 2005-11-01 2006-05-03 Treatment of obesity and related disorders
PCT/US2006/022584 WO2007055743A2 (en) 2005-11-01 2006-06-09 Treatment of obesity and related disorders
IL182764A IL182764A (en) 2004-11-01 2007-04-23 Use of amylin or an amylin agonist for the manufacture of a medicament for treating obesity together with leptin
ZA2007/04239A ZA200704239B (en) 2004-11-01 2007-05-24 Methods for treating obesity and obesity related diseases and disorders
US11/940,317 US8394765B2 (en) 2004-11-01 2007-11-14 Methods of treating obesity with two different anti-obesity agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62435704P 2004-11-01 2004-11-01
US60/624,357 2004-11-01

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/665,675 A-371-Of-International US20090156474A1 (en) 2004-11-01 2005-11-01 Methods for treating obesity and obesity related diseases and disorders
US11/940,317 Continuation-In-Part US8394765B2 (en) 2004-11-01 2007-11-14 Methods of treating obesity with two different anti-obesity agents

Publications (2)

Publication Number Publication Date
WO2006052608A2 WO2006052608A2 (en) 2006-05-18
WO2006052608A3 true WO2006052608A3 (en) 2006-12-07

Family

ID=36336990

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/039686 Ceased WO2006052608A2 (en) 2004-11-01 2005-11-01 Treatment of obesity and related disorders

Country Status (14)

Country Link
US (1) US20090156474A1 (en)
EP (6) EP2286839A3 (en)
JP (1) JP4926069B2 (en)
KR (1) KR101123549B1 (en)
CN (1) CN101094689B (en)
AT (1) ATE427759T1 (en)
BR (1) BRPI0518241A (en)
CA (2) CA2584806C (en)
DE (1) DE602005013811D1 (en)
DK (1) DK1814590T4 (en)
ES (1) ES2325773T5 (en)
IL (1) IL182764A (en)
WO (1) WO2006052608A2 (en)
ZA (1) ZA200704239B (en)

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ES2325773T5 (en) 2014-02-24
DE602005013811D1 (en) 2009-05-20
DK1814590T3 (en) 2009-07-27
IL182764A (en) 2014-05-28
KR101123549B1 (en) 2012-04-18
EP2127676A2 (en) 2009-12-02
IL182764A0 (en) 2007-07-24
CA2584806A1 (en) 2006-05-18
CN101094689B (en) 2013-06-12
BRPI0518241A (en) 2008-04-22
JP4926069B2 (en) 2012-05-09
EP2286839A3 (en) 2013-09-04
WO2006052608A2 (en) 2006-05-18
EP2286837A2 (en) 2011-02-23
EP2286840A3 (en) 2013-09-04
ES2325773T3 (en) 2009-09-16
EP1814590A2 (en) 2007-08-08
EP2286838A3 (en) 2013-09-04
EP2286840A2 (en) 2011-02-23
EP1814590B1 (en) 2009-04-08
EP2286838A2 (en) 2011-02-23
CN101094689A (en) 2007-12-26
KR20070089683A (en) 2007-08-31
JP2008518963A (en) 2008-06-05
EP1814590B2 (en) 2013-12-11
ZA200704239B (en) 2008-04-30

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