WO2006071466A3 - Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders - Google Patents

Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders Download PDF

Info

Publication number
WO2006071466A3
WO2006071466A3 PCT/US2005/043974 US2005043974W WO2006071466A3 WO 2006071466 A3 WO2006071466 A3 WO 2006071466A3 US 2005043974 W US2005043974 W US 2005043974W WO 2006071466 A3 WO2006071466 A3 WO 2006071466A3
Authority
WO
WIPO (PCT)
Prior art keywords
prognosis
analysis
nucleic acids
cell proliferative
proliferative disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/043974
Other languages
French (fr)
Other versions
WO2006071466A2 (en
WO2006071466A8 (en
Inventor
Susan Cottrell
Fabian Model
Carolina Haefliger
Gunter Weiss
Juergen Distler
Andrew Z Sledziewski
Xiaoling Song
Thomas L Skillman
Jeffrey G Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epigenomics AG
Original Assignee
Epigenomics AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE602005015893T priority Critical patent/DE602005015893D1/en
Priority to EP05853011A priority patent/EP1831399B1/en
Priority to JP2007544601A priority patent/JP5745202B2/en
Priority to US11/720,744 priority patent/US20090197250A1/en
Priority to AT05853011T priority patent/ATE438740T1/en
Priority to ES05853011T priority patent/ES2331146T3/en
Priority to AU2005322435A priority patent/AU2005322435B2/en
Priority to CA002593546A priority patent/CA2593546A1/en
Application filed by Epigenomics AG filed Critical Epigenomics AG
Publication of WO2006071466A2 publication Critical patent/WO2006071466A2/en
Publication of WO2006071466A3 publication Critical patent/WO2006071466A3/en
Anticipated expiration legal-status Critical
Publication of WO2006071466A8 publication Critical patent/WO2006071466A8/en
Priority to US14/757,840 priority patent/US20160312287A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57555—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the prostate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Particular aspects provide novel methods and compositions (e.g., nucleic acids, kits, etc.) having substantial utility for providing a prognosis of prostate cell proliferative disorders. In particular aspects, this is achieved by the analysis of the expression status of a panel of genes, or subsets thereof.
PCT/US2005/043974 2004-12-02 2005-12-02 Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders Ceased WO2006071466A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU2005322435A AU2005322435B2 (en) 2004-12-02 2005-12-02 Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders
JP2007544601A JP5745202B2 (en) 2004-12-02 2005-12-02 Methods and nucleic acids for gene expression analysis associated with prognosis of prostate cell proliferation disorder
US11/720,744 US20090197250A1 (en) 2004-12-02 2005-12-02 Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders
AT05853011T ATE438740T1 (en) 2004-12-02 2005-12-02 METHOD AND NUCLEIC ACIDS FOR ANALYZING GENE EXPRESSION ASSOCIATED WITH THE PREDICTION OF DISORDERS IN THE PROLIFERATION OF PROSTATE CELLS
ES05853011T ES2331146T3 (en) 2004-12-02 2005-12-02 PROCEDURES AND NUCLEIC ACIDS FOR THE ANALYSIS OF GENETIC EXPRESSION ASSOCIATED WITH THE FORECAST OF PROLIFERATIVE DISORDERS OF PROSTATIC CELLS.
DE602005015893T DE602005015893D1 (en) 2004-12-02 2005-12-02 METHOD AND NUCLEIC ACIDS FOR THE ANALYSIS OF GENE EXPRESSION ASSOCIATED WITH THE PROGNOSIS OF PROBLEMS OF PROLIFERATION OF PROSTATE CELLS
EP05853011A EP1831399B1 (en) 2004-12-02 2005-12-02 Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders
CA002593546A CA2593546A1 (en) 2004-12-02 2005-12-02 Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders
US14/757,840 US20160312287A1 (en) 2004-12-02 2015-12-23 Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US63325004P 2004-12-02 2004-12-02
US63242604P 2004-12-02 2004-12-02
US60/632,426 2004-12-02
US60/633,250 2004-12-02
US66222005P 2005-03-14 2005-03-14
US60/662,220 2005-03-14
US72305405P 2005-10-03 2005-10-03
US72312505P 2005-10-03 2005-10-03
US60/723,054 2005-10-03
US60/723,125 2005-10-03
US74073605P 2005-11-30 2005-11-30

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/720,744 A-371-Of-International US20090197250A1 (en) 2004-12-02 2005-12-02 Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders
US14/757,840 Division US20160312287A1 (en) 2004-12-02 2015-12-23 Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders

Publications (3)

Publication Number Publication Date
WO2006071466A2 WO2006071466A2 (en) 2006-07-06
WO2006071466A3 true WO2006071466A3 (en) 2007-03-15
WO2006071466A8 WO2006071466A8 (en) 2009-06-18

Family

ID=39661458

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/043974 Ceased WO2006071466A2 (en) 2004-12-02 2005-12-02 Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders

Country Status (9)

Country Link
US (2) US20090197250A1 (en)
EP (5) EP2284279A1 (en)
JP (2) JP5745202B2 (en)
AT (1) ATE438740T1 (en)
AU (1) AU2005322435B2 (en)
CA (1) CA2593546A1 (en)
DE (1) DE602005015893D1 (en)
ES (2) ES2534139T3 (en)
WO (1) WO2006071466A2 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331393B1 (en) 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
KR101708544B1 (en) * 2005-04-15 2017-02-20 에피제노믹스 아게 Methods and nucleic acids for analyses of cellular proliferative disorders
EP1945806B1 (en) * 2005-09-21 2013-02-27 Epigenomics AG Markers for the prediction of outcome of anthracycline treatment
WO2007039291A2 (en) * 2005-10-03 2007-04-12 Epigenomics Ag Methods, apparatus and nomograms to determine prostate cancer progression
US20080254470A1 (en) * 2005-10-03 2008-10-16 Epigenomics Ag Methods and Nucleic Acids For the Analysis of Gene Expression Associated With the Prognosis of Cell Proliferative Disorders
WO2007042041A1 (en) * 2005-10-12 2007-04-19 Scanvaegt International A/S Device for transfer of items
WO2007060671A2 (en) * 2005-11-27 2007-05-31 Compugen Ltd. Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis
GB0625321D0 (en) * 2006-12-19 2007-01-24 Univ Surrey Cancer biomarker
US20090062645A1 (en) * 2007-09-03 2009-03-05 Jens Fehre Method for diagnosis and treatment of prostate cancer
AU2008328222A1 (en) * 2007-11-23 2009-05-28 Epigenomics Ag Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
US20110003292A1 (en) * 2007-12-11 2011-01-06 Dimo Dietrich Methods and nucleic acids for analyses of cell proliferative disorders
JP5513375B2 (en) * 2008-05-07 2014-06-04 北海道公立大学法人 札幌医科大学 Cancer detection method and detection kit, and cancer therapeutic agent
US9315802B2 (en) 2009-12-30 2016-04-19 Quest Diagnostics Investments Incorporated RNA isolation from soluble urine fractions
DE102010028105A1 (en) * 2010-04-22 2011-10-27 Siemens Aktiengesellschaft Method, device and device system for the treatment of prostate cancer
US9663781B2 (en) 2010-12-30 2017-05-30 Quest Diagnostics Investments Incorporated Diagnosis of prostate cancer
EP2514836B1 (en) * 2011-04-19 2016-06-29 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Prostate cancer markers
US9598735B2 (en) * 2012-11-14 2017-03-21 JBS Science Inc. Detection of a panel of urine DNA markers for HCC screening and disease management
KR101467289B1 (en) * 2013-01-22 2014-12-02 한국원자력의학원 Composition for diagnosis of radio-resistance or radio-sensitive WDFY3 marker and use thereof
US20150010518A1 (en) * 2013-07-03 2015-01-08 The University Of British Columbia Nr2e1 mini-promoters
WO2015023285A1 (en) * 2013-08-15 2015-02-19 Xia Xueliang James Biomarkers for use in colorectal cancer
JP6427750B2 (en) * 2013-10-02 2018-11-28 コニカミノルタ株式会社 CXCL1 and data collection method and kit for determining prognosis of lung cancer patients based on expression levels of SMOX and / or ID1
GB2524948A (en) * 2014-03-07 2015-10-14 Oxford Gene Technology Operations Ltd Detecting Increase or Decrease in the Amount of a Nucleic Acid having a Sequence of Interest
GB201404998D0 (en) * 2014-03-20 2014-05-07 Univ Birmingham Atrial fibrillation therapy
EP3037545A1 (en) * 2014-12-23 2016-06-29 The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin A DNA-methylation test for prostate cancer
EP3246415A1 (en) * 2016-05-18 2017-11-22 Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE Methods for the prognosis of prostate cancer
US20210318324A1 (en) * 2018-07-05 2021-10-14 The Board Of Regents Of The University Of Oklahoma Gene signatures for cancer characterization and methods of use
KR102637032B1 (en) * 2020-01-28 2024-02-15 주식회사 젠큐릭스 Composition for diagnosing bladder cancer using CpG methylation status of specific gene and uses thereof
US11901083B1 (en) 2021-11-30 2024-02-13 Vignet Incorporated Using genetic and phenotypic data sets for drug discovery clinical trials
US11705230B1 (en) 2021-11-30 2023-07-18 Vignet Incorporated Assessing health risks using genetic, epigenetic, and phenotypic data sources
CN114015771A (en) * 2022-01-05 2022-02-08 北京华诺奥美基因医学检验实验室有限公司 Detection primer group and kit for SNRPN paternal source deletion and detection method for non-diagnosis purpose

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001019845A1 (en) * 1999-09-15 2001-03-22 The Johns Hopkins University School Of Medicine Cacna1g polynucleotide, polypeptide and methods of use therefor
WO2002070742A1 (en) * 2001-03-01 2002-09-12 Epigenomics Ag Method for the development of gene panels for diagnostic and therapeutic purposes based on the expression and methylatoin status of the genes
EP1379694A2 (en) * 2001-03-01 2004-01-14 Epigenomics AG Methods, systems and computer program products for determining the biological effect and/or activity of drugs, chemical substances and/or pharmaceutical compositions based on their effect on the methylation status of the dna
WO2004035803A2 (en) * 2002-10-01 2004-04-29 Epigenomics Ag Method and nucleic acids for the treatment of breast cell proliferative disorders
WO2005121360A2 (en) * 2004-06-05 2005-12-22 Epigenomics Ag Prognostic markers for prediction of treatment response and/or survival of breast cell proliferative disorder patients

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585481A (en) * 1987-09-21 1996-12-17 Gen-Probe Incorporated Linking reagents for nucleotide probes
US5457183A (en) * 1989-03-06 1995-10-10 Board Of Regents, The University Of Texas System Hydroxylated texaphyrins
US5245022A (en) * 1990-08-03 1993-09-14 Sterling Drug, Inc. Exonuclease resistant terminally substituted oligonucleotides
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5565552A (en) * 1992-01-21 1996-10-15 Pharmacyclics, Inc. Method of expanded porphyrin-oligonucleotide conjugate synthesis
US5574142A (en) * 1992-12-15 1996-11-12 Microprobe Corporation Peptide linkers for improved oligonucleotide delivery
SE501439C2 (en) 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Method and apparatus for analyzing polynucleotide sequences
DE69417918T2 (en) 1993-11-30 2000-01-05 Mcgill University, Montreal DNA METHYL TRANSFERASE INHIBITION
US5597696A (en) 1994-07-18 1997-01-28 Becton Dickinson And Company Covalent cyanine dye oligonucleotide conjugates
US5514758A (en) 1994-09-30 1996-05-07 The Goodyear Tire & Rubber Company Process for making latex for high performance masking tape
US6017704A (en) 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US5786146A (en) 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
AU7829398A (en) 1997-06-09 1998-12-30 University Of Southern California A cancer diagnostic method based upon dna methylation differences
DE19754482A1 (en) 1997-11-27 1999-07-01 Epigenomics Gmbh Process for making complex DNA methylation fingerprints
US7700324B1 (en) 1998-11-03 2010-04-20 The Johns Hopkins University School Of Medicine Methylated CpG island amplification (MCA)
US5958773A (en) * 1998-12-17 1999-09-28 Isis Pharmaceuticals Inc. Antisense modulation of AKT-1 expression
US6331393B1 (en) 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
AU2002214576A1 (en) * 2000-10-13 2002-04-22 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Genes related to development of refractory prostate cancer
EP1410304A2 (en) * 2001-03-26 2004-04-21 Epigenomics AG Method for epigenetic feature selection
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
SE524468C2 (en) * 2002-12-09 2004-08-10 Axlon Int Ab Device and method for sorting coins
US20040146868A1 (en) * 2003-01-24 2004-07-29 Epigenomics Ag Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the development of peripheral zone prostate cancer
CA2548528A1 (en) 2003-12-01 2005-06-16 Epigenomics Ag Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
JP2007513621A (en) 2003-12-11 2007-05-31 エピゲノミクス アーゲー Methods and nucleic acids for improved treatment of breast cell proliferative disorders
ATE508207T1 (en) * 2006-02-28 2011-05-15 Charite Universitaetsmedizin DETECTION AND QUALITY CONTROL OF REGULATOR T CELLS USING DNA METHYLATION ANALYSIS OF THE FOXP3 GENE

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001019845A1 (en) * 1999-09-15 2001-03-22 The Johns Hopkins University School Of Medicine Cacna1g polynucleotide, polypeptide and methods of use therefor
WO2002070742A1 (en) * 2001-03-01 2002-09-12 Epigenomics Ag Method for the development of gene panels for diagnostic and therapeutic purposes based on the expression and methylatoin status of the genes
EP1379694A2 (en) * 2001-03-01 2004-01-14 Epigenomics AG Methods, systems and computer program products for determining the biological effect and/or activity of drugs, chemical substances and/or pharmaceutical compositions based on their effect on the methylation status of the dna
WO2004035803A2 (en) * 2002-10-01 2004-04-29 Epigenomics Ag Method and nucleic acids for the treatment of breast cell proliferative disorders
WO2005121360A2 (en) * 2004-06-05 2005-12-22 Epigenomics Ag Prognostic markers for prediction of treatment response and/or survival of breast cell proliferative disorder patients

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PAKNESHAN POUYA ET AL: "Methylation status of uPA promoter as a molecular mechanism regulating prostate cancer invasion and growth in vitro and in vivo.", FASEB JOURNAL, vol. 17, no. 9, June 2003 (2003-06-01), pages 1081 - 1088 URL, XP002385912, ISSN: 0892-6638 *

Also Published As

Publication number Publication date
WO2006071466A2 (en) 2006-07-06
EP2311984A1 (en) 2011-04-20
AU2005322435B2 (en) 2012-02-23
EP2280084B1 (en) 2015-02-11
CA2593546A1 (en) 2006-07-06
ES2331146T3 (en) 2009-12-22
EP1831399B1 (en) 2009-08-05
US20160312287A1 (en) 2016-10-27
JP2012120538A (en) 2012-06-28
DE602005015893D1 (en) 2009-09-17
ES2534139T3 (en) 2015-04-17
EP2213749A1 (en) 2010-08-04
EP2311984A8 (en) 2011-12-28
US20090197250A1 (en) 2009-08-06
AU2005322435A1 (en) 2006-07-06
JP2008522590A (en) 2008-07-03
EP2284279A1 (en) 2011-02-16
ATE438740T1 (en) 2009-08-15
JP5745202B2 (en) 2015-07-08
EP2280084A1 (en) 2011-02-02
JP5883677B2 (en) 2016-03-15
WO2006071466A8 (en) 2009-06-18
EP1831399A2 (en) 2007-09-12

Similar Documents

Publication Publication Date Title
WO2006071466A8 (en) Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders
EP1985715A3 (en) ESR1 and cervical cancer
WO2005054517A3 (en) Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
WO2007039290A3 (en) Methods and nucleic acids for the analysis of gene expression associated with the prognosis of cell proliferative disorders
EP2253718A3 (en) Solid surface for biomolecule delivery and high-throughput assay
WO2005068664A3 (en) Cell-type-specific patterns of gene expression
WO2006138275A3 (en) Compositions and methods for treating and diagnosing cancer
WO2008069906A3 (en) Digital expression of gene analysis
WO2007120627A3 (en) Repair of nucleic acids for improved amplification
EP1961827A3 (en) Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders
AU2008222649A8 (en) Primers for melting analysis
WO2008076842A3 (en) Sequencing methods
WO2009145945A3 (en) Thermophilic and thermoacidophilic metabolism genes and enzymes from alicyclobacillus acidocaldarius and related organisms
WO2003072812A3 (en) Method and nucleic acids for the analysis of colorectal cell proliferative disorders
WO2006088623A3 (en) Selection probe amplification
WO2005087951A3 (en) Reagents, methods and kits for use in deactivating nucleic acids
WO2005054270A3 (en) Identification and design of sirna molecules
ATE321138T1 (en) POLYKETIDES, THEIR PREPARATION, AND MATERIALS USED THEREIN
WO2009055656A3 (en) Vectors, host cells, and methods of production and uses
WO2007012811A9 (en) Prostate stem cell markers
WO2004003493A3 (en) Methods and kits for determining energy expenditure in living organisms by metabolic water production
WO2008025961A3 (en) Method of diagnosis
WO2005108622A3 (en) Methods and kits to increase the efficiency of oligonucleotide-directed nucleic acid sequence alteration
WO2006071804A3 (en) Anti-il-12 antibody based vectors, host cells, and methods of production and uses
WO2008137629A3 (en) Identifying germline competent embryonic stem cells

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 2005322435

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2593546

Country of ref document: CA

Ref document number: 2007544601

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2005322435

Country of ref document: AU

Date of ref document: 20051202

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2005322435

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2005853011

Country of ref document: EP

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWP Wipo information: published in national office

Ref document number: 2005853011

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 11720744

Country of ref document: US