WO2006071777A3 - Soft tissue repair and regeneration using postpartum-derived cells and cell products - Google Patents

Soft tissue repair and regeneration using postpartum-derived cells and cell products Download PDF

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Publication number
WO2006071777A3
WO2006071777A3 PCT/US2005/046808 US2005046808W WO2006071777A3 WO 2006071777 A3 WO2006071777 A3 WO 2006071777A3 US 2005046808 W US2005046808 W US 2005046808W WO 2006071777 A3 WO2006071777 A3 WO 2006071777A3
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postpartum
soft tissue
derived cells
regeneration
tissue repair
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WO2006071777A2 (en
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Laura Brown
Alexander M Harmon
Anna Gosiewska
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Ethicon Inc
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Ethicon Inc
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Publication of WO2006071777A3 publication Critical patent/WO2006071777A3/en
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Abstract

Cells derived from postpartum tissue and products thereof having the potential to support cells of and/or differentiate to cells of a soft tissue lineage, and methods of preparation and use of those postpartum tissue-derived cells, are provided by the invention. The invention also provides methods for the use of such postpartum-derived cells and products related thereto in therapies for conditions of soft tissue.
PCT/US2005/046808 2004-12-23 2005-12-22 Soft tissue repair and regeneration using postpartum-derived cells and cell products Ceased WO2006071777A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05855379A EP1831355A2 (en) 2004-12-23 2005-12-22 Soft tissue repair and regeneration using postpartum-derived cells and cell products

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63870204P 2004-12-23 2004-12-23
US60/638,702 2004-12-23

Publications (2)

Publication Number Publication Date
WO2006071777A2 WO2006071777A2 (en) 2006-07-06
WO2006071777A3 true WO2006071777A3 (en) 2007-03-01

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PCT/US2005/046808 Ceased WO2006071777A2 (en) 2004-12-23 2005-12-22 Soft tissue repair and regeneration using postpartum-derived cells and cell products

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EP (1) EP1831355A2 (en)
WO (1) WO2006071777A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
US9234172B2 (en) 2003-06-27 2016-01-12 DePuy Synthes Products, Inc. Repair and regeneration of ocular tissue using postpartum-derived cells
US9498501B2 (en) 2003-06-27 2016-11-22 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US20110280838A1 (en) * 2007-12-27 2011-11-17 Advanced Technologies And Regenerative Medicine, Llc Treatment of intervertebral disc degeneration using human umbilical cord tissue-derived cells
EP1835924B1 (en) 2004-12-23 2013-08-21 Ethicon, Incorporated Treatment of parkinson's disease and related disorders using postpartum derived cells
WO2007070870A1 (en) 2005-12-16 2007-06-21 Ethicon, Inc. Compositions and methods for inhibiting adverse immune response in histocompatibility-mismatched transplantation
CN101622007A (en) * 2006-10-06 2010-01-06 人类起源公司 Natural (telopeptide) placental collagen compositions
CA2688504A1 (en) 2007-06-18 2008-12-24 Children's Hospital & Research Center At Oakland Method of isolating stem and progenitor cells from placenta
US10179900B2 (en) 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
JP5518893B2 (en) 2008-12-19 2014-06-11 アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー Treatment of lungs and lung diseases and disorders
US8771677B2 (en) 2008-12-29 2014-07-08 Vladimir B Serikov Colony-forming unit cell of human chorion and method to obtain and use thereof
EP2411504B1 (en) 2009-03-26 2017-05-10 DePuy Synthes Products, Inc. Human umbilical cord tissue cells as therapy for alzheimer's disease
US8574899B2 (en) 2010-12-22 2013-11-05 Vladimir B Serikov Methods for augmentation collection of placental hematopoietic stem cells and uses thereof
EP2794854B1 (en) 2011-12-23 2018-06-20 DePuy Synthes Products, Inc. Detection of human umbilical cord tissue-derived cells
CN107567494A (en) 2015-03-04 2018-01-09 迈索布拉斯特国际有限公司 Cell culture method of mesenchymal stem cells
CN110988352B (en) * 2019-11-11 2023-06-27 广州医科大学附属第三医院(广州重症孕产妇救治中心、广州柔济医院) Kit for auxiliary detection of placenta accreta and its application

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919702A (en) * 1996-10-23 1999-07-06 Advanced Tissue Science, Inc. Production of cartilage tissue using cells isolated from Wharton's jelly
US20030032179A1 (en) * 2000-12-06 2003-02-13 Hariri Robert J. Post-partum mammalian placenta, its use and placental stem cells therefrom
WO2003068937A2 (en) * 2002-02-13 2003-08-21 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta and uses and methods of treatment using said cells
US20030161818A1 (en) * 2002-02-25 2003-08-28 Kansas State University Research Foundation Cultures, products and methods using stem cells
WO2004072273A1 (en) * 2003-02-11 2004-08-26 Davies John E Progenitor cells from wharton's jelly of human umbilical cord
WO2005001079A2 (en) * 2003-06-27 2005-01-06 Ethicon, Incorporated Soft tissue repair and regeneration using postpartum-derived cells

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919702A (en) * 1996-10-23 1999-07-06 Advanced Tissue Science, Inc. Production of cartilage tissue using cells isolated from Wharton's jelly
US20030032179A1 (en) * 2000-12-06 2003-02-13 Hariri Robert J. Post-partum mammalian placenta, its use and placental stem cells therefrom
WO2003068937A2 (en) * 2002-02-13 2003-08-21 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta and uses and methods of treatment using said cells
US20030161818A1 (en) * 2002-02-25 2003-08-28 Kansas State University Research Foundation Cultures, products and methods using stem cells
WO2004072273A1 (en) * 2003-02-11 2004-08-26 Davies John E Progenitor cells from wharton's jelly of human umbilical cord
WO2005001079A2 (en) * 2003-06-27 2005-01-06 Ethicon, Incorporated Soft tissue repair and regeneration using postpartum-derived cells

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ISHII M ET AL: "Molecular markers distinguish bone marrow mesenchymal stem cells from fibroblasts", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 332, no. 1, 24 June 2005 (2005-06-24), pages 297 - 303, XP004892979, ISSN: 0006-291X *
JACKSON K A ET AL: "Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 107, no. 11, June 2001 (2001-06-01), pages 1395 - 1402, XP002976368, ISSN: 0021-9738 *
LODIE T A ET AL: "Systematic analysis of reportedly distinct populations of multipotent bone marrow-derived stem cells reveals a lack of distinction", TISSUE ENGINEERING, LARCHMONT, NY, US, vol. 8, no. 5, October 2002 (2002-10-01), pages 739 - 751, XP002306489, ISSN: 1076-3279 *
MITCHELL K E ET AL: "Matrix cells from Wharton's jelly form neurons and glia", STEM CELLS, ALPHAMED PRESS, DAYTON, OH, US, vol. 21, no. 1, January 2003 (2003-01-01), pages 50 - 60, XP002281007, ISSN: 1066-5099 *
QIAN YE ET AL: "RECOVERY OF PLACENTAL-DERIVED ADHERENT CELLS WITH MESENCHYMAL STEM CELL CHARACTERISTICS", BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, US, vol. 98, no. 11, PART 2, 7 December 2001 (2001-12-07), pages 147B, XP009026843, ISSN: 0006-4971 *
RABBANY SINA Y ET AL: "Molecular pathways regulating mobilization of marrow-derived stem cells for tissue revascularization.", TRENDS IN MOLECULAR MEDICINE, vol. 9, no. 3, March 2003 (2003-03-01), pages 109 - 117, XP002312847, ISSN: 1471-4914 *
RAFII SHAHIN ET AL: "Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration.", NATURE MEDICINE, vol. 9, no. 6, June 2003 (2003-06-01), pages 702 - 712, XP002312846, ISSN: 1078-8956 *
TREMAIN N ET AL: "MICROSAGE ANALYSIS OF 2,353 EXPRESSED GENES IN A SINGLE CELL-DERIVED COLONY OF UNDIFFERENTIATED HUMAN MESENCHYMAL STEM CELLS REVEALS MRNAS OF MULTIPLE CELL LINEAGES", STEM CELLS, ALPHAMED PRESS, DAYTON, OH, US, vol. 19, 2001, pages 408 - 418, XP002907879, ISSN: 1066-5099 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9234172B2 (en) 2003-06-27 2016-01-12 DePuy Synthes Products, Inc. Repair and regeneration of ocular tissue using postpartum-derived cells
US9498501B2 (en) 2003-06-27 2016-11-22 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
US9585918B2 (en) 2005-12-28 2017-03-07 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells

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EP1831355A2 (en) 2007-09-12
WO2006071777A2 (en) 2006-07-06

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