WO2006074264A3 - Preparation of ketone amides - Google Patents

Preparation of ketone amides Download PDF

Info

Publication number
WO2006074264A3
WO2006074264A3 PCT/US2006/000251 US2006000251W WO2006074264A3 WO 2006074264 A3 WO2006074264 A3 WO 2006074264A3 US 2006000251 W US2006000251 W US 2006000251W WO 2006074264 A3 WO2006074264 A3 WO 2006074264A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
piperidone
carbonyl
novel process
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/000251
Other languages
French (fr)
Other versions
WO2006074264A2 (en
Inventor
Shen-Chun Kuo
David Jieh-Shyh Tsai
Hongbiao Liao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp & Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to CA002594106A priority Critical patent/CA2594106A1/en
Priority to MX2007008214A priority patent/MX2007008214A/en
Priority to JP2007550444A priority patent/JP4728350B2/en
Priority to EP06717452A priority patent/EP1838695A2/en
Priority to CN2006800065103A priority patent/CN101133046B/en
Publication of WO2006074264A2 publication Critical patent/WO2006074264A2/en
Publication of WO2006074264A3 publication Critical patent/WO2006074264A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention discloses a novel process to prepare ketone amides, which are useful intermediates for the preparation of antagonists of CCR5 receptor and therefore useful for the treatment of HIV virus infected mammals. It specifically discloses a novel process to synthesize 1 -(2,4-dimethylpyrimidine-5-carbonyl)-4-piperidone, 1 -[(2,4-dimethyl-3- pyridinyl)carbonyl]-4-piperidone and related compounds. A salient feature of the invention is the use of a three-phase reaction medium with an organic phase and a buffer salt slurry. (formule I)
PCT/US2006/000251 2005-01-06 2006-01-05 Preparation of ketone amides Ceased WO2006074264A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002594106A CA2594106A1 (en) 2005-01-06 2006-01-05 Preparation of ketone amides
MX2007008214A MX2007008214A (en) 2005-01-06 2006-01-05 Preparation of ketone amides.
JP2007550444A JP4728350B2 (en) 2005-01-06 2006-01-05 Preparation of ketone amide
EP06717452A EP1838695A2 (en) 2005-01-06 2006-01-05 Preparation of ketone amides
CN2006800065103A CN101133046B (en) 2005-01-06 2006-01-05 Preparation of ketoamides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64189905P 2005-01-06 2005-01-06
US60/641,899 2005-01-06

Publications (2)

Publication Number Publication Date
WO2006074264A2 WO2006074264A2 (en) 2006-07-13
WO2006074264A3 true WO2006074264A3 (en) 2006-11-02

Family

ID=36283752

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/000251 Ceased WO2006074264A2 (en) 2005-01-06 2006-01-05 Preparation of ketone amides

Country Status (10)

Country Link
US (3) US7759487B2 (en)
EP (1) EP1838695A2 (en)
JP (2) JP4728350B2 (en)
CN (1) CN101133046B (en)
AR (1) AR052864A1 (en)
CA (1) CA2594106A1 (en)
MX (1) MX2007008214A (en)
SG (1) SG158857A1 (en)
WO (1) WO2006074264A2 (en)
ZA (1) ZA200705515B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04009428A (en) * 2002-03-29 2005-01-25 Schering Corp Synthesis of piperidine and piperazine compounds as ccr5 antagonists.
EP1838695A2 (en) * 2005-01-06 2007-10-03 Shering Corporation Preparation of ketone amides
WO2009128947A1 (en) 2008-04-17 2009-10-22 Concert Pharmaceuticals, Inc. Piperazine derivatives
KR20210046668A (en) * 2018-08-21 2021-04-28 헌트스만 인터내셔날, 엘엘씨 Catalysts for the production of PIR/PUR foams

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030004185A1 (en) * 1999-05-04 2003-01-02 Baroudy Bahige M. Piperidine derivatives useful as CCR5 antagonists
US20030069252A1 (en) * 1999-05-04 2003-04-10 Baroudy Bahige M. Piperazine derivatives useful as CCR5 antagonists
WO2003084950A1 (en) * 2002-03-29 2003-10-16 Schering Corporation Synthesis of piperidine and piperazine compounds as ccr5 antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466687A (en) * 1992-10-22 1995-11-14 Dr. Karl Thomae Gmbh Arylidene-1-azacycloalkanes and arylalkyl-1-azacyclo-alkanes, their salts, medicaments containing these compounds and their use, and processes for their preparation
US5376666A (en) * 1992-11-30 1994-12-27 The Du Pont Merck Pharmaceutical Company Angiotension-II receptor blocking, azacycloalkyl or azacycloalkenyl
DE4426671A1 (en) * 1994-07-28 1996-02-01 Hoechst Ag Process for cross-coupling aromatic boron compounds with aromatic halogen compounds or perfluoroalkyl sulfonates
US5889006A (en) * 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
US6410750B1 (en) * 1999-06-18 2002-06-25 Pfizer Inc. Processes and intermediates for preparing 3(S)-[(5-chloro-1H-indole-2-carbonyl)-amino]-2(R)-hydroxy-4-phenyl-butyric acid
BR0213961A (en) * 2001-10-19 2004-08-31 Ortho Mcneil Pharm Inc Phosphonic Acid Compounds as Serine Protease Inhibitors
EP1838695A2 (en) * 2005-01-06 2007-10-03 Shering Corporation Preparation of ketone amides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030004185A1 (en) * 1999-05-04 2003-01-02 Baroudy Bahige M. Piperidine derivatives useful as CCR5 antagonists
US20030069252A1 (en) * 1999-05-04 2003-04-10 Baroudy Bahige M. Piperazine derivatives useful as CCR5 antagonists
WO2003084950A1 (en) * 2002-03-29 2003-10-16 Schering Corporation Synthesis of piperidine and piperazine compounds as ccr5 antagonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
G. XU, A. KANNAN, T. L. HARTMAN, H. WARGO, K. WATSON, J. A. TURPIN, R. W. BUCKHEIT, A. A. JOHNSON, Y. POMMIER, M. CUSHMAN: "Synthesis of Substituted Diarylmethylenepiperidines (DAMPs), a Novel Class of Anti-HIV Agents", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 10, 2002, pages 2807 - 2816, XP002381120 *

Also Published As

Publication number Publication date
AR052864A1 (en) 2007-04-11
JP4728350B2 (en) 2011-07-20
MX2007008214A (en) 2007-08-17
ZA200705515B (en) 2008-05-28
WO2006074264A2 (en) 2006-07-13
EP1838695A2 (en) 2007-10-03
US20100029939A1 (en) 2010-02-04
JP2008526860A (en) 2008-07-24
JP2011102328A (en) 2011-05-26
SG158857A1 (en) 2010-02-26
US20060247437A1 (en) 2006-11-02
US20120065397A1 (en) 2012-03-15
CA2594106A1 (en) 2006-07-13
CN101133046A (en) 2008-02-27
US7759487B2 (en) 2010-07-20
CN101133046B (en) 2011-08-03

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