WO2006076231A3 - Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood glp-1 level - Google Patents

Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood glp-1 level Download PDF

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Publication number
WO2006076231A3
WO2006076231A3 PCT/US2006/000510 US2006000510W WO2006076231A3 WO 2006076231 A3 WO2006076231 A3 WO 2006076231A3 US 2006000510 W US2006000510 W US 2006000510W WO 2006076231 A3 WO2006076231 A3 WO 2006076231A3
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WO
WIPO (PCT)
Prior art keywords
treatment
level
conditions
increasing
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/000510
Other languages
French (fr)
Other versions
WO2006076231A2 (en
WO2006076231A8 (en
Inventor
Zhi-Liang Chu
James N Leonard
Hussien A Al-Shamma
Robert M Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arena Pharmaceuticals Inc
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Arena Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36570727&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2006076231(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to NZ578504A priority Critical patent/NZ578504A/en
Priority to ES06717678T priority patent/ES2327268T5/en
Priority to EP06717678A priority patent/EP1758565B2/en
Priority to UAA200709149A priority patent/UA91698C2/en
Priority to DK06717678.4T priority patent/DK1758565T4/en
Priority to EA200701469A priority patent/EA011883B1/en
Priority to CA2593427A priority patent/CA2593427C/en
Priority to PL06717678T priority patent/PL1758565T5/en
Priority to BRPI0606727-1A priority patent/BRPI0606727A/en
Priority to DE602006006765T priority patent/DE602006006765D1/en
Priority to MX2007008376A priority patent/MX2007008376A/en
Priority to DK07004743T priority patent/DK1808168T3/en
Priority to KR1020127029863A priority patent/KR20120139849A/en
Priority to HK07102574.3A priority patent/HK1096537C/en
Priority to RSP-2009/0354A priority patent/RS51127B/en
Priority to NZ556219A priority patent/NZ556219A/en
Priority to HRP20090403TT priority patent/HRP20090403T4/en
Application filed by Arena Pharmaceuticals Inc filed Critical Arena Pharmaceuticals Inc
Priority to AU2006205164A priority patent/AU2006205164B2/en
Priority to KR1020137032119A priority patent/KR20130140226A/en
Priority to AT06717678T priority patent/ATE431139T1/en
Priority to JP2007550512A priority patent/JP4118323B1/en
Publication of WO2006076231A2 publication Critical patent/WO2006076231A2/en
Publication of WO2006076231A8 publication Critical patent/WO2006076231A8/en
Publication of WO2006076231A3 publication Critical patent/WO2006076231A3/en
Priority to IL184364A priority patent/IL184364A0/en
Anticipated expiration legal-status Critical
Priority to NO20073816A priority patent/NO331089B1/en
Priority to AU2009202898A priority patent/AU2009202898B2/en
Priority to AU2009202900A priority patent/AU2009202900B8/en
Priority to NO20101746A priority patent/NO20101746L/en
Ceased legal-status Critical Current

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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
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    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
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    • G01N2800/2871—Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event

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  • Urology & Nephrology (AREA)
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  • Endocrinology (AREA)
  • Diabetes (AREA)
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  • Food Science & Technology (AREA)
  • Cardiology (AREA)
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Abstract

The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the amount of the GPR119 agonist or the amount of the DPP-IV inhibitor alone and the use of such a combination for treating or preventing diabetes and conditions related thereto or conditions ameliorated by increasing a blood GLP-1 level. The present invention also relates to the use of a G protein-coupled receptor to screen for GLP-1 secretagogues.
PCT/US2006/000510 2005-01-10 2006-01-09 Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood glp-1 level Ceased WO2006076231A2 (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
JP2007550512A JP4118323B1 (en) 2005-01-10 2006-01-09 Combination therapy for the treatment of diabetes and conditions related to diabetes and for the treatment of conditions ameliorated by an increase in blood GLP-1 levels
RSP-2009/0354A RS51127B (en) 2005-01-10 2006-01-09 GLP-1 SECRETAGOG INDENTIFICATION PROCEDURE
EP06717678A EP1758565B2 (en) 2005-01-10 2006-01-09 Method of identifying GLP-1 secretagogues
UAA200709149A UA91698C2 (en) 2005-01-10 2006-01-09 Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood glp-1 level
DK06717678.4T DK1758565T4 (en) 2005-01-10 2006-01-09 Method for Identifying GLP-1 Secretion Inducers.
EA200701469A EA011883B1 (en) 2005-01-10 2006-01-09 Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood glp-1 level
CA2593427A CA2593427C (en) 2005-01-10 2006-01-09 Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood glp-1 level
PL06717678T PL1758565T5 (en) 2005-01-10 2006-01-09 Method of identifying GLP-1 secretagogues
HRP20090403TT HRP20090403T4 (en) 2005-01-10 2006-01-09 GLP-1 SECRETOGOG IDENTIFICATION PROCEDURE
DE602006006765T DE602006006765D1 (en) 2005-01-10 2006-01-09 Method for the identification of GLP-1 secretion promoters
MX2007008376A MX2007008376A (en) 2005-01-10 2006-01-09 Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood glp-1 level.
DK07004743T DK1808168T3 (en) 2005-01-10 2006-01-09 Combination therapy for the treatment of diabetes and conditions related to it and for the treatment of conditions that are relieved by raising a blood GLP-1 level
KR1020127029863A KR20120139849A (en) 2005-01-10 2006-01-09 Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood glp-1 level
HK07102574.3A HK1096537C (en) 2005-01-10 2006-01-09 Method of identifying glp-1 secretagogues
NZ556219A NZ556219A (en) 2005-01-10 2006-01-09 Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level
NZ578504A NZ578504A (en) 2005-01-10 2006-01-09 Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level
BRPI0606727-1A BRPI0606727A (en) 2005-01-10 2006-01-09 combination therapy for the treatment of diabetes and related conditions and for the treatment of improved conditions by increasing the level of glp-1 in the blood
ES06717678T ES2327268T5 (en) 2005-01-10 2006-01-09 GLP-1 secretagogue identification method
AU2006205164A AU2006205164B2 (en) 2005-01-10 2006-01-09 Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level
KR1020137032119A KR20130140226A (en) 2005-01-10 2006-01-09 Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood glp-1 level
AT06717678T ATE431139T1 (en) 2005-01-10 2006-01-09 METHOD FOR IDENTIFYING GLP-1 SECRETION PROMOTERS
IL184364A IL184364A0 (en) 2005-01-10 2007-07-02 Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood glp-1 level
NO20073816A NO331089B1 (en) 2005-01-10 2007-07-20 A composition comprising a GPR119 agonist and a DPP-IV inhibitor as well as a method for preparing them.
AU2009202898A AU2009202898B2 (en) 2005-01-10 2009-07-17 Method of identifying GLP-1 secretagogues
AU2009202900A AU2009202900B8 (en) 2005-01-10 2009-07-17 Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level
NO20101746A NO20101746L (en) 2005-01-10 2010-12-09 Combination therapy for the treatment of diabetes and related conditions and for the treatment of conditions that are relieved by increasing the blood GLP-1 level

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US64308605P 2005-01-10 2005-01-10
US60/643,086 2005-01-10
US68317205P 2005-05-19 2005-05-19
US60/683,172 2005-05-19
US72688005P 2005-10-14 2005-10-14
US60/726,880 2005-10-14

Publications (3)

Publication Number Publication Date
WO2006076231A2 WO2006076231A2 (en) 2006-07-20
WO2006076231A8 WO2006076231A8 (en) 2006-09-21
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