WO2006083630A3 - Diiodomethyl-p-tolylsulfone as a particulate dispersion in a liquid solvent in combination with an anti-dandruff active - Google Patents

Diiodomethyl-p-tolylsulfone as a particulate dispersion in a liquid solvent in combination with an anti-dandruff active Download PDF

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Publication number
WO2006083630A3
WO2006083630A3 PCT/US2006/002493 US2006002493W WO2006083630A3 WO 2006083630 A3 WO2006083630 A3 WO 2006083630A3 US 2006002493 W US2006002493 W US 2006002493W WO 2006083630 A3 WO2006083630 A3 WO 2006083630A3
Authority
WO
WIPO (PCT)
Prior art keywords
tolylsulfone
diiodomethyl
combination
liquid solvent
particulate dispersion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/002493
Other languages
French (fr)
Other versions
WO2006083630A2 (en
Inventor
James Robert Schwartz
David Thomas Warnke
David Joseph Kaufman
Gregory V Tormos
Theodore Jay Verbrugge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Priority to JP2007553174A priority Critical patent/JP2008528591A/en
Priority to MX2007008906A priority patent/MX2007008906A/en
Priority to CA002595214A priority patent/CA2595214A1/en
Priority to AT06719380T priority patent/ATE447394T1/en
Priority to DE602006010182T priority patent/DE602006010182D1/en
Priority to AU2006211444A priority patent/AU2006211444A1/en
Priority to BRPI0606876-6A priority patent/BRPI0606876A2/en
Priority to EP06719380A priority patent/EP1855645B1/en
Publication of WO2006083630A2 publication Critical patent/WO2006083630A2/en
Publication of WO2006083630A3 publication Critical patent/WO2006083630A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/32—Manganese; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4933—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having sulfur as an exocyclic substituent, e.g. pyridinethione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a composition comprising an effective amount of diiodomethyl-p-tolylsulfone wherein the diiodomethyl-p-tolylsulfone is present as a particulate dispersion, an effective amount of a surfactant, and an effective amount of an antidandruff active.
PCT/US2006/002493 2005-01-28 2006-01-25 Diiodomethyl-p-tolylsulfone as a particulate dispersion in a liquid solvent in combination with an anti-dandruff active Ceased WO2006083630A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2007553174A JP2008528591A (en) 2005-01-28 2006-01-25 Diiodomethyl-p-tolylsulfone as dispersed particles present with anti-dandruff active substance in liquid solvent
MX2007008906A MX2007008906A (en) 2005-01-28 2006-01-25 DIYODOMETIL-P-TOLILSULFONA AS A PARTICULATED DISPERSION IN A LIQUID SOLVENT IN COMBINATION WITH AN ANTI-SPORTS ASSET.
CA002595214A CA2595214A1 (en) 2005-01-28 2006-01-25 Diiodomethyl-p-tolylsulfone as a particulate dispersion in a liquid solvent in combination with an anti-dandruff active
AT06719380T ATE447394T1 (en) 2005-01-28 2006-01-25 DIIODOMETHYL-P-TOLYLSULFONE AS A PARTICLE DISPERSION IN A LIQUID SOLVENT IN COMBINATION WITH AN ACTIVE AGENT AGAINST SKIN DANDRUFF
DE602006010182T DE602006010182D1 (en) 2005-01-28 2006-01-25 DIIODOMETHYL-P-TOLYLSULPHONE AS PARTICLE DISPERSION IN A LIQUID SOLVENT IN COMBINATION WITH AN ACTIVE AGGREGATE AGAINST SKIN
AU2006211444A AU2006211444A1 (en) 2005-01-28 2006-01-25 Diiodomethyl-p-tolylsulfone as a particulate dispersion in a liquid solvent in combination with an anti-dandruff active
BRPI0606876-6A BRPI0606876A2 (en) 2005-01-28 2006-01-25 diiodomethyl p-tolyl sulfone as a particulate dispersion in a liquid solvent in combination with an anti-dandruff active
EP06719380A EP1855645B1 (en) 2005-01-28 2006-01-25 Diiodomethyl-p-tolylsulfone as a particulate dispersion in a liquid solvent in combination with an anti-dandruff active

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64823905P 2005-01-28 2005-01-28
US60/648,239 2005-01-28

Publications (2)

Publication Number Publication Date
WO2006083630A2 WO2006083630A2 (en) 2006-08-10
WO2006083630A3 true WO2006083630A3 (en) 2006-11-30

Family

ID=36493251

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/002493 Ceased WO2006083630A2 (en) 2005-01-28 2006-01-25 Diiodomethyl-p-tolylsulfone as a particulate dispersion in a liquid solvent in combination with an anti-dandruff active

Country Status (11)

Country Link
US (1) US20060171911A1 (en)
EP (1) EP1855645B1 (en)
JP (1) JP2008528591A (en)
CN (1) CN101111220A (en)
AT (1) ATE447394T1 (en)
AU (1) AU2006211444A1 (en)
BR (1) BRPI0606876A2 (en)
CA (1) CA2595214A1 (en)
DE (1) DE602006010182D1 (en)
MX (1) MX2007008906A (en)
WO (1) WO2006083630A2 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1923043A1 (en) * 2006-11-16 2008-05-21 KPSS-Kao Professional Salon Services GmbH Anti-dandruff conditioner composition
FR2943914A1 (en) * 2009-04-06 2010-10-08 Fabre Pierre Dermo Cosmetique MOISTURE BOTTLE COMPRISING A PHARMACEUTICAL COMPOSITION
WO2010149424A1 (en) * 2009-06-24 2010-12-29 Unilever Plc Antidandruff shampoo based on a gel network
JP5562592B2 (en) * 2009-07-31 2014-07-30 持田製薬株式会社 Hair cosmetics containing azole antifungal agents
JP5697318B2 (en) * 2009-07-31 2015-04-08 持田製薬株式会社 Hair cosmetics containing azole antifungal agents
US8420054B2 (en) * 2009-09-18 2013-04-16 The Procter & Gamble Company Noninvasive method for measuring histamine from skin as an objective measurement of itch
DE102011000048A1 (en) * 2011-01-06 2012-07-12 Hans-Jürgen Arndt Agent for the topical treatment of skin diseases
EP2712292B1 (en) 2011-07-01 2018-04-25 Rohm and Haas Company Microbicide combinations containing silver
EP2793833B1 (en) * 2011-12-20 2020-06-24 Vyome Therapeutics Limited Topical oil composition for the treatment of fungal infections
CA2901658A1 (en) * 2013-03-14 2014-09-18 The Procter & Gamble Company Bar soap compositions containing zinc pyrithione and a zinc-pyridine oxide complex
EP3134064B1 (en) * 2014-04-24 2022-04-13 The Procter & Gamble Company Scalp care composition
US11291616B2 (en) * 2015-04-23 2022-04-05 The Procter And Gamble Company Delivery of surfactant soluble anti-dandruff agent
JP6770339B2 (en) * 2015-08-11 2020-10-14 株式会社コーセー Miconazole nitrate-containing composition
CN108697599B (en) 2016-03-24 2024-09-17 宝洁公司 Hair care compositions comprising malodor reducing compositions
JP6974928B2 (en) 2017-10-10 2021-12-01 ザ プロクター アンド ギャンブル カンパニーThe Procter & Gamble Company Compact shampoo composition
JP7132356B2 (en) * 2018-05-15 2022-09-06 ザ プロクター アンド ギャンブル カンパニー Synergistic antioxidant composition
US12226505B2 (en) 2018-10-25 2025-02-18 The Procter & Gamble Company Compositions having enhanced deposition of surfactant-soluble anti-dandruff agents
JP7473637B2 (en) 2019-10-24 2024-04-23 ザ プロクター アンド ギャンブル カンパニー Optimizing preservative concentrations in personal care compositions
WO2021081557A1 (en) * 2019-10-24 2021-04-29 The Procter & Gamble Company Personal care composition preservatives level optimization
WO2021113583A1 (en) 2019-12-06 2021-06-10 The Procter & Gamble Company Sulfate free composition with enhanced deposition of scalp active
WO2021127318A1 (en) 2019-12-19 2021-06-24 The Procter & Gamble Company Transparent composition with soluble scalp health active
MX2022008755A (en) * 2020-01-15 2022-07-27 Unilever Ip Holdings B V COMPOSITION FOR HAIR CARE.
JP7826209B2 (en) * 2020-01-17 2026-03-09 ユニリーバー・アイピー・ホールディングス・ベスローテン・ヴェンノーツハップ Hair Treatment Composition
WO2021173203A1 (en) 2020-02-27 2021-09-02 The Procter & Gamble Company Anti-dandruff compositions with sulfur having enhanced efficacy and aesthetics
WO2022109094A1 (en) 2020-11-23 2022-05-27 The Procter & Gamble Company Personal care compositions free of sulfated surfactants
JP7768985B2 (en) 2020-12-04 2025-11-12 ザ プロクター アンド ギャンブル カンパニー Hair care compositions containing malodor-reducing substances
US12409125B2 (en) 2021-05-14 2025-09-09 The Procter & Gamble Company Shampoo compositions containing a sulfate-free surfactant system and sclerotium gum thickener
US11986543B2 (en) 2021-06-01 2024-05-21 The Procter & Gamble Company Rinse-off compositions with a surfactant system that is substantially free of sulfate-based surfactants
US12083210B2 (en) 2021-06-15 2024-09-10 The Procter & Gamble Company Multi-function hair care composition
CA3235522A1 (en) 2021-12-09 2023-06-15 The Procter & Gamble Company Sulfate free personal cleansing composition comprising effective preservation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3806351A (en) * 1973-02-07 1974-04-23 H Bromberg Pigment dispersion composition
KR0141416B1 (en) * 1994-11-08 1998-06-01 성재갑 Hair cosmetic compositions
US20030096545A1 (en) * 2001-11-21 2003-05-22 Payne Stephen A. Antimicrobial, sporicidal composition and treated products thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4185120A (en) * 1978-10-02 1980-01-22 Abbott Laboratories Topical treatment of fungal or yeast infections using p-tolyl diiodomethyl sulfone
US5081134A (en) * 1991-03-25 1992-01-14 Betz Laboratories, Inc. Biocidal compositions and use thereof containing a synergistic mixture of diiodomethyl-p-tolylsulfone and sodium 2-pyridinethiol-1-oxide
US5089484A (en) * 1991-04-10 1992-02-18 Betz Laboratories, Inc. Biocidal compositions and use thereof containing a synergistic mixture of diiodomethyl-p-tolylsulfone and n-tributyl tetradecyl phosphonium chloride
US5118713A (en) * 1991-06-21 1992-06-02 Betz Laboratories, Inc. Biocidal compositions and use thereof containing a synergistic mixture of diiodomethyl-p-tolysulfone and 2-bromo-2-nitropropane-1,3-diol
JPH06183914A (en) * 1992-12-16 1994-07-05 Permachem Asia Ltd Industrial sterilization composition
US5292776A (en) * 1993-03-26 1994-03-08 Betz Laboratories, Inc. Microbial inhibiting compositions and their use
JPH0717809A (en) * 1993-07-05 1995-01-20 Shinto Paint Co Ltd Industrial mildewproofing composition
JPH0717812A (en) * 1993-07-05 1995-01-20 Shinto Paint Co Ltd Industrial mildewproofing composition
US5352706A (en) * 1993-07-22 1994-10-04 Betz Laboratories, Inc. Method and composition for controlling the growth of microorganisms
US5624666A (en) * 1995-01-20 1997-04-29 The Procter & Gamble Company Anti-dandruff shampoos with particulate active agent and cationic polymer
JPH11279139A (en) * 1998-03-27 1999-10-12 San Apro Kk Inclusion compound of diiodomethyl-p-tolylsulfone and cyclodextrin derivative and preservative comprising the same
AU5884600A (en) * 1999-06-25 2001-01-31 Arch Chemicals, Inc. Topical anti-microbial compositions
JP2003522734A (en) * 1999-06-25 2003-07-29 アーチ ケミカルズ,インコーポレイテッド Pyrithione biocides enhanced by silver, copper, or zinc ions
US8491877B2 (en) * 2003-03-18 2013-07-23 The Procter & Gamble Company Composition comprising zinc-containing layered material with a high relative zinc lability
WO2006066204A1 (en) * 2004-12-17 2006-06-22 Dow Global Technologies, Inc. Use of water-soluble polymers to improve stability of diiodomethyl-para-tolylsulfone in complex matrices

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3806351A (en) * 1973-02-07 1974-04-23 H Bromberg Pigment dispersion composition
KR0141416B1 (en) * 1994-11-08 1998-06-01 성재갑 Hair cosmetic compositions
US20030096545A1 (en) * 2001-11-21 2003-05-22 Payne Stephen A. Antimicrobial, sporicidal composition and treated products thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KIM, CHANG-DUK ET AL: "Hair cosmetic compositions", XP002398529, retrieved from STN Database accession no. 2004:150147 *

Also Published As

Publication number Publication date
CN101111220A (en) 2008-01-23
DE602006010182D1 (en) 2009-12-17
EP1855645B1 (en) 2009-11-04
US20060171911A1 (en) 2006-08-03
WO2006083630A2 (en) 2006-08-10
BRPI0606876A2 (en) 2009-07-21
AU2006211444A1 (en) 2006-08-10
MX2007008906A (en) 2007-12-07
JP2008528591A (en) 2008-07-31
EP1855645A2 (en) 2007-11-21
CA2595214A1 (en) 2006-08-10
ATE447394T1 (en) 2009-11-15

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