WO2006084130A3 - Ultra-sensitive detection systems using multidimension signals - Google Patents

Ultra-sensitive detection systems using multidimension signals Download PDF

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Publication number
WO2006084130A3
WO2006084130A3 PCT/US2006/003842 US2006003842W WO2006084130A3 WO 2006084130 A3 WO2006084130 A3 WO 2006084130A3 US 2006003842 W US2006003842 W US 2006003842W WO 2006084130 A3 WO2006084130 A3 WO 2006084130A3
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WO
WIPO (PCT)
Prior art keywords
analysis
isobaric
multidimension signals
level
sensitive detection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/003842
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French (fr)
Other versions
WO2006084130A2 (en
WO2006084130A9 (en
Inventor
Cesar E Guerra
Darin R Latimer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Revvity Health Sciences Inc
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PerkinElmer LAS Inc
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Filing date
Publication date
Application filed by PerkinElmer LAS Inc filed Critical PerkinElmer LAS Inc
Priority to CA002596117A priority Critical patent/CA2596117A1/en
Priority to EP06734290A priority patent/EP1851551A2/en
Priority to AU2006210551A priority patent/AU2006210551A1/en
Priority to JP2007554240A priority patent/JP2008529035A/en
Publication of WO2006084130A2 publication Critical patent/WO2006084130A2/en
Publication of WO2006084130A9 publication Critical patent/WO2006084130A9/en
Publication of WO2006084130A3 publication Critical patent/WO2006084130A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Genetics & Genomics (AREA)
  • Optics & Photonics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

Disclosed are compositions and methods for sensitive detection of one or multiple analytes. In general, the methods involve the use of special label components, referred to as multidimension signals. In the disclosed methods, analysis of multidimension signals can result in one or more predetermined patterns that serve to indicate whether a further level of analysis can or should be performed and/or which portion(s) of the analyzed material can or should be analyzed in a further level of analysis. In some forms, isobaric and non-isobaric elements can be used together in the same assay or assay system. Isobaric and non-isobaric multidimension signals used together can generate one or more predetermined patterns during analysis. The pattern generated in this first level of analysis indicates whether the second level of analysis should be performed. The second level of analysis can involve distinguishing the isobaric multidimension signals.
PCT/US2006/003842 2005-02-03 2006-02-01 Ultra-sensitive detection systems using multidimension signals Ceased WO2006084130A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002596117A CA2596117A1 (en) 2005-02-03 2006-02-01 Ultra-sensitive detection systems using multidimension signals
EP06734290A EP1851551A2 (en) 2005-02-03 2006-02-01 Ultra-sensitive detection systems using multidimension signals
AU2006210551A AU2006210551A1 (en) 2005-02-03 2006-02-01 Ultra-sensitive detection systems using multidimension signals
JP2007554240A JP2008529035A (en) 2005-02-03 2006-02-01 Ultra-sensitive detection system using multidimensional signals

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64989705P 2005-02-03 2005-02-03
US60/649,897 2005-02-03

Publications (3)

Publication Number Publication Date
WO2006084130A2 WO2006084130A2 (en) 2006-08-10
WO2006084130A9 WO2006084130A9 (en) 2006-10-19
WO2006084130A3 true WO2006084130A3 (en) 2006-12-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/003842 Ceased WO2006084130A2 (en) 2005-02-03 2006-02-01 Ultra-sensitive detection systems using multidimension signals

Country Status (6)

Country Link
US (1) US20070207555A1 (en)
EP (1) EP1851551A2 (en)
JP (1) JP2008529035A (en)
AU (1) AU2006210551A1 (en)
CA (1) CA2596117A1 (en)
WO (1) WO2006084130A2 (en)

Cited By (3)

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CN102077092A (en) * 2008-05-23 2011-05-25 电泳有限公司 Mass spectrometric analysis
US10145818B2 (en) 2012-10-22 2018-12-04 President And Fellows Of Harvard College Accurate and interference-free multiplexed quantitative proteomics using mass spectrometry
US11085927B2 (en) 2016-06-03 2021-08-10 President And Fellows Of Harvard College Techniques for high throughput targeted proteomic analysis and related systems and methods

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WO2015128723A1 (en) * 2014-02-28 2015-09-03 Dh Technologies Development Pte. Ltd. Microbial identification and quantitation using ms cleavable tags
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102077092A (en) * 2008-05-23 2011-05-25 电泳有限公司 Mass spectrometric analysis
CN102077092B (en) * 2008-05-23 2014-10-29 电泳有限公司 mass spectrometric analysis
US10145818B2 (en) 2012-10-22 2018-12-04 President And Fellows Of Harvard College Accurate and interference-free multiplexed quantitative proteomics using mass spectrometry
US11085927B2 (en) 2016-06-03 2021-08-10 President And Fellows Of Harvard College Techniques for high throughput targeted proteomic analysis and related systems and methods

Also Published As

Publication number Publication date
EP1851551A2 (en) 2007-11-07
WO2006084130A2 (en) 2006-08-10
JP2008529035A (en) 2008-07-31
WO2006084130A9 (en) 2006-10-19
AU2006210551A1 (en) 2006-08-10
US20070207555A1 (en) 2007-09-06
CA2596117A1 (en) 2006-08-10

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