WO2006084272A3 - Methods of predicting chemotherapy responsiveness in breast cancer patients - Google Patents

Methods of predicting chemotherapy responsiveness in breast cancer patients Download PDF

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Publication number
WO2006084272A3
WO2006084272A3 PCT/US2006/004280 US2006004280W WO2006084272A3 WO 2006084272 A3 WO2006084272 A3 WO 2006084272A3 US 2006004280 W US2006004280 W US 2006004280W WO 2006084272 A3 WO2006084272 A3 WO 2006084272A3
Authority
WO
WIPO (PCT)
Prior art keywords
patient
breast cancer
methods
cancer patients
predicting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/004280
Other languages
French (fr)
Other versions
WO2006084272A9 (en
WO2006084272A2 (en
Inventor
Hongyue Dai
Stephen H Friend
Paul Deutsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rosetta Inpharmatics LLC
Merck and Co Inc
Original Assignee
Rosetta Inpharmatics LLC
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rosetta Inpharmatics LLC, Merck and Co Inc filed Critical Rosetta Inpharmatics LLC
Priority to CA002596640A priority Critical patent/CA2596640A1/en
Priority to EP06720440A priority patent/EP1848825A2/en
Priority to JP2007554325A priority patent/JP2008536094A/en
Publication of WO2006084272A2 publication Critical patent/WO2006084272A2/en
Anticipated expiration legal-status Critical
Publication of WO2006084272A9 publication Critical patent/WO2006084272A9/en
Publication of WO2006084272A3 publication Critical patent/WO2006084272A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides a method of predicting the responsiveness of a breast cancer patient to chemotherapy based on the patient's cellular constituent profile comprising measurements of a plurality of cellular constituents in a sample derived from the patient, the patient's estrogen receptor level, and the patient's estrogen receptor level relative to the patient's age. The invention also provides a method for selecting patients for enrollment in a clinical trial of a drug for treating breast cancer based on these factors.
PCT/US2006/004280 2005-02-04 2006-02-06 Methods of predicting chemotherapy responsiveness in breast cancer patients Ceased WO2006084272A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002596640A CA2596640A1 (en) 2005-02-04 2006-02-06 Methods of predicting chemotherapy responsiveness in breast cancer patients
EP06720440A EP1848825A2 (en) 2005-02-04 2006-02-06 Methods of predicting chemotherapy responsiveness in breast cancer patients
JP2007554325A JP2008536094A (en) 2005-02-04 2006-02-06 Methods for predicting chemotherapy responsiveness in breast cancer patients

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65036505P 2005-02-04 2005-02-04
US60/650,365 2005-02-04

Publications (3)

Publication Number Publication Date
WO2006084272A2 WO2006084272A2 (en) 2006-08-10
WO2006084272A9 WO2006084272A9 (en) 2007-10-04
WO2006084272A3 true WO2006084272A3 (en) 2008-08-28

Family

ID=36778033

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/004280 Ceased WO2006084272A2 (en) 2005-02-04 2006-02-06 Methods of predicting chemotherapy responsiveness in breast cancer patients

Country Status (4)

Country Link
EP (1) EP1848825A2 (en)
JP (1) JP2008536094A (en)
CA (1) CA2596640A1 (en)
WO (1) WO2006084272A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1410011E (en) 2001-06-18 2011-07-25 Rosetta Inpharmatics Llc DIAGNOSIS AND PROGNOSIS OF PATIENTS WITH BREAST CANCER
EP1730308A4 (en) 2004-03-05 2008-10-08 Rosetta Inpharmatics Llc Classification of breast cancer patients using a combination of clinical criteria and informative genesets
CN101484806A (en) 2006-05-17 2009-07-15 协乐民公司 Method for automated tissue analysis
WO2008011046A2 (en) 2006-07-17 2008-01-24 The H.Lee Moffitt Cancer And Research Institute, Inc. Computer systems and methods for selecting subjects for clinical trials
EP3135773A1 (en) * 2006-09-27 2017-03-01 Sividon Diagnostics GmbH Methods for breast cancer prognosis
EP2162459B1 (en) 2007-05-01 2017-10-04 University of Miami Transcriptomic biomarkers for individual risk assessment in new onset heart failure
WO2009095319A1 (en) * 2008-01-28 2009-08-06 Siemens Healthcare Diagnostics Gmbh Cancer prognosis by majority voting
JP5425814B2 (en) * 2008-02-08 2014-02-26 ヘルス ディスカバリー コーポレイション Method and system for analyzing flow cytometry data using a support vector machine
WO2010118782A1 (en) * 2009-04-17 2010-10-21 Universite Libre De Bruxelles Methods and tools for predicting the efficiency of anthracyclines in cancer
US20120142544A1 (en) 2009-06-02 2012-06-07 University Of Miami Diagnostic transcriptomic biomarkers in inflammatory cardiomyopathies
EP2553118B1 (en) 2010-03-31 2014-10-15 Sividon Diagnostics GmbH Method for breast cancer recurrence prediction under endocrine treatment
EP2589665A4 (en) 2010-06-29 2013-11-20 Univ Kurume METHOD FOR PREDICTING THE THERAPEUTIC EFFECT OF IMMUNOTHERAPY ON CANCER PATIENT, AND SET OF GENES AND KIT FOR USE IN THE METHOD
JP5854346B2 (en) * 2010-07-21 2016-02-09 公立大学法人秋田県立大学 Transcriptome analysis method, disease determination method, computer program, storage medium, and analysis apparatus
ES2739623T3 (en) 2011-03-17 2020-02-03 Cernostics Inc Systems and compositions for diagnosing Barrett's esophagus and methods for using them
WO2012135845A1 (en) 2011-04-01 2012-10-04 Qiagen Gene expression signature for wnt/b-catenin signaling pathway and use thereof
US20140255954A1 (en) * 2011-10-24 2014-09-11 Atossa Genetics, Inc. Method of breast cancer detection
US20150376714A1 (en) 2013-02-01 2015-12-31 Sividon Diagnostics Gmbh Method for predicting the benefit from inclusion of taxane in a chemotherapy regimen in patients with breast cancer
US20150269355A1 (en) * 2014-03-19 2015-09-24 Peach Intellihealth, Inc. Managing allocation of health-related expertise and resources
EP3679160A4 (en) 2017-09-08 2021-05-19 Myriad Genetics, Inc. METHOD OF USING BIOMARKERS AND CLINICAL VARIABLES TO PREDICT THE INTEREST OF CHEMOTHERAPY
US20200372636A1 (en) * 2017-11-22 2020-11-26 The Trustees Of Columbia University In The City Of New York System method and computer-accessible medium for determining breast cancer response using a convolutional neural network
CN119614707A (en) * 2025-01-13 2025-03-14 中山大学 ER alpha biomarkers in ER+Application of breast cancer bone metastasis diagnosis, treatment and prognosis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BRAMBILLA ET AL., BR. MED. J., vol. 1, no. 6013, April 1976 (1976-04-01), pages 801 - 804 *
MAGGARD ET AL., JOURNAL OF SURGICAL RESEARCH, vol. 113, 2003, pages 109 - 113 *
SORLIE T. ET AL.: "Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications", PNAS, vol. 98, no. 19, 11 September 2001 (2001-09-11), pages 10869 - 10874, XP002215483 *

Also Published As

Publication number Publication date
WO2006084272A9 (en) 2007-10-04
CA2596640A1 (en) 2006-08-10
EP1848825A2 (en) 2007-10-31
WO2006084272A2 (en) 2006-08-10
JP2008536094A (en) 2008-09-04

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