WO2006085302A2 - Composition for treatment of skin disorders - Google Patents

Composition for treatment of skin disorders Download PDF

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Publication number
WO2006085302A2
WO2006085302A2 PCT/IL2006/000144 IL2006000144W WO2006085302A2 WO 2006085302 A2 WO2006085302 A2 WO 2006085302A2 IL 2006000144 W IL2006000144 W IL 2006000144W WO 2006085302 A2 WO2006085302 A2 WO 2006085302A2
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WO
WIPO (PCT)
Prior art keywords
composition
treatment
treating psoriasis
carrier
psoriasis vulgaris
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2006/000144
Other languages
French (fr)
Other versions
WO2006085302A3 (en
Inventor
Zvi Ben Moshe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BMZ DIAGNOSIS (2004) Ltd
Original Assignee
BMZ DIAGNOSIS (2004) Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BMZ DIAGNOSIS (2004) Ltd filed Critical BMZ DIAGNOSIS (2004) Ltd
Priority to EP06711135A priority Critical patent/EP1853286A2/en
Priority to US11/815,772 priority patent/US20100129477A1/en
Publication of WO2006085302A2 publication Critical patent/WO2006085302A2/en
Publication of WO2006085302A3 publication Critical patent/WO2006085302A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/33—Cactaceae (Cactus family), e.g. pricklypear or Cereus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics

Definitions

  • the present invention is in the field of skin care.
  • the composition of the invention is preferably used for treating skin predicaments.
  • Psoriasis is a relatively common chronic disease associated with inflammation of the skin, causing also enhanced shedding of the skin. Psoriasis is not passed from person to person but is probably genetically linked. Although psoriasis is incurable, it can be managed to varying degrees by applying one or more treatment schemes.
  • Topical treatments include, among others, the application of emollients, vitamin D or derivatives thereof (calcipotriol), and cortisone. Cortisone may also be injected in specific locations in which the disease is especially persistent. Another type of topical treatment utilizes retinoids which are related to vitamin A. Such may be applied locally alone or in combination with cortisone.
  • Systemic treatments used for psoriasis are drugs that affect the whole body. For example cyclosporine that is used in cases of widespread psoriasis. This treatment is potentially harmful and must be monitored carefully.
  • Phototherapy is a method of treatment exploiting light. Especially UV light at various wavelengths and combination thereof is used.
  • compositions for treating dermatological disorders are prepared, containing several active components.
  • the application of the preparations in accordance with the embodiments of the invention to skin of patients provide a relief to symptoms of psoriasis to some extent.
  • a principal component of the composition of invention is vitamin C, also known in its chemical name L-ascorbic acid.
  • the plain acid is used as a component, as well as salts thereof, typically sodium and calcium ascorbate.
  • Two more components are mixed together with the vitamin C in a basic preparation of the invention.
  • One is tartaric acid, and the other one is vinegar.
  • Vinegar is a fermentation product of plant extracts, juices or starch, containing dilute acetic acid and some other organic acids.
  • a typical preparation in accordance with an embodiment of the invention contains also a carrier.
  • a preferred carrier used is glycerine.
  • Water is used as a common solvent, for solubilising and help mixing all the ingredients homogeneously together.
  • a formula of the fundamental preparation of the invention is given in Table 1 , in weight per weight percentages.
  • a preparation type referred to hereinafter as advanced preparation For obtaining a more potent and a faster reacting preparation, several more components are added, to form a preparation type referred to hereinafter as advanced preparation.
  • the additional components are classified as follows: plant extracts and vitamin B2 (riboflavin).
  • the plant extracts used in an advanced preparation are lemon juice, extracts of Taraxacum officinale (dandelion), Opuntia coccinellifera (a cactus) fruit extract, Cereus grandiflorus (a cactus) young stems and flowers extract.
  • a full description of the advanced preparation in weight per weight percentages is in given in Table 2.
  • the preparations of the invention can be used as paste or ointment, ng to the skin of the patient.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A preparation for treating psoriasis vulgaris containing ascorbic acids and salts thereof, tartaric acid and vinegar, water and a carrier. A more potent preparation contains in addition vitamin B2 and several plant extracts.

Description

COMPOSITION FOR TREATMENT OF SKIN DISORDERS
FIELD OF THE INVENTION
The present invention is in the field of skin care. The composition of the invention is preferably used for treating skin predicaments.
BACKGROUND OF THE INVENTION
Psoriasis is a relatively common chronic disease associated with inflammation of the skin, causing also enhanced shedding of the skin. Psoriasis is not passed from person to person but is probably genetically linked. Although psoriasis is incurable, it can be managed to varying degrees by applying one or more treatment schemes.
Treatment methods for psoriasis are diverse. Topical treatments include, among others, the application of emollients, vitamin D or derivatives thereof (calcipotriol), and cortisone. Cortisone may also be injected in specific locations in which the disease is especially persistent. Another type of topical treatment utilizes retinoids which are related to vitamin A. Such may be applied locally alone or in combination with cortisone. Systemic treatments used for psoriasis are drugs that affect the whole body. For example cyclosporine that is used in cases of widespread psoriasis. This treatment is potentially harmful and must be monitored carefully.
Phototherapy is a method of treatment exploiting light. Especially UV light at various wavelengths and combination thereof is used.
DETAILED DESCRIPTION OFTHE PRESENT INVENTION
In accordance with the present invention, compositions for treating dermatological disorders are prepared, containing several active components. The application of the preparations in accordance with the embodiments of the invention to skin of patients provide a relief to symptoms of psoriasis to some extent. A principal component of the composition of invention is vitamin C, also known in its chemical name L-ascorbic acid. The plain acid is used as a component, as well as salts thereof, typically sodium and calcium ascorbate. Two more components are mixed together with the vitamin C in a basic preparation of the invention. One is tartaric acid, and the other one is vinegar. Vinegar is a fermentation product of plant extracts, juices or starch, containing dilute acetic acid and some other organic acids. A typical preparation in accordance with an embodiment of the invention contains also a carrier. A preferred carrier used is glycerine. Water is used as a common solvent, for solubilising and help mixing all the ingredients homogeneously together. A formula of the fundamental preparation of the invention is given in Table 1 , in weight per weight percentages.
Figure imgf000005_0001
Table 1
For obtaining a more potent and a faster reacting preparation, several more components are added, to form a preparation type referred to hereinafter as advanced preparation. The additional components are classified as follows: plant extracts and vitamin B2 (riboflavin). The plant extracts used in an advanced preparation are lemon juice, extracts of Taraxacum officinale (dandelion), Opuntia coccinellifera (a cactus) fruit extract, Cereus grandiflorus (a cactus) young stems and flowers extract. A full description of the advanced preparation in weight per weight percentages is in given in Table 2.
Figure imgf000006_0001
Table 2
The preparations of the invention can be used as paste or ointment, ng to the skin of the patient.

Claims

1. A composition for treating psoriasis vulgaris comprising:
• a mixture of components comprising:
■ ascorbic acid and salts of said acid, at 1 o - 25%;
■ tartaric acid, at 0.2-4%;
■ vinegar, at 1 - 10%; • water, at 30 - 60, and
• a carrier; at 20- 50%, and wherein said composition is used as paste and ointment.
2. A composition for treating psoriasis vulgaris as in claim 1 further comprising:
• vitamin B2, at 0.05 - 0.2%;
• lemon juice, at 0.5 - 4%;
• Cereus grandiflorus extract, at 0.5 - 2%;
• Opuntia cocinellifera extract, at 0.5 - 2%, and • Taraxacum officinale extract, at 1-10%.
3. A composition for treating psoriasis vulgaris as in claim 1 wherein said carrier is glycerine.
4. A composition for treating psoriasis vulgaris as in claim 2 wherein said carrier is glycerine.
PCT/IL2006/000144 2005-02-08 2006-02-06 Composition for treatment of skin disorders Ceased WO2006085302A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP06711135A EP1853286A2 (en) 2005-02-08 2006-02-06 Composition for treatment of skin disorders
US11/815,772 US20100129477A1 (en) 2005-02-08 2006-02-06 Composition for treatment of skin disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65110805P 2005-02-08 2005-02-08
US60/651,108 2005-02-08

Publications (2)

Publication Number Publication Date
WO2006085302A2 true WO2006085302A2 (en) 2006-08-17
WO2006085302A3 WO2006085302A3 (en) 2006-12-14

Family

ID=36793431

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2006/000144 Ceased WO2006085302A2 (en) 2005-02-08 2006-02-06 Composition for treatment of skin disorders

Country Status (3)

Country Link
US (1) US20100129477A1 (en)
EP (1) EP1853286A2 (en)
WO (1) WO2006085302A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101010575B1 (en) 2008-07-16 2011-01-24 장길자 Composition for improving atopic skin disease containing persimmon vinegar

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5789012A (en) * 1986-01-31 1998-08-04 Slimak; Kara M. Products from sweet potatoes, cassava, edible aroids, amaranth, yams, lotus, potatoes and other roots, seeds and fruit
US7585645B2 (en) * 1997-05-27 2009-09-08 Sembiosys Genetics Inc. Thioredoxin and thioredoxin reductase containing oil body based products
WO2001046110A2 (en) * 1999-12-23 2001-06-28 The University Of Georgia Research Foundation, Inc. Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states
US6436948B1 (en) * 2000-03-03 2002-08-20 University Of Georgia Research Foundation Inc. Method for the treatment of psoriasis and genital warts
SG167656A1 (en) * 2001-02-09 2011-01-28 Mickey Miller Composition for the treatment of skin conditions
US20040057958A1 (en) * 2002-05-17 2004-03-25 Waggoner David W. Immunogenicity-enhancing carriers and compositions thereof and methods of using the same
ATE372770T1 (en) * 2002-08-01 2007-09-15 Neurosearch As COMPOUNDS USEFUL IN THE TREATMENT OF DISEASES THAT RESPOND TO ANTI-ANGIOGENIC THERAPY

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101010575B1 (en) 2008-07-16 2011-01-24 장길자 Composition for improving atopic skin disease containing persimmon vinegar

Also Published As

Publication number Publication date
WO2006085302A3 (en) 2006-12-14
EP1853286A2 (en) 2007-11-14
US20100129477A1 (en) 2010-05-27

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