WO2006088385A3 - Bioactive complex of triterpene acids, its production process and medicinal products with therapeutical uses - Google Patents

Bioactive complex of triterpene acids, its production process and medicinal products with therapeutical uses Download PDF

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Publication number
WO2006088385A3
WO2006088385A3 PCT/RO2006/000003 RO2006000003W WO2006088385A3 WO 2006088385 A3 WO2006088385 A3 WO 2006088385A3 RO 2006000003 W RO2006000003 W RO 2006000003W WO 2006088385 A3 WO2006088385 A3 WO 2006088385A3
Authority
WO
WIPO (PCT)
Prior art keywords
triterpene acids
bioactive complex
acids
production process
medicinal products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/RO2006/000003
Other languages
French (fr)
Other versions
WO2006088385A2 (en
Inventor
Liudmila Turcanu
Liliana Manzatu
Gheorghe Taralunga
Lenuta Zglimbea
Maria Tilica
Roxana Andreea Nita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sc Biotehnos Sa
S C Biotehnos S A
Original Assignee
Sc Biotehnos Sa
S C Biotehnos S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sc Biotehnos Sa, S C Biotehnos S A filed Critical Sc Biotehnos Sa
Priority to EP06716833A priority Critical patent/EP1848449A2/en
Publication of WO2006088385A2 publication Critical patent/WO2006088385A2/en
Publication of WO2006088385A3 publication Critical patent/WO2006088385A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention relates to a bioactive complex of triterpene acids, as such or in the form of Na, K, NH4 salts of minimum 90 % purity, with a standardized content formed of: minimum 75 % ursolic acid, 10...15 oleanolic acid and 4...10 % other triterpene acids consisting of one or more of the following acids: hydroxyursolic, hydroxyoleanolic, betulinic, dehydrobetulinic, produced from the plants Salvia sp., Lavandula sp., Sambucus nigra and Crataegus sp. The production process recommends increase of selectivity and efficiencies of extraction, purification and crystallization steps by using structured waters ('I' - acid pH water and 'S' - alkaline pH water) in the composition of solvents used. The bioactive complex of triterpene acids has a marked and diversified pharmacological activity for bioregulating proteinic, glucidic and lipidic metabolism, particularly on aged organisms, as well as immunoprotective, antioxidizing, hepatoprotective, and retarding activity in tumour progression, being conditioned as new medicinal products for internal and/or external use with applicability in human and veterinary therapy.
PCT/RO2006/000003 2005-02-18 2006-02-15 Bioactive complex of triterpene acids, its production process and medicinal products with therapeutical uses Ceased WO2006088385A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06716833A EP1848449A2 (en) 2005-02-18 2006-02-15 Bioactive complex of triterpene acids, its production process and medicinal products with therapeutical uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ROA200500117A RO120950B1 (en) 2005-02-18 2005-02-18 Bioactive complex of triterpene acids, process of preparation, medicinal products with therapeutical applications
ROA200500117 2005-02-18

Publications (2)

Publication Number Publication Date
WO2006088385A2 WO2006088385A2 (en) 2006-08-24
WO2006088385A3 true WO2006088385A3 (en) 2006-12-28

Family

ID=36608522

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RO2006/000003 Ceased WO2006088385A2 (en) 2005-02-18 2006-02-15 Bioactive complex of triterpene acids, its production process and medicinal products with therapeutical uses

Country Status (3)

Country Link
EP (1) EP1848449A2 (en)
RO (1) RO120950B1 (en)
WO (1) WO2006088385A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006020582A1 (en) * 2006-05-03 2007-11-15 Gesellschaft zur Förderung der Krebstherapie e.V. Process for the preparation of a triterpenic acid-containing aqueous solution, triterpenic acid-containing aqueous solution and their use
EP1925302A1 (en) 2006-11-24 2008-05-28 DSMIP Assets B.V. Dietary or pharmaceutical compositions containing tricyclic diterpenes and derivatives thereof for the treatment of depression
EP1925213A1 (en) * 2006-11-24 2008-05-28 DSMIP Assets B.V. Dietary and pharmaceutical compositions comprising a sage extract comprising a mixture of tricyclic diterpenes and their derivatives and their uses
WO2011144639A1 (en) * 2010-05-18 2011-11-24 Bionorica Se Extract of parts of sambucus for use in the treatment of inflammatory processes, intimal hyperplasia and vein graft disease
CN102697901A (en) * 2010-06-23 2012-10-03 天津中医药大学 Fructus crataegi leaf and novel application of extract of fructus crataegi leaf
ITGE20110041A1 (en) * 2011-04-12 2012-10-13 Ct Di Sperimentazione Ed Assist Enza Agricola METHOD OF ACHIEVING CARNOSIC ACID AND TRITERPEN, AS PURE COMPOUNDS OR AS ENRICHED PHYTOCOMPLETES, FROM PLANTS OF THE LAMIACEAE FAMILY
EA026733B1 (en) * 2011-05-12 2017-05-31 Юнилевер Н.В. Skin lightening composition
WO2013021258A1 (en) * 2011-08-05 2013-02-14 Council Of Scientific & Industrial Research Anti-tubercular compounds
PT106278B (en) 2012-04-26 2018-01-03 Raiz Inst De Investigação Da Floresta E Papel METHOD FOR OBTAINING A RICH EXTRACT IN TRITERPENIC ACIDS FROM EUCALYPTUS SHELL
PT106536A (en) * 2012-09-13 2014-03-13 Ecbio Investigaç O E Desenvolvimento Em Biotecnologia S A COMPOSITION OF TRITERPENOID ACID OBTAINED FROM THYMUS MASTICHINE EXTRACT AND ITS MEDICINAL UTILIZATIONS
WO2014071506A1 (en) * 2012-11-09 2014-05-15 Bioniche Life Sciences Inc. Compounds for reducing glucocorticoids, and methods of treatment thereof
TWI535447B (en) * 2013-04-11 2016-06-01 馮文光 Herbal extract that inhibits tumor growth
CN103285112A (en) * 2013-05-23 2013-09-11 山东省中医药研究院 Method for extracting hawthorn triterpene acid from hawthorn
RU2582297C1 (en) * 2014-10-30 2016-04-20 Государственное бюджетное образовательное учреждение высшего профессионального образования "Нижегородская государственная медицинская академия" Министерства Здравоохранения Российской Федерации (ГБОУ ВПО НижГМА Минздрава России) Therapeutic agent possessing hypocholesteremic, hypolipidemic action
CN112409440A (en) * 2021-01-04 2021-02-26 湖南德诺健康管理集团有限公司 Method for producing ursolic acid emulsion by using rosemary ointment as raw material
CN114159406B (en) * 2021-09-15 2022-08-30 山东农业大学 Composite anti-inflammatory nano-particles and preparation method and application thereof
CN114609298B (en) * 2022-03-30 2024-05-10 湖南中医药大学 Method for measuring content of triterpenic acid compounds in poria cocos and application of method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5731620A (en) * 1980-07-30 1982-02-20 Naotake Jiyuunishiyo Candy enabling to give up smoking
CN1439648A (en) * 2003-03-28 2003-09-03 中国医学科学院药用植物研究所 Loquat leaf triterpene acid composition and its uses in preparation of medicine against inflammation and antitussive

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5731620A (en) * 1980-07-30 1982-02-20 Naotake Jiyuunishiyo Candy enabling to give up smoking
CN1439648A (en) * 2003-03-28 2003-09-03 中国医学科学院药用植物研究所 Loquat leaf triterpene acid composition and its uses in preparation of medicine against inflammation and antitussive

Non-Patent Citations (9)

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Title
COSTA V B ET AL: "Anti-inflammatory and analgesic activity of Bouchea fluminensis.", June 2003, FITOTERAPIA, VOL. 74, NR. 4, PAGE(S) 364-371, ISSN: 0367-326X, XP009069234 *
DATABASE WPI Section Ch Week 198213, Derwent World Patents Index; Class B04, AN 1982-25087E, XP002389428 *
DATABASE WPI Section Ch Week 200414, Derwent World Patents Index; Class B04, AN 2004-133431, XP002389427 *
JU J-H ET AL: "Studies on constituents of triterpene acids from Eriobotrya japonica and their anti-inflammatory and antitussive effects", 2003, CHINESE PHARMACEUTICAL JOURNAL 2003 CHINA, VOL. 38, NR. 10, PAGE(S) 752-757, ISSN: 1001-2494, XP009068958 *
LIU J ET AL: "THE EFFECTS OF 10 TRITERPENOID COMPOUNDS ON EXPERIMENTAL LIVER INJURY IN MICE", FUNDAMENTAL AND APPLIED TOXICOLOGY, SOCIETY OF TOXICOLOGY, AKRON, OH, US, vol. 22, no. 1, 1994, pages 34 - 40, XP009069262, ISSN: 0272-0590 *
SETZER WILLIAM N ET AL: "Biologically active triterpenoids of Syncarpia glomulifera bark extract from Paluma, north Queensland, Australia", March 2000, PLANTA MEDICA, VOL. 66, NR. 2, PAGE(S) 176-177, ISSN: 0032-0943, XP009068960 *
SOUSA MENEZES DE F ET AL: "CHEMICAL CONSTITUENTS FROM MARSYPIANTHES CHAMAEDRYS", ANAIS DA ACADEMIA BRASILEIRA DE CINCIAS, ACADEMIA BRASILEIRA DE CINCIAS, RIO DE JANEIRO, BR, vol. 70, no. 4, 1998, pages 761 - 766, XP000929286, ISSN: 0001-3765 *
TANIGUCHI S ET AL: "Production of bioactive triterpenes by Eriobotrya japonica calli", February 2002, PHYTOCHEMISTRY, PERGAMON PRESS, GB, PAGE(S) 315-323, ISSN: 0031-9422, XP004335024 *
URECH K ET AL: "Apoptosis inducing activity of viscin, a lipophilic extract from Viscum album L.", January 2005, JOURNAL OF PHARMACY AND PHARMACOLOGY, VOL. 57, NR. 1, PAGE(S) 101-109, ISSN: 0022-3573, XP009068957 *

Also Published As

Publication number Publication date
RO120950B1 (en) 2006-10-30
WO2006088385A2 (en) 2006-08-24
EP1848449A2 (en) 2007-10-31

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