WO2006096791A3 - Nanofilament scaffold for tissue regeneration - Google Patents

Nanofilament scaffold for tissue regeneration Download PDF

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Publication number
WO2006096791A3
WO2006096791A3 PCT/US2006/008325 US2006008325W WO2006096791A3 WO 2006096791 A3 WO2006096791 A3 WO 2006096791A3 US 2006008325 W US2006008325 W US 2006008325W WO 2006096791 A3 WO2006096791 A3 WO 2006096791A3
Authority
WO
WIPO (PCT)
Prior art keywords
scaffold
tissue regeneration
nanofilament
regeneration
nanofibers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/008325
Other languages
French (fr)
Other versions
WO2006096791A2 (en
Inventor
Ravi V Bellamkonda
Young-Tae Kim
Satish Kumar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgia Tech Research Institute
Georgia Tech Research Corp
Original Assignee
Georgia Tech Research Institute
Georgia Tech Research Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgia Tech Research Institute, Georgia Tech Research Corp filed Critical Georgia Tech Research Institute
Priority to JP2008500893A priority Critical patent/JP2008536539A/en
Priority to AU2006220565A priority patent/AU2006220565A1/en
Priority to US11/817,923 priority patent/US8652215B2/en
Priority to EP06748319A priority patent/EP1855618A2/en
Priority to CA002599946A priority patent/CA2599946A1/en
Publication of WO2006096791A2 publication Critical patent/WO2006096791A2/en
Anticipated expiration legal-status Critical
Publication of WO2006096791A3 publication Critical patent/WO2006096791A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

A scaffold for tissue regeneration is provided. In a preferred embodiment, the scaffold is implantable in a patient in need of nerve or other tissue regeneration and includes a structure which has a plurality of uniaxially oriented nanofibers made of at least one synthetic polymer. Preferably, at least 75 % of the nanofibers are oriented within 20 degrees of the uniaxial orientation. The scaffold beneficially provides directional cues for cell and tissue regeneration, presumably by mimicking the natural strategy using filamentous structures during development and regeneration.
PCT/US2006/008325 2005-03-07 2006-03-07 Nanofilament scaffold for tissue regeneration Ceased WO2006096791A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2008500893A JP2008536539A (en) 2005-03-07 2006-03-07 Nanofilament scaffolds for tissue regeneration
AU2006220565A AU2006220565A1 (en) 2005-03-07 2006-03-07 Nanofilament scaffold for tissue regeneration
US11/817,923 US8652215B2 (en) 2005-03-07 2006-03-07 Nanofilament scaffold for tissue regeneration
EP06748319A EP1855618A2 (en) 2005-03-07 2006-03-07 Nanofilament scaffold for tissue regeneration
CA002599946A CA2599946A1 (en) 2005-03-07 2006-03-07 Nanofilament scaffold for tissue regeneration

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65921805P 2005-03-07 2005-03-07
US60/659,218 2005-03-07

Publications (2)

Publication Number Publication Date
WO2006096791A2 WO2006096791A2 (en) 2006-09-14
WO2006096791A3 true WO2006096791A3 (en) 2008-08-14

Family

ID=36954014

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/008325 Ceased WO2006096791A2 (en) 2005-03-07 2006-03-07 Nanofilament scaffold for tissue regeneration

Country Status (6)

Country Link
US (1) US8652215B2 (en)
EP (1) EP1855618A2 (en)
JP (1) JP2008536539A (en)
AU (1) AU2006220565A1 (en)
CA (1) CA2599946A1 (en)
WO (1) WO2006096791A2 (en)

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