WO2006102063A3 - Prosthetic implants including ecm composite material - Google Patents

Prosthetic implants including ecm composite material Download PDF

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Publication number
WO2006102063A3
WO2006102063A3 PCT/US2006/009685 US2006009685W WO2006102063A3 WO 2006102063 A3 WO2006102063 A3 WO 2006102063A3 US 2006009685 W US2006009685 W US 2006009685W WO 2006102063 A3 WO2006102063 A3 WO 2006102063A3
Authority
WO
WIPO (PCT)
Prior art keywords
extracellular matrix
composite material
prosthetic implants
implants including
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/009685
Other languages
French (fr)
Other versions
WO2006102063A2 (en
Inventor
Michael C Hiles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cook Biotech Inc
Original Assignee
Cook Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cook Biotech Inc filed Critical Cook Biotech Inc
Priority to EP06748418.8A priority Critical patent/EP1863545B1/en
Publication of WO2006102063A2 publication Critical patent/WO2006102063A2/en
Publication of WO2006102063A3 publication Critical patent/WO2006102063A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2475—Venous valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3629—Intestinal tissue, e.g. small intestinal submucosa
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/044—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0066—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements stapled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0075—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Surgery (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Described are preferred prosthetic valve devices including a first extracellular matrix material having a second extracellular matrix material deposited thereon. The preferred materials are made by culturing cells in contact with an extracellular matrix graft material in a fashion to cause the cells to biosynthesize and deposit extracellular matrix components on the material. The cells are then removed to provide the extracellular matrix composite material. In preferred embodiments, the prosthetic valve devices are configured for use in vascular applications.
PCT/US2006/009685 2005-03-19 2006-03-17 Prosthetic implants including ecm composite material Ceased WO2006102063A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06748418.8A EP1863545B1 (en) 2005-03-19 2006-03-17 Prosthetic implants including ECM composite material

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66354905P 2005-03-19 2005-03-19
US60/663,549 2005-03-19

Publications (2)

Publication Number Publication Date
WO2006102063A2 WO2006102063A2 (en) 2006-09-28
WO2006102063A3 true WO2006102063A3 (en) 2007-03-08

Family

ID=37024410

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/009685 Ceased WO2006102063A2 (en) 2005-03-19 2006-03-17 Prosthetic implants including ecm composite material

Country Status (3)

Country Link
US (1) US8454678B2 (en)
EP (1) EP1863545B1 (en)
WO (1) WO2006102063A2 (en)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6254564B1 (en) 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
DE10010073B4 (en) 2000-02-28 2005-12-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anchoring for implantable heart valve prostheses
DE10010074B4 (en) 2000-02-28 2005-04-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Device for fastening and anchoring heart valve prostheses
US8038708B2 (en) 2001-02-05 2011-10-18 Cook Medical Technologies Llc Implantable device with remodelable material and covering material
FR2828263B1 (en) 2001-08-03 2007-05-11 Philipp Bonhoeffer DEVICE FOR IMPLANTATION OF AN IMPLANT AND METHOD FOR IMPLANTATION OF THE DEVICE
AU2004270239C1 (en) * 2003-09-04 2011-07-07 Cook Biotech Incorporated Extracellular matrix composite materials, and manufacture and use thereof
DE102005003632A1 (en) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Catheter for the transvascular implantation of heart valve prostheses
WO2006125055A2 (en) * 2005-05-17 2006-11-23 Cook Incorporated Prosthetic valve devices and methods of making and using such devices
US9072816B2 (en) * 2006-01-18 2015-07-07 Cormatrix Cardiovascular, Inc. Composition for modulating inflammation of cardiovascular tissue
DE102005051849B4 (en) 2005-10-28 2010-01-21 JenaValve Technology Inc., Wilmington Device for implantation and attachment of heart valve prostheses
DE102005052628B4 (en) 2005-11-04 2014-06-05 Jenavalve Technology Inc. Self-expanding, flexible wire mesh with integrated valvular prosthesis for the transvascular heart valve replacement and a system with such a device and a delivery catheter
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US20160082153A1 (en) * 2006-01-18 2016-03-24 Cormatrix Cardiovascular, Inc. Method and System for Treatment of Damaged Biological Tissue
US8092517B2 (en) * 2006-05-25 2012-01-10 Deep Vein Medical, Inc. Device for regulating blood flow
US7811316B2 (en) 2006-05-25 2010-10-12 Deep Vein Medical, Inc. Device for regulating blood flow
US8790414B2 (en) * 2006-11-10 2014-07-29 Cook Biotech Incorporated Graft for hysterotomy closure
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US9138315B2 (en) 2007-04-13 2015-09-22 Jenavalve Technology Gmbh Medical device for treating a heart valve insufficiency or stenosis
CA2683193A1 (en) 2007-05-15 2008-11-20 Jenavalve Technology Inc. Handle for manipulating a catheter tip, catheter system and medical insertion system for inserting a self-expandable heart valve stent
WO2009052207A2 (en) 2007-10-17 2009-04-23 Hancock Jaffe Laboratories Biological valve for venous valve insufficiency
US7806921B2 (en) * 2007-11-08 2010-10-05 Cook Incorporated Monocusp valve design
CA2706855A1 (en) * 2007-11-28 2009-06-04 Organogenesis, Inc. Bioengineered tissue constructs and methods for production and use
US8057532B2 (en) * 2007-11-28 2011-11-15 Cook Medical Technologies Llc Implantable frame and valve design
US8679176B2 (en) 2007-12-18 2014-03-25 Cormatrix Cardiovascular, Inc Prosthetic tissue valve
US8257434B2 (en) 2007-12-18 2012-09-04 Cormatrix Cardiovascular, Inc. Prosthetic tissue valve
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
US8317858B2 (en) 2008-02-26 2012-11-27 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
BR112012021347A2 (en) 2008-02-26 2019-09-24 Jenavalve Tecnology Inc stent for positioning and anchoring a valve prosthesis at an implantation site in a patient's heart
US8398704B2 (en) 2008-02-26 2013-03-19 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US9168130B2 (en) 2008-02-26 2015-10-27 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8465540B2 (en) 2008-02-26 2013-06-18 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis
US8980296B2 (en) 2009-02-18 2015-03-17 Cormatrix Cardiovascular, Inc. Compositions and methods for preventing cardiac arrhythmia
US20100292779A1 (en) 2009-05-15 2010-11-18 Helmut Straubinger Device for compressing a stent and a system as well as a method for loading a stent into a medical delivery system
MX354068B (en) * 2010-01-14 2018-02-09 Organogenesis Inc Bioengineered tissue constructs and methods for producing and using thereof.
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
US11278406B2 (en) 2010-05-20 2022-03-22 Jenavalve Technology, Inc. Catheter system for introducing an expandable heart valve stent into the body of a patient, insertion system with a catheter system and medical device for treatment of a heart valve defect
US10856978B2 (en) 2010-05-20 2020-12-08 Jenavalve Technology, Inc. Catheter system
CA2799459A1 (en) 2010-05-25 2011-12-01 Jenavalve Technology Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
JP6005168B2 (en) 2011-10-21 2016-10-12 イエナバルブ テクノロジー インク Catheter system for introducing an expandable heart valve stent into a patient's body, insertion system equipped with a catheter system, and medical device for treating heart valve defects
EP3281608B1 (en) 2012-02-10 2020-09-16 CVDevices, LLC Medical product comprising a frame and visceral pleura
EP2849678B1 (en) 2012-05-16 2022-08-10 JenaValve Technology, Inc. Catheter delivery system for introducing an expandable heart valve prosthesis and medical device for the treatment of a heart valve defect
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9757106B2 (en) 2012-12-03 2017-09-12 Cook Medical Technologies Llc Degradable expanding closure plug
AU2014214700B2 (en) 2013-02-11 2018-01-18 Cook Medical Technologies Llc Expandable support frame and medical device
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
WO2015028209A1 (en) 2013-08-30 2015-03-05 Jenavalve Technology Gmbh Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
EP2921139B1 (en) * 2014-03-18 2018-11-21 Nvt Ag Heartvalve implant
KR20180029274A (en) * 2014-05-27 2018-03-20 노바헵 아브 Bioengineered allogeneic valve
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
EP4353203B1 (en) 2015-03-20 2026-08-19 JenaValve Technology, Inc. Heart valve prosthesis delivery system
EP3632378B1 (en) 2015-05-01 2024-05-29 JenaValve Technology, Inc. Device with reduced pacemaker rate in heart valve replacement
JP7002451B2 (en) 2015-12-15 2022-01-20 ニオバスク ティアラ インコーポレイテッド Transseptal delivery system
CN108882981B (en) 2016-01-29 2021-08-10 内奥瓦斯克迪亚拉公司 Prosthetic valve for preventing outflow obstruction
WO2017195125A1 (en) 2016-05-13 2017-11-16 Jenavalve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
AU2017361296B2 (en) 2016-11-21 2022-09-29 Neovasc Inc. Methods and systems for rapid retraction of a transcatheter heart valve delivery system
WO2018102826A1 (en) * 2016-12-02 2018-06-07 Vascudyne, Llc Engineered tissue prosthesis
EP3573579B1 (en) 2017-01-27 2023-12-20 JenaValve Technology, Inc. Heart valve mimicry
EP3645068A4 (en) 2017-06-30 2021-04-07 Vascudyne Inc REGENERATIVE AND NATURAL FABRIC IMPLANTS
EP3672530A4 (en) 2017-08-25 2021-04-14 Neovasc Tiara Inc. SEQUENTIAL DEPLOYMENT TRANSCATHETER MITRAL VALVE PROSTHESIS
AU2019374743B2 (en) 2018-11-08 2022-03-03 Neovasc Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
CN113747863B (en) 2019-03-08 2024-11-08 内奥瓦斯克迪亚拉公司 Retrievable Prosthesis Delivery System
AU2020256195B2 (en) 2019-04-01 2022-10-13 Neovasc Inc. Controllably deployable prosthetic valve
US11491006B2 (en) 2019-04-10 2022-11-08 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
CA3282225A1 (en) 2019-05-20 2026-03-02 Neovasc Tiara Inc. Introducer with hemostasis mechanism
JP7520897B2 (en) 2019-06-20 2024-07-23 ニオバスク ティアラ インコーポレイテッド Thin prosthetic mitral valve
EP4135624A1 (en) * 2020-04-17 2023-02-22 Cortronik GmbH Venous valve prosthesis
US11826490B1 (en) 2020-12-29 2023-11-28 Acell, Inc. Extracellular matrix sheet devices with improved mechanical properties and method of making
TWI779450B (en) * 2021-01-04 2022-10-01 國立清華大學 Decellularized extracellular matrix, preparation process and uses thereof
WO2024102411A1 (en) 2022-11-09 2024-05-16 Jenavalve Technology, Inc. Catheter system for sequential deployment of an expandable implant

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995022301A1 (en) * 1994-02-18 1995-08-24 Organogenesis, Inc. Bioremodelable collagen graft prosthesis
WO1996008213A1 (en) * 1994-09-12 1996-03-21 Advanced Tissue Sciences, Inc. Three-dimensional human cell cultures on cardiac valve frameworks and their uses
WO2001003750A1 (en) * 1999-07-09 2001-01-18 Advanced Tissue Sciences, Inc. Human naturally secreted extracellular matrix-coated device
US20010051824A1 (en) * 2000-04-07 2001-12-13 Hopkins Richard A. Cardiac valve replacement
WO2004080352A1 (en) * 2003-03-12 2004-09-23 Cook Incorporated Prosthetic valve that permits retrograde flow
WO2005013857A1 (en) * 2003-08-05 2005-02-17 Cook Incorporated Implantable venous valve

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK229077A (en) * 1977-05-25 1978-11-26 Biocoating Aps HEARTBALL PROSTHET AND PROCEDURE FOR MANUFACTURING IT
US4361552A (en) * 1980-09-26 1982-11-30 Board Of Regents, The University Of Texas System Wound dressing
US4902508A (en) * 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US4956178A (en) * 1988-07-11 1990-09-11 Purdue Research Foundation Tissue graft composition
DK124690D0 (en) * 1990-05-18 1990-05-18 Henning Rud Andersen FAT PROTECTION FOR IMPLEMENTATION IN THE BODY FOR REPLACEMENT OF NATURAL FLEET AND CATS FOR USE IN IMPLEMENTING A SUCH FAT PROTECTION
US5411552A (en) * 1990-05-18 1995-05-02 Andersen; Henning R. Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis
US5156620A (en) * 1991-02-04 1992-10-20 Pigott John P Intraluminal graft/stent and balloon catheter for insertion thereof
US5281422A (en) * 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5275826A (en) * 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US5713950A (en) * 1993-11-01 1998-02-03 Cox; James L. Method of replacing heart valves using flexible tubes
DE69330003T2 (en) * 1993-12-14 2001-10-04 Sante Camilli Percutaneously implantable valve for blood vessels
JPH09512184A (en) * 1994-04-29 1997-12-09 ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティド Improved blood contact surface utilizing endothelium on subendothelial extracellular matrix
JPH09512463A (en) * 1994-04-29 1997-12-16 ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティド Improved blood contact surface utilizing natural subendothelial matrix and method of making and using same
US5716394A (en) * 1994-04-29 1998-02-10 W. L. Gore & Associates, Inc. Blood contact surfaces using extracellular matrix synthesized in vitro
US5695998A (en) * 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US6485723B1 (en) * 1995-02-10 2002-11-26 Purdue Research Foundation Enhanced submucosal tissue graft constructs
US5733337A (en) * 1995-04-07 1998-03-31 Organogenesis, Inc. Tissue repair fabric
US5554389A (en) * 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
AU5564996A (en) * 1995-04-19 1996-11-07 St. Jude Medical Inc. Matrix substrate for a viable body tissue-derived prosthesis and method for making the same
US7611533B2 (en) * 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US5855601A (en) * 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
DE19632945A1 (en) * 1996-08-16 1998-02-19 Bayer Ag Substituted sulfonylamino (thio) carbonyl compounds
KR100650295B1 (en) 1996-08-23 2006-11-28 쿠크 바이오텍, 인코포레이티드 Graft prosthesis, materials and methods
JP2001505807A (en) * 1996-12-10 2001-05-08 パーデュー・リサーチ・ファウンデーション Artificial vascular valve
EP0946186B1 (en) * 1996-12-10 2003-03-26 Purdue Research Foundation Stomach submucosa derived tissue graft
ES2263185T3 (en) * 1996-12-10 2006-12-01 Purdue Research Foundation BIOMATERIAL DERIVED FROM VERPABRADO HEPATIC FABRIC.
NL1004827C2 (en) 1996-12-18 1998-06-19 Surgical Innovations Vof Device for regulating blood circulation.
US5993844A (en) * 1997-05-08 1999-11-30 Organogenesis, Inc. Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix
US6287637B1 (en) * 1997-07-18 2001-09-11 Ramtron International Corporation Multi-layer approach for optimizing ferroelectric film performance
JP2001515706A (en) * 1997-09-11 2001-09-25 パーデュー・リサーチ・ファウンデーション Galactosidase-modified submucosal tissue
WO1999062431A1 (en) 1998-06-02 1999-12-09 Cook Incorporated Multiple-sided intraluminal medical device
US7452371B2 (en) * 1999-06-02 2008-11-18 Cook Incorporated Implantable vascular device
US6110201A (en) * 1999-02-18 2000-08-29 Venpro Bifurcated biological pulmonary valved conduit
US7628803B2 (en) * 2001-02-05 2009-12-08 Cook Incorporated Implantable vascular device
AU771904B2 (en) * 1999-06-22 2004-04-08 Research Development Foundation Enhanced wound coverage to enhance wound healing
US6299637B1 (en) 1999-08-20 2001-10-09 Samuel M. Shaolian Transluminally implantable venous valve
KR100664408B1 (en) 1999-09-10 2007-01-03 엘렌 토르페 패트리샤 Endovascular treatment for chronic venous insufficiency
US6440164B1 (en) * 1999-10-21 2002-08-27 Scimed Life Systems, Inc. Implantable prosthetic valve
JP3261456B2 (en) * 1999-10-29 2002-03-04 独立行政法人産業技術総合研究所 Cell culture carrier and method for culturing cells using the carrier
KR100880550B1 (en) * 2000-01-31 2009-01-30 쿠크 바이오텍, 인코포레이티드 Valve instruments and heart valve instruments
ES2236204T3 (en) * 2000-03-03 2005-07-16 Cook Incorporated BULBIFORM AND STENT VALVE FOR THE TREATMENT OF VASCULAR REFLUX.
US6599526B2 (en) * 2000-08-18 2003-07-29 The University Of North Texas Health Science Center At Fort Worth Pericardial anti-adhesion patch
EP1320390A2 (en) * 2000-09-18 2003-06-25 Organogenesis Inc. Bioengineered flat sheet graft prosthesis and its use
IL139708A0 (en) 2000-11-15 2002-02-10 Amiel Gilad Process of decellularizing biological matrices and acellular biological matrices useful in tissue engineering
US6585761B2 (en) * 2001-03-01 2003-07-01 Syde A. Taheri Prosthetic vein valve and method
AU2002254758A1 (en) 2001-04-30 2002-11-11 Francisco J. Osse Replacement venous valve
US7029689B2 (en) * 2001-05-10 2006-04-18 Georgia Tech Research Corporation Tubular construct for implantation
KR100393548B1 (en) * 2001-06-05 2003-08-02 주식회사 엠아이텍 Stent
WO2003002165A1 (en) 2001-06-28 2003-01-09 Cook Biotech Incorporated Graft prosthesis devices containing renal capsule collagen
WO2003070124A2 (en) 2002-02-20 2003-08-28 Osse Francisco J Venous bi-valve
US6716241B2 (en) * 2002-03-05 2004-04-06 John G. Wilder Venous valve and graft combination
US6752828B2 (en) * 2002-04-03 2004-06-22 Scimed Life Systems, Inc. Artificial valve
EP1503652A4 (en) 2002-05-02 2006-02-08 Purdue Research Foundation VASCULARIZED REINFORCED PROSTHESIS CONSTRUCTS
ATE536148T1 (en) * 2002-06-28 2011-12-15 Cook Medical Technologies Llc THORAX INSERTION INSTRUMENT
EP2601910B1 (en) * 2002-08-15 2018-09-19 Cook Medical Technologies LLC Implantable vascular device
US7175652B2 (en) * 2002-08-20 2007-02-13 Cook Incorporated Stent graft with improved proximal end
AU2002951147A0 (en) * 2002-09-02 2002-09-19 Cook Incorporated Branch grafting device and method
WO2004047687A1 (en) * 2002-11-22 2004-06-10 Cook Incorporated Stent tissue graft prosthesis
AU2003293269B2 (en) * 2002-12-04 2008-02-21 Cook Incorporated Method and device for treating aortic dissection
WO2004096100A1 (en) * 2003-04-24 2004-11-11 Cook Incorporated Artificial valve prosthesis with improved flow dynamics
AU2004270239C1 (en) * 2003-09-04 2011-07-07 Cook Biotech Incorporated Extracellular matrix composite materials, and manufacture and use thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995022301A1 (en) * 1994-02-18 1995-08-24 Organogenesis, Inc. Bioremodelable collagen graft prosthesis
WO1996008213A1 (en) * 1994-09-12 1996-03-21 Advanced Tissue Sciences, Inc. Three-dimensional human cell cultures on cardiac valve frameworks and their uses
WO2001003750A1 (en) * 1999-07-09 2001-01-18 Advanced Tissue Sciences, Inc. Human naturally secreted extracellular matrix-coated device
US20010051824A1 (en) * 2000-04-07 2001-12-13 Hopkins Richard A. Cardiac valve replacement
WO2004080352A1 (en) * 2003-03-12 2004-09-23 Cook Incorporated Prosthetic valve that permits retrograde flow
WO2005013857A1 (en) * 2003-08-05 2005-02-17 Cook Incorporated Implantable venous valve

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CIMINI MASSIMO ET AL: "Dermal fibroblasts cultured on small intestinal submucosa: Conditions for the formation of a neotissue", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, WILEY, NEW YORK, NY, US, vol. 75, no. 4, 15 December 2005 (2005-12-15), pages 895 - 906, XP002369749, ISSN: 0021-9304 *
LINDBERG K ET AL: "Porcine small intestinal submucosa (SIS): a bioscaffold supporting in vitro primary human epidermal cell differentiation and synthesis of basement membrane proteins", BURNS, BUTTERWORTH HEINEMANN, GB, vol. 27, no. 3, May 2001 (2001-05-01), pages 254 - 266, XP002395139, ISSN: 0305-4179 *
WOODS A M ET AL: "Improved biocompatibility of small intestinal submucosa (SIS) following conditioning by human endothelial cells", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 25, no. 3, February 2004 (2004-02-01), pages 515 - 525, XP004469646, ISSN: 0142-9612 *
ZELTINGER J ET AL: "Development and characterization of tissue-engineered aortic valves.", TISSUE ENGINEERING, vol. 7, no. 1, February 2001 (2001-02-01), pages 9 - 22, XP002409313, ISSN: 1076-3279 *

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