WO2006106115A3 - Polypeptidmarker zur diagnose von alzheimer - Google Patents

Polypeptidmarker zur diagnose von alzheimer Download PDF

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Publication number
WO2006106115A3
WO2006106115A3 PCT/EP2006/061336 EP2006061336W WO2006106115A3 WO 2006106115 A3 WO2006106115 A3 WO 2006106115A3 EP 2006061336 W EP2006061336 W EP 2006061336W WO 2006106115 A3 WO2006106115 A3 WO 2006106115A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptide marker
disease
diagnosing alzheimer
markers
amplitude
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2006/061336
Other languages
English (en)
French (fr)
Other versions
WO2006106115A8 (de
WO2006106115A2 (de
Inventor
Harald Mischak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mosaiques Diagnostics and Therapeutics AG
Original Assignee
Mosaiques Diagnostics and Therapeutics AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mosaiques Diagnostics and Therapeutics AG filed Critical Mosaiques Diagnostics and Therapeutics AG
Priority to EP06725566A priority Critical patent/EP1869473A2/de
Priority to CA002604033A priority patent/CA2604033A1/en
Priority to US11/887,603 priority patent/US20100036094A1/en
Priority to JP2008504760A priority patent/JP5147684B2/ja
Priority to AU2006231597A priority patent/AU2006231597B2/en
Publication of WO2006106115A2 publication Critical patent/WO2006106115A2/de
Publication of WO2006106115A3 publication Critical patent/WO2006106115A3/de
Anticipated expiration legal-status Critical
Publication of WO2006106115A8 publication Critical patent/WO2006106115A8/de
Priority to US14/486,307 priority patent/US20150087554A1/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Verfahren zur Diagnose von Alzheimer umfassend den Schritt der Bestimmung einer An- oder Abwesenheit mindestens eines Polypeptid markers in einer Probe, wobei der Polypeptidmarker ausgewählt ist aus den Markern 1-50 (Frequenzmarker), oder der Bestimmung der Amplitude mindestens eines Polypeptidmarkers, ausgewählt aus den Markern 51-279 (Amplitudenmarker), die durch folgende Werte für die Molekularmassen und die Migrationszeit charakterisiert sind:
PCT/EP2006/061336 2005-04-06 2006-04-05 Polypeptidmarker zur diagnose von alzheimer Ceased WO2006106115A2 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP06725566A EP1869473A2 (de) 2005-04-06 2006-04-05 Polypeptidmarker zur diagnose von alzheimer
CA002604033A CA2604033A1 (en) 2005-04-06 2006-04-05 Polypeptide markers for the diagnosis of alzheimer's disease
US11/887,603 US20100036094A1 (en) 2005-04-06 2006-04-05 Polypeptide Markers for the Diagnosis of Alzheimer's Disease
JP2008504760A JP5147684B2 (ja) 2005-04-06 2006-04-05 アルツハイマー病の診断のためのポリペプチドマーカー
AU2006231597A AU2006231597B2 (en) 2005-04-06 2006-04-05 Polypeptide marker for diagnosing Alzheimer's disease
US14/486,307 US20150087554A1 (en) 2005-04-06 2014-09-15 Polypeptide markers for the diagnosis of alzheimer's disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05102705.0 2005-04-06
EP05102705 2005-04-06

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/887,603 A-371-Of-International US20100036094A1 (en) 2005-04-06 2006-04-05 Polypeptide Markers for the Diagnosis of Alzheimer's Disease
US14/486,307 Continuation US20150087554A1 (en) 2005-04-06 2014-09-15 Polypeptide markers for the diagnosis of alzheimer's disease

Publications (3)

Publication Number Publication Date
WO2006106115A2 WO2006106115A2 (de) 2006-10-12
WO2006106115A3 true WO2006106115A3 (de) 2006-11-23
WO2006106115A8 WO2006106115A8 (de) 2007-11-08

Family

ID=34939162

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/061336 Ceased WO2006106115A2 (de) 2005-04-06 2006-04-05 Polypeptidmarker zur diagnose von alzheimer

Country Status (6)

Country Link
US (2) US20100036094A1 (de)
EP (1) EP1869473A2 (de)
JP (1) JP5147684B2 (de)
AU (1) AU2006231597B2 (de)
CA (1) CA2604033A1 (de)
WO (1) WO2006106115A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7076075B2 (ja) * 2016-03-03 2022-05-27 東亞合成株式会社 シグナルペプチドを指標にしたアルツハイマー病の診断方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10021737C2 (de) * 2000-05-04 2002-10-17 Hermann Haller Verfahren und Vorrichtung zur qualitativen und/oder quantitativen Bestimmung eines Protein- und/oder Peptidmusters einer Flüssigkeitsprobe, die dem menschlichen oder tierischen Körper entnommen wird
PT1535076E (pt) * 2002-08-23 2008-11-03 Bayer Healthcare Ag Marcadores biológicos para diagnóstico da doença de alzheimer
DE10304106A1 (de) * 2003-01-31 2004-08-26 Mosaiques Diagnostics And Therapeutics Ag Verfahren und Vorrichtung zur qualitativen und/oder quantitativen Bestimmung eines Protein- und/oder Peptidmusters einer Flüssigkeitsprobe, die dem menschlichen oder tierischen Körper entnommen wird
DE10341193A1 (de) * 2003-09-06 2005-03-31 Mosaiques Diagnostics And Therapeutics Ag Vorrichtung und Verfahren zur quantitativen Auswertung der in einer Körperflüssigkeitsprobe enthaltenden Polypeptide sowie Marker zur Erkennung von pathologischen Zuständen
JP4796967B2 (ja) * 2003-11-07 2011-10-19 ヴァーミリオン インコーポレイテッド アルツハイマー病のためのバイオマーカー

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BOSS M A: "Diagnostic approaches to Alzheimer's disease.", BIOCHIMICA ET BIOPHYSICA ACTA. 26 JUL 2000, vol. 1502, no. 1, 26 July 2000 (2000-07-26), pages 188 - 200, XP002396298, ISSN: 0006-3002 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2003, HYE A ET AL: "Proteomics in the early diagnosis of Alzheimer's disease.", XP002396300, Database accession no. PREV200400196130 *
PUCHADES MAJA ET AL: "Proteomic studies of potential cerebrospinal fluid protein markers for Alzheimer's disease.", MOLECULAR BRAIN RESEARCH, vol. 118, no. 1-2, 21 October 2003 (2003-10-21), pages 140 - 146, XP002396297, ISSN: 0169-328X *
SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, vol. 2003, 2003, 33RD ANNUAL MEETING OF THE SOCIETY OF NEUROSCIENCE; NEW ORLEANS, LA, USA; NOVEMBER 08-12, 2003, pages Abstract No. 202.24 URL - http://sf *
VON NEUHOFF ET AL: "Mass spectrometry-based methods for biomarker detection and analysis", DRUG DISCOVERY TODAY: TECHNOLOGIES, ELSEVIER, vol. 2, no. 4, January 2005 (2005-01-01), pages 361 - 367, XP005215335, ISSN: 1740-6749 *
WITTKE S ET AL: "Determination of peptides and proteins in human urine with capillary electrophoresis-mass spectrometry, a suitable tool for the establishment of new diagnostic markers", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER, AMSTERDAM, NL, vol. 1013, no. 1-2, 26 September 2003 (2003-09-26), pages 173 - 181, XP004458214, ISSN: 0021-9673 *

Also Published As

Publication number Publication date
EP1869473A2 (de) 2007-12-26
WO2006106115A8 (de) 2007-11-08
JP2008534973A (ja) 2008-08-28
US20150087554A1 (en) 2015-03-26
WO2006106115A2 (de) 2006-10-12
US20100036094A1 (en) 2010-02-11
CA2604033A1 (en) 2006-10-12
AU2006231597A1 (en) 2006-10-12
JP5147684B2 (ja) 2013-02-20
AU2006231597B2 (en) 2011-11-17

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