WO2006112709A3 - Biochip and process for the production of a biochip - Google Patents

Biochip and process for the production of a biochip Download PDF

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Publication number
WO2006112709A3
WO2006112709A3 PCT/NL2006/050078 NL2006050078W WO2006112709A3 WO 2006112709 A3 WO2006112709 A3 WO 2006112709A3 NL 2006050078 W NL2006050078 W NL 2006050078W WO 2006112709 A3 WO2006112709 A3 WO 2006112709A3
Authority
WO
WIPO (PCT)
Prior art keywords
coating
biochip
compartments
providing
support
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/NL2006/050078
Other languages
French (fr)
Other versions
WO2006112709A2 (en
Inventor
Johan Gerrit Bomer
Adrianus Joseph Sprenkels
Colin Ingham
Hylckama Vlieg Johannes Ep Van
Vos Willem Meindert De
Den Berg Albert Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Priority to US11/918,570 priority Critical patent/US20090042736A1/en
Priority to EP06733057A priority patent/EP1877533A2/en
Priority to US11/918,612 priority patent/US20100021959A1/en
Priority to EP06733066A priority patent/EP1871893A2/en
Priority to PCT/NL2006/050087 priority patent/WO2006112713A2/en
Publication of WO2006112709A2 publication Critical patent/WO2006112709A2/en
Publication of WO2006112709A3 publication Critical patent/WO2006112709A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00385—Printing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00427—Means for dispensing and evacuation of reagents using masks
    • B01J2219/00432—Photolithographic masks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00574—Chemical means radioactive
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00576—Chemical means fluorophore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/0074—Biological products
    • B01J2219/00743—Cells

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to a biochip (5) comprising a porous support (10), wherein the porous support (10) comprises at least one surface coated with a coating, preferably a polymer coating (20), wherein the coating is patterned with a micro compartments (25) pattern, with the support providing a bottom surface to the compartments and the coating providing edges to the compartments, and wherein the pattern comprises at least 400 compartments per mm2. The biochip (5) can be obtained by a process comprising providing a porous support (10); coating at least one surface of the support with a coating (20); arranging between the coated surface and an ion etching device a shadow mask with a predetermined hole pattern; and ion etching at least part of the coating such that a patterned coating with micro compartments (25) is obtained.
PCT/NL2006/050078 2005-04-18 2006-04-10 Biochip and process for the production of a biochip Ceased WO2006112709A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US11/918,570 US20090042736A1 (en) 2005-04-18 2006-04-10 Biochip and process for the production of a biochip
EP06733057A EP1877533A2 (en) 2005-04-18 2006-04-10 Biochip and process for the production of a biochip
US11/918,612 US20100021959A1 (en) 2005-04-18 2006-04-18 High Throughput Screening Method for Assessing Heterogeneity of Microorganisms
EP06733066A EP1871893A2 (en) 2005-04-18 2006-04-18 High throughput screening method for assessing heterogeneity of microorganisms
PCT/NL2006/050087 WO2006112713A2 (en) 2005-04-18 2006-04-18 High throughput screening method for assessing heterogeneity of microorganisms

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05103080 2005-04-18
EP05103080.7 2005-04-18

Publications (2)

Publication Number Publication Date
WO2006112709A2 WO2006112709A2 (en) 2006-10-26
WO2006112709A3 true WO2006112709A3 (en) 2007-07-26

Family

ID=34939353

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL2006/050078 Ceased WO2006112709A2 (en) 2005-04-18 2006-04-10 Biochip and process for the production of a biochip

Country Status (3)

Country Link
US (2) US20090042736A1 (en)
EP (2) EP1877533A2 (en)
WO (1) WO2006112709A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8241539B2 (en) 2006-04-25 2012-08-14 National University Of Singapore Method of patterning and product(s) obtained therefrom
CA2669939A1 (en) 2006-10-12 2008-05-22 Massachusetts Institute Of Technology Multi-well micropatterning by ablation
JP5739666B2 (en) 2007-11-20 2015-06-24 スリーエム イノベイティブ プロパティズ カンパニー Environmental sampling articles and methods
EP2235203B1 (en) 2007-12-21 2014-10-08 3M Innovative Properties Company Microbiological systems and methods of fluid sample analysis
KR101129090B1 (en) * 2009-09-01 2012-04-13 성균관대학교산학협력단 Method of manufacturing patterned substrate for culturing cells, patterned substrate for culturing cells, patterning method of culturing cells, and patterned cell chip
US9580681B2 (en) 2009-09-01 2017-02-28 Sungkyunkwan University Foundation For Corporate Collaboration Method of manufacturing patterned substrate for culturing cells, patterned substrate, and patterned cell chip
BR112012016132A2 (en) 2009-12-30 2020-09-08 3M Innovative Properties Company microbial detection article
CA2798246C (en) 2010-05-03 2023-09-12 Creatv Microtech, Inc. Polymer microfilters and methods of manufacturing the same
US11175279B2 (en) 2010-05-03 2021-11-16 Creatv Microtech, Inc. Polymer microfilters, devices comprising the same, methods of manufacturing the same, and uses thereof
EP2720731B1 (en) 2011-06-15 2020-11-18 The Charles Stark Draper Laboratory, Inc. Systems, methods, and devices relating to a biomimetic cellularized nephron unit
GB201120991D0 (en) * 2011-12-07 2012-01-18 Univ Manchester Microsensor
US20130230911A1 (en) * 2012-03-02 2013-09-05 The Charles Stark Draper Laboratory, Inc. Porous structure with independently controlled surface patterns
US9103921B2 (en) * 2012-09-24 2015-08-11 Savannah River Nuclear Solutions, Llc Photonic crystal scintillators and methods of manufacture
CN114089597B (en) 2013-12-19 2025-03-14 Illumina公司 Substrate comprising a nano-patterned surface and method for preparing the same
US10712356B2 (en) 2015-04-21 2020-07-14 General Automation Lab Technologies Inc. Apparatus and method for picking biological sample
CN107810277B (en) 2015-04-21 2021-11-02 通用自动化实验技术公司 High-resolution systems, kits, devices and methods for high-throughput microbiology applications
CN105603361B (en) * 2016-01-14 2018-02-27 深圳市国创新能源研究院 The preparation method and application of high flux biofilm
US10453551B2 (en) 2016-06-08 2019-10-22 X Development Llc Simulating living cell in silico
WO2019079725A1 (en) * 2017-10-19 2019-04-25 Georgia Tech Research Corporation Mesofluidic device for culture of cell aggregates

Citations (11)

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US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
WO1995011755A1 (en) * 1993-10-28 1995-05-04 Houston Advanced Research Center Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions
WO1997010365A1 (en) * 1995-09-15 1997-03-20 Affymax Technologies N.V. Expression monitoring by hybridization to high density oligonucleotide arrays
EP0895083A2 (en) * 1997-08-01 1999-02-03 Canon Kabushiki Kaisha Reaction site array, preparation of it, reaction process using it and quantitative determination method of substance in sample solution using it
US20020072116A1 (en) * 2000-10-12 2002-06-13 Bhatia Sangeeta N. Nanoporous silicon bioreactor
US20020146715A1 (en) * 1997-08-01 2002-10-10 Tadashi Okamoto Ink jet method of spotting probe, probe array and indentification methods
US20020192600A1 (en) * 2001-04-27 2002-12-19 Nobuyuki Okamura Probe carrier, probe fixing carrier and method of manufacturing the same
WO2003044484A2 (en) * 2001-11-16 2003-05-30 Sloan-Kettering Institute For Cancer Research High-density cell microarrays for parallel functional determinations
WO2003102578A2 (en) * 2002-06-03 2003-12-11 Pamgene B.V. High throughput cellular response assay using microarrays
WO2005016841A1 (en) * 2003-07-29 2005-02-24 Corning Incorporated Porous glass substrates with reduced auto-fluorescence
WO2005052582A2 (en) * 2003-11-28 2005-06-09 Pamgene B.V. Methods and apparatus for cell based microarray assays

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US4528269A (en) * 1980-04-14 1985-07-09 The State Of Oregon By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon State University Method for producing single and/or mixed strain concentrates of bacteria
DE10019881A1 (en) * 2000-04-20 2001-11-15 Gerhard Miksch Process for overexpression and extracellular production of bacterial phytases in Escherichia coli
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Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
WO1995011755A1 (en) * 1993-10-28 1995-05-04 Houston Advanced Research Center Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions
WO1997010365A1 (en) * 1995-09-15 1997-03-20 Affymax Technologies N.V. Expression monitoring by hybridization to high density oligonucleotide arrays
EP0895083A2 (en) * 1997-08-01 1999-02-03 Canon Kabushiki Kaisha Reaction site array, preparation of it, reaction process using it and quantitative determination method of substance in sample solution using it
US20020146715A1 (en) * 1997-08-01 2002-10-10 Tadashi Okamoto Ink jet method of spotting probe, probe array and indentification methods
US20020072116A1 (en) * 2000-10-12 2002-06-13 Bhatia Sangeeta N. Nanoporous silicon bioreactor
US20020192600A1 (en) * 2001-04-27 2002-12-19 Nobuyuki Okamura Probe carrier, probe fixing carrier and method of manufacturing the same
WO2003044484A2 (en) * 2001-11-16 2003-05-30 Sloan-Kettering Institute For Cancer Research High-density cell microarrays for parallel functional determinations
WO2003102578A2 (en) * 2002-06-03 2003-12-11 Pamgene B.V. High throughput cellular response assay using microarrays
WO2005016841A1 (en) * 2003-07-29 2005-02-24 Corning Incorporated Porous glass substrates with reduced auto-fluorescence
WO2005052582A2 (en) * 2003-11-28 2005-06-09 Pamgene B.V. Methods and apparatus for cell based microarray assays

Also Published As

Publication number Publication date
EP1871893A2 (en) 2008-01-02
WO2006112709A2 (en) 2006-10-26
US20100021959A1 (en) 2010-01-28
EP1877533A2 (en) 2008-01-16
US20090042736A1 (en) 2009-02-12

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