WO2006116210A3 - Dermal fillers for biomedical applications in mammals and methods of using the same - Google Patents

Dermal fillers for biomedical applications in mammals and methods of using the same Download PDF

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Publication number
WO2006116210A3
WO2006116210A3 PCT/US2006/015292 US2006015292W WO2006116210A3 WO 2006116210 A3 WO2006116210 A3 WO 2006116210A3 US 2006015292 W US2006015292 W US 2006015292W WO 2006116210 A3 WO2006116210 A3 WO 2006116210A3
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WO
WIPO (PCT)
Prior art keywords
tissue
mammals
methods
same
injecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/015292
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French (fr)
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WO2006116210A2 (en
Inventor
Eric F Bernstein
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Individual
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EP06751112A priority Critical patent/EP1887967A2/en
Priority to CA002604856A priority patent/CA2604856A1/en
Publication of WO2006116210A2 publication Critical patent/WO2006116210A2/en
Anticipated expiration legal-status Critical
Publication of WO2006116210A3 publication Critical patent/WO2006116210A3/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Botany (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Birds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A method of tissue augmentation in mammals comprising implanting or injecting into the tissue of a mammal elastic material derived from solar elastosis or other sun-damaged sites in humans is disclosed. The method further comprises injecting into the tissue of a mammal, alone, or in combination with the solar elastosis, at least one filler material, such as fibrillin, recombinant fibrillin, fibulin, and recombinant fibulin. A method of treating various skin conditions, such as wrinkles, photoaging, acne scarring, scars, and HIV-associated lipoatrophy, by injecting into the tissue elastic material derived from solar elastosis and/or filler material is also disclosed.
PCT/US2006/015292 2005-04-25 2006-04-24 Dermal fillers for biomedical applications in mammals and methods of using the same Ceased WO2006116210A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP06751112A EP1887967A2 (en) 2005-04-25 2006-04-24 Dermal fillers for biomedical applications in mammals and methods of using the same
CA002604856A CA2604856A1 (en) 2005-04-25 2006-04-24 Dermal fillers for biomedical applications in mammals and methods of using the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67431405P 2005-04-25 2005-04-25
US60/674,314 2005-04-25

Publications (2)

Publication Number Publication Date
WO2006116210A2 WO2006116210A2 (en) 2006-11-02
WO2006116210A3 true WO2006116210A3 (en) 2008-03-20

Family

ID=36954814

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/015292 Ceased WO2006116210A2 (en) 2005-04-25 2006-04-24 Dermal fillers for biomedical applications in mammals and methods of using the same

Country Status (4)

Country Link
US (1) US20070071729A1 (en)
EP (1) EP1887967A2 (en)
CA (1) CA2604856A1 (en)
WO (1) WO2006116210A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8455459B2 (en) 2007-08-02 2013-06-04 Medicis Pharmaceutical Corporation Method of applying an injectable filler

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7666588B2 (en) * 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
WO2008098007A1 (en) * 2007-02-05 2008-08-14 Freedom-2, Inc. Tissue fillers and methods of using the same
US8198245B2 (en) 2007-07-27 2012-06-12 Humacyte, Inc. Compositions and methods for soft tissue augmentation
US20090204101A1 (en) * 2007-08-20 2009-08-13 Wortzman Mitchell S Method of applying an injectable filler
US8486467B1 (en) * 2007-09-20 2013-07-16 Albert G. Prescott Dermal filler and method of using same
US8431141B2 (en) * 2007-10-29 2013-04-30 Ayman Boutros Alloplastic injectable dermal filler and methods of use thereof
US8709395B2 (en) 2007-10-29 2014-04-29 Ayman Boutros Method for repairing or replacing damaged tissue
US8475815B2 (en) * 2007-10-29 2013-07-02 Ayman Boutros Alloplastic injectable dermal filler and methods of use thereof
US7910134B2 (en) * 2007-10-29 2011-03-22 Ayman Boutros Alloplastic injectable dermal filler and methods of use thereof
WO2009119073A1 (en) 2008-03-28 2009-10-01 北海道公立大学法人札幌医科大学 Agent for treating skin aging and scars
US20110020271A1 (en) * 2009-05-20 2011-01-27 Humacyte, Inc. Elastin for soft tissue augmentation
US8815228B2 (en) 2010-04-30 2014-08-26 Ayman Boutros Alloplastic injectable dermal filler and methods of use thereof
CA2832838C (en) 2011-04-14 2019-08-13 Lifecell Corporation Regenerative tissue matrix flakes
US11123375B2 (en) 2017-10-18 2021-09-21 Lifecell Corporation Methods of treating tissue voids following removal of implantable infusion ports using adipose tissue products
WO2019079570A1 (en) 2017-10-18 2019-04-25 Lifecell Corporation Adipose tissue products and methods of production
WO2019079672A1 (en) 2017-10-19 2019-04-25 Lifecell Corporation Flowable acellular tissue matrix products and methods of production
US11246994B2 (en) 2017-10-19 2022-02-15 Lifecell Corporation Methods for introduction of flowable acellular tissue matrix products into a hand
ES3056561T3 (en) 2019-05-30 2026-02-23 Lifecell Corp Biologic breast implant

Citations (6)

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Publication number Priority date Publication date Assignee Title
DE19959750C1 (en) * 1999-12-11 2001-05-31 Axel Thierauf Production of skin implant, e.g. for treating burn or other open wound, uses flat element of fine biocompatible, biodegradable or bioresorbable fibers of hydrolytically condensed silicon compound on nutrient solution
WO2001085224A1 (en) * 2000-05-12 2001-11-15 The Nottingham Trent University Medical implant materials
EP1216718A1 (en) * 2000-12-21 2002-06-26 Ethicon, Inc. Reinforced foam implants for soft tissue repair and regeneration
US20020119177A1 (en) * 2000-12-21 2002-08-29 Bowman Steven M. Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
WO2004034890A2 (en) * 2002-10-17 2004-04-29 Vacanti, Joseph, P. Biological scaffolding material
WO2004063225A2 (en) * 2002-12-27 2004-07-29 Applied Research Systems Ars Holding N.V. Novel fibulin-like polypeptides

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WO2003072157A1 (en) * 2002-02-21 2003-09-04 Encelle, Inc. Immobilized bioactive hydrogel matrices as surface coatings
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Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19959750C1 (en) * 1999-12-11 2001-05-31 Axel Thierauf Production of skin implant, e.g. for treating burn or other open wound, uses flat element of fine biocompatible, biodegradable or bioresorbable fibers of hydrolytically condensed silicon compound on nutrient solution
WO2001085224A1 (en) * 2000-05-12 2001-11-15 The Nottingham Trent University Medical implant materials
EP1216718A1 (en) * 2000-12-21 2002-06-26 Ethicon, Inc. Reinforced foam implants for soft tissue repair and regeneration
US20020119177A1 (en) * 2000-12-21 2002-08-29 Bowman Steven M. Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
WO2004034890A2 (en) * 2002-10-17 2004-04-29 Vacanti, Joseph, P. Biological scaffolding material
WO2004063225A2 (en) * 2002-12-27 2004-07-29 Applied Research Systems Ars Holding N.V. Novel fibulin-like polypeptides

Non-Patent Citations (8)

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Title
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BERNSTEIN E F ET AL: "ENHANCED ELASTIN AND FIBRILLIN GENE EXPRESSION IN CHRONINALLY PHOTODAMAGED SKIN", JOURNAL OF INVESTIGATIVE DERMATOLOGY, NEW YORK, NY, US, vol. 103, 1994, pages 182 - 186, XP008018457, ISSN: 0022-202X *
BERNSTEIN E F ET AL: "ULTRAVIOLET RADIATION ACTIVATES THE HUMAN ELASTIN PROMOTER IN TRANSGENIC MICE: A NOVEL IN VIVO AND IN VITRO MODEL OF CUTANEOUS PHOTOAGING", JOURNAL OF INVESTIGATIVE DERMATOLOGY, NEW YORK, NY, US, vol. 105, August 1995 (1995-08-01), pages 269 - 273, XP000995138, ISSN: 0022-202X *
CHEN V L ET AL: "IMMUNOCHEMISTRY OF ELASTOTIC MATERIAL IN SUN-DAMAGED SKIN", JOURNAL OF INVESTIGATIVE DERMATOLOGY, NEW YORK, NY, US, no. 87, 1986, pages 334 - 337, XP008018628, ISSN: 0022-202X *
HEGEDUS ET AL: "Non-surgical treatment modalities of facial photodamage: practical knowledge for the oral and maxillofacial professional", INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, COPENHAGEN, DK, vol. 35, no. 5, May 2006 (2006-05-01), pages 389 - 398, XP005417078, ISSN: 0901-5027 *
HUNZELMANN N ET AL: "Increased deposition of fibulin-2 in solar elastosis and its colocalization with elastic fibres.", THE BRITISH JOURNAL OF DERMATOLOGY. AUG 2001, vol. 145, no. 2, August 2001 (2001-08-01), pages 217 - 222, XP002410917, ISSN: 0007-0963 *
UITTO J ET AL: "MOLECULAR ASPECTS OF PHOTOAGING", EUROPEAN JOURNAL OF DERMATOLOGY, vol. 7, no. 3, 1997, pages 210 - 214, XP002927950, ISSN: 1167-1122 *
ZIMMERMANN U S ET AL: "The histological aspects of fillers complications", SEMINARS IN CUTANEOUS MEDICINE AND SURGERY, W.B. SAUNDERS, PHILADELPHIA, US, vol. 23, no. 4, December 2004 (2004-12-01), pages 241 - 250, XP004700719, ISSN: 1085-5629 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8455459B2 (en) 2007-08-02 2013-06-04 Medicis Pharmaceutical Corporation Method of applying an injectable filler
US8778909B2 (en) 2007-08-02 2014-07-15 Medicis Pharmaceutical Corporation Method of applying an injectable filler

Also Published As

Publication number Publication date
US20070071729A1 (en) 2007-03-29
EP1887967A2 (en) 2008-02-20
WO2006116210A2 (en) 2006-11-02
CA2604856A1 (en) 2006-11-02

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