WO2006134546A3 - Accurate magnetic biosensor - Google Patents

Accurate magnetic biosensor Download PDF

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Publication number
WO2006134546A3
WO2006134546A3 PCT/IB2006/051866 IB2006051866W WO2006134546A3 WO 2006134546 A3 WO2006134546 A3 WO 2006134546A3 IB 2006051866 W IB2006051866 W IB 2006051866W WO 2006134546 A3 WO2006134546 A3 WO 2006134546A3
Authority
WO
WIPO (PCT)
Prior art keywords
sort
labels
binding sites
magnetic
magnetic labels
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2006/051866
Other languages
French (fr)
Other versions
WO2006134546A2 (en
Inventor
Menno W J Prins
Albert H J Immink
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips Electronics NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Electronics NV filed Critical Koninklijke Philips Electronics NV
Priority to BRPI0612623A priority Critical patent/BRPI0612623A2/en
Priority to JP2008516478A priority patent/JP2008544246A/en
Priority to US11/917,211 priority patent/US20080206104A1/en
Priority to EP06765725A priority patent/EP1894009A2/en
Publication of WO2006134546A2 publication Critical patent/WO2006134546A2/en
Publication of WO2006134546A3 publication Critical patent/WO2006134546A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Electrochemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention provides a method, a device and a system for determining the concentration of at least one sort of targets in a fluid containing at least one sort of polarizable of polarized magnetic labels in a fluid, the sensing surface comprising at least one sort of binding sites capable to specifically attach to at least one sort of biological entities linked to the magnetic labels, the sensing device further comprising at least one magnetic sensor element, the sensing device further comprising distinction means for time-resolved distinguishing between magnetic labels specifically attached to the binding sites versus labels non-specifically attached. The method and device according to the present invention may be applied to biomolecular diagnostics.
PCT/IB2006/051866 2005-06-17 2006-06-12 Accurate magnetic biosensor Ceased WO2006134546A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
BRPI0612623A BRPI0612623A2 (en) 2005-06-17 2006-06-12 sensor device, system and method for determining the concentration of at least one species of target in a fluid containing at least one species of polarizable or polarized magnetic labels
JP2008516478A JP2008544246A (en) 2005-06-17 2006-06-12 Accurate magnetic biosensor
US11/917,211 US20080206104A1 (en) 2005-06-17 2006-06-12 Accurate Magnetic Biosensor
EP06765725A EP1894009A2 (en) 2005-06-17 2006-06-12 Accurate magnetic biosensor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05105361.9 2005-06-17
EP05105361 2005-06-17

Publications (2)

Publication Number Publication Date
WO2006134546A2 WO2006134546A2 (en) 2006-12-21
WO2006134546A3 true WO2006134546A3 (en) 2007-03-08

Family

ID=37309075

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/051866 Ceased WO2006134546A2 (en) 2005-06-17 2006-06-12 Accurate magnetic biosensor

Country Status (7)

Country Link
US (1) US20080206104A1 (en)
EP (1) EP1894009A2 (en)
JP (1) JP2008544246A (en)
CN (1) CN101198870A (en)
BR (1) BRPI0612623A2 (en)
RU (1) RU2415432C2 (en)
WO (1) WO2006134546A2 (en)

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DE102006016334B4 (en) * 2006-04-06 2018-11-15 Boehringer Ingelheim Vetmedica Gmbh Method and device for detecting magnetizable particles
BRPI0711346A8 (en) * 2006-05-09 2015-10-06 Koninklije Philips Electronics N V METHOD TO DETECT A TARGET IN A SAMPLE SUSPECTED TO CONTAIN THE TARGET, AND, USE OF A MAGNETO
CN101438142B (en) * 2006-05-10 2013-10-30 皇家飞利浦电子股份有限公司 fast magnetic biosensor
CN101479590A (en) * 2006-06-28 2009-07-08 皇家飞利浦电子股份有限公司 Magnetic sensor device and method for sensing magnetic particles
US20090251136A1 (en) * 2006-07-17 2009-10-08 Koninklijke Philips Electronics N.V. Attraction and repulsion of magnetic of magnetizable objects to and from a sensor surface
WO2008044174A1 (en) * 2006-10-12 2008-04-17 Koninklijke Philips Electronics N.V. Magnetic and/or electric label assisted detection system and method
CN101632018B (en) * 2007-02-23 2017-12-08 皇家飞利浦电子股份有限公司 Sensor device and method for sensing magnetic particles
EP2115467A1 (en) * 2007-02-23 2009-11-11 Koninklijke Philips Electronics N.V. Magnetic sensor device with field generator and sensor element
DE102007015543A1 (en) * 2007-03-30 2008-10-09 Siemens Ag Method for detection of biological reaction products on sensor surfaces, involves moving beads into desired direction, particularly from berth to detected biologically active substances, where biological reaction products have Biotins
EP2017619A1 (en) * 2007-07-20 2009-01-21 Koninklijke Philips Electronics N.V. Magnetic sensor device
EP2017618A1 (en) * 2007-07-20 2009-01-21 Koninklijke Philips Electronics N.V. Methods and systems for detecting
JP2009042104A (en) * 2007-08-09 2009-02-26 Canon Inc Substance fixing device, substance detecting device and substance fixing method
EP2028491A1 (en) * 2007-08-22 2009-02-25 Koninklijke Philips Electronics N.V. Method of directing magnetic or magnetisable objects to prepare bio-sensor device
GB0716968D0 (en) * 2007-08-31 2007-10-10 Vivacta Ltd Sensor
WO2009072045A1 (en) * 2007-12-04 2009-06-11 Koninklijke Philips Electronics N. V. Method of measuring molecules in a fluid using label particles
EP2073016A1 (en) * 2007-12-20 2009-06-24 Koninklijke Philips Electronics N.V. Magnetic label based detection
JP5466651B2 (en) 2008-01-17 2014-04-09 ザ リージェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア Integrated magnetic field generation and detection platform
JP5628784B2 (en) * 2008-03-17 2014-11-19 コーニンクレッカ フィリップス エヌ ヴェ Cartridge for assay with magnetic particles
US8053250B2 (en) * 2008-06-27 2011-11-08 Rex Chin-Yih Hong Method and system for suppressing bindings on magnetic particles
CN102187241B (en) 2008-10-17 2015-11-25 皇家飞利浦电子股份有限公司 Pulsed magnetic for sensitive determination encourages
EP2208531A1 (en) 2008-12-30 2010-07-21 Atonomics A/S Distribution of particles in capillary channel by application of magnetic field
US9599591B2 (en) 2009-03-06 2017-03-21 California Institute Of Technology Low cost, portable sensor for molecular assays
WO2010121223A2 (en) * 2009-04-17 2010-10-21 California Institute Of Technology Electromagnetic molecular sensors and methods of using same
WO2011021142A1 (en) 2009-08-19 2011-02-24 Koninklijke Philips Electronics N.V. Detection of different target components by cluster formation
EP2483661B1 (en) 2009-09-28 2020-02-05 Koninklijke Philips N.V. Substance determining apparatus and method
EP2488871B1 (en) 2009-10-16 2017-01-04 Åmic AB An assay method involving the use of magnetic particles
EP2492665A1 (en) * 2009-10-19 2012-08-29 Tokyo Institute of Technology Biosensor using magnetic microparticles
WO2011073866A1 (en) 2009-12-18 2011-06-23 Koninklijke Philips Electronics N.V. Substance determining apparatus
EP2362219A1 (en) * 2010-02-19 2011-08-31 Nxp B.V. Sensor measuring method and sensing apparatus
US20140099663A1 (en) * 2010-11-15 2014-04-10 Regents Of The University Of Minnesota Gmr sensor
US9304130B2 (en) 2010-12-16 2016-04-05 International Business Machines Corporation Trenched sample assembly for detection of analytes with electromagnetic read-write heads
US8855957B2 (en) 2011-05-03 2014-10-07 International Business Machines Corporation Method for calibrating read sensors of electromagnetic read-write heads
US9040311B2 (en) 2011-05-03 2015-05-26 International Business Machines Corporation Calibration assembly for aide in detection of analytes with electromagnetic read-write heads
US9958416B2 (en) 2011-11-23 2018-05-01 The General Hospital Corporation Analyte detection using magnetic hall effect
US9977015B2 (en) 2012-05-15 2018-05-22 Massachusetts Institute Of Technology Systems and methods for detecting molecular interactions using magnetic beads
RU2653145C2 (en) * 2012-09-04 2018-05-07 Конинклейке Филипс Н.В. Sensor device and method of sampling
US9435800B2 (en) 2012-09-14 2016-09-06 International Business Machines Corporation Sample assembly with an electromagnetic field to accelerate the bonding of target antigens and nanoparticles
KR101517594B1 (en) 2013-10-16 2015-05-04 (주)타스컴 Biosensor
EP3143386A4 (en) * 2014-05-12 2017-11-29 Qi, Huan Method and system for analyte sensing
JP6594995B2 (en) 2015-03-26 2019-10-23 コーニンクレッカ フィリップス エヌ ヴェ Manufacture of biosensor cartridge
EP3290938A1 (en) 2016-09-05 2018-03-07 Industrial Technology Research Institute Biomolecule magnetic sensor
US20180266991A1 (en) * 2017-03-15 2018-09-20 Qualcomm Incorporated Magneto-impedance (mi) sensors employing current confinement and exchange bias layer(s) for increased sensitivity
GB201720162D0 (en) * 2017-12-04 2018-01-17 Univ Oxford Innovation Ltd Method
US12241851B2 (en) 2018-07-27 2025-03-04 Zepto Life Technology, Inc. System and method for processing analyte signals in GMR-based detection of biomarkers
US12600825B2 (en) 2020-01-08 2026-04-14 Zepto Life Technology, Inc. Polymer compositions and biosurfaces comprising them on sensors
EP4090987A4 (en) 2020-01-17 2024-01-17 Zepto Life Technology, LLC SYSTEMS AND METHODS FOR MEASURING ANALYTES IN GMR-BASED DETECTION OF BIOMARRKERS
EP4592678A1 (en) 2024-01-26 2025-07-30 Technische Universität München Method and device for detecting a concentration of at least one analyte in a sample

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WO2005010543A1 (en) * 2003-07-30 2005-02-03 Koninklijke Philips Electronics N.V. On-chip magnetic sensor device with suppressed cross-talk
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Also Published As

Publication number Publication date
BRPI0612623A2 (en) 2016-11-29
EP1894009A2 (en) 2008-03-05
US20080206104A1 (en) 2008-08-28
RU2415432C2 (en) 2011-03-27
WO2006134546A2 (en) 2006-12-21
JP2008544246A (en) 2008-12-04
CN101198870A (en) 2008-06-11
RU2008101786A (en) 2009-07-27

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