WO2007002261A3 - IL-1β BINDING ANTIBODIES AND FRAGMENTS THEREOF - Google Patents

IL-1β BINDING ANTIBODIES AND FRAGMENTS THEREOF Download PDF

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Publication number
WO2007002261A3
WO2007002261A3 PCT/US2006/024261 US2006024261W WO2007002261A3 WO 2007002261 A3 WO2007002261 A3 WO 2007002261A3 US 2006024261 W US2006024261 W US 2006024261W WO 2007002261 A3 WO2007002261 A3 WO 2007002261A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding
fragments
binding antibodies
antibodies
affinity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/024261
Other languages
French (fr)
Other versions
WO2007002261A2 (en
Inventor
Linda Masat
Mary Haak-Frendscho
Gang Chen
Arnold Horwitz
Marina Roell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xoma Technology Ltd USA
Original Assignee
Xoma Technology Ltd USA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AT06773749T priority Critical patent/ATE446972T1/en
Priority to KR1020137015781A priority patent/KR101502920B1/en
Priority to CA2612760A priority patent/CA2612760C/en
Priority to DE602006010072T priority patent/DE602006010072D1/en
Priority to JP2008518374A priority patent/JP4931919B2/en
Priority to RU2008102135/10A priority patent/RU2518295C2/en
Priority to NZ565138A priority patent/NZ565138A/en
Priority to EP16154804.5A priority patent/EP3056511B1/en
Priority to EP06773749A priority patent/EP1899378B1/en
Priority to KR1020147030783A priority patent/KR20140139618A/en
Priority to DK06773749.4T priority patent/DK1899378T3/en
Priority to BRPI0612273A priority patent/BRPI0612273C1/en
Priority to MX2015004669A priority patent/MX348154B/en
Priority to PL06773749T priority patent/PL1899378T3/en
Priority to MX2007016032A priority patent/MX2007016032A/en
Priority to AU2006262179A priority patent/AU2006262179B2/en
Application filed by Xoma Technology Ltd USA filed Critical Xoma Technology Ltd USA
Priority to KR1020087001520A priority patent/KR101366450B1/en
Publication of WO2007002261A2 publication Critical patent/WO2007002261A2/en
Publication of WO2007002261A3 publication Critical patent/WO2007002261A3/en
Priority to IL188094A priority patent/IL188094A/en
Anticipated expiration legal-status Critical
Priority to IL202630A priority patent/IL202630A/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)

Abstract

An IL- 1β binding antibody or IL- 1β binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 2, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease, and a method of preparing an affinity matured IL- 1β binding polypeptide. IL- 1βbinding antibodies or IL- 1β binding fragments thereof are provided which have desirable affinity and potency.
PCT/US2006/024261 2005-06-21 2006-06-21 IL-1β BINDING ANTIBODIES AND FRAGMENTS THEREOF Ceased WO2007002261A2 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
DK06773749.4T DK1899378T3 (en) 2005-06-21 2006-06-21 IL-1 beta-binding antibodies and fragments thereof
CA2612760A CA2612760C (en) 2005-06-21 2006-06-21 Il-1.beta. binding antibodies and fragments thereof
DE602006010072T DE602006010072D1 (en) 2005-06-21 2006-06-21 IL-1 BINDING ANTIBODIES AND FRAGMENTS THEREOF
JP2008518374A JP4931919B2 (en) 2005-06-21 2006-06-21 IL-1β binding antibody and fragment thereof
RU2008102135/10A RU2518295C2 (en) 2005-06-21 2006-06-21 IL-1beta-BINDING ANTIBODIES AND FRAGMENTS THEREOF
KR1020137015781A KR101502920B1 (en) 2005-06-21 2006-06-21 IL-1β Binding antibodies and fragments thereof
EP16154804.5A EP3056511B1 (en) 2005-06-21 2006-06-21 Il-1beta binding antibodies and fragments thereof
EP06773749A EP1899378B1 (en) 2005-06-21 2006-06-21 Il-1 beta binding antibodies and fragments thereof
KR1020147030783A KR20140139618A (en) 2005-06-21 2006-06-21 IL-1 [beta] -binding antibodies and fragments thereof
BRPI0612273A BRPI0612273C1 (en) 2005-06-21 2006-06-21 il-1 beta binding antibody or il-1 beta binding fragment thereof, nucleic acid, vector, and composition
NZ565138A NZ565138A (en) 2005-06-21 2006-06-21 IL-1beta Binding antibodies and fragments thereof
AT06773749T ATE446972T1 (en) 2005-06-21 2006-06-21 IL-1 BINDING ANTIBODIES AND FRAGMENTS THEREOF
PL06773749T PL1899378T3 (en) 2005-06-21 2006-06-21 Il-1 beta binding antibodies and fragments thereof
MX2007016032A MX2007016032A (en) 2005-06-21 2006-06-21 Il-1 beta binding antibodies and fragments thereof.
AU2006262179A AU2006262179B2 (en) 2005-06-21 2006-06-21 IL-1 beta, binding antibodies and fragments thereof
MX2015004669A MX348154B (en) 2005-06-21 2006-06-21 IL-1ß BINDING ANTIBODIES AND FRAGMENTS THEREOF.
KR1020087001520A KR101366450B1 (en) 2005-06-21 2006-06-21 IL-1β Binding antibodies and fragments thereof
IL188094A IL188094A (en) 2005-06-21 2007-12-12 Il-1?? binding antibodies or fragments thereof and compositions comprising the same
IL202630A IL202630A (en) 2005-06-21 2009-12-09 Nucleic acids encoding il-1?? binding antibodies, variable regions or fragments thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69283005P 2005-06-21 2005-06-21
US60/692,830 2005-06-21

Publications (2)

Publication Number Publication Date
WO2007002261A2 WO2007002261A2 (en) 2007-01-04
WO2007002261A3 true WO2007002261A3 (en) 2007-07-12

Family

ID=37595818

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/024261 Ceased WO2007002261A2 (en) 2005-06-21 2006-06-21 IL-1β BINDING ANTIBODIES AND FRAGMENTS THEREOF

Country Status (23)

Country Link
US (11) US7531166B2 (en)
EP (5) EP3056511B1 (en)
JP (2) JP4931919B2 (en)
KR (3) KR20140139618A (en)
CN (2) CN102775493B (en)
AT (1) ATE446972T1 (en)
AU (1) AU2006262179B2 (en)
BR (1) BRPI0612273C1 (en)
CA (2) CA2873914A1 (en)
CY (3) CY1109715T1 (en)
DE (1) DE602006010072D1 (en)
DK (4) DK1899378T3 (en)
ES (5) ES2335232T3 (en)
HU (1) HUE029021T2 (en)
IL (2) IL188094A (en)
MX (2) MX348154B (en)
NZ (1) NZ565138A (en)
PL (4) PL2163562T3 (en)
PT (3) PT1899378E (en)
RU (1) RU2518295C2 (en)
SI (4) SI2163562T1 (en)
WO (1) WO2007002261A2 (en)
ZA (1) ZA200800555B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10611832B2 (en) 2009-05-29 2020-04-07 Xoma (Us) Llc Cardiovascular related uses of IL-1β antibodies and binding fragments thereof

Families Citing this family (70)

* Cited by examiner, † Cited by third party
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DK1899378T3 (en) 2005-06-21 2010-02-01 Xoma Technology Ltd IL-1 beta-binding antibodies and fragments thereof
TR201802449T4 (en) 2005-10-26 2018-03-21 Novartis Ag Treatment of familial mediterranean fever with anti-1beta antibodies.
US20080118496A1 (en) * 2006-04-10 2008-05-22 Medich John R Uses and compositions for treatment of juvenile rheumatoid arthritis
EP3669878A1 (en) 2006-08-10 2020-06-24 Roy C. Levitt Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors
CA2673592C (en) * 2006-12-20 2014-03-25 Xoma Technology Ltd. Methods for the treatment of il-1.beta. related diseases
CA2839162A1 (en) * 2006-12-20 2008-06-26 Xoma Technology Ltd. Methods for the treatment of il-1-.beta. related diseases
EP2468301A1 (en) * 2007-05-29 2012-06-27 Novartis AG New indications for anti-IL-1-beta therapy
EP2171451A4 (en) 2007-06-11 2011-12-07 Abbott Biotech Ltd Methods for treating juvenile idiopathic arthritis
US8637029B2 (en) * 2007-12-20 2014-01-28 Xoma Technology Ltd. Methods for the treatment of gout
ES2398693T3 (en) * 2008-06-06 2013-03-21 Xoma Technology Ltd. Methods for the treatment of rheumatoid arthritis
EP2341936A4 (en) * 2008-09-05 2012-07-25 Xoma Technology Ltd METHODS FOR THE TREATMENT OR PREVENTION OF IL-1ß RELATED DISEASES
EP2362767B1 (en) * 2008-10-29 2017-12-06 Ablynx N.V. Formulations of single domain antigen binding molecules
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US8389474B1 (en) * 2009-07-14 2013-03-05 Alan Anson Wanderer Rationale for IL-1 β targeted therapy to improve harvested organ viability, allograft tolerance, replant success and for conditions characterized by reduced or absent arterial perfusion
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JP5918275B2 (en) 2011-02-08 2016-05-18 アッヴィ・インコーポレイテッド Treatment of osteoarthritis and pain
JP2014519480A (en) 2011-04-15 2014-08-14 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Anti-IL-1R1 inhibitor used in cancer
WO2012162754A1 (en) 2011-06-03 2012-12-06 Mesoblast, Inc Methods of treating or preventing neurological diseases
WO2013007763A1 (en) 2011-07-12 2013-01-17 Universität Zürich MODULATORS OF THE NLRP3 INFLAMMASOME IL-1ß PATHWAY FOR THE PREVENTION AND TREATMENT OF ACNE
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DE102011083595A1 (en) * 2011-09-28 2013-03-28 Bayer Pharma AG Inhibition of the effect of interleukin 1 beta for the treatment of endometriosis
BR112014007253A2 (en) 2011-09-30 2017-03-28 Novartis Ag use of antibodies that bind to il-1beta
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JP6225197B2 (en) * 2013-02-15 2017-11-01 アール−ファーム・ジョイント・ストック・カンパニーＲ−Ｐｈａｒｍ，Ｊｓｃ IL-1β inhibitor composition and use thereof
JP2016520615A (en) * 2013-05-31 2016-07-14 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Methods of using IL-1 antagonists for treating Alzheimer's disease
CN104341501B (en) * 2013-07-29 2019-08-30 上海睿智化学研究有限公司 Anti-il-i-beta Humanized monoclonal antibodies and its preparation method and application
BR112016013347B1 (en) * 2013-12-26 2023-12-12 Mitsubishi Tanabe Pharma Corporation ANTI-IL-33 NEUTRALIZING HUMAN MONOCLONAL ANTIBODY, PHARMACEUTICAL COMPOSITION, INHIBITOR OF CYTOKINE EXPRESSION, NUCLEIC ACID MOLECULE, VECTOR, TRANSGENIC BACTERIAL CELL, METHOD OF PRODUCTION AND USE THEREOF
US12180264B2 (en) 2014-03-24 2024-12-31 R-Pharm Overseas, Inc. IL1-R1 derived inhibitor of IL-1β and use thereof
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US20090214545A1 (en) 2009-08-27
CY1113153T1 (en) 2016-04-13
DK2314623T3 (en) 2012-09-17
US20100055110A1 (en) 2010-03-04
PL2163562T3 (en) 2014-03-31
US20090214568A1 (en) 2009-08-27
PT1899378E (en) 2010-01-26
US20090060918A1 (en) 2009-03-05
PL2314623T3 (en) 2012-11-30
HK1157351A1 (en) 2012-06-29
DK1899378T3 (en) 2010-02-01
ZA200800555B (en) 2009-09-30
ES2827247T3 (en) 2021-05-20
US20140004125A1 (en) 2014-01-02
SI2163562T1 (en) 2014-01-31
KR20140139618A (en) 2014-12-05
US20120014967A1 (en) 2012-01-19
EP2322552B1 (en) 2016-02-10
US9206252B2 (en) 2015-12-08
MX2007016032A (en) 2008-03-10
PL2322552T3 (en) 2016-08-31
CN102775493A (en) 2012-11-14
CN101228188A (en) 2008-07-23
EP2314623B1 (en) 2012-07-04
SI1899378T1 (en) 2010-02-26
KR20130076901A (en) 2013-07-08
KR101366450B1 (en) 2014-03-14
CA2612760A1 (en) 2007-01-04
PT2163562E (en) 2013-12-19
AU2006262179A1 (en) 2007-01-04
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AU2006262179B2 (en) 2011-05-12
US7531166B2 (en) 2009-05-12
US20080044414A1 (en) 2008-02-21
CA2873914A1 (en) 2007-01-04
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DE602006010072D1 (en) 2009-12-10
EP2163562A2 (en) 2010-03-17
RU2008102135A (en) 2009-07-27
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HK1158218A1 (en) 2012-07-13
IL188094A (en) 2011-01-31
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