WO2007006033A3 - Microfluidic separators for multiphase fluid-flow based on membranes - Google Patents

Microfluidic separators for multiphase fluid-flow based on membranes Download PDF

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Publication number
WO2007006033A3
WO2007006033A3 PCT/US2006/026464 US2006026464W WO2007006033A3 WO 2007006033 A3 WO2007006033 A3 WO 2007006033A3 US 2006026464 W US2006026464 W US 2006026464W WO 2007006033 A3 WO2007006033 A3 WO 2007006033A3
Authority
WO
WIPO (PCT)
Prior art keywords
membranes
flow based
multiphase fluid
fluid
separators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/026464
Other languages
French (fr)
Other versions
WO2007006033A2 (en
Inventor
Klavs F Jensen
Jason G Kralj
Hemantkumar Ramesh Sahoo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Priority to US11/988,326 priority Critical patent/US20090282978A1/en
Priority to EP06786574A priority patent/EP1917097A2/en
Publication of WO2007006033A2 publication Critical patent/WO2007006033A2/en
Anticipated expiration legal-status Critical
Publication of WO2007006033A3 publication Critical patent/WO2007006033A3/en
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/08—Flat membrane modules
    • B01D63/087—Single membrane modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/08—Flat membrane modules
    • B01D63/088—Microfluidic devices comprising semi-permeable flat membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

One aspect of the invention relates to fluid-phase separators and devices containing them. Another aspect of the invention relates to the use of said fluid-phase separators and devices containing them for separating individual phases from gas-liquid and liquid-liquid two-phase mixtures for a range of flow regimes. The present invention also relates to methods of making said fluid-phase separators and devices containing them.
PCT/US2006/026464 2005-07-05 2006-07-05 Microfluidic separators for multiphase fluid-flow based on membranes Ceased WO2007006033A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US11/988,326 US20090282978A1 (en) 2005-07-05 2006-07-05 Microfluidic Separators for Multiphase Fluid-Flow Based On Membranes
EP06786574A EP1917097A2 (en) 2005-07-05 2006-07-05 Microfluidic separators for multiphase fluid-flow based on membranes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69661305P 2005-07-05 2005-07-05
US60/696,613 2005-07-05

Publications (2)

Publication Number Publication Date
WO2007006033A2 WO2007006033A2 (en) 2007-01-11
WO2007006033A3 true WO2007006033A3 (en) 2008-05-02

Family

ID=37605235

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/026464 Ceased WO2007006033A2 (en) 2005-07-05 2006-07-05 Microfluidic separators for multiphase fluid-flow based on membranes

Country Status (3)

Country Link
US (1) US20090282978A1 (en)
EP (1) EP1917097A2 (en)
WO (1) WO2007006033A2 (en)

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CN102357352B (en) 2004-01-26 2015-08-12 哈佛大学 Fluid delivery system and method
US9409252B2 (en) 2010-03-26 2016-08-09 Waters Technologies Corporation Chromatography apparatus having diffusion-bonded and surface-modified components
DE102010018981B3 (en) 2010-05-03 2011-07-21 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 80686 Process for the plasma-assisted treatment of inner surfaces of a hollow body, fluid separator and its use
FR2960452B1 (en) 2010-05-31 2017-01-06 Corning Inc DEVICE FORMING MICROREACTOR EQUIPPED WITH MEANS FOR COLLECTING AND DRAINING IN SITU GAS FORMED AND METHOD THEREOF
FR2966057B1 (en) * 2010-10-15 2012-11-30 Rhodia Operations METHOD AND DEVICE FOR CHEMICAL TRANSFORMATION BY BALANCED REACTION BETWEEN REAGENTS, AND METHOD FOR DETERMINING AT LEAST ONE PARAMETER OF SUCH A CHEMICAL PROCESSING
EP2882509B1 (en) 2012-08-10 2020-05-27 Massachusetts Institute of Technology Pressure control in fluidic systems
US9588027B2 (en) 2013-03-13 2017-03-07 UPKO Diagnostics, LLC Mixing of fluids in fluidic systems
GB2526999B (en) 2013-03-14 2020-02-19 Univ Leland Stanford Junior Capillary barriers for staged loading of microfluidic devices
FR3016441B1 (en) * 2014-01-14 2017-06-16 Centre Nat De La Rech Scient (Cnrs) MICROFLUIDIC DEVICE FOR THE ANALYSIS OF FLOW POLLUTANTS
US20160349188A1 (en) * 2014-01-14 2016-12-01 Center National De La Recherche Scientifique (Cnrs) Microfluidic device for analysis of flowing pollutants
KR102558427B1 (en) 2014-08-15 2023-07-24 메사추세츠 인스티튜트 오브 테크놀로지 Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients
EP3229963B1 (en) 2014-12-12 2023-08-23 Opko Diagnostics, LLC Fluidic systems comprising an incubation channel, including fluidic systems formed by molding, and method
US10330218B2 (en) * 2015-02-09 2019-06-25 President And Fellows Of Harvard College Fluid-based gating mechanism with tunable multiphase selectivity and antifouling behavior
CN109415722A (en) 2016-01-29 2019-03-01 普瑞珍生物系统公司 Isotachophoresis for nucleic acid purification
EP3452220A4 (en) 2016-05-02 2020-01-01 Massachusetts Institute of Technology RECONFIGURABLE MULTI-STAGE CHEMICAL SYNTHESIS SYSTEM AND RELATED COMPONENTS AND METHODS
DE102016108258A1 (en) 2016-05-03 2017-11-09 Plan Optik Ag Phase separation chamber and method for separation of two phases
JP7577292B2 (en) 2017-02-17 2024-11-05 マサチューセッツ インスティテュート オブ テクノロジー Systems and methods for the manufacture of tablets, including pharmaceutical tablets
WO2018200236A1 (en) 2017-04-26 2018-11-01 Massachusetts Institute Of Technology Reconfigurable chemical synthesis systems and methods
AU2018312570B2 (en) 2017-08-02 2024-01-11 Purigen Biosystems, Inc. Systems, devices, and methods for isotachophoresis
US10987671B2 (en) 2019-04-05 2021-04-27 Zaiput Flow Technologies LLC Reservoir-based management of volumetric flow rate in fluidic systems
WO2023244646A1 (en) 2022-06-15 2023-12-21 Zaiput Flow Technologies LLC Systems and methods for separation of chemical species, such as cannabinoids, using multiple liquid phases

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US6309550B1 (en) * 1994-06-22 2001-10-30 Fls Miljo A/S Mass transfer method and apparatus

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US5932100A (en) * 1995-06-16 1999-08-03 University Of Washington Microfabricated differential extraction device and method
US6274089B1 (en) * 1998-06-08 2001-08-14 Caliper Technologies Corp. Microfluidic devices, systems and methods for performing integrated reactions and separations
GB9822185D0 (en) * 1998-10-13 1998-12-02 Zeneca Ltd Device
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Patent Citations (1)

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Non-Patent Citations (2)

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Also Published As

Publication number Publication date
EP1917097A2 (en) 2008-05-07
WO2007006033A2 (en) 2007-01-11
US20090282978A1 (en) 2009-11-19

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